Nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: A full in vitro analysis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 96, Issue 13, 1999, Pages 7563-7568

  Warner, Timothy D ^a   Giuliano, Francesco ^a   Vojnovic, Ivana ^a   Bukasa, Antoaneta ^a   Mitchell, Jane A ^b   Vane, John R ^a  

^a ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CELECOXIB; DYFLOS; MONOCLONAL ANTIBODY; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN SYNTHASE; ROFECOXIB; UNCLASSIFIED DRUG;

ARTICLE; CELL LINE; CONTROLLED STUDY; DRUG SELECTIVITY; GASTROINTESTINAL TOXICITY; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLS, CULTURED; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIGESTIVE SYSTEM; DRUG EVALUATION, PRECLINICAL; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MEMBRANE PROTEINS; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES;

EID: 0033594911     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.96.13.7563     Document Type: Article

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