Black mamba venom peptides target acid-sensing ion channels to abolish pain

Nature

Volumn 490, Issue 7421, 2012, Pages 552-555

  Diochot, Sylvie ^a,b,c   Baron, Anne ^a,b,c   Salinas, Miguel ^a,b,c   Douguet, Dominique ^a,b   Scarzello, Sabine ^a,b,f   Dabert Gay, Anne Sophie ^a,b   Debayle, Delphine ^a,b   Friend, Valérie ^a,b,c   Alloui, Abdelkrim ^d,e   Lazdunski, Michel ^a,b   Lingueglia, Eric ^a,b,c  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c Laboratory of Excellence Ion Channel Science and Therapeutics   (France)

^d UNIVERSITÉ CLERMONT AUVERGNE   (France)

^e Inserm U1107 ^*  (France)

^f UNIVERSITY OF NICE SOPHIA ANTIPOLIS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ACID SENSING ION CHANNEL 2A; MAMBALGIN 1; MAMBALGIN 2; MORPHINE; NALOXONE; SNAKE VENOM; UNCLASSIFIED DRUG;

DRUG; INHIBITION; ION; NEUROLOGY; PATHOLOGY; PEPTIDE; RESPIRATORY DISEASE; SNAKE; TOLERANCE; TOXIN; VENOM;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLACK MAMBA; CONTROLLED STUDY; DRUG TOLERANCE; HYPERALGESIA; MALE; MOUSE; NONHUMAN; PAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RESPIRATORY DISTRESS; SNAKE; SPINAL GANGLION; STATIC ELECTRICITY;

ACID SENSING ION CHANNEL BLOCKERS; ACID SENSING ION CHANNELS; ANALGESICS; ANIMALS; DRUG TOLERANCE; ELAPID VENOMS; INJECTIONS, SPINAL; MALE; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MORPHINE; NALOXONE; NOCICEPTORS; OOCYTES; PAIN; PEPTIDES; PROTEIN SUBUNITS; RATS; RESPIRATORY INSUFFICIENCY; XENOPUS LAEVIS;

ANIMALIA; DENDROASPIS POLYLEPIS POLYLEPIS; MUS;

EID: 84867851768     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11494     Document Type: Article

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