Epithelial sodium channels: Function, structure and regulation

Physiological Reviews

Volumn 77, Issue 2, 1997, Pages 359-396

  Garty, Haim ^a   Palmer, Lawrence G ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ALDOSTERONE; SODIUM CHANNEL; VASOPRESSIN;

AMPHIBIA; APICAL MEMBRANE; ARTICLE; BLADDER; COLON; ELECTROLYTE BALANCE; EPITHELIUM; FLUID BALANCE; KIDNEY; KIDNEY COLLECTING TUBULE; LUNG; MOLECULAR CLONING; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN PURIFICATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; SALIVARY GLAND; SKIN; SODIUM ABSORPTION; SODIUM CONDUCTANCE; SWEAT GLAND; TASTE BUD;

EID: 0030945484     PISSN: 00319333     EISSN: None     Source Type: Journal    
DOI: 10.1152/physrev.1997.77.2.359     Document Type: Article

References (451)

1. + permeability of tight epithelia. J. Gen. Physiol. 85: 555-582, 1985.
2. ADELMAN, J. P. Proteins that interact with the pore-forming subunits of voltage-gated ion channels. Curr. Opin. Neurol. 5: 286-295, 1995.
3. AHMAD, I., C. KORBMACHER, A. S. SEGAL, P. CHEUNG, E. L. BOULPAEP, AND C. J. BARNSTABLE. Mouse cortical collecting duct cells show nonselective cation channel activity and express a gene related to the cGMP-gated rod photoreceptor channel. Proc. Natl. Acad. Sci. USA 89: 10262-10266, 1992.
4. - transport in canine tracheal mucosa. J. Appl. Physiol. 46: 111-119, 1979.
5. ALMEIDA, A. J., AND M. B. BURG. Sodium transport in the rabbit connecting tubule. Am. J. Physiol. 243 (Cell Physiol. 12): C842-C847, 1982.
6. + transport in toad bladder membrane vesicles. Evidence for two electrogenic transporters with different affinities toward pyrazinecarboxamides. J. Biol. Chem. 262: 8566-8573, 1987.
7. + channel by RNA from control versus aldosterone-stimulated tissue. J. Biol. Chem. 267: 16061-16065, 1992.
8. + permeability of toad bladder by two different mechanisms. Proc. Natl. Acad. Sci. USA 85: 7413-7417, 1988.
9. + channels in membrane vesicles from cultured toad bladder cells. Am. J. Physiol 254 (Cell Physiol. 23): C512-C518, 1988.
10. + channel in Xenopus oocytes. Am. J. Physiol. 262 (Gastrointest. Liver Physiol. 25): G244-G248, 1992.
11. + channel subunits. Am. J. Physiol. 271 (Cell Physiol. 40): C605-C611, 1996.
12. + channel activity in Xenopus oocytes. Proc. Natl. Acad. Sci. USA 92: 6092-6096, 1995.
13. AUSIELLO, D. A., AND J. ORLOFF. Regulation of water and electrolyte movement by vasopressin and cyclic nucleotides in kidney. In: Handbook of Experimental Pharmacology, edited by J. W. Kebabian and J. A. Nathanson. New York: Springer-Verlag, 1982, vol. 58, p. 271-303.
14. AUSIELLO, D. A., K. L. SKORECKI, A. S. VERKMAN, AND J. V. BONVENTRE. Vasopressin signaling in kidney cells. Kidney Int. 31: 521-529, 1987.
15. i-3 protein. J. Biol. Chem. 267: 4759-4765, 1992.
16. AVENET, P., AND B. LINDEMANN. Amiloride-blockable sodium currents in isolated taste receptor cells. J. Membr. Biol. 105: 245-255, 1988.
17. AVENET, P., AND B. LINDEMANN. Perspective of taste reception. J. Membr. Biol. 112: 1-8, 1989.
18. + channel protein displays stretch activation in planar lipid bilayers. Am. J. Physiol. 268 (Cell Physiol. 37): C1450-C1459, 1995.
19. + channel. J. Gen. Physiol. 108: 49-65, 1996.
20. + channel (Abstract). Biochem. Soc. Trans. 23: 130S, 1995.
21. BARBRY, P., M. CHAMPE, O. CHASSANDE, S. MUNEMITSU, G. CHAMPIGNY, E. LINGUEGLIA, P. MAES, C. FRELIN, A. TARTAR, A. ULLRICH, AND M. LAZDUNSKI. Human kidney amiloride-binding protein: cDNA structure and functional expression. Proc. Natl. Acad. Sci. USA 87: 7347-7351, 1990.
22. + channels. Biochemistry 28: 3744-3749, 1989.
23. + channel. Purification, affinity labeling, and functional reconstitution. Biochemistry 29: 1039-1045, 1990.
24. + channel. Proc. Natl. Acad. Sci. USA 84: 4836-4840, 1987.
25. + channels in kidney membranes. Biochem. Biophys. Res. Commun. 135: 25-32, 1986.
26. BARBRY, P., AND M. LAZDUNSKI. Structure and regulation of the amiloride-sensitive epithelial sodium channel. In: Ion Channels, edited by T. Narahashi. New York: Plenum, 1996, p. 115-167.
27. BASSET, G., C. CRONE, AND G. SAUMON. Fluid absorption by rat lung in situ: pathways for sodium entry in the luminal membrane of alveolar epithelium. J. Physiol. Lond. 384: 325-345, 1987.
28. BASTL, C. P., AND J. P. HAYSLETT. The cellular action of aldosterone in target epithelia. Kidney Int. 42: 250-264, 1992.
29. BENJAMIN, W. B., AND I. SINGER. Aldosterone-induced protein in toad urinary bladder. Science Wash. DC 186: 269-272, 1974.
30. BENOS, D. J. Amiloride: a molecular probe of sodium transport in tissues and cells. Am. J. Physiol. 242 (Cell Physiol. 11): C131-C145, 1982.
31. + channels. J. Membr. Biol. 143: 1-18, 1995.
32. BENOS, D. J., S. CUNNINGHAM, R. R. BAKER, K. B. BEASON, Y. OH, AND P. R. SMITH. Molecular characteristics of amiloride-sensitive sodium channels. Rev. Physiol. Biochem. Pharmacol. 120: 31-113, 1992.
33. BENOS, D. J., B. A. HYDE, AND R. LATORRE. Sodium flux ratio through the amiloride-sensitive pathway of frog skin. J. Gen. Physiol. 81: 667-685, 1983.
34. BENOS, D. J., L. J. MANDEL, AND R. S. BALABAN. On the mechanism of the amiloride-sodium entry site interaction in anuran skin epithelia. J. Gen. Physiol. 73: 307-326, 1979.
35. BENOS, D. J., L. J. MANDEL, AND S. A. SIMON. Cation selectivity and competition at the sodium entry site in frog skin. J. Gen. Physiol. 76: 223-247, 1980.
36. BENOS, D. J., G. SACCOMANI, B. M. BRENNER, AND S. SARIBAN-SOHRABY. Purification and characterization of the amiloride-sensitive sodium channel from A6 cultured cells and bovine renal papilla. Proc. Natl. Acad. Sci. USA 83: 8525-8529, 1986.
37. BENOS, D. J., G. SACCOMANI, AND S. SARIBAN-SOHRABY. The epithelial sodium channel. Subunit number and location of the amiloride binding site. J. Biol. Chem. 262: 10613-10618, 1987.
38. BENOS, D. J., S. A. SIMON, L. J. MANDEL, AND P. M. CALA. Effect of amiloride and some of its analogues on cation transport in isolated frog skin and thin lipid membranes. J. Gen. Physiol. 68: 43-63, 1976.
39. BENTLEY, P. J. Amiloride: a potent inhibitor of sodium transport across the toad bladder. J. Physiol. Lond. 195: 317-333, 1968.
40. BERDIEV, B. K., A. G. PRAT, H. F. CANTIELLO, D. A. AUSIELLO, C. M. FULLER, B. JOVOV, D. J. BENOS, AND I. I. ISMAILOV. Regulation of epithelial sodium channels by short actin filaments. J. Biol. Chem. 271: 17704-17710, 1996.
41. BIBER, U. L. T. Effect of changes in transepithelial transport on the uptake of sodium across the outer surface of frog skin. J. Gen. Physiol. 58: 131-144, 1971.
42. BIEL, M., X. ZONG, M. DISTLER, E. BOSSE, N. KLUGBAUER, M. MURAKAMI, V. FLOCKERZI, AND F. HOFMANN. Another member of the cyclic nucleotide-gated channel family, expressed in testis, kidney, and heart. Proc. Natl. Acad. Sci. USA 91: 3505-3509, 1994.
43. BINDSLEV, N., A. W. CUTHBERT, J. M. EDWARDSON, AND E. SKADHAUGE. Kinetics of amiloride action in the hen coprodaeum in vitro. Pfluegers Arch. 392: 340-346, 1982.
44. BLAZER-YOST, B., AND M. COX. Aldosterone-induced proteins: characterization using lectin-affinity chromatography. Am. J. Physiol. 249 (Cell Physiol. 18): C215-C225, 1985.
45. + transport in toad urinary bladders. Am. J. Physiol 257 (Cell Physiol. 26): C612-C620, 1989.
46. + transport. Am. J. Physiol. 255 (Cell Physiol. 24): C413-C417, 1988.
47. BOTERO-VELEZ, M., J. J. CURTIS, AND D. G. WARNOCK. Liddle's syndrome revisited: a disorder of sodium reabsorption in the distal tubule. N. Engl. J. Med. 330: 178-181, 1994.
48. BOUCHER, R. C., T. CHINET, N. WILLUMSEN, M. R. KNOWLES, AND M. J. STUTTS. Ion transport in normal and CF airway epithelia. Adv. Exp. Med. Biol. 290: 105-115, 1991.
49. + permeability in cystic fibrosis human primary cell cultures. J. Physiol. Lond. 405: 77-103, 1988.
50. BOUCHER, R. C., AND J. T. GATZY. Characteristics of sodium transport by excised rabbit trachea. J. Appl. Physiol. 55: 1877-1883, 1983.
51. + transport in cystic fibrosis respiratory epithelia. Abnormal basal rate and response to adenylate cyclase activation. J. Clin. Invest. 78: 1245-1252, 1986.
52. + channel complex from rat lymphocytes. Am. J. Physiol. 269 (Cell Physiol. 38): C601-C611, 1995.
53. BRANCO, L. G., AND W. A. VARANDA. Toad bladder amiloride-sensitive channels reconstituted into planar lipid bilayers. J Membr. Biol. 127: 121-128, 1992.
54. 2+ entry. J. Clin. Invest. 88: 1502-1510, 1991.
55. + transport by amiloride analogues. Am. J. Physiol. 256 (Cell Physiol. 25): C67-C74, 1989.
56. + channels in rat kidney medulla. Am. J. Physiol 256 (Renal Fluid Electrolyte Physiol. 25): F366-F369, 1989.
57. + channels by β-subunit mutation. Am. J. Physiol. 270 (Cell Physiol. 39): C208-C213, 1996.
58. BUBIEN, J. K., AND D. G. WARNOCK. Amiloride-sensitive sodium conductance in human B lymphoid cells. Am. J. Physiol. 265 (Cell Physiol. 34): C1175-C1183, 1993.
59. + channel subunits in normal and cystic fibrosis airways. Am. J. Physiol. 269 (Cell Physiol. 38): C511-C518, 1995.
60. + channels by triamterenes - underlying mechanisms and molecular basis. Pfluegers Arch. 432: 760-766, 1996.
61. CANESSA, C. M., J.-D. HORISBERGER, AND B. C. ROSSIER. Epithelial sodium channel related to proteins involved in neurodegeneration. Nature Lond. 361: 467-470, 1993.
62. CANESSA, C. M., A.-M. MÉRILLAT, AND B. C. ROSSIER. Membrane topology of the epithelial sodium channel. Am. J. Physiol. 267 (Cell Physiol. 36): C1682-C1690, 1994.
63. + channel is made of three homologous subunits. Nature Lond. 367: 463-467, 1994.
64. + channel regulation. Kidney Int. 48: 970-984, 1995.
65. 1. Biochem. Biophys. Res. Commun. 134: 852-860, 1986.
66. + channel from the epithelial cell line, A6. J. Biol. Chem. 264: 20867-20870, 1989.
67. 2 and lipoxygenase pathways. J. Biol. Chem. 265: 21624-21628, 1990.
68. CAPURRO, C., J. P. BONVALET, B. ESCOUBET, H. GARTY, AND N. FARMAN. Cellular localization and regulation of CHIF in kidney and colon. Am. J. Physiol. 271 (Cell Physiol. 40): C753-C762, 1996.
69. + channels in intestinal epithelia. Am. J. Physiol. 266 (Gastrointest. Liver Physiol. 29): G504-G510, 1994.
70. + permeability by protein kinase C is tissue specific. J. Membr. Biol. 152: 207-215, 1996.
71. + channels from M-1 cortical collecting duct cells. Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol. 40): F861-F870, 1996.
72. CHALFIE, M., M. DRISCOLL, AND M. HUANG. Degenerin similarities. Nature Lond. 361: 504, 1993.
73. CHALFIE, M., AND E. WOLINSKY. The identification and suppression of inherited neurodegeneration in Caenorhabditis elegans. Nature Lond. 345: 410-416, 1990.
74. + channel by steroid hormones. EMBO J. 13: 2177-2181, 1994.
75. CHANG, S. S., S. GRUNDER, A. HANUKOGLU, A. ROSLER, P. M. MATHEW, I. HANUKOGLU, L. SCHILD, Y. LU, R. A. SHIMKETS, C. NELSON-WILLIAMS, B. C. ROSSIER, AND R. P. LIFTON. Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1. Nature Genet. 12: 248-253, 1996.
76. CHASE, H. S., JR. Does calcium couple the apical and basolateral membrane permeabilities in epithelia? Am. J. Physiol. 247 (Renal Fluid Electrolyte Physiol. 16): F869-F876, 1984.
77. CHASE, H. S., JR., AND Q. AL-AWQATI. Calcium reduces the sodium permeability of luminal membrane vesicles from toad bladder. J. Gen. Physiol. 77: 643-665, 1983.
78. CHASE, H. S., JR., AND Q. AL-AWQATI. Regulation of the sodium permeability of the luminal border of toad bladder by intracellular sodium and calcium. J. Gen. Physiol. 77: 693-712, 1981.
79. CHEEK, D., AND J. W. PERRY. A salt wasting syndrome in infancy. Arch. Dis. Child. 33: 252-256, 1958.
80. + and water transport in rat and rabbit CCD. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F126-F136, 1991.
81. CHINET, T. C., J. M. FULLTON, J. R. YANKASKAS, R. C. BOUCHER, AND M. J. STUTTS. Sodium-permeable channels in the apical membrane of human nasal epithelial cells. Am. J. Physiol. 265 (Cell Physiol. 34): C1050-C1060, 1993.
82. + conducting ion channels in the kidney. Am. J. Physiol. 271 (Cell Physiol. 40): C1303-C1315, 1996.
83. + transport across frog skin. Am. J. Physiol. 256 (Cell Physiol. 25): C569-C578, 1989.
84. + transport through a common pathway. Proc. Natl. Acad. Sci. USA 85: 963-967, 1988.
85. CIVAN, M. M., D. RUBENSTEIN, T. MAURO, AND T. G. O'BRIEN. Effects of tumor promoters on sodium ion transport across frog skin. Am. J. Physiol 248 (Cell Physiol. 17): C457-C465, 1985.
86. CLAUSS, W., S. S. ARNASON, B. G. MUNCK, AND E. SKADHAUGE. Aldosterone-induced sodium transport in the lower intestine. Effects of varying NaCl intake. Pfluegers Arch. 401: 354-360, 1984.
87. CLAUSS, W., J. E. DURR, D. GUTH, AND E. SKADHAUGE. Effects of adrenal steroids on Na transport in the lower intestine (Coprodeum) of the hen. J. Membr. Biol. 96: 141-152, 1987.
88. CLAUSS, W., AND E. SKADHAUGE. Modulation of Na and Cl transport by mineralocorticoids. Comp. Biochem. Physiol. A Comp. Physiol. 90: 583-589, 1988.
89. COREY, D. P., AND J. GARCIA-ANOVEROS. Mechanosensation and the DEG/ENaC ion channels. Science Wash. DC 273: 323-324, 1996.
90. COSTANZO, L. S. Comparison of calcium and sodium transport in early and late rat distal tubules: effect of amiloride. Am. J. Physiol. 246 (Renal Fluid Electrolyte Physiol. 15): F937-F945, 1984.
91. + transport in a model renal epithelial cell line. Biochim. Biophys. Acta 1190: 449-456, 1994.
92. CRABBÉ, J. Stimulation of active sodium transport by the isolated toad bladder with aldosterone in vitro. J. Clin. Invest. 40: 2103-2110, 1961.
93. CUTHBERT, A. W. Importance of guanidinium groups for blocking sodium channels in epithelia. Mol. Pharmacol. 12: 945-957, 1976.
94. CUTHBERT, A. W., AND W. K. SHUM. Induction of transporting sites in a sodium transporting epithelium. J. Physiol. Lond. 260: 223-235, 1976.
95. DAS, S., M. GAREPAPAGHI, AND L. G. PALMER. Stimulation by cGMP of apical Na channels and cation channels in toad urinary bladder. Am. J. Physiol 260 (Cell Physiol. 29): C234-C241, 1991.
96. DELONG, J., AND M. M. CIVAN. Apical sodium entry in split frog skin: current-voltage relationship. J. Membr. Biol. 82: 25-40, 1984.
97. DENAULT, D., E. RUSVAI, W. R. CHEN, G. FEJES-TOTH, AND A. NARAY-FEJES-TOTH. Aldosterone-induced proteins and mRNAs in cortical collecting duct (CCD) cells (Abstract). J. Am. Soc. Nephrol. 4: 437, 1993.
98. DIEZI, J., P. MICHOVD, J. ACEVER, AND G. GIEBISCH. Micropuncture study of electrolyte transport across papillary collecting duct of the rat. Am. J. Physiol. 222: 623-634, 1973.
99. DILLON, M. J., J. V. LEONARD, J. M. BUCKLER, D. OGILVIE, D. LILLYSTONE, J. W. HONOUR, AND C. H. SHACKLETON. Pseudohypoaldosteronism. Arch. Dis. Child. 55: 427-434, 1980.
100. DJOUADI, F., A. WIJKHUISEN, AND J. BASTIN. Coordinate development of oxidative enzymes and Na-K-ATPase in thick ascending limb: role of corticosteroids. Am. J. Physiol. 263 (Renal Fluid Electrolyte Physiol. 32): F237-F242, 1992.
101. DRISCOLL, M., AND M. CHALFIE. The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration. Nature Lond. 349: 588-593, 1991.
102. DRISCOLL, M., AND M. CHALFIE. Developmental and abnormal cell death in C. elegans. Trends Neurosci. 15: 15-19, 1992.
103. DUC, C., N. FARMAN, C. CANESSA, J.-P. BONVALET, AND B. ROSSIER. Cell-specific expression of epithelial sodium channel α, β and γ subunits in aldosterone-responsive epithelia from the rat: localization by in situ hybridization and immunocytochemistry. J. Cell Biol. 127: 1907-1921, 1994.
104. EATON, D. C. Intracellular sodium ion activity and sodium transport in rabbit urinary bladder. J. Physiol. Lond. 316: 527-544, 1981.
105. EATON, D. C., A. BECCHETTI, H. P. MA, AND B. N. LING. Renal sodium channels: regulation and single channel properties. Kidney Int. 48: 941-949, 1995.
106. EATON, D. C., AND K. L. HAMILTON. The amiloride-blockable sodium channel of epithelial tissue. In: Ion Channels, edited by T. Narahashi. New York: Plenum, 1988, vol. 1, p. 151-182.
107. EATON, D. C., AND Y. MARUNAKA. Ion channel fluctuations: "noise" and single-channel measurements. Curr. Top. Membr. Transp. 37: 61-113, 1990.
108. + transport. In: Membrane Transport Processes, edited by J. F. Hoffman. New York: Raven, 1978, vol. 1, p. 125-140.
109. EDELMAN, I. S., AND D. MARVER. Mediating events in the action of aldosterone. J. Steroid Biochem. 12: 219-224, 1980.
110. + absorption in human rectum in vitro. Am. J. Physiol 269 (Gastrointest. Liver Physiol. 32): G42-G48, 1995.
111. 1 cells. Proc. Natl. Acad. Sci. USA 87: 4635-4639, 1990.
112. + channel density of apical membrane of cultured toad kidney cells. J. Physiol. Lond. 481: 533-542, 1994.
113. ERLIJ, D., AND M. W. SMITH. Sodium uptake by frog skin and its modification by inhibitors of transepithelial transport. J. Physiol. Lond. 228: 221-239, 1973.
114. FARMAN, N., C. R. TALBOT, R. BOUCHER, M. FAY, C. CANESSA, B. C. ROSSIER, AND J. P. BONVALET. Non-coordinated expression of α, β, and γ subunit mRNAs of the epithelial sodium channel along the rat respiratory tract. Am. J. Physiol. 272 (Cell Physiol. 41): C131-C141, 1997.
115. FIMOGNARI, G. M., G. A. PORTER, AND I. S. EDELMAN. The role of the tricarboxylic acid cycle in the action of aldosterone on sodium transport. Biochim. Biophys. Acta 135: 89-99, 1967.
116. + channels in frog lung epithelium: a target for aldosterone action. Pfluegers Arch. 416: 62-67, 1990.
117. FISCHER, H., W. VAN DRIESSCHE, AND W. CLAUSS. Evidence for apical sodium channels in frog lung epithelial cells. Am. J. Physiol. 256 (Cell Physiol 25): C764-C771, 1989.
118. + channels in epithelia. Am. J. Physiol. 270 (Cell Physiol. 39): C138-C147, 1996.
119. FORMAN, B. H., AND P. J. MULROW. Effects of corticosteroids on water and electrolyte metabolism. In: Handbook of Physiology. Endocrinology. Adrenal Gland. Washington, DC: Am. Physiol. Soc., 1975, sect. 7, vol. VI, chapt. 13, p. 179-189.
120. FRINDT, G., AND L. G. PALMER. Regulation of Na channels in the rat cortical collecting tubule: effects of cAMP and methyl donors. Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol. 40): F1086-F1092, 1996.
121. FRINDT, G., L. G. PALMER, AND E. E. WINDHAGER. Feedback inhibition of Na channels in rat CCT. IV. Mediation by activation of PKC. Am. J. Physiol. 270 (Renal Fluid Electrolyte Physiol. 39): F371-F376, 1996.
122. FRINDT, G., R. B. SILVER, E. E. WINDHAGER, AND L. G. PALMER. Feedback regulation of Na channels in rat CCT. II. Effects of inhibition of Na entry. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F565-F574, 1993.
123. FRINDT, G., R. B. SILVER, E. E. WINDHAGER, AND L. G. PALMER. Feedback regulation of Na channels in rat CCT. III. Response to cAMP. Am. J. Physiol. 268 (Renal Fluid Electrolyte Physiol 37): F480-F489, 1995.
124. 2+-dependent inhibition of sodium transport in rabbit cortical collecting tubules. Am. J. Physiol. 258 (Renal Fluid Electrolyte Physiol. 27): F568-F582, 1990.
125. FRINGS, S., R. D. PURVES, AND A. D. C. MACKNIGHT. Single-channel recordings from the apical membrane of the toad urinary bladder epithelial cell. J. Membr. Biol. 106: 157-172, 1988.
126. FRINGS, S. M., R. D. PURVES, AND A. D. MACKNIGHT. Ion channels in urinary bladder. Renal. Physiol. Biochem. 13: 112-128, 1990.
127. FRIZZELL, R. A., AND S. G. SCHULTZ. Effect of aldosterone on ion transport by rabbit colon in vitro. J. Membr. Biol. 39: 1-26, 1978.
128. + absorption in rat late distal colon by nanomolar aldosterone added in vitro. Am. J. Physiol. 264 (Endocrinol Metab. 27): E68-E73, 1993.
129. FUCHS, W., E. HVIID-LARSEN, AND B. LINDEMANN. Current-voltage curve of sodium channels and concentration dependence of sodium permeability in frog skin. J. Physiol. Lond. 267: 137-166, 1977.
130. + channel subunit. Am. J. Physiol. 269 (Cell Physiol. 38): C641-C654, 1995.
131. FUNDER, J. W. ALdosterone action. Annu. Rev. Physiol. 55: 115-130, 1993.
132. GARTY, H. Mechanisms of aldosterone action in tight epithelia. J. Membr. Biol. 90: 193-205, 1986.
133. + permeability by aldosterone. Semin. Nephrol. 12: 24-29, 1992.
134. + channels. FASEB J. 8: 522-528, 1994.
135. + channels in toad bladder epithelium. J. Biol. Chem. 261: 7400-7406, 1986.
136. 2+ and other divalent cations. J. Membr. Biol. 95: 151-162, 1987.
137. + channel. Physiol. Rev. 68: 309-373, 1988.
138. + transport across toad urinary bladder vesicles. J. Membr. Biol. 87: 67-75, 1985.
139. GARTY, H., AND I. S. EDELMAN. Amiloride-sensitive trypsinization of apical sodium channels. Analysis of hormonal regulation of sodium transport in toad bladder. J. Gen. Physiol. 81: 785-803, 1983.
140. GARTY, H., I. S. EDELMAN, AND B. LINDEMANN. Metabolic regulation of apical sodium permeability in toad urinary bladder in the presence and absence of aldosterone. J. Membr. Biol. 74: 15-24, 1983.
141. +-depolarized toad urinary bladder, Biochim. Biophys. Acta 771: 89-98, 1984.
142. + permeability of toad urinary bladder. Am. J. Physiol. 266 (Renal Fluid Electrolyte Physiol. 35): F108-F116, 1994.
143. + channel. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F965-F969, 1989.
144. 3H]phenamil, an irreversible amiloride analog, to toad urinary bladder: effects of aldosterone and vasopressin. J. Membr. Biol. 90: 107-113, 1986.
145. GATZY, J. T. Ion transport across excised bullfrog lung. Am. J. Physiol. 228: 1162-1171, 1975.
146. GEERING, K., M. CLAIRE, H.-P. GAEGGELER, AND B. C. ROSSIER. Receptor occupancy vs. induction of Na-K-ATPase and Na transport by aldosterone. Am. J. Physiol. 248 (Cell Physiol 17): C102-C108, 1985.
147. GEHEB, M., R. ALVIS, E. HERCKER, AND M. COX. Mineralocorticoid-specificity of aldosterone induced protein synthesis in giant-toad (Bufo marinus) urinary bladders. Biochem. J. 214: 29-35, 1983.
148. GEHEB, M., E. HERCKER, I. SINGER, AND M. COX. Subcellular localization of aldosterone-induced proteins in toad urinary bladder. Biochim. Biophys. Acta 641: 422-426, 1981.
149. GEHEB, M., G. HUBER, E. HERCKER, AND M. COX. Aldosterone-induced proteins in toad urinary bladders. Identification and characterization using two-dimensional polyacrylamide gel electrophoresis. J. Biol. Chem. 256: 11716-11723, 1981.
150. +-selective channels in the apical membrane of rabbit late proximal tubules (pars recta). Pfluegers Arch. 406: 198-203, 1986.
151. + channel. J. Biol. Chem. 268: 7856-7862, 1993.
152. GOLDSTEIN, O., C. ASHER, E. J. CRAGOE, T. R. KLEYMAN, AND H. GARTY. An aldosterone regulated, chicken intestine protein, with high affinity to amiloride. Comp. Biochem. Physiol. In press.
153. + channel subunits. Am. J. Physiol 272 (Cell Physiol. 41): C270-C277, 1996.
154. GOODMAN, B. E., K.-J. KIM, AND E. D. CRANDALL. Evidence for active sodium transport across alveolar epithelium of isolated rat lung. J. Appl. Physiol. 62: 2460-2466, 1987.
155. GRANITZER, M., I. MOUNTIAN, AND W. VAN DRIESSCHE. Effect of dexamethasone on sodium channel block and densities in A6 cells. Pfluegers Arch. 430: 493-500, 1995.
156. 2 (FMRFamide) directly gates two ion channels in an identified Helix neurone. Pfluegers Arch. 428: 232-240, 1994.
157. GRINSTEIN, S., AND D. ERLIJ. Intracellular calcium and the regulation of sodium transport in the frog skin. Proc. R. Soc. Lond. B Biol. Sci. 202: 353-360, 1978.
158. GRUBB, B. R., A. M. PARADISO, AND R. C. BOUCHER. Anomalies in ion transport in CF mouse tracheal epithelium. Am. J. Physiol. 267 (Cell Physiol. 36): C293-C300, 1994.
159. HACKNEY, C. M., D. N. FURNESS, AND D. J. BENOS. Localization of putative mechanoelectrical transducer channels in cochlear hair cells by immunoelectron microscopy. Scanning Microsc. 5: 741-745, 1991.
160. HACKNEY, C. M., D. N. FURNESS, D. J. BENOS, J. F. WOODLEY, AND J. BARRATT. Putative immunolocalization of the mechanoelectrical transduction channels in mammalian cochlear hair cells. Proc. R. Soc. Lond. B Biol. Sci. 248: 215-221, 1992.
161. HAGIWARA, N., H. TOHDA, Y. DOI, H. O'BRODOVICH, AND Y. MARUNAKA. Effects of insulin and tyrosine kinase inhibitor on ion transport in the alveolar cell of the fetal lung. Biochem. Biophys. Res. Commun. 187: 802-808, 1992.
162. HAMILL, O. P., J. W. LANE, AND D. W. J. MCBRIDE. Amiloride: a molecular probe for mechanosensitive channels. Trends Pharmacol. Sci. 13: 373-376, 1992.
163. HAMILL, O. P., AND D. W. J. MCBRIDE. A supramolecular complex underlying touch sensitivity. Trends Neurosci. 7: 258-261, 1996.
164. HAMILTON, K. L., AND D. C. EATON. Single-channel recordings from amiloride-sensitive epithelial sodium channel. Am. J. Physiol. 249 (Cell Physiol. 18): C200-C207, 1985.
165. HAMILTON, K. L., AND D. C. EATON. Regulation of single sodium channels in renal tissue: a role in sodium homeostasis. Federation Proc. 45: 2713-2717, 1986.
166. HANDLER, J. S., AND J. ORLOFF. Antidiuretic hormone. Annu. Rev. Physiol. 43: 611-624, 1981.
167. HANSSON, J. H., C. NELSON-WILLIAMS, H. SUZUKI, L. SCHILD, R. SHIMKETS, Y. LU, C. CANESSA, T. IWASAKI, B. ROSSIER, AND R. P. LIFTON. Hypertension caused by a truncated epithelial sodium channel gamma subunit: genetic heterogeneity of Liddle syndrome. Nature Genet. 11: 76-82, 1995.
168. HANSSON, J. H., L. SCHILD, Y. LU, T. A. WILSON, I. GAUTSCHI, R. SHIMKETS, C. NELSONWILLIAMS, B. C. ROSSIER, AND R. P. LIFTON. A de novo missense mutation of the beta subunit of the epithelial sodium channel causes hypertension and Liddle syndrome, identifying a proline-rich segment critical for regulation of channel activity. Proc. Natl. Acad. Sci. USA 92: 11495-11499, 1995.
169. HARVEY, B. J. Cross-talk between sodium and potassium channels in tight epithelia. Kidney Int. 48: 1191-1199, 1995.
170. + exchange in the control of intracellular pH and cell membrane conductances in frog skin epithelium. J. Gen. Physiol. 92: 793-810, 1988.
171. + conductances and transport in frog skin epithelium. J. Gen. Physiol. 92: 767-791, 1988.
172. HASKELL, J. F., G. YUE, D. J. BENOS, AND S. MATALON. Upregulation of sodium conductive pathways in alveolar type II cells in sublethal hyperoxia. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L30-L37, 1994.
173. 2 transport in rabbit cortical collecting tubule. J. Clin. Invest. 80: 1561-1570, 1987.
174. i-dependent mechanism. Kidney Int. 47: 1576-1584, 1995.
175. 2+-mobilizing signal mechanism. J. Biol. Chem. 270: 16082-16088, 1995.
176. HECK, G. L., S. MIERSON, AND J. A. DESIMONE. Salt transduction occurs through an amiloride-sensitive transport pathway. Science Wash. DC 223: 403-405, 1984.
177. + channels in cultured A6 epithelia (Abstract). Federation Proc. 45: 516, 1986.
178. HELMAN, S. I., AND L. M. BAXENDALE. Blocker-related changes of channel density. Analysis of a three-state model for apical Na channels of frog skin. J. Gen. Physiol. 95: 647-678, 1990.
179. HELMAN, S. I., T. C. COX, AND W. VAN DRIESSCHE. Hormonal control of apical membrane Na transport in epithelia. Studies with fluctuation analysis. J. Gen. Physiol. 82: 201-220, 1983.
180. HELMAN, S. I., W. NAGEL, AND R. S. FISHER. Ouabain on active transepithelial Na transport by frog skin: studies with microelectrodes. J. Gen. Physiol. 74: 105-127, 1979.
181. 1 renal cells and characterization of the porcine G alpha i-3 gene promoter. J. Biol. Chem. 268: 3964-3975, 1993.
182. HONG, K., AND M. DRISCOLL. A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans. Nature Lond. 367: 470-473, 1994.
183. HORISBERGER, J.-D., AND B. C. ROSSIER. Aldosterone regulation of gene transcription leading to control of ion transport. Hypertension Dallas 19: 221-227, 1992.
184. HUANG, M., AND M. CHALFIE. Gene interactions affecting mechanosensory transduction in Caenorhabditis elegans. Nature Lond. 367: 467-470, 1994.
185. HUMMLER, E., P. BARKER, J. GATZY, F. BEERMANN, C. VERDUMO, A. SCHMIDT, R. BOUCHER, AND B. C. ROSSIER. Early death due to defective neonatal lung liquid clearance in alpha ENaC-deficient mice. Nature Genet. 12: 325-328, 1996.
186. HUNTER, M., J.-D. HORISBERGER, B. A. STANTON, AND G. GIEBISCH. The collecting tubule of Amphiuma. I. Electrophysiological characterization. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol. 22): F263-F272, 1987.
187. HVIID-LARSEN, E. Chloride transport by high resistance heterocellular epithelia. Physiol. Rev. 71: 235-283, 1991.
188. HVIID-LARSEN, E., H. H. USSING, AND K. R. SPRING. Ion transport by mitochondria-rich cells in toad skin. J. Membr. Biol. 99: 25-40, 1987.
189. IMAI, M., AND R. NAKAMURA. Function of distal convoluted and connecting tubules studied by isolated nephron segments. Kidney Int. 22: 465-472, 1982.
190. + channel. J. Biol. Chem. 271: 807-816, 1996.
191. ISMAILOV, I. I., M. S. AWAYDA, B. JOVOV, B. K. BERDIEV, C. M. FULLER, J. R. DEDMAN, M. A. KAETZEL, AND D. J. BENOS. Regulation of epithelial sodium channels by the cystic fibrosis transmembrane conductance regulator. J. Biol. Chem. 271: 4725-4732, 1996.
192. + channels determines apparent channel conductance, ion selectivity and amiloride sensitivity. Biophys. J. 69: 1789-1800, 1995.
193. + channels reconstituted into planar lipid bilayers. J. Gen. Physiol. 106: 445-466, 1995.
194. + channel function. J. Membr. Biol. 149: 123-132, 1996.
195. + channels in Liddle's disease. Am. J. Physiol. 270 (Cell Physiol. 39): C214-C223, 1996.
196. + channels in planar bilayer membranes. J. Biol. Chem. 269: 10235-10241, 1994.
197. + channels in planar lipid bilayers. J. Biol. Chem. 269: 22193-22197, 1994.
198. IWASA, K. H., K. MIZUTA, D. J. LIM, D. J. BENOS, AND M. TACHIBANA. Amiloride-sensitive channels in marginal cells in the stria vascularis of the guinea pig cochlea. Neurosci. Lett. 172: 163-166, 1994.
199. JORGENSEN, F., AND H. OHMORI. Amiloride blocks the mechanoelectrical transduction channel of hair cells of the chick. J. Physiol. Lond. 403: 577-588, 1988.
200. + channel. Pfluegers Arch. 414: 369-372, 1989.
201. JOVOV, B., N. K. WILLS, P. J. DONALDSON, AND S. A. LEWIS. Vectorial secretion of a kallikrein-like enzyme by cultured renal cells. I. General properties. Am. J. Physiol 259 (Cell Physiol. 28): C869-C882, 1990.
202. KAISSLING, B., AND B. A. STANTON. Adaptation of distal tubule and collecting duct to increased sodium delivery. I. Ultrastructure. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F1256-F1268, 1990.
203. KARLSON, K. H., F. CIAMPOLILLO-BATES, D. E. MCCOY, N. L. KIZER, AND B. A. STANTON. Cloning of a cGMP-gated cation channel from mouse kidney inner medullary collecting duct. Biochim. Biophys. Acta 1236: 197-200, 1995.
204. KATZ, U., AND W. VAN DRIESSCHE. Effect of theophylline on the apical sodium and chloride permeabilities of amphibian skin. J. Physiol. Lond. 397: 223-236, 1988.
205. KAUPP, U. B. The cyclic nucleotide-gated channels of vertebrate photoreceptors and olfactory epithelium. Trends Neurosci. 14: 150-157, 1991.
206. KEMENDY, A. E., T. R. KLEYMAN, AND D. C. EATON. Aldosterone alters the open probability of amiloride-blockable sodium channels in A6 epithelia. Am. J. Physiol. 263 (Cell Physiol. 32): C825-C837, 1992.
207. KIEBER-EMMONS, T., C. M. LIN, K. V. PRAMMER, A. VILLALOBOS, F. KOSARI, AND T. R. KLEYMAN. Defining topological similarities among ion transport proteins with anti-amiloride antibodies. Kidney Int. 48: 956-964, 1995.
208. KINNAMON, S. C. Role of apical ion channels in sour taste transduction. CIBA Found. Symp. 179: 201-210, 1993.
209. + transport. Am. J. Physiol. 245 (Renal Fluid Electrolyte Physiol. 14): F726-F734, 1983.
210. KIRK, K. L., AND D. C. DAWSON. Passive cation permeability of turtle colon. Evidence for a negative interaction between intracellular sodium and apical sodium permeability. Pfluegers Arch. 403: 82-89, 1985.
211. KIRSTEN, E., R. KIRSTEN, A. LEAF, AND G. W. G. SHARP. Increased activity of enzymes of the tricarboxylic acid cycle in response to aldosterone in the toad bladder. Pfluegers Arch. 300: 213-225, 1968.
212. KIRSTEN, E., R. KIRSTEN, AND G. W. G. SHARP. Effects of sodium transport stimulating substances on enzyme activities in the toad bladder. Pfluegers Arch. 316: 26-33, 1970.
213. KLAUSNER, R. D., J. G. DONALDSON, AND J. LIPPINCOTT-SCHWARTZ. Brefeldin A: insights into the control of membrane traffic and organelle structure. J. Cell Biol. 116: 1071-1080, 1992.
214. + channels in the amphibian cell line - A6. J. Biol. Chem. 267: 9622-9628, 1992.
215. KLEYMAN, T. R., AND E. J. CRAGOE, JR. Amiloride and its analogs as tools in the study of ion transport. J. Membr. Biol. 105: 1-21, 1988.
216. KLEYMAN, T. R., AND E. J. CRAGOE, JR. Cation transport probes: the amiloride series. Methods Enzymol. 191: 739-755, 1990.
217. + channels in the amphibian cell line A6 is not altered by mineralocorticoids. J. Biol. Chem. 264: 11995-12000, 1989.
218. + channels in A6 cells. Am. J. Physiol. 266 (Renal Fluid Electrolyte Physiol. 35): F506-F511, 1994.
219. + channel antibody raised by an anti-idiotypic route. J. Biol. Chem. 266: 3907-3915, 1991.
220. + channels in toad urinary bladder. Am. J. Physiol. 266 (Cell Physiol 35): C1105-C1111, 1994.
221. KNAUF, H. The isolated salivary duct as a model for electrolyte transport studies. Pfluegers Arch. 333: 82-94, 1972.
222. 3 by rat salivary duct epithelium. Pfluegers Arch. 361: 55-60, 1975.
223. KNOWLES, M., G. MURRAY, J. SHALLAL, F. ASKIN, V. RANGA, J. GATZY, AND R. BOUCHER. Bioelectric properties and ion flow across excised human bronchi. J. Appl. Physiol. 56: 868-877, 1984.
224. KNOWLES, M. R., J. T. GATZY, AND R. C. BOUCHER. Increased bioelectric potential difference across respiratory epithelia in cystic fIbrosis. N. Engl. J. Med. 71: 1410-1417, 1981.
225. KOEFOED-JOHNSEN, V., AND H. H. USSING. On the nature of the frog skin potential. Acta Physiol. Scand. 42: 298-308, 1958.
226. KOEPPEN, B. M. Conductive properties of the rabbit outer medullary collecting duct: outer stripe. Am. J. Physiol. 250 (Renal Fluid Electrolyte Physiol. 19): F70-F76, 1986.
227. + channels in a distal nephron cell line (A6). Am. J. Physiol. 267 (Cell Physiol. 36): C1414-C1425, 1994.
228. o guanine nucleotide-binding regulatory protein. Proc. Natl Acad. Sci. USA 93: 8107-8111, 1996.
229. KORBMACHER, C., T. VOLK, A. S. SEGAL, E. L. BOULPAEP, AND E. FRÖMTER. A calcium-activated and nucleotide-sensitive nonselective cation channel in M-1 mouse cortical collecting duct cells. J. Membr. Biol. 146: 29-45, 1995.
230. KRATTENMACHER, R., AND W. CLAUSS. Electrophysiological analysis of sodium-transport in the colon of the frog (Rana esculenta). Modulation of apical membrane properties by antidiuretic hormone. Pfluegers Arch. 411: 606-612, 1988.
231. KRATTENMACHER, R., H. FISCHER, W. VAN DRIESSCHE, AND W. CLAUSS. Noise analysis of cAMP-stimulated Na current in frog colon. Pfluegers Arch. 412: 568-573, 1988.
232. + conductances in airway epithelial cells. Pfluegers Arch. 431: 578-586, 1996.
233. LAW, P. Y., AND I. S. EDELMAN. Induction of citrate synthase by aldosterone in the rat kidney. J. Membr. Biol. 41: 41-64, 1978.
234. LESTER, D. S., C. ASHER, AND H. GARTY. Characterization of cAMP-induced activation of epithelial sodium channels. Am. J. Physiol. 254 (Cell Physiol. 23): C802-C808, 1988.
235. + absorption. Proc. Natl. Acad. Sci. USA 83: 5345-5348, 1986.
236. LEWIS, S. A., AND C. CLAUSEN. Urinary proteases degrade epithelial sodium channels. J. Membr. Biol. 122: 77-88, 1991.
237. + transport by rabbit urinary bladder, a tight epithelium. J. Membr. Biol. 28: 1-40, 1976.
238. LEWIS, S. A., M. S. IFSHIN, D. D. LOO, AND J. DIAMOND. Studies of sodium channels in rabbit urinary bladder by noise analysis. J. Membr. Biol. 80: 135-151, 1984.
239. LEWIS, S. A., AND N. K. WILLS. Apical membrane permeability and kinetic properties of the sodium pump in rabbit urinary bladder. J. Physiol Lond. 341: 169-184, 1983.
240. LI, J. H.-Y., E. J. CRAGOE, JR., AND B. LINDEMANN. Structure-activity relationship of amiloride analogs as blockers of epithelial Na channels. I. Pyrazine-ring modifications. J. Membr. Biol. 83: 45-56, 1985.
241. LI, J. H.-Y., E. J. CRAGOE, JR., AND B. LINDEMANN. Structure-activity relationship of amiloride analogs as blockers of epithelial Na channels. II. Side-chain modifications. J. Membr. Biol. 95: 171-185, 1987.
242. + transport through amiloride-blockable channels of frog skin epithelium. J. Membr. Biol. 75: 179-192, 1983.
243. LI, J. H.-Y., AND B. LINDEMANN. Competitive blocking of epithelial sodium channels by organic cations: the relationship between macroscopic and microscopic inhibition constants. J. Membr. Biol. 76: 235-251, 1983.
244. LI, J. H.-Y., L. G. PALMER, I. S. EDELMAN, AND B. LINDEMANN. The role of the sodium channel density in the natriferic response of the toad urinary bladder to an antidiuretic hormone. J. Membr. Biol. 64: 79-89, 1982.
245. LI, J. H.-Y., J. S. ZUZACK, AND S. T. KAN. Effects of detergents on sodium transport in toad urinary bladder. J. Pharmacol. Exp. Ther. 238: 415-421, 1986.
246. LI, X.-J., S. BLACKSHAW, AND S. H. SNYDER. Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception. Proc. Natl. Acad. Sci. USA 91: 1814-1818, 1994.
247. LI, X. J., R. H. XU, W. B. GUGGINO, AND S. H. SNYDER. Alternatively spliced forms of the alpha subunit of the epithelial sodium channel: distinct sites for amiloride binding and channel pore. Mol. Pharmacol. 47: 1133-1140, 1995.
248. LIANG, P., AND A. B. PARDEE. Differential display of eukaryotic messenger RNA by means of the polymerase chain reaction. Science Wash. DC 257: 967-971, 1992.
249. LIDDLE, G. W., T. BLEDSOE, AND S. W. COPPAGE. A familial renal disorder simulating primary aldosteronism but with negligible aldosterone secretion. Trans. Assoc. Am. Physicians 76: 199-213, 1963.
250. i-3, directly activates a cation channel in rat renal inner medullary collecting duct cells. J. Clin. Invest. 84: 352-356, 1989.
251. LIGHT, D. B., J. D. CORBIN, AND B. A. STANTON. Amiloride-sensitive cation channel in apical membrane of inner medullary collecting duct. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F278-F286, 1990.
252. LIGHT, D. B., J. D. CORBIN, AND B. A. STANTON. Dual ion-channel regulation by cyclic GMP and cyclic GMP-dependent protein kinase. Nature Lond. 344: 336-339, 1990.
253. LIGHT, D. B., F. V. MCCANN, T. M. KELLER, AND B. A. STANTON. Amiloride-sensitive cation channel in apical membrane of inner medullary collecting duct. Am. J. Physiol. 255 (Renal Fluid Electrolyte Physiol. 24): F278-F286, 1988.
254. LIGHT, D. B., E. M. SCHWIEBERT, K. H. KARLSON, AND B. A. STANTON. Atrial natriuretic peptide inhibits a cation channel in renal inner medullary collecting duct cells. Science Wash. DC 243: 383-385, 1989.
255. LIN, C., T. KIEBER-EMMONS, A. P. VILLALOBOS, M. H. FOSTER, C. WAHLGREN, AND T. R. KLEYMAN. Topology of an amiloride-binding protein. J. Biol. Chem. 269: 2805-2813, 1994.
256. + channel (Abstract). Am. J. Soc. Nephrol. 5: 291, 1994.
257. LINDEMANN, B. Fluctuation analysis of sodium channels in epithelia. Annu. Rev. Physiol. 46: 497-515, 1984.
258. LINDEMANN, B. Sweet and salty: transduction in taste. News Physiol. Sci. 10: 166-170, 1995.
259. LINDEMANN, B. Taste reception. Physiol. Rev. 76: 719-766, 1996.
260. LINDEMANN, B., AND W. VAN DRIESSCHE. Sodium specific membrane channels in frog skin are pores: current fluctuations reveal high turnover. Science Wash. DC 195: 292-294, 1977.
261. + channels in A6 cells, a regulatory role for protein kinase C. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F1094-F1103, 1989.
262. LING, B. N., C. F. HINTON, AND D. C. EATON. Amiloride-sensitive sodium channels in rabbit cortical collecting tubule primary cultures. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F933-F944, 1991.
263. 2 is modulated by protein kinase C. J. Clin. Invest. 90: 1328-1334, 1992.
264. LINGUEGLIA, E., G. CHAMPIGNY, M. LAZDUNSKI, AND P. BARBRY. Cloning of the amiloride-sensitive FMRFamide peptide-gated sodium channel. Nature Lond. 378: 730-733, 1995.
265. LINGUEGLIA, E., S. RENARD, R. WALDMANN, N. VOILLEY, G. CHAMPIGNY, H. PLASS, M. LAZDUNSKI, AND P. BARBRY. Different homologous subunits of the amiloride-sensitive Na channel are differently regulated by aldosterone. J. Biol. Chem. 269: 13736-13739, 1994.
266. + channel. FEBS Lett. 318: 95-99, 1993.
267. LIPTON, P. Effect of changes in osmolarity on sodium transport across isolated toad bladder. Am. J. Physiol. 222: 821-828, 1972.
268. LIU, J. D., B. SCHRANK, AND R. H. WATERSTON. Interaction between a putative mechanosensory membrane channel and a collagen. Science Wash. DC 273: 361-364, 1996.
269. + conductances in rat distal colon. Am. J. Physiol. 267 (Gastrointest. Liver Physiol. 30): G485-G493, 1994.
270. MACROBBIE, E. A. C., AND H. H. USSING. Osmotic behavior of the epithelial cells of frog skin. Acta Physiol. Scand. 53: 348-365, 1961.
271. + conductance when coexpressed in Xenopus oocytes. FEBS Lett. 381: 47-52, 1996.
272. + conductance. Pfluegers Arch. 432: 516-522, 1996.
273. MARUNAKA, Y., AND D. C. EATON. Effects of vasopressin and cAMP on single amiloride-blockable Na channels. Am. J. Physiol. 260 (Cell Physiol. 29): C1071-C1084, 1991.
274. MARUNAKA, Y., N. HAGIWARA, AND H. TOHDA. Insulin activates single amiloride-blockable Na channels in a distal nephron cell line (A6). Am. J. Physiol. 263 (Renal Fluid Electrolyte Physiol. 32): F392-F400, 1992.
275. + channels. Am. J. Physiol. 264 (Lung Cell. Mol. Physiol. 8): L357-L364, 1993.
276. + channels in alveolar epithelial cells. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L1-L22, 1996.
277. + conductance in adult alveolar pneumocytes. Am. J. Physiol 262 (Cell Physiol. 31): C1228-C1238, 1992.
278. MATSUMOTO, P. S., A. OHARA, P. DUCHATELLE, AND D. C. EATON. Tyrosine kinase regulates epithelial sodium transport in A6 cells. Am. J. Physiol. 264 (Cell Physiol. 33): C246-C250, 1993.
279. MATSUSHITA, K., B. P. MCCRAY, R. D. SIGMUND, M. J. WELSH, AND J. B. STOKES. Localization of the epithelial sodium channel subunit mRNAs in adult rat lung by in situ hybridization. Am. J. Physiol. 271 (Lung Cell. Mol. Physiol. 15): L332-L339, 1996.
280. MCCOY, D. E., S. E. GUGGINO, AND B. A. STANTON. The renal cGMP-gated cation channel: its molecular structure and physiological role. Kidney Int. 48: 1125-1133, 1995.
281. MCDONALD, F. J., M. P. PRICE, P. M. SNYDER, AND M. J. WELSH. Cloning and expression of the beta and gamma subunits of the human epithelial sodium channel. Am. J. Physiol. 268 (Cell Physiol. 37): C1157-C1163, 1995.
282. + channel. Am. J. Physiol. 266 (Lung Cell. Mol. Physiol. 10): L728-L734, 1994.
283. + channel to SH3 domains and its association with specific cellular proteins. Biochem. J. 312: 491-497, 1995.
284. + channel (ROMK2) to the inhibitory sulfonylurea compound glibenclamide is enhanced by coexpression with the ATP-binding cassette transporter cystic fibrosis transmembrane regulator. Proc. Natl Acad. Sci. USA 93: 8083-8088, 1996.
285. MINUTH, W. W., M. STRUCK, M. ZWANZIG, AND P. GROSS. Action of aldosterone on citrate synthase in cultured renal collecting duct cells. Renal Physiol. Biochem. 12: 85-95, 1989.
286. MINUTH, W. W., M. ZWANZIG, AND P. GROSS. Action of aldosterone on protein expression in cultured collecting duct cells from neonatal rabbit kidney. Renal Physiol. Biochem. 12: 213-227, 1989.
287. + channel-like immunoreactivity in the luminal membrane of some non-sensory epithelia of the inner ear. Hearing Res. 88: 199-205, 1995.
288. 1 cells and other epithelia. J. Biol. Chem. 263: 19586-19591, 1988.
289. NAGEL, W., AND J. CRABBÉ. Mechanism of action of aldosterone on active sodium transport across toad skin. Pfluegers Arch. 385: 181-187, 1980.
290. NARAY-FEJES-TOTH, A., AND G. FEJES-TOTH. Glucocorticoid receptors mediate mineralocorticoid-like effects in cultured collecting duct cells. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol. 28): F672-F678, 1990.
291. NOVOTNY, W. F., O. CHASSANDE, M. BAKER, M. LAZDUNSKI, AND P. BARBRY. Diamine oxidase is the amiloride binding protein and is inhibited by amiloride analogues. J. Biol. Chem. 269: 9921-9925, 1994.
292. + exchange and raises cytoplasmic pH in target cells of the amphibian kidney. Proc. Natl. Acad. Sci. USA 84: 1464-1468, 1987.
293. + channel in the developing rat lung. Am. J. Physiol. 265 (Cell Physiol. 34): C491-C496, 1993.
294. + channel in planar lipid bilayers. Am. J. Physiol 264 (CellPhysiol. 33): C1489-C1499, 1993.
295. OH, Y., S. MATALON, T. R. KLEYMAN, AND D. J. BENOS. Biochemical evidence for the presence of an amiloride binding protein in adult alveolar type II pneumocytes. J. Biol. Chem. 267: 18498-18504, 1992.
296. OH, Y. S., P. R. SMITH, A. L. BRADFORD, D. KEETON, AND D. J. BENOS. Regulation by phosphorylation of purified epithelial Na channels in planar lipid bilayers. Am. J. Physiol. 265 (Cell Physiol. 34): C85-C91, 1993.
297. OHARA, A., H. MATSUNAGA, AND D. C. EATON. G protein activation inhibits amiloride-blockable highly selective sodium channels in A6 cells. Am. J. Physiol. 264 (Cell Physiol. 33): C352-C360, 1993.
298. O'NEIL, R. G., AND R. A. HAYHURST. Functional differentiation of cell types of cortical collecting duct. Am. J. Physiol. 248 (Renal Fluid Electrolyte Physiol. 17): F449-F453, 1985.
299. PACHA, J., G. FRINDT, L. ANTONIAN, R. SILVER, AND L. G. PALMER. Regulation of Na channels of the rat cortical collecting tubule by aldosterone. J. Gen. Physiol. 102: 25-42, 1993.
300. PACHA, J., G. FRINDT, H. SACKIN, AND L. G. PALMER. Apical maxi K channels in intercalated cells of CCT. Am. J. Physiol. 261 (Renal Fluid Electrolyte Physiol. 30): F696-F705, 1991.
301. PALMER, L. G. Ion selectivity of the apical membrane Na channel in the toad urinary bladder. J. Membr. Biol. 67: 91-98, 1982.
302. + channels in toad bladder. Nature Lond. 297: 688-690, 1982.
303. PALMER, L. G. Voltage-dependent block by amiloride and other monovalent cations of apical Na channels in the toad urinary bladder. J. Membr. Biol. 80: 153-165, 1984.
304. PALMER, L. G. Modulation of apical Na permeability of the toad urinary bladder by intracellular Na, Ca, and H. J. Membr. Biol. 83: 57-69, 1985.
305. PALMER, L. G. Interactions of amiloride and other blocking cations with the apical Na channel in the toad urinary bladder. J. Membr. Biol. 87: 191-199, 1985.
306. + channels. J. Membr. Biol. 96: 97-106, 1987.
307. PALMER, L. G. The epithelial Na channel: inferences about the nature of the conducting pore. Comments Mol. Cell. Biophys. 7: 259-283, 1991.
308. PALMER, L. G. Epithelial Na channels: function and diversity. Annu. Rev. Physiol. 54: 51-66, 1992.
309. PALMER, L. G. Epithelial Na channels and their kin. News Physiol. Sci. 10: 61-67, 1995.
310. PALMER, L. G., AND O. S. ANDERSEN. Interactions of amiloride and small monovalent cations with the epithelial sodium channel. Inferences about the nature of the channel pore. Biophys. J. 55: 779-787, 1989.
311. PALMER, L. G., I. CORTHESY-THEULAZ, H.-P. GAEGGELER, J.-P. KRAEHENBUHL, AND B. ROSSIER. Expression of epithelial Na channels in Xenopus oocytes. J. Gen. Physiol. 96: 23-46, 1990.
312. PALMER, L. G., AND I. S. EDELMAN. Control of apical sodium permeability in the toad urinary bladder by aldosterone. Ann. NY Acad. Sci. 372: 1-14, 1981.
313. PALMER, L. G., I. S. EDELMAN, AND B. LINDEMANN. Current-voltage analysis of apical sodium transport in toad urinary bladder effects of inhibitors of transport and metabolism. J. Membr. Biol. 57: 59-71, 1980.
314. + channels from the apical membrane of the rat cortical collecting tubule. Proc. Natl. Acad. Sci. USA 83: 2767-2770, 1986.
315. PALMER, L. G., AND G. FRINDT. Epithelial sodium channels: characterization by using the patch-clamp technique. Federation Proc. 45: 2708-2712, 1986.
316. + channels from rat cortical collecting tubule. Am. J. Physiol. 253 (Renal Fluid Electrolyte Physiol. 22): F333-F339, 1987.
317. + channels from rat cortical collecting tubule. Effects of luminal Na and Li. J. Gen. Physiol. 92: 121-138, 1988.
318. PALMER, L. G., AND G. FRINDT. Regulation of apical membrane Na and K channels in rat renal collecting tubules by aldosterone. Semin. Nephrol. 12: 37-43, 1992.
319. PALMER, L. G., AND G. FRINDT. Amiloride-sensitive Na channels in the rat cortical collecting tubule are activated by GDPβS (Abstract). FASEB J. 10: A77, 1996.
320. PALMER, L. G., AND G. FRINDT. Gating of Na channels in the rat cortical collecting tubule: effects of voltage and membrane stretch. J. Gen. Physiol. 107: 35-45, 1996.
321. PALMER, L. G., G. FRINDT, R. B. SILVER, AND J. STRIETER. Feedback regulation of epithelial sodium channels. Curr. Top. Membr. Transp. 34: 45-60, 1989.
322. PALMER, L. G., AND T. R. KLEYMAN. Potassium-sparing diuretics: amiloride. In: Handbook of Experimental Pharmacology, Diuretics, edited by E. Mutschler and R. Greger. Heidelberg, Germany: Springer-Verlag, 1994, vol. 17, p. 363-394.
323. PALMER, L. G., J. H.-Y. LI, B. LINDEMANN, AND I. S. EDELMAN. Aldosterone control of the density of sodium channels in the toad urinary bladder. J. Membr. Biol. 64: 91-102, 1982.
324. PALMER, L. G., AND M. LORENZEN. Antidiuretic hormone-dependent membrane capacitance and water permeability in the toad urinary bladder. Am. J. Physiol. 244 (Renal Fluid Electrolyte Physiol. 13): F195-F204, 1983.
325. PALMER, L. G., AND N. SPEEZ. Modulation of antidiuretic hormone-dependent capacitance and water flow in toad urinary bladder. Am. J. Physiol 246 (Renal Fluid Electrolyte Physiol 15): F501-F508, 1984.
326. 2+ is the second messenger for stimulation of apical membrane conductance. J. Clin. Invest. 89: 150-156, 1992.
327. + channels. Am. J. Physiol. 265 (Cell Physiol. 34): C218-C223, 1993.
328. + channels by protein kinase A requires actin filaments. Am. J. Physiol. 265 (Cell Physiol. 34): C224-C233, 1993.
329. + channel. J. Biol. Chem. 271: 18045-18053, 1996.
330. + channel. J. Biol. Chem. 271: 7879-7882, 1996.
331. PUOTI, A., A. MAY, C. M. CANESSA, J. D. HORISBERGER, L. SCHILD, AND B. C. ROSSIER. The highly selective, low conductance, epithelial sodium channel of Xenopus laevis A6 kidney cells. Am. J. Physiol. 269 (Cell Physiol. 38): C188-C197, 1995.
332. QUINTON, P. M. Effects of some ion transport inhibitors on secretion and reabsorption in intact and perfused single human sweat glands. Pfluegers Arch. 391: 309-313, 1981.
333. QUINTON, P. M. Cystic fibrosis: a disease in electrolyte transport. FASEB J. 4: 2709-2717, 1990.
334. RACHAMIM, N., H. LATTER, C. ASHER, H. WALD, AND H. GARTY. Dexamethasone enhances expression of mitochondrial oxidative-phosphorylation genes in rat distal colon. Am. J. Physiol. 269 (Cell Physiol. 38): C1305-C1310, 1995.
335. REIF, M. C., S. L. TROUTMAN, AND J. A. SCHAFER. Sodium transport by rat cortical collecting tubule. Effects of vasopressin and deoxycorticosterone. J. Clin. Invest. 77: 1291-1298, 1986.
336. REN, R., B. J. MAYER, P. CICCHETTI, AND D. BALTIMORE. Identification of a ten-amino acid proline-rich SH3 binding site. Science Wash. DC 259: 1157-1161, 1993.
337. + channel. J. Biol. Chem. 269: 12981-12986, 1994.
338. + channel in colon, lung and kidney. Pfluegers Arch. 430: 299-307, 1995.
339. RICK, R., A. DSRGE, E. VON ARNIM, AND K. THURAU. Electron microprobe analysis of frog skin epithelium: evidence for a syncitial sodium transport compartment. J. Membr. Biol. 39: 313-331, 1978.
340. RODRIGUEZ-COMMES, J., J. N. FORREST, R. LOPEZ, J. GASALLAHERRAIZ, AND C. M. ISALES. Parathyroid hormone stimulates electrogenic sodium transport in A6 cells. Biochem. Biophys. Res. Commun. 213: 688-698, 1995.
341. RODRIGUEZ-COMMES, J., C. ISALES, L. KALGHATI, J. GASALLA-HERRAIZ, AND J. P. HAYSLETT. Mechanism of insulin-stimulated electrogenic sodium transport. Kidney Int. 46: 666-674, 1994.
342. ROKAW, M. D., D. J. BENOS, P. M. PALEVSKY, S. A. CUNNINGHAM, M. E. WEST, AND J. P. JOHNSON. Regulation of a sodium channel-associated G-protein by aldosterone. J. Biol. Chem. 271: 4491-4496, 1996.
343. ROSSIER, B. C., C. M. CANESSA, L. SCHILD, AND J.-D. HORISBERGER. Epithelial sodium channels. Curr. Opin. Nephrol. Hypertens. 3: 487-496, 1994.
344. ROSSIER, B. C., K. GEERING, J. ATKINSON, AND F. ROCH-RAMEL. Renal receptors. In: The Kidney: Physiology and Pathophysiology, edited by D. W. Seldin and G. Giebisch. New York: Raven, 1985, p. 775-806.
345. ROSSIER, B. C., AND L. G. PALMER. Mechanisms of aldosterone action on sodium and potassium transport. In: The Kidney: Physiology and Pathophysiology, edited by D. W. Seldin and G. Giebisch. New York: Raven, 1992, vol. 1, p. 1373-1409.
346. + channel (alpha rENaC) mediates its localization at the apical membrane. EMBO J. 13: 4440-4450, 1994.
347. + and water transport in rat CCD. Am. J. Physiol. 265 (Renal Fluid Electrolyte Physiol 34): F569-F577, 1993.
348. + transport in isolated rat CCD: effects of bradykinin, ANP, clonidine, and hydrochlorothiazide. Am. J. Physiol. 260 (Renal Fluid Electrolyte Physiol. 29): F86-F95, 1991.
349. ROUDIERPUJOL, C., A. ROCHAT, B. ESCOUBET, E. EUGENE, Y. BARRANDON, J. P. BONVALET, AND N. FARMAN. Differential expression of epithelial sodium channel subunit mRNAs in rat skin. J. Cell Sci. 109: 379-385, 1996.
350. RUSSO, R., R. L. LUBMAN, AND E. D. CRANDALL. Evidence for amiloride-sensitive sodium channels in alveolar epithelial cells. Am. J. Physiol 262 (Lung Cell. Mol. Physiol. 6): L405-L411, 1992.
351. SACHS, F. Stretch-sensitive ion channels: an update. In: Sensory Transduction, edited by D. P. Corey and S. D. Roper. New York: Rockefeller Univ. Press, 1992, p. 241-260.
352. SACKIN, H. Stretch-activated ion channels. In: Cellular and Molecular Physiology of Cell Volume Regulation, edited by K. L. Strange. Boca Raton, FL: CRC, 1994, p. 215-240.
353. + channel subunit that binds amiloride. Am. J. Physiol. 263 (Cell Physiol. 32): C1111-C1117, 1992.
354. SARIBAN-SOHRABY, S., AND D. J. BENOS. Detergent solubilization, functional reconstitution, and partial purification of epithelial amiloride-binding protein. Biochemistry 25: 4639-4640, 1986.
355. SARIBAN-SOHRABY, S., M. BURG, W. P. WIESMANN, P. K. CHIANG, AND J. P. JOHNSON. Methylation increases sodium transport into A6 apical membrane vesicles: possible mode of aldosterone action. Science Wash. DC 225: 745-746, 1984.
356. SARIBAN-SOHRABY, S., R. S. FISHER, AND M. ABRAMOW. Aldosterone-induced and GTP-stimulated methylation of a 90-kDa polypeptide in the apical membrane of A6 epithelia. J. Biol. Chem. 268: 26613-26617, 1993.
357. + channels reconstituted into planar lipid bilayer membrane. Nature Lond. 308: 80-82, 1984.
358. SARIBAN-SOHRABY, S., F. MIES, M. ABRAMOW, AND R. S. FISHER. Aldosterone stimulation of GTP hydrolysis in membranes from renal epithelia. Am. J. Physiol. 268 (Cell Physiol. 37): C557-C562, 1995.
359. + channel protein following vasopressin treatment of A6 cells. J. Biol. Chem. 263: 13875-13879, 1988.
360. + channels in the cortical collecting duct by AVP and mineralocorticoids (Editorial). Kidney Int. 41: 255-268, 1992.
361. + salts and sweeteners. Proc. Natl. Acad. Sci. USA 80: 6136-6140, 1983.
362. SCHILD, L., C. M. CANESSA, R. A. SHIMKETS, I. GAUTSCHI, R. P. LIFTON, AND B. C. ROSSIER. A mutation in the epithelial sodium channel causing Liddle disease increases channel activity in the Xenopus laevis oocyte expression system. Proc. Natl. Acad. Sci. USA 92: 5699-5703, 1995.
363. SCHILD, L., Y. LU, I. GAUTSCHI, E. SCHNEEBERGER, R. P. LIFTON, AND B. C. ROSSIER. Identification of a PY motif in the epithelial Na channel subunits as a target sequence for mutations causing channel activation found in Liddle syndrome. EMBO J. 15: 2381-2387, 1996.
364. + transport in A6 cells is mediated via glucocorticoid receptors. Am. J. Physiol. 264 (Cell Physiol. 33): C875-C884, 1993.
365. SCHNEYER, L. H. Amiloride inhibition of ion transport in perfused excretory duct of rat submaxillary gland. Am. J. Physiol. 219: 1050-1055, 1970.
366. SCHOEN, H. F., AND D. ERLIJ. Insulin action on electrophysiological properties of apical and basolateral membranes of frog skin. Am. J. Physiol. 252 (Cell Physiol. 21): C411-C417, 1987.
367. SCHWARTZ, G. J., AND M. B. BURG. Mineralocorticoid effects on cation transport by cortical collecting tubules in vitro. Am. J. Physiol 235 (Renal Fluid Electrolyte Physiol. 4): F576-F585, 1978.
368. SCOTT, W. N., I. M. REICH, J. A. J. BROWN, AND C.-P. H. YOUNG. Comparison of toad bladder aldosterone-induced proteins and proteins synthesized in vitro using aldosterone-induced messenger RNA as a template. J. Membr. Biol. 40: 213-220, 1978.
369. SCOTT, W. N., AND V. S. SAPIRSTEIN. Identification of aldosterone-induced proteins in the toad's urinary bladder. Proc. Natl. Acad. Sci. USA 72: 4056-4060, 1975.
370. + channel protein into planar lipid bilayers. Am. J. Physiol. 268 (Cell Physiol. 37): C1148-C1156, 1995.
371. SHAREGHI, G. R., AND L. C. STONER. Calcium transport across segments of the rabbit nephron in vitro. Am. J. Physiol. 235 (Renal Fluid Electrolyte Physiol 4): F367-F375, 1978.
372. SHIMKETS, R. A., D. G. WARNOCK, C. M. BOSITIS, C. N. WILLIAMS, J. H. HANSSON, M. SCHAMELAN, J. R. J. GILL, S. ULICK, R. V. MILORA, J. W. FINDLING, C. M. CANESSA, B. C. ROSSIER, AND R. P. LIFTON. Liddle's syndrome: heritable human hypertension caused by mutations in the β subunit of the epithelial sodium channel. Cell 79: 407-414, 1994.
373. SILVER, R. B., G. FRINDT, E. E. WINDHAGER, AND L. G. PALMER. Feedback regulation of Na channels in rat CCT. I. Effects of inhibition of the Na pump. Am. J. Physiol. 264 (Renal Fluid Electrolyte Physiol. 33): F557-F564, 1993.
374. SKADHAUGE, E. Introduction of an epithelium with huge variation in sodium transport and novel aldosterone effect. In: Intestinal Absorption and Secretion, edited by E. Skadhauge and K. Heintze. Lancaster, UK: MTP, 1984, p. 201-208.
375. + channels. Annu. Rev. Physiol. 53: 509-530, 1991.
376. SMITH, P. R., A. L. BRADFORD, V. DANTZER, D. J. BENOS, AND E. SKADHAUGE. Immunocytochemical localization of amiloride-sensitive sodium channels in the lower intestine of the hen. Cell Tissue Res. 272: 129-136, 1993.
377. SMITH, P. R., G. SACCOMANI, E. H. JOE, K. J. ANGELIDES, AND D. J. BENOS. Amiloride-sensitive sodium channel is linked to the cytoskeleton in renal epithelial cells. Proc. Natl. Acad. Sci. USA 88: 6971-6975, 1991.
378. + channels in A6 renal epithelial cells. J. Membr. Biol. 147: 195-205, 1995.
379. SNYDER, P. M., F. J. MCDONALD, J. B. STOKES, AND M. J. WELSH. Membrane topology of the amiloride-sensitive epithelial sodium channel. J. Biol. Chem. 269: 24379-24383, 1994.
380. + channel. Cell 83: 969-978, 1995.
381. SODRING ELBROND, V., V. DANTZER, T. M. MAYHEW, AND E. SKADHAUGE. Avian lower intestine adapts to dietary salt (NaCl) depletion by increasing transepithelial sodium transport and microvillous membrane surface area. Exp. Physiol. 76: 733-744, 1991.
382. SONNENBERG, H., U. HONRATH, AND D. R. WILSON. Effects of amiloride in the medullary collecting duct of rat kidney. Kidney Int. 31: 1121-1125, 1987.
383. SORSCHER, E. J., M. A. ACCAVITTI, D. KEETON, E. STEADMAN, R. A. FRIZZELL, AND D. J. BENOS. Antibodies against purified epithelial sodium channel protein from bovine renal papilla. Am. J. Physiol 255 (Cell Physiol 24): C835-C843, 1988.
384. SPINDLER, B., L. MASTROBERARDINO, AND F. VERREY. Early aldosterone-regulated mRNAs in A6 kidney cells (Abstract). Pfluegers Arch. 431, Suppl. 182, 1996.
385. STANTON, B. A. Role of adrenal hormones in regulating distal nephron structure and ion transport. Federation Proc. 44: 2717-2722, 1985.
386. STANTON, B. A. Characterization of apical and basolateral membrane conductances of rat inner medullary collecting duct. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F862-F868, 1989.
387. + channel deleted in Liddle's syndrome. EMBO J. 15: 2371-2380, 1996.
388. STAUB, O., AND D. ROTIN. WW domains. Structure 4: 495-499, 1996.
389. STAUB, O., F. VERREY, T. R. KLEYMAN, D. J. BENOS, B. C. ROSSIER, AND J. P. KRAEHENBUHL. Primary structure of an apical protein from Xenopus laevis that participates in amiloride-sensitive sodium channel activity. J. Cell Biol. 119: 1497-1506, 1992.
390. STETSON, D. L., S. A. LEWIS, W. ALLES, AND J. B. WADE. Evaluation by capacitance measurements of antidiuretic hormone-induced membrane area changes in toad bladder. Biochim. Biophys. Acta 689: 267-274, 1982.
391. STEWART, R. E., P. S. LASITER, D. J. BENOS, AND D. L. HILL. Immunohistochemical correlates of peripheral gustatory sensitivity to sodium and amiloride. Acta Anal. 153: 310-319, 1995.
392. STONER, L. C., M. B. BURG, AND J. ORLOFF. Ion transport in cortical collecting tubule: effect of amiloride. Am. J. Physiol. 227: 453-459, 1974.
393. STONER, L. C., B. G. ENGBRETSON, S. C. VIGGIANO, D. J. BENOS, AND P. R. SMITH. Amiloride-sensitive apical membrane sodium channels of everted Ambystoma collecting tubule. J. Membr. Biol. 144: 147-156, 1995.
394. STRAUTNIEKS, S. S., R. J. THOMPSON, R. M. GARDINER, AND E. CHUNG. A novel splice-site mutation in the gamma subunit of the epithelial sodium channel gene in three pseudohypoaldosteronism type 1 families. Nature Genet. 13: 248-250, 1996.
395. STUTTS, M. J., C. M. CANESSA, J. C. OLSEN, M. HAMRICK, J. A. COHN, B. C. ROSSIER, AND R. C. BOUCHER. CFTR as a cAMP-dependent regulator of sodium channels. Science Wash. DC 269: 847-850, 1995.
396. SUDOU, K., AND T. HOSHI. Mode of action of amiloride in toad urinary bladder. An electrophysiological study of drug action on sodium permeability of the mucosal border. J. Membr. Biol. 32: 115-132, 1977.
397. + channel. J. Am. Soc. Nephrol. 2: 1108-1114, 1991.
398. SZERLIP, H. M., AND M. COX. Aldosterone-induced glycoproteins: further characterization. J. Steroid Biochem. 32: 815-822, 1989.
399. SZERLIP, H. M., L. WEISBERG, M. CLAYMAN, E. NEILSON, J. B. WADE, AND M. COX. Aldosterone-induced proteins: purification and localization of GP65,70. Am. J. Physiol. 256 (Cell Physiol. 25): C865-C872, 1989.
400. SZERLIP, H. M., L. WEISBERG, K. GEERING, B. C. ROSSIER, AND M. COX. Aldosterone-induced glycoproteins: electrophysiological-biochemical correlation. Biochim. Biophys. Acta 940: 1-9, 1988.
401. + channel gene. J. Clin. Invest. 97: 1780-1784, 1996.
402. TAYLOR, A., AND E. E. WINDHAGER. Possible role of cytosolic calcium and Na-Ca exchange in regulation of transepithelial sodium transport. Am. J. Physiol. 236 (Renal Fluid Electrolyte Physiol. 5): F505-F512, 1979.
403. THOMAS, S. R., Y. SUZUKI, S. M. THOMPSON, AND S. G. SCHULTZ. Electrophysiology of Necturus urinary bladder. I. "Instantaneous" current voltage relations in the presence of varying mucosal sodium concentrations. J. Membr. Biol. 73: 157-175, 1983.
404. TOUSSON, A., C. D. ALLEY, E. J. SORSCHER, B. R. BRINKLEY, AND D. J. BENOS. Immunochemical localization of amiloride-sensitive sodium channels in sodium transporting epithelia. J. Cell Sci. 93: 349-362, 1989.
405. TRACHEWSKY, D., M. L. OAKES, AND D. J. MORRIS. Induction of flavokinase (EC 2.7.1.26) by aldosterone in the rat kidney. Endocrinology 116: 879-888, 1985.
406. TRUSCELLO, A., H. P. GAGGELER, AND B. C. ROSSIER. Thyroid hormone antagonizes an aldosterone-induced protein: a candidate mediator for the late mineralocorticoid response. J. Membr. Biol. 89: 173-183, 1986.
407. TURNAMIAN, S. G., AND H. J. BINDER. Regulation of active sodium and potassium transport in the distal colon of the rat. Role of the aldosterone and glucocorticoid receptors. J. Clin. Invest. 84: 1924-1929, 1989.
408. TURNHEIM, K. Intrinsic regulation of apical sodium entry in epithelia. Physiol Rev. 71: 429-445, 1991.
409. TURNHEIM, K., R. A. FRIZZELL, AND S. G. SCHULTZ. Interaction between cell sodium and the amiloride-sensitive entry step in the rabbit colon. J. Membr. Biol. 39: 233-256, 1978.
410. TURNHEIM, K., S. M. THOMPSON, AND S. G. SCHULTZ. Relation between intracellular sodium and active sodium transport in rabbit colon: current-voltage relations of the apical sodium entry mechanism in the presence of varying luminal sodium concentrations. J. Membr. Biol. 76: 299-309, 1983.
411. USSING, H. H. Relationship between osmotic reactions and active sodium transport in frog skin epithelium. Acta Physiol. Scand. 63: 141-155, 1965.
412. USSING, H. H., AND K. ZERAHN. Active transport of sodium as the source of electric current in the short-circuited isolated frog skin. Acta Physiol. Scand. 23: 110-127, 1951.
413. 2x receptor for extracellular ATP. Nature Lond. 371: 516-519, 1994.
414. + currents across the apical border of ouabain-treated frog skin. Pfluegers Arch. 398: 179-188, 1983.
415. VAN DRIESSCHE, W., AND D. ERLIJ. Cyclic AMP increases electrical capacitance of apical membrane of toad urinary bladder. Arch. Int. Physiol. Biochim. Biophys. 99: 409-411, 1991.
416. VAN DRIESSCHE, W., AND B. LINDEMAN. Concentration dependence of currents through single sodium-selective pores in frog skin. Nature Lond. 282: 519-520, 1979.
417. VANDORPE, C., C. SANDOE, K. KARLSON, AND B. STANTON. Cloning and characterization of the cGMP-gated cation channel from mouse kidney inner medullary collecting duct (IMCD) (Abstract). J. Am. Soc. Nephrol. 6: 354, 1995.
418. VERREY, F. Transcriptional control of sodium transport in tight epithelia by adrenal steroids. J. Membr. Biol. 144: 93-110, 1995.
419. VERREY, F., M. DIGICAYLIOGLU, AND U. BOLLIGER. Polarized membrane movements in A6 kidney cells are regulated by aldosterone and vasopressin/vasotocin. J. Membr. Biol. 133: 213-226, 1993.
420. +-permeable amiloride-sensitive channel in thyroid cells. Eur. J. Biochem. 183: 499-505, 1989.
421. VIGNE, P., G. CHAMPIGNY, R. MARSAULT, P. BARBRY, C. FRELIN, AND M. LAZDUNSH. A new type of amiloride-sensitive cationic channel in endothelial cells of brain microvessels. J. Biol. Chem. 264: 7663-7668, 1989.
422. VOILLEY, N., F. BASSILANA, C. MIGNON, S. MERSCHER, M. G. MATTEI, G. F. CARLE, M. LAZDUNSKI, AND P. BARBRY. Cloning, chromosomal localization, and physical linkage of the beta and gamma subunits (SCNN1B and SCNN1G) of the human epithelial amiloride-sensitive sodium channel. Genomics 28: 560-565, 1995.
423. VOILLEY, N., E. LINGUEGLIA, G. CHAMPIGNY, M. G. MATTEI, R. WALDMAN, M. LAZDUNSKI, AND P. BARBRY. The lung amiloride-sensitive Na channel: biophysical properties, pharmacology, ontogenesis and molecular cloning. Proc. Natl. Acad. Sci. USA 91: 247-251, 1994.
424. + channel in the apical membrane of the rat inner medullary collecting duct. J. Clin. Invest. 96: 2748-2757, 1995.
425. WADE, J. B. Membrane structural studies of the action of vasopressin. Federation Proc. 44: 2687-2692, 1985.
426. WADE, J. B., B. A. STANTON, M. J. FIELD, M. KASHGARIAN, AND G. GIEBISCH. Morphological and physiological responses to aldosterone: time course and sodium dependence. Am. J. Physiol. 259 (Renal Fluid Electrolyte Physiol. 28): F88-F94, 1990.
427. WALD, H., O. GOLDSTEIN, C. ASHER, Y. YAGIL, AND H. GARTY. Aldosterone-induction and epithelial distribution of CHIF. Am. J. Physiol. 271 (Renal Fluid Electrolyte Physiol 40): F322-F329, 1996.
428. + channel. J. Biol. Chem. 270: 27411-27414, 1995.
429. + channel function. J. Biol. Chem. 270: 11735-11737, 1995.
430. WALDMANN, R., G. CHAMPIGNY, N. VOILLEY, I. LAURITZEN, AND M. LAZDUNSKI. The mammalian degenerin MDEG, an amiloride-sensitive cation channel activated by mutations causing neurodegeneration in Caenorhabditis elegans. J. Biol. Chem. 271: 10433-10436, 1996.
431. WANG, W., H. SACKIN, AND G. GIEBISCH. Renal potassium channels and their regulation. Annu. Rev. Physiol. 54: 81-96, 1992.
432. + currents in intact fetal distal lung epithelial cells. Can. J. Physiol. Pharmacol. 71: 58-62, 1993.
433. + channel blockage by amiloride: relaxation effects in admittance spectra. J. Membr. Biol. 86: 255-265, 1985.
434. WARNCKE, J., AND B. LINDEMANN. Voltage dependence of the blocking rate constants of amiloride at apical Na channels. Pfluegers Arch. 405, Suppl.: S89-S94, 1985.
435. + transport in cultured kidney cells. Am. J. Physiol. 242 (Renal Fluid Electrolyte Physiol 11): F610-F619, 1982.
436. + channel. J. Comp. Physiol. B Biochem. Syst. Environ. Physiol 163: 153-159, 1993.
437. WEHLING, M., M. CHRIST, AND R. GERZER. Aldosterone-specific membrane receptors and related rapid, non-genomic effects. Trends Pharmacol Sci. 14: 1-4, 1993.
438. + exchange in distal nephron of frog kidney. An early response to aldosterone. Pfluegers Arch. 408: 609-614, 1987.
439. WELSH, M. J. Abnormal regulation of ion channels in cystic fibrosis. FASEB J. 4: 2718-2725, 1990.
440. WIESMANN, W. P., J. P. JOHNSON, G. A. MIURA, AND P. K. CHIANG. Aldosterone-stimulated transmethylations are linked to sodium transport. Am. J. Physiol. 248 (Renal Fluid Electrolyte Physiol. 17): F43-F47, 1985.
441. WILL, P. C., R. N. CORTRIGHT, R. C. DELISLE, J. G. DOUGLAS, AND U. HOPFER. Regulation of amiloride-sensitive electrogenic sodium transport in the rat colon by steroid hormones. Am. J. Physiol 248 (Gastrointest. Liver Physiol. 11): G124-G132, 1985.
442. WILL, P. C., R. N. CORTRIGHT, R. G. GROSECLOSE, AND U. HOPFER. Amiloride-sensitive salt and fluid absorption in small intestine of sodium-depleted rats. Am. J. Physiol. 248 (Gastrointest. Liver Physiol. 11): G133-G141, 1985.
443. + channel activity in cultured renal (A6) epithelium: regulation by solution osmolarity. J. Membr. Biol. 121: 79-90, 1991.
444. WILLUMSEN, N. J., AND R. C. BOUCHER. Transcellular sodium transport in cultured cystic fibrosis human nasal epithelium. Am. J. Physiol. 261 (Cell Physiol. 30): C332-C341, 1991.
445. YANASE, M., AND J. S. HANDLER. Activators of protein kinase C inhibit sodium transport in A6 epithelia. Am. J. Physiol. 250 (Cell Physiol. 19): C517-C522, 1986.
446. YOSHITOMI, K., T. SHIMIZU, J. TANIGUCHI, AND M. IMAI. Electrophysiological characterization of rabbit distal convoluted tubule cell. Pfluegers Arch. 414: 457-463, 1989.
447. + conductance. Am. J. Physiol. 265 (Cell Physiol. 34): C630-C640, 1993.
448. YUE, G., W. J. RUSSELL, D. J. BENOS, R. M. JACKSON, M. A. OLMAN, AND S. MATALON. Increased expression and activity of sodium channels in alveolar type II cells of hyperoxic rats. Proc. Natl. Acad. Sci. USA 92: 8418-8422, 1995.
449. ZEIDEL, M. L., J. L. SEIFTER, S. LEAR, B. M. BRENNER, AND P. SILVA. Atrial peptides inhibit oxygen consumption in kidney medullary collecting duct cells. Am. J. Physiol. 251 (Renal Fluid Electrolyte Physiol. 20): F379-F383, 1986.
450. + permeability in frog skin to hypertonic stress. Pfluegers Arch. 400: 130-139, 1984.
451. ZHOU, H., S. S. TATE, AND L. G. PALMER. Primary structure and functional properties of an epithelial K channel. Am. J. Physiol. 266 (Cell Physiol. 35): C809-C824, 1994.