Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels

Toxicon

Volumn 75, Issue , 2013, Pages 187-204

  Baron, Anne ^a,b,c   Diochot, Sylvie ^a,b,c   Salinas, Miguel ^a,b,c   Deval, Emmanuel ^a,b,c   Noël, Jacques ^a,b,c   Lingueglia, Eric ^a,b,c  

^a INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b UNIVERSITÉ CÔTE D'AZUR   (France)

^c Laboratory of Excellence in Ion Channel Science and Therapeutics   (France)

Author keywords

ASIC; Nervous system; Pain; Pathophysiology; Sodium channels; Toxins

Indexed keywords

ACID SENSING ION CHANNEL; ACID SENSING ION CHANNEL 1A; ACID SENSING ION CHANNEL 1B; ACID SENSING ION CHANNEL 2A; ACID SENSING ION CHANNEL 2B; ACID SENSING ION CHANNEL 3; ACID SENSING ION CHANNEL 4; ANTISENSE OLIGONUCLEOTIDE; MAMBALGIN; PEPTIDE APETX2; PEPTIDE MITTX; PEPTIDE PCTX1; SEA ANEMONE TOXIN; SMALL INTERFERING RNA; SNAKE VENOM; SPIDER VENOM; UNCLASSIFIED DRUG; VENOM; VENOM TOXIN;

ABDOMINAL PAIN; ANALGESIC ACTIVITY; ANTIDEPRESSANT ACTIVITY; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; BLOOD VESSEL TONE; BRAIN INFARCTION; BRAIN ISCHEMIA; CARTILAGE CELL; CENTRAL NERVOUS SYSTEM; CHANNEL GATING; COMPLEX FORMATION; CRYSTAL STRUCTURE; DEPRESSION; DRUG POTENCY; DRUG RESEARCH; EPILEPSY; EXCITOTOXICITY; FEAR; GENE SILENCING; GLUCOSE INTOLERANCE; GLYCEMIC CONTROL; HUMAN; HYPERALGESIA; IC 50; INFLAMMATORY PAIN; INHIBITION KINETICS; INSULIN RESISTANCE; MECHANOTRANSDUCTION; MYALGIA; NEUROPATHIC PAIN; NEUROPATHOLOGY; NEUROPROTECTION; NONHUMAN; PAIN; PATHOPHYSIOLOGY; POSTOPERATIVE PAIN; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; SIGNAL TRANSDUCTION; SKIN PAIN; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING; TOXICOKINETICS; TOXIN ANALYSIS; TOXIN STRUCTURE; TRANQUILIZING ACTIVITY; VASODILATATION;

ACTINIARIA; ARANEAE; RODENTIA; SERPENTES;

ASIC; NERVOUS SYSTEM; PAIN; PATHOPHYSIOLOGY; SODIUM CHANNELS; TOXINS;

ACID SENSING ION CHANNELS; AMINO ACID SEQUENCE; AMYGDALA; ANIMALS; ANTI-ANXIETY AGENTS; ANTI-INFLAMMATORY AGENTS; ANTIDEPRESSIVE AGENTS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN-ION CONCENTRATION; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; NEURONS; NEUROPROTECTIVE AGENTS; PEPTIDES; PROTEIN CONFORMATION; RODENTIA; SEA ANEMONES; SNAKES; SPIDERS; STRUCTURE-ACTIVITY RELATIONSHIP; TOXINS, BIOLOGICAL; VASOCONSTRICTION; VENOMS;

EID: 84885323818     PISSN: 00410101     EISSN: 18793150     Source Type: Journal    
DOI: 10.1016/j.toxicon.2013.04.008     Document Type: Review

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