Renal tubular NEDD4-2 defciency causes NCC-mediated salt-dependent hypertension

Journal of Clinical Investigation

Volumn 123, Issue 2, 2013, Pages 657-665

  Ronzaud, Caroline ^a   Loffing Cueni, Dominique ^b   Hausel, Pierrette ^a   Debonneville, Anne ^a   Malsure, Sumedha Ram ^a   Fowler Jaeger, Nicole ^a   Boase, Natasha A ^c   Perrier, Romain ^a   Maillard, Marc ^d   Yang, Baoli ^e   Stokes, John B ^e   Koesters, Robert ^f   Kumar, Sharad ^c   Hummler, Edith ^a   Loffing, Johannes ^b   Staub, Olivier ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c CENTRE FOR CANCER BIOLOGY   (Australia)

^d LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

^e UNIVERSITY OF IOWA   (United States)

^f INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; MESSENGER RNA; SODIUM CHLORIDE; SODIUM CHLORIDE COTRANSPORTER; THIAZIDE DIURETIC AGENT; UBIQUITIN PROTEIN LIGASE NEDD4; UBIQUITIN PROTEIN LIGASE NEDD4 2; UNCLASSIFIED DRUG;

ALDOSTERONE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENZYME DEFICIENCY; HIGH SODIUM INTAKE; HYPERCALCIURIA; HYPERTENSION; MOUSE; NONHUMAN; POTASSIUM BALANCE; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RECEPTOR UPREGULATION; SALT SENSITIVE HYPERTENSION; SODIUM BALANCE;

ANIMALS; BLOOD PRESSURE; DISEASE MODELS, ANIMAL; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; EPITHELIAL SODIUM CHANNELS; HUMANS; HYPERTENSION; KIDNEY TUBULES; LIDDLE SYNDROME; MICE; MICE, KNOCKOUT; POTASSIUM; POTASSIUM CHANNELS, INWARDLY RECTIFYING; RECEPTORS, DRUG; SODIUM; SODIUM, DIETARY; SYMPORTERS; UBIQUITIN-PROTEIN LIGASES;

EID: 84873350794     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61110     Document Type: Article

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