Nonproton ligand sensing domain is required for paradoxical stimulation of Acid-sensing Ion Channel 3 (ASIC3) channels by amiloride

Journal of Biological Chemistry

Volumn 286, Issue 49, 2011, Pages 42635-42646

  Li, Wei Guang ^a,b   Yu, Ye ^a,b   Huang, Chen ^b   Cao, Hui ^a,b   Xu, Tian Le ^a,b  

^a Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACID-SENSING ION CHANNELS; AMILORIDE; CHANNEL ACTIVATION; COVALENT MODIFICATIONS; EPITHELIAL SODIUM CHANNELS; EXTRACELLULAR; INHIBITION EFFECT; INHIBITORY EFFECT; NEUTRAL PH; NON-PROTON; PAIN SYNDROMES; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATIONSHIPS;

ENZYME ACTIVITY; LIGANDS; PROTONS;

BIOACTIVITY;

2 GUANIDINE 4 METHYLQUINAZOLINE; 5 AMINO GROUP; ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1B; ACID SENSING ION CHANNEL 3; AMILORIDE; FUNCTIONAL GROUP; UNCLASSIFIED DRUG;

ACIDOSIS; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; COVALENT BOND; FEMALE; MOLECULAR RECOGNITION; NONHUMAN; NONPROTON LIGAND SENSING DOMAIN; PAIN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN INTERACTION; RAT; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION;

AMILORIDE; ANIMALS; BEHAVIOR, ANIMAL; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; HYDROGEN-ION CONCENTRATION; LIGANDS; MODELS, CHEMICAL; MUTAGENESIS, SITE-DIRECTED; NERVE TISSUE PROTEINS; PAIN; PROTEIN STRUCTURE, TERTIARY; RATS; SODIUM CHANNEL BLOCKERS; SODIUM CHANNELS;

EID: 82755176257     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.289058     Document Type: Article

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