Binding site and inhibitory mechanism of the mambalgin-2 pain-relieving peptide on acid-sensing ion channel 1a

Journal of Biological Chemistry

Volumn 289, Issue 19, 2014, Pages 13363-13373

  Salinas, Miguel ^a,b,c   Besson, Thomas ^a,b,c   Delettre, Quentin ^a,b   Diochot, Sylvie ^a,b,c   Boulakirba, Sonia ^a,b   Douguet, Dominique ^a,b   Lingueglia, Eric ^a,b,c  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c CNRS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOINFORMATICS; HEALTH; PROTONS;

ACID-SENSING ION CHANNELS; CONFORMATIONAL CHANGE; FUNCTIONAL APPROACH; INHIBITORY EFFECT; INHIBITORY MECHANISM; MOLECULAR MECHANISM; PHARMACOLOGICAL PROFILES; PSYCHIATRIC DISORDERS;

PEPTIDES;

ACID SENSING ION CHANNEL; MAMBALGIN 2; SNAKE VENOM; UNCLASSIFIED DRUG;

ARTICLE; BIOINFORMATICS; CHANNEL GATING; COMPUTER INTERFACE; COMPUTER MODEL; DRUG BINDING SITE; DRUG MECHANISM; IN VIVO STUDY; ION TRANSPORT; MOLECULAR DOCKING; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PH; PRIORITY JOURNAL; PROTEIN CONFORMATION;

ACID-SENSING ION CHANNELS (ASIC); PAIN; PHARMACOLOGY; SODIUM CHANNELS; TOXINS;

ACID SENSING ION CHANNELS; ANALGESICS; ANIMALS; BINDING SITES; ELAPID VENOMS; MOLECULAR DOCKING SIMULATION; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84900389579     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.561076     Document Type: Article

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