Open probability of the epithelial sodium channel is regulated by intracellular sodium

Journal of Physiology

Volumn 574, Issue 2, 2006, Pages 333-347

  Anantharam, Arun ^a   Tian, Yuan ^a   Palmer, Lawrence G ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BREFELDIN A; SODIUM CHANNEL; AMILORIDE; EPITHELIAL SODIUM CHANNEL; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG; [2 (TRIMETHYLAMMONIUM) ETHYL] METHANE THIOSULFONATE;

ANIMAL CELL; ARTICLE; BETA CHAIN; CELL MEMBRANE; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; ELECTRODE; ENDOCYTOSIS; EPITHELIUM CELL; FEEDBACK SYSTEM; GENE MUTATION; INCUBATION TIME; INHIBITION KINETICS; LIDDLE SYNDROME; MEMBRANE ELECTROPHYSIOLOGY; NONHUMAN; OOCYTE; PATCH CLAMP; PRIORITY JOURNAL; PROBABILITY; PROTEIN EXPRESSION; RAT; SITE DIRECTED MUTAGENESIS; SODIUM CELL LEVEL; SODIUM CURRENT; SODIUM TRANSPORT; VOLTAGE CLAMP; WILD TYPE; XENOPUS; REGULATORY MECHANISM; XENOPUS LAEVIS;

ANIMALS; BREFELDIN A; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROPHYSIOLOGY; EPITHELIAL SODIUM CHANNEL; FEEDBACK, BIOCHEMICAL; FEMALE; GENE EXPRESSION REGULATION; MEMBRANE POTENTIALS; MESYLATES; MUTATION; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN SYNTHESIS INHIBITORS; RATS; SODIUM; SODIUM CHANNELS; XENOPUS LAEVIS;

EID: 33745761352     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2006.109173     Document Type: Article

References (37)

1. Abriel H & Horisberger JD (1999). Feedback inhibition of rat amiloride-sensitive epithelial sodium channels expressed in Xenopus laevis oocytes. J Physiol 516, 31-43.
2. + channel by Nedd4 in Liddle's syndrome. J Clin Invest 103, 667-673.
3. + Am J Physiol Cell Physiol 277, 216-224.
4. + channels. Am J Physiol Cell Physiol 288, C190-C194.
5. + channel is made of 3 homologous subunits. Nature 367, 463-467.
6. + channels. Proc Natl Acad Sci U S A 101, 11886-11890.
7. + J Biol Chem 276, 13744-13749.
8. +. Proc Natl Acad Sci U S A 95, 7169-7173.
9. Firsov D, Schild L, Gautschi I, Merillat AM, Schneeberger E & Rossier BC (1996). Cell surface expression of the epithelial Na channel and a mutant causing Liddle syndrome: A quantitative approach. Proc Natl Acad Sci U S A 93, 15370-15375.
10. Fotia AB, Dinudom A, Shearwin KE, Koch J-P, Korbmacher C, Cook DI & Kumar S (2003). The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J 17, 70-72.
11. Frindt G, Silver RB, Windhager EE & Palmer LG (1993). Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry. Am J Physiol 264, F565-F574.
12. Fyfe GK & Canessa CM (1998). Subunit composition determines the single channel kinetics of the epithelial sodium channel. J Gen Physiol 112, 423-432.
13. Garty H & Palmer LG (1997). Epithelial sodium channels: Function, structure, and regulation. Physiol Rev 77, 359-396.
14. Hansson JH, Nelson-Williams C, Suzuki H, Schild L, Shimkets R, Lu Y, Canessa C, Iwasaki T, Rossier B & Lifton RP (1995). Hypertension caused by a truncated epithelial sodium channel gamma subunit: Genetic heterogeneity of Liddle syndrome. Nature Genet 11, 76-82.
15. Horisberger J-D & Kharoubi-Hess S (2002). Functional differences between α subunit isoforms of the rat Na,K-ATPase expressed in Xenopus oocytes. J Physiol 539, 669-680.
16. Hughey RP, Bruns JB, Kinlough CL & Kleyman TR (2004). Distinct pools of epithelial sodium channels are expressed at the plasma membrane. J Biol Chem 279, 48491-48494.
17. +. J Gen Physiol 111, 825-846.
18. Kellenberger S, Gautschi I, Rossier BC & Schild L (1998). Mutations causing Liddle syndrome reduce sodium-dependent downregulation of the epithelial sodium channel in the Xenopus oocyte expression system. J Clin Invest 101, 2741-2750.
19. Kellenberger S & Schild L (2002). Epithelial sodium channel/ degenerin family of ion channels: A variety of functions for a shared structure. Physiol Rev 82, 735-767.
20. + channel surface expression and proteolytic cleavage. Proc Natl Acad Sci U S A 103, 2805-2808.
21. + channel via the G o guanine nucleotide-binding regulatory protein. Proc Natl Acad Sci U S A 93, 8107-8111.
22. Konstas A-A, Shearwin-Whyatt LM, Fotia AB, Degger B, Riccardi D, Cook DI, Korbmacher C & Kumar S (2002). Regulation of the epithelial sodium channel by N4WBP5A, a novel Nedd4/Nedd4-3-interacting protein. J Biol Chem 277, 29406-29416.
23. Marunaka Y & Eaton DC (1991). Effects of vasopressin and cAMP on single amiloride-blockable Na channels. Am J Physiol 260, 1071-1084.
24. Palmer LG & Frindt G (1986). Amiloride-sensitive Na channels from the apical membrane of the rat cortical collecting tubule. Proc Natl Acad Sci U S A 83, 2767-2770.
25. Rauh R, Dinudom A, Fotia AB, Paulides M, Kumar S, Korbmacher C & Cook DI (2006). Stimulation of the epithelial sodium channel (ENaC) by the serum- and glucocorticoid-inducible kinase (Sgk) involves the PY motifs of the channel but is independent of sodium feedback inhibition. Pflugers Arch 452, 290-299.
26. Schild L, Lu Y, Gautschi I, Schneeberger E, Lifton RP & Rossier BC (1996). Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J 15, 2381-2387.
27. Sheng SH, Li JQ, McNulty KA, Avery D & Kleyman TR (2000). Characterization of the selectivity filter of the epithelial sodium channel. J Biol Chem 275, 8572-8581.
28. Shi HK, Asher C, Chigaev A, Yung Y, Reuveny E, Seger R & Garty H (2002). Interactions of beta and gamma ENaC with Nedd4 can be facilitated by an ERK-mediated phosphorylation. J Biol Chem 277, 13539-13547.
29. Shimkets RA, Lifton RP & Canessa CM (1997). The activity of the epithelial sodium channel is regulated by clathrin-mediated endocytosis. J Biol Chem 272, 25537-25541.
30. Shimkets RA, Warnock DG, Bositis CM, Nelson-Williams C, Hansson JH, Schambelan M, Gill JR, Ulick S, Milora RV, Findling JW, Canessa CM, Rossier BC & Lifton RP (1994). Liddles syndrome: Heritable human hypertension caused by mutations in the beta subunit of the epithelial sodium channel. Cell 79, 407-414.
31. Silver RB, Frindt G, Windhager EE & Palmer LG (1993). Feedback regulation of Na channels in rat CCT. I. Effects of inhibition of Na pump. Am J Physiol 264, F557-F564.
32. + homeostasis and hypertension. Endocrine Rev 23, 258-275.
33. Snyder PM, Bucher DB & Olson DR (2000). Gating induces a conformational change in the outer vestibule of ENaC. J Gen Physiol 116, 781-790.
34. + channel. Cell 83, 969-978.
35. + channel (ENaC) by ubiquitination. EMBO J 16, 6325-6336.
36. +-channel (ENaC) by reducing the rate of channel retrieval. Pflugers Arch 447, 884-894.
37. Weisz OA, Wang JM, Edinger RS, & Johnson JP (2000). Non-coordinate regulation of endogenous epithelial sodium channel (ENaC) subunit expression at the apical membrane of A6 cells in response to various transporting conditions. J Biol Chem 275, 39886-39893.