Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 32, 2012, Pages 13124-13129

  Delaunay, Anne ^a,b,c   Gasull, Xavier ^a,d,e   Salinas, Miguel ^a,b,c   Noed̈l, Jacques ^a,b,c   Friend, Valérie ^a,b,c   Lingueglia, Eric ^a,b,c   Deval, Emmanuel ^a,b,c  

^a CNRS   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c Laboratory of Excellence Ion Channel Science and Therapeutics   (France)

^d UNIVERSITY OF BARCELONA   (Spain)

^e INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Nociception; Sodium channels

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 3; ARGININE; UNCLASSIFIED DRUG;

ACIDIFICATION; ACIDITY; ALKALINITY; ALKALINIZATION; ANIMAL CELL; ARTICLE; CELL PH; CLONE; CONTROLLED STUDY; EXTRACELLULAR FLUID; HUMAN; NERVE CELL MEMBRANE POTENTIAL; NONHUMAN; PH; PRIORITY JOURNAL; PROTEIN FUNCTION; SENSITIZATION; SENSORY NERVE CELL;

ANIMALS; CERCOPITHECUS AETHIOPS; COS CELLS; EXTRACELLULAR FLUID; FLUORESCENCE; HUMANS; HYDROGEN-ION CONCENTRATION; MEMBRANE POTENTIALS; NEURONS; PATCH-CLAMP TECHNIQUES; SODIUM CHANNELS;

RODENTIA;

EID: 84864656610     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1120350109     Document Type: Article

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