Cannabinoids Inhibit Acid-Sensing Ion Channel Currents in Rat Dorsal Root Ganglion Neurons

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Liu, Yu Qiang ^a   Qiu, Fang ^a   Qiu, Chun Yu ^a   Cai, Qi ^a   Zou, Pengcheng ^b   Wu, Heming ^b   Hu, Wang Ping ^a  

^a HUBEI UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b Hubei Furen Pharmaceutical Corporation Ltd Shinanqiao   (China)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N MORPHOLINO 1H PYRAZOLE 3 CARBOXAMIDE; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; ACETIC ACID; ACID SENSING ION CHANNEL; CYCLIC AMP; FORSKOLIN;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHANNEL GATING; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; DOSE RESPONSE; DRUG POTENTIATION; DRUG SELECTIVITY; EVOKED RESPONSE; MALE; MONOTHERAPY; NERVE EXCITABILITY; NERVE POTENTIAL; NOCICEPTION; NOCICEPTIVE STIMULATION; NONHUMAN; PHARMACOLOGICAL BLOCKING; RAT; SENSORY NERVE; SPINAL GANGLION;

ACETATES; ACID SENSING ION CHANNELS; ANIMALS; CANNABINOIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; GANGLIA, SPINAL; MALE; NEURONS; PROTONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CANNABINOID; SIGNAL TRANSDUCTION; SYNAPTIC POTENTIALS;

RATTUS;

EID: 84866529319     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0045531     Document Type: Article

References (44)

1. Reeh PW, Steen KH, (1996) Tissue acidosis in nociception and pain. Prog Brain Res 113: 143-151.
2. Wemmie JA, Price MP, Welsh MJ, (2006) Acid-sensing ion channels: advances, questions and therapeutic opportunities. Trends Neurosci 29: 578-586.
3. Millan MJ, (1999) The induction of pain: an integrative review. Prog Neurobiol 57: 1-164.
4. Steen KH, Reeh PW, Anton F, Handwerker HO, (1992) Protons selectively induce lasting excitation and sensitization to mechanical stimulation of nociceptors in rat skin, in vitro. J Neurosci 12: 86-95.
5. Jones NG, Slater R, Cadiou H, McNaughton P, McMahon SB, (2004) Acid-induced pain and its modulation in humans. J Neurosci 24: 10974-10979.
6. Steen KH, Issberner U, Reeh PW, (1995) Pain due to experimental acidosis in human skin: evidence for non-adapting nociceptor excitation. Neurosci Lett 199: 29-32.
7. Krishtal O, (2003) The ASICs: signaling molecules? Modulators? Trends Neurosci 26: 477-483.
8. Benson CJ, Xie J, Wemmie JA, Price MP, Henss JM, et al. (2002) Heteromultimers of DEG/ENaC subunits form H+-gated channels in mouse sensory neurons. Proc Natl Acad Sci U S A 99: 2338-2343.
9. Alvarez de la Rosa D, Zhang P, Shao D, White F, Canessa CM, (2002) Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous system. Proc Natl Acad Sci U S A 99: 2326-2331.
10. Lingueglia E, (2007) Acid-sensing ion channels in sensory perception. J Biol Chem 282: 17325-17329.
11. Deval E, Noel J, Lay N, Alloui A, Diochot S, et al. (2008) ASIC3, a sensor of acidic and primary inflammatory pain. EMBO J 27: 3047-3055.
12. Walder RY, Rasmussen LA, Rainier JD, Light AR, Wemmie JA, et al. (2010) ASIC1 and ASIC3 play different roles in the development of Hyperalgesia after inflammatory muscle injury. J Pain 11: 210-218.
13. Mazzuca M, Heurteaux C, Alloui A, Diochot S, Baron A, et al. (2007) A tarantula peptide against pain via ASIC1a channels and opioid mechanisms. Nat Neurosci 10: 943-945.
14. Dube GR, Elagoz A, Mangat H, (2009) Acid sensing ion channels and acid nociception. Curr Pharm Des 15: 1750-1766.
15. Deval E, Gasull X, Noel J, Salinas M, Baron A, et al. (2010) Acid-sensing ion channels (ASICs): pharmacology and implication in pain. Pharmacol Ther 128: 549-558.
16. Ahluwalia J, Urban L, Capogna M, Bevan S, Nagy I, (2000) Cannabinoid 1 receptors are expressed in nociceptive primary sensory neurons. Neuroscience 100: 685-688.
17. Mitrirattanakul S, Ramakul N, Guerrero AV, Matsuka Y, Ono T, et al. (2006) Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain. Pain 126: 102-114.
18. Hohmann AG, Herkenham M, (1999) Localization of central cannabinoid CB1 receptor messenger RNA in neuronal subpopulations of rat dorsal root ganglia: a double-label in situ hybridization study. Neuroscience 90: 923-931.
19. Tsou K, Lowitz KA, Hohmann AG, Martin WJ, Hathaway CB, et al. (1996) Suppression of noxious stimulus-evoked expression of Fos protein-like immunoreactivity in rat spinal cord by a selective cannabinoid agonist. Neuroscience 70: 791-798.
20. Walker JM, Huang SM, (2002) Cannabinoid analgesia. Pharmacol Ther 95: 127-135.
21. Guindon J, Guijarro A, Piomelli D, Hohmann AG, (2011) Peripheral antinociceptive effects of inhibitors of monoacylglycerol lipase in a rat model of inflammatory pain. Br J Pharmacol 163: 1464-1478.
22. Richardson JD, Kilo S, Hargreaves KM, (1998) Cannabinoids reduce hyperalgesia and inflammation via interaction with peripheral CB1 receptors. Pain 75: 111-119.
23. Fox A, Kesingland A, Gentry C, McNair K, Patel S, et al. (2001) The role of central and peripheral Cannabinoid1 receptors in the antihyperalgesic activity of cannabinoids in a model of neuropathic pain. Pain 92: 91-100.
24. Bridges D, Ahmad K, Rice AS, (2001) The synthetic cannabinoid WIN55,212-2 attenuates hyperalgesia and allodynia in a rat model of neuropathic pain. Br J Pharmacol 133: 586-594.
25. Pertwee RG, (2001) Cannabinoid receptors and pain. Prog Neurobiol 63: 569-611.
26. Ledent C, Valverde O, Cossu G, Petitet F, Aubert JF, et al. (1999) Unresponsiveness to cannabinoids and reduced addictive effects of opiates in CB1 receptor knockout mice. Science 283: 401-404.
27. Zimmer A, Zimmer AM, Hohmann AG, Herkenham M, Bonner TI, (1999) Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci U S A 96: 5780-5785.
28. Agarwal N, Pacher P, Tegeder I, Amaya F, Constantin CE, et al. (2007) Cannabinoids mediate analgesia largely via peripheral type 1 cannabinoid receptors in nociceptors. Nat Neurosci 10: 870-879.
29. Yu XH, Cao CQ, Martino G, Puma C, Morinville A, et al. (2010) A peripherally restricted cannabinoid receptor agonist produces robust anti-nociceptive effects in rodent models of inflammatory and neuropathic pain. Pain 151: 337-344.
30. Calignano A, La Rana G, Giuffrida A, Piomelli D, (1998) Control of pain initiation by endogenous cannabinoids. Nature 394: 277-281.
31. Gavva NR, Tamir R, Qu Y, Klionsky L, Zhang TJ, et al. (2005) AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4] dioxin-6-yl)acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties. J Pharmacol Exp Ther 313: 474-84.
32. Howlett AC (2005) Cannabinoid receptor signaling. Handb Exp Pharmacol: 53-79.
33. Omori M, Yokoyama M, Matsuoka Y, Kobayashi H, Mizobuchi S, et al. (2008) Effects of selective spinal nerve ligation on acetic acid-induced nociceptive responses and ASIC3 immunoreactivity in the rat dorsal root ganglion. Brain Res 1219: 26-31.
34. Cadiou H, Studer M, Jones NG, Smith ES, Ballard A, et al. (2007) Modulation of acid-sensing ion channel activity by nitric oxide. J Neurosci 27: 13251-13260.
35. Smith ES, Cadiou H, McNaughton PA, (2007) Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action. Neuroscience 145: 686-698.
36. Childers SR, Deadwyler SA, (1996) Role of cyclic AMP in the actions of cannabinoid receptors. Biochem Pharmacol 52: 819-827.
37. Chai S, Li M, Lan J, Xiong ZG, Saugstad JA, et al. (2007) A kinase-anchoring protein 150 and calcineurin are involved in regulation of acid-sensing ion channels ASIC1a and ASIC2a. J Biol Chem 282: 22668-22677.
38. Mamet J, Baron A, Lazdunski M, Voilley N, (2002) Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels. J Neurosci 22: 10662-10670.
39. Ugawa S, Ueda T, Ishida Y, Nishigaki M, Shibata Y, et al. (2002) Amiloride-blockable acid-sensing ion channels are leading acid sensors expressed in human nociceptors. J Clin Invest 110: 1185-1190.
40. Clapper JR, Moreno-Sanz G, Russo R, Guijarro A, Vacondio F, et al. (2010) Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism. Nat Neurosci 13: 1265-1270.
41. Talwar R, Potluri VK, (2011) Cannabinoid 1 (CB1) receptor- pharmacology, role in pain and recent developments in emerging CB1 agonists. CNS Neurol Disord Drug Targets 10: 536-544.
42. Pacher P, Batkai S, Kunos G, (2006) The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev 58: 389-462.
43. Hohmann AG, Herkenham M, (1999) Cannabinoid receptors undergo axonal flow in sensory nerves. Neuroscience 92: 1171-1175.
44. Price MP, McIlwrath SL, Xie J, Cheng C, Qiao J, et al. (2001) The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron 32: 1071-1083.