A dynamic pharmacophore drives the interaction between psalmotoxin-1 and the putative drug target acid-sensing ion channel 1a

Molecular Pharmacology

Volumn 80, Issue 5, 2011, Pages 796-808

  Saez, Natalie J ^a   Mobli, Mehdi ^a   Bieri, Michael ^b   Chassagnon, Ireǹe R ^a   Malde, Alpeshkumar K ^a   Gamsjaeger, Roland ^c   Mark, Alan E ^a   Gooley, Paul R ^b   Rash, Lachlan D ^a   King, Glenn F ^a  

^a UNIVERSITY OF QUEENSLAND   (Australia)

^b UNIVERSITY OF MELBOURNE   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ANALGESIC AGENT; PSALMOTOXIN 1; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; DRUG BINDING; DRUG MECHANISM; DRUG STRUCTURE; MOLECULAR DYNAMICS; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; RECEPTOR BINDING;

AMINO ACID SEQUENCE; CHROMATOGRAPHY, AFFINITY; ELECTROPHORESIS, POLYACRYLAMIDE GEL; MODELS, MOLECULAR; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; POINT MUTATION; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SODIUM CHANNELS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SPIDER VENOMS;

EID: 80054777668     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.111.072207     Document Type: Article

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