High concentration electrophysiology-based fragment screen: Discovery of novel acid-sensing ion channel 3 (ASIC3) inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 9, 2011, Pages 2646-2649

  Wolkenberg, Scott E ^a   Zhao, Zhijian ^a   Mulhearn, James J ^a   Harrison, Scott T ^a   Sanders, John M ^a   Cato, Matthew J ^a   Jovanovska, Aneta ^a   Panigel, Jacqueline ^a   Cook, Sean P ^a   Henze, Darrell A ^a   Kane, Stefanie A ^a   Hartman, George D ^a   Barrow, James C ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Acid sensing ion channel 3; Electrophysiology; Fragment screening

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 3; TETRAHYDROISOQUINOLINE DERIVATIVE; UNCLASSIFIED DRUG;

CONFERENCE PAPER; DRUG POTENCY; DRUG SCREENING; ELECTROPHYSIOLOGY; MOLECULAR WEIGHT; NONHUMAN;

ANIMALS; DRUG DISCOVERY; ELECTROPHYSIOLOGICAL PHENOMENA; MOLECULAR STRUCTURE; NERVE TISSUE PROTEINS; PEPTIDE FRAGMENTS; RATS; SMALL MOLECULE LIBRARIES; SODIUM CHANNELS;

RATTUS;

EID: 79955467065     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2010.12.115     Document Type: Conference Paper

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