Highly conserved salt bridge stabilizes rigid signal patch at extracellular loop critical for surface expression of acid-sensing ion channels

Journal of Biological Chemistry

Volumn 287, Issue 18, 2012, Pages 14443-14455

  Yang, Yang ^a,b,e   Yu, Ye ^b,e   Cheng, Jin ^b,e   Liu, Yan ^b,e   Liu, Di Shi ^b,e   Wang, Jin ^e   Zhu, Michael X ^c,d   Wang, Rui ^a   Xu, Tian Le ^b,e,f  

^a LANZHOU UNIVERSITY   (China)

^b Shanghai Jiao Tong University Affiliated Sixth People s Hospital   (China)

^c SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^d UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

^e SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^f NONE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CELL MEMBRANES; CELL SIGNALING; ELECTROPHYSIOLOGY; MOLECULAR DYNAMICS; MUTAGENESIS;

ACID-SENSING ION CHANNELS; CELL SURFACE EXPRESSION; ELECTROPHYSIOLOGICAL RECORDINGS; FUNCTIONAL EXPRESSION; MOLECULAR DYNAMICS SIMULATIONS; NON-SELECTIVE CATION CHANNELS; PATHOLOGICAL CONDITIONS; STRUCTURAL REQUIREMENTS;

APPLICATION SPECIFIC INTEGRATED CIRCUITS;

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ACID SENSING ION CHANNEL 3; ARGININE; ASPARTIC ACID; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CELL SURFACE; CONTROLLED STUDY; ELECTROPHYSIOLOGY; FEMALE; MOLECULAR DYNAMICS; MOLECULAR STABILITY; MUTAGENESIS; MUTATION; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; RIGID SIGNAL PATCH; SALT BRIDGE;

RATTUS;

EID: 84860352363     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.334250     Document Type: Article

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