Structural plasticity and dynamic selectivity of acid-sensing ion channelspider toxin complexes

Nature

Volumn 489, Issue 7416, 2012, Pages 400-405

  Baconguis, Isabelle ^a   Gouaux, Eric ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACID SENSING ION CHANNEL; PSALMOTOXIN; SPIDER VENOM; UNCLASSIFIED DRUG;

CROSS SECTION; CRYSTAL STRUCTURE; HYDROPHOBICITY; ION; PH; PHYSIOLOGY; PLASTICITY; STABILIZATION; TOXIN;

ARTICLE; BINDING AFFINITY; BINDING SITE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; EXTRACELLULAR MATRIX; GEL PERMEATION CHROMATOGRAPHY; HYDROPHOBICITY; MOLECULAR DYNAMICS; NONHUMAN; PH; PLASTICITY; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

ANIMALS; BINDING SITES; CATIONS, MONOVALENT; CESIUM; CHICKENS; CHO CELLS; CRICETINAE; CRYSTALLOGRAPHY, X-RAY; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MODELS, MOLECULAR; NERVE TISSUE PROTEINS; PROTEIN CONFORMATION; PROTEIN SUBUNITS; SEQUENCE DELETION; SODIUM; SODIUM CHANNELS; SPIDER VENOMS; SPIDERS; SUBSTRATE SPECIFICITY;

EID: 84866519244     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11375     Document Type: Article

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