Sea anemone peptide with uncommon β-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3) and reveals analgesic activity

Journal of Biological Chemistry

Volumn 288, Issue 32, 2013, Pages 23116-23127

  Osmakov, Dmitry I ^a   Kozlov, Sergey A ^a   Andreev, Yaroslav A ^a   Koshelev, Sergey G ^a   Sanamyan, Nadezhda P ^b   Sanamyan, Karen E ^b   Dyachenko, Igor A ^a   Bondarenko, Dmitry A ^a   Murashev, Arkadii N ^a   Mineev, Konstantin S ^a   Arseniev, Alexander S ^a   Grishin, Eugene V ^a  

^a SHEMYAKIN OVCHINNIKOV INSTITUTE OF BIOORGANIC CHEMISTRY   (Russian Federation)

^b PACIFIC INSTITUTE OF GEOGRAPHY   (Russian Federation)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-SENSING ION CHANNELS; ANALGESIC ACTIVITY; ANALGESIC EFFECT; HAIRPIN STRUCTURES; MECHANISM OF ACTION; PHYSIOLOGICAL FUNCTIONS; SEA ANEMONES; SPATIAL STRUCTURE;

IONS;

PEPTIDES;

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 3; DISULFIDE; PEPTIDE UGR 9 1; PEPTIDE UGR 9 2; PEPTIDE UGR 9 3; PROTEIN PRECURSOR; SEA ANEMONE TOXIN; UNCLASSIFIED DRUG;

ANALGESIC ACTIVITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRAYFISH; CROSS LINKING; DISULFIDE BOND; DRUG CYTOTOXICITY; DRUG ISOLATION; DRUG STRUCTURE; GENE STRUCTURE; IC 50; IN VIVO STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OOCYTE; PEPTIDE ANALYSIS; PRIORITY JOURNAL; SEA ANEMONE; VISCERAL PAIN; XENOPUS LAEVIS;

ACID SENSING ION CHANNELS (ASIC); GENE STRUCTURE; NUCLEAR MAGNETIC RESONANCE; PEPTIDES; PROTEIN CHEMISTRY; PROTEIN PURIFICATION; PROTEIN SEQUENCE; PROTEIN STRUCTURE;

ACID SENSING ION CHANNELS; AMINO ACID SEQUENCE; ANALGESICS; ANIMALS; HUMANS; MALE; MICE; MOLECULAR SEQUENCE DATA; PAIN; PEPTIDES; PROTEIN STRUCTURE, SECONDARY; SEA ANEMONES; XENOPUS LAEVIS;

EID: 84881396530     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.485516     Document Type: Article

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