Synergistic activation of ENaC by three membrane-bound channel-activating serine proteases (mCAP1, mCAP2, and mCAP3) and serum- and glucocorticoid-regulated kinase (Sgk1) in Xenopus oocytes

Journal of General Physiology

Volumn 120, Issue 2, 2002, Pages 191-201

  Vuagniaux, Grégoire ^a   Vallet, Véronique ^a   Jaeger, Nicole Fowler ^a   Hummler, Edith ^a   Rossier, Bernard C ^a,b  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b University of Lausanne Departement de Pharmacologie et de Toxicologie   (Switzerland)

Author keywords

Aldosterone; Amiloride; Epithelial sodium channel; NEDD4; Serum glucocorticoid regulated kinase 1 (Sgk1)

Indexed keywords

MONOCLONAL ANTIBODY I 125; PROTEIN; PROTEIN KINASE; PROTEIN MCAP1; PROTEIN MCAP2; PROTEIN MCAP3; SERINE PROTEINASE; SERUM AND GLUCOCORTICOID REGULATED KINASE 1; SODIUM CHANNEL; UNCLASSIFIED DRUG; EPITHELIAL SODIUM CHANNEL; IMMEDIATE EARLY PROTEIN; MEMBRANE PROTEIN; NUCLEAR PROTEIN; PROTEIN SERINE THREONINE KINASE; PRSS8 PROTEIN, MOUSE; SERINE PROTEINASE INHIBITOR; SERPINB9 PROTEIN, MOUSE; SGK PROTEIN; TMPRSS4 PROTEIN, MOUSE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; ENZYME ANALYSIS; EPITHELIUM CELL; KIDNEY COLLECTING TUBULE; KIDNEY CORTEX; NONHUMAN; OOCYTE; PROBABILITY; PROTEIN EXPRESSION; XENOPUS; ANIMAL; CELL LINE; CHEMISTRY; DRUG EFFECT; DRUG INTERACTION; DRUG POTENTIATION; ISOLATION AND PURIFICATION; METABOLISM; MOUSE; PHYSIOLOGY; RAT;

ANIMAL; CELL LINE; DRUG INTERACTIONS; DRUG SYNERGISM; MEMBRANE PROTEINS; MICE; OOCYTES; PROTEIN-SERINE-THREONINE KINASES; RATS; SERINE ENDOPEPTIDASES; SODIUM CHANNELS; SUPPORT, NON-U.S. GOV'T; XENOPUS; ANIMALS; EPITHELIAL SODIUM CHANNEL; IMMEDIATE-EARLY PROTEINS; NUCLEAR PROTEINS; SERPINS;

EID: 0036023427     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.20028598     Document Type: Article

References (40)

1. Activation of epithelial sodium channels by prostasin in Xenopus oocytes
2. The serum and glucocorticoid kinase sgk increases the abundance of epithelial sodium channels in the plasma membrane of Xenopus oocytes
3. Corticosteroid-dependent sodium transport in a novel immortalized mouse collecting duct principal cell line
4. Na+ transport in normal and CF human bronchial epithelial cells is inhibited by BAY 39-9437
5. The amiloride-sensitive epithelial sodium channel is made of three homologous subunits
6. Epithelial sodium channel regulated by aldosterone-induced protein sgk
7. Protease modulation of the activity of the epithelial sodium channel expressed in Xenopus oocytes
8. Residue 225 determines the Na(+)-induced allosteric regulation of catalytic activity in serine proteases
9. Phosphorylation of Nedd4-2 by Sgk1 I regulates epithelial Na+ channel cell surface expression
10. Regulation of the epithelial sodium channel by serine proteases in human airways
11. The heterotetrameric architecture of the epithelial sodium channel (ENaC)
12. Quantitation of cell surface expressed epithelial sodium channel: A novel approach to determine the channel open probability in a whole cell
13. Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach
14. Type II transmembrane serine proteases. Insights into an emerging class of cell surface proteolytic enzymes
15. Cloning and chromosomal mapping of a gene isolated from thymic stromal cells encoding a new mouse type II membrane serine protease, epithin, containing four LDL receptor modules and two CUB domains
16. Molecular cloning of cDNA for matriptase, a matrix-degrading serine protease with trypsin-like activity
17. Aldosterone induces rapid apical translocation of ENaC in early portion of renal collecting system: Possible role of SGK
18. Aldosterone-mediated regulation of ENaC alpha, beta, and gamma subunit proteins in rat kidney
19. sgk is an aldosterone-induced kinase in the renal collecting duct - Effects on epithelial Na+ channels
20. Regulation of prostasin by aldosterone in the kidney
21. Regulation of Na channels of the rat cortical collecting tubule by aldosterone
22. Conductance and gating of epithelial Na channels from rat cortical collecting tubule. Effects of luminal Na and Li
23. Gating of Na channels in the rat cortical collecting tubule - Effects of voltage and membrane stretch
24. Structural basis of substrate specificity in the serine proteases
25. Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold
26. Transcriptome of a mouse kidney cortical collecting duct cell line: Effects of aldosterone and vasopressin
27. A conditional allele at the mouse channel activating protease 1 (Prss8) gene locus
28. On the size of the active site in proteases. I. Papain
29. SGK modulates Nedd4-2-mediated inhibition of ENaC
30. Reverse biochemistry: Use of macromolecular protease inhibitors to dissect complex biological processes and identify a membrane-type serine protease in epithelial cancer and normal tissue
31. An epithelial serine protease activates the amiloride-sensitive sodium channel
32. Epithelial sodium channel regulatory proteins identified by functional expression cloning
33. Cell surface expression of the channel activating protease xCAP1 is required for activation of ENaC in the Xenopus oocyte
34. Control of Na+ transport by aldosterone
35. Activation of the amiloride-sensitive epithelial sodium channel by the serine protease mCAP1 expressed in a mouse cortical collecting duct cell line
36. A novel transmembrane serine protease (TMPRSS3) overexpressed in pancreatic cancer
37. Characterization of sgk, a novel member of the serine/threonine protein kinase gene family which is transcriptionally induced by glucocorticoids and serum
38. Deficient salt retention in the SGK1 knockout mouse
39. Molecular cloning, tissue-specific expression, and cellular localization of human prostasin mRNA
40. Apical sorting of bovine enteropeptidase does not involve detergent-resistant association with sphingolipid-cholesterol rafts