Inhibition of neuronal degenerin/epithelial Na+ channels by the multiple sclerosis drug 4-aminopyridine

Journal of Biological Chemistry

Volumn 288, Issue 13, 2013, Pages 9418-9427

  Boiko, Nina ^a   Kucher, Volodymyr ^a   Eaton, Benjamin A ^a   Stockand, James D ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-SENSING ION CHANNELS; INFLAMMATORY CONDITIONS; MULTIPLE SCLEROSIS; NEUROTRANSMITTER RELEASE; PERIPHERAL SENSORY; PRE-SYNAPTIC NEURON; SINGLE BINDING SITES; VOLTAGE DEPENDENCE;

PATHOLOGY;

NEURONS;

4 AMINOPYRIDINE; ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ACID SENSING ION CHANNEL 3; BRAIN LIVER INTESTINE SODIUM CHANNEL; DEGENERIN SODIUM CHANNEL; PICOLINE; PYRIDINE; PYRIDINE DERIVATIVE; SODIUM CHANNEL; UNCLASSIFIED DRUG; VOLTAGE GATED POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DROSOPHILA; DRUG ACTIVITY; DRUG EFFECT; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTRICAL POTENTIAL PARAMETERS; EMBRYO; FEMALE; HAMSTER; HIPPOCAMPAL CA1 REGION; IC 50; INTERNEURON; MOUSE; NEWBORN; NONHUMAN; PERIPHERAL NERVE; PHARMACOLOGICAL BLOCKING; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SODIUM CONDUCTANCE; SODIUM CURRENT; STRUCTURE ACTIVITY RELATION; VOLTAGE DEPENDENCE;

4-AMINOPYRIDINE; ANIMALS; ANIMALS, NEWBORN; CHO CELLS; CRICETINAE; DEGENERIN SODIUM CHANNELS; DROSOPHILA MELANOGASTER; EPITHELIAL SODIUM CHANNELS; HIPPOCAMPUS; INHIBITORY CONCENTRATION 50; MICE; MICE, INBRED C57BL; MULTIPLE SCLEROSIS; NEURODEGENERATIVE DISEASES; NEURONS; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84875982679     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.449413     Document Type: Article

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