Genetics of taste receptors

Current Pharmaceutical Design

Volumn 20, Issue 16, 2014, Pages 2669-2683

  Bachmanov, Alexander A ^a   Bosak, Natalia P ^a   Lin, Cailu ^a   Matsumoto, Ichiro ^a   Ohmoto, Makoto ^a   Reed, Danielle R ^a   Nelson, Theodore M ^a,b  

^a MONELL CHEMICAL SENSES CENTER   (United States)

^b GEORGETOWN UNIVERSITY   (United States)

Author keywords

Bitter; Gene; Gustatory; Receptor; Salty; Sour; Sweet; Umami

Indexed keywords

ALCOHOL; CALCIUM; CARBOHYDRATE; EPITHELIAL SODIUM CHANNEL; FATTY ACID TRANSPORTER; G PROTEIN COUPLED RECEPTOR; RECEPTOR; SODIUM; SUGAR; SWEETENING AGENT; WATER;

ALCOHOL CONSUMPTION; ALLELE; ARTICLE; BITTER TASTE; CHEMICAL ENVIRONMENT; CHIMPANZEE; FEEDING ECOLOGY; FLUID INTAKE; GENE EXPRESSION; GENE STRUCTURE; GENETIC VARIABILITY; GENETICS; GUSTATORY SYSTEM; HUMAN; INVERTEBRATE; MOLECULAR EVOLUTION; MOUSE STRAIN; NONHUMAN; PALATABILITY; PRIORITY JOURNAL; PSEUDOGENE; RECEPTOR GENE; SALTY TASTE; SMELL AND TASTE PARAMETERS; SOUR TASTE; SPECIES DIFFERENCE; SWEETNESS; TASTE; TASTE BUD; TASTE PREFERENCE; TASTE RECEPTOR TYPE 1; TASTE RECEPTOR TYPE 2; UMAMI TASTE; ANIMAL; PHYSIOLOGY;

ANIMALS; HUMANS; RECEPTORS, G-PROTEIN-COUPLED; TASTE; TASTE BUDS;

EID: 84903746597     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/13816128113199990566     Document Type: Article

References (264)

1. Yarmolinsky DA, Zuker CS, Ryba NJ. Common sense about taste: from mammals to insects. Cell 2009; 139: 234-44.
2. Montell C. A taste of the Drosophila gustatory receptors. Curr Opin Neurobiol 2009; 19: 345-53.
3. Bachmanov AA, Beauchamp GK. Taste receptor genes. Annu Rev Nutr 2007; 27: 389-414.
4. Bachmanov AA, Bosak NP, Floriano WB, et al. Genetics of sweet taste preferences. Flavour Fragr J 2011; 26: 286-294.
5. Boughter JD, Bachmanov AA. Genetics and evolution of taste. In: Firestein S, Beauchamp GK, eds., Olfaction and Taste. Elsevier/ Academic Press: San Diego 2008; pp. 371-390.
6. Bachmanov AA, Boughter JD. Genetics of Taste Perception In: eLS 2012, http://www.els.net/ [DOI: 10.1002/9780470015902.a0023587]. John Wiley & Sons, Ltd: Chichester 2012.
7. Boughter JD, Jr., Bachmanov AA. Behavioral genetics and taste. BMC Neurosci 2007; 8 Suppl 3: S3.
8. Bachmanov AA. Genetic approach to characterize interaction of sweeteners with sweet taste receptors in vivo. Chem Senses 2005; 30 Suppl 1: i82-i83.
9. Slack JP, Brockhoff A, Batram C, et al. Modulation of bitter taste perception by a small molecule hTAS2R antagonist. Curr Biol 2010; 20: 1104-9.
10. Greene TA, Alarcon S, Thomas A, et al. Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin. PLoS One 2011; 6: e20123.
11. Servant G, Tachdjian C, Tang XQ, et al. Positive allosteric modulators of the human sweet taste receptor enhance sweet taste. Proc Natl Acad Sci USA 2010; 107: 4746-51.
12. Margolskee RF, Dyer J, Kokrashvili Z, et al. T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci USA 2007; 104: 15075-80.
13. Lee RJ, Xiong G, Kofonow JM, et al. T2R38 taste receptor polymorphisms underlie susceptibility to upper respiratory infection. J Clin Invest 2012; 122: 4145-59.
14. Janssen S, Depoortere I. Nutrient sensing in the gut: new roads to therapeutics? Trends Endocrinol Metab 2013; 24: 92-100.
15. Behrens M, Meyerhof W. Gustatory and extragustatory functions of mammalian taste receptors. Physiol Behav 2011; 105: 4-13.
16. McCaughey SA. The taste of sugars. Neurosci Biobehav Rev 2008; 32: 1024-43.
17. Steiner JE, Glaser D, Hawilo ME, Berridge KC. Comparative expression of hedonic impact: affective reactions to taste by human infants and other primates. Neurosci Biobehav Rev 2001; 25: 53-74.
18. Berridge KC. Measuring hedonic impact in animals and infants: microstructure of affective taste reactivity patterns. Neurosci Biobehav Rev 2000; 24: 173-98.
19. DuBois GE. New insights on the coding of the sweet taste message in chemical structure. In: Salvadori G, ed., Firmenich Jubilee Symposium 1895-1995. Allured Publishing Corp., Carol Stream, IL, USA: Geneva, Switzerland 1995; pp. 32-95.
20. Schiffman SS, Gatlin CA. Sweeteners: State of knowledge review. Neurosci Biobehav Rev 1993; 17: 313-345.
21. Ikeda K. New seasonings. Chem Senses 2002; 27: 847-9.
22. Bachmanov AA. Umami: Fifth taste? Flavor enhancer? Perfumer and Flavorist 2010; 35: 52-57.
23. Ninomiya Y, Funakoshi M. Behavioural discrimination between glutamate and the four basic taste substances in mice. Comp Biochem Physiol 1989; 92: 365-370.
24. Ninomiya Y, Funakoshi M. Peripheral neural basis for behavioural discrimination between glutamate and the four basic taste substances in mice. Comp Biochem Physiol 1989; 92: 371-376.
25. Murata Y, Beauchamp GK, Bachmanov AA. Taste perception of monosodium glutamate and inosine monophosphate by 129P3/J and C57BL/6ByJ mice. Physiol Behav 2009; 98: 481-8.
26. Nelson G, Hoon MA, Chandrashekar J, et al. Mammalian sweet taste receptors. Cell 2001; 106: 381-90.
27. Li X, Staszewski L, Xu H, et al. Human receptors for sweet and umami taste. Proc Natl Acad Sci USA 2002; 99: 4692-6.
28. Zhao GQ, Zhang Y, Hoon MA, et al. The receptors for mammalian sweet and umami taste. Cell 2003; 115: 255-66.
29. Nelson G, Chandrashekar J, Hoon MA, et al. An amino-acid taste receptor. Nature 2002; 416: 199-202.
30. Kolakowski LF, Jr. GCRDb: a G-protein-coupled receptor database. Receptors Channels 1994; 2: 1-7.
31. Attwood TK, Findlay JB. Fingerprinting G-protein-coupled receptors. Protein Eng 1994; 7: 195-203.
32. GPCRDB: Information system for G protein-coupled receptors (GPCRs), http://www.gpcr.org/7tm/.
33. Fredriksson R, Lagerstrom MC, Lundin LG, Schioth HB. The Gprotein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol Pharmacol 2003; 63: 1256-72.
34. Max M, Shanker YG, Huang L, et al. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet 2001; 28: 58-63.
35. Montmayeur JP, Liberles SD, Matsunami H, Buck LB. A candidate taste receptor gene near a sweet taste locus. Nat Neurosci 2001; 4: 492-8.
36. Damak S, Rong M, Yasumatsu K, et al. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 2003; 301: 850-3.
37. Yee KK, Sukumaran SK, Kotha R, Gilbertson TA, Margolskee RF. Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells. Proc Natl Acad Sci USA 2011; 108: 5431-5436.
38. Naim M, Nir S, Spielman AI, et al. Hypothesis of receptordependent and receptor-independent mechanisms for bitter and sweet taste transduction: Implications for slow taste onset and lingering aftertaste. In: Given P, Parades D, eds., Chemistry of Taste: Mechanisms, Behaviors, and Mimics. ACS symposium series; 825. American Chemical Society: Washington, DC 2002; pp.2-17.
39. Peri I, Mamrud-Brains H, Rodin S, et al. Rapid entry of bitter and sweet tastants into liposomes and taste cells: implications for signal transduction. Am J Physiol Cell Physiol 2000; 278: C17-25.
40. Zubare-Samuelov M, Shaul ME, Peri I, et al. Inhibition of signal termination-related kinases by membrane-permeant bitter and sweet tastants: potential role in taste signal termination. Am J Physiol Cell Physiol 2005; 289: C483-92.
41. Chaudhari N, Yang H, Lamp C, et al. The taste of monosodium glutamate: membrane receptors in taste buds. J Neurosci 1996; 16: 3817-3826.
42. Chaudhari N, Roper SD. Molecular and physiological evidence for glutamate (umami) taste transduction via a G protein-coupled receptor. Ann N Y Acad Sci 1998; 855: 398-406.
43. Chaudhari N, Landin AM, Roper SD. A metabotropic glutamate receptor variant functions as a taste receptor. Nat Neurosci 2000; 3: 113-9.
44. San Gabriel A, Uneyama H, Yoshie S, Torii K. Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli. Chem Senses 2005; 30 Suppl 1: i25-i26.
45. Brand JG. Receptor and transduction processes for umami taste. J Nutr 2000; 130: 942S-5S.
46. 2+]i in cell ensembles: application to the study of glutamate taste in mice. Biophys J 1996; 71: 1057-1070.
47. Toyono T, Seta Y, Kataoka S, et al. Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell Tissue Res 2003; 313: 29-35.
48. Toyono T, Seta Y, Kataoka S, et al. Expression of the metabotropic glutamate receptor, mGluR4a, in the taste hairs of taste buds in rat gustatory papillae. Arch Histol Cytol 2002; 65: 91-6.
49. Lin W, Ogura T, Kinnamon SC. Responses to di-sodium guanosine 5'-monophosphate and monosodium L-glutamate in taste receptor cells of rat fungiform papillae. J Neurophysiol 2003; 89: 1434-9.
50. Grosvenor W, Kaulin Y, Spielman AI, et al. Biochemical enrichment and biophysical characterization of a taste receptor for Larginine from the catfish, Ictalurus puntatus. BMC Neurosci 2004; 5: 25.
51. Grosvenor W, Feigin AM, Spielman AI, et al. The arginine taste receptor. Physiology, biochemistry, and immunohistochemistry. Ann N Y Acad Sci 1998; 855: 134-42.
52. Kumazawa T, Brand JG, Teeter JH. Amino acid-activated channels in the catfish taste system. Biophys J 1998; 75: 2757-66.
53. Finger TE, Bryant BP, Kalinoski DL, et al. Differential localization of putative amino acid receptors in taste buds of the channel catfish, Ictalurus punctatus. J Comp Neurol 1996; 373: 129-38.
54. Beauchamp GK, Maller O, Rogers JG. Flavor preferences in cats (Felis catus and Panthera sp.). J Comp Physiol Psychol 1977; 91: 1118-1127.
55. Bartoshuk LM, Jacobs HL, Nichols TL, Hoff LA, Ryckman JJ. Taste rejection of nonnutritive sweeteners in cats. J Comp Physiol Psychol 1975; 89: 971-5.
56. Halpern BP. Gustatory nerve responses in the chicken. Am J Physiol 1962; 203: 541-4.
57. Ganchrow JR, Steiner JE, Bartana A. Behavioral reactions to gustatory stimuli in young chicks (Gallus gallus domesticus). Dev Psychobiol 1990; 23: 103-17.
58. Kare MR. Comparative aspects of the sense of taste. In: Kare MR, Halpern BP, eds., Physiological and Behavioral Aspects of Taste. The University of Chicago Press: Chicago 1961; pp. 6-15.
59. Li X, Glaser D, Li W, et al. Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora. J Hered 2009; 100 Suppl 1: S90-100.
60. Glaser D, Tinti JM, Nofre C. Evolution of the sweetness receptor in primates. I. Why does alitame taste sweet in all Prosimians and Simians, and aspartame only in Old World Simians? Chem Senses 1995; 20: 573-584.
61. Bachmanov AA, Tordoff MG, Beauchamp GK. Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem Senses 2001; 26: 905-13.
62. Roura E, Humphre B, Klasingc K, Swartd M. Is the pig a good umami sensing model for humans? A comparative taste receptor study. Flavour Fragr J 2011; 26: 282-285.
63. Ishimaru Y, Okada S, Naito H, et al. Two families of candidate taste receptors in fishes. Mech Dev 2005; 122: 1310-21.
64. Shi P, Zhang J. Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol Biol Evol 2006; 23: 292-300.
65. Zhao H, Yang JR, Xu H, Zhang J. Pseudogenization of the umami taste receptor gene Tas1r1 in the giant panda coincided with its dietary switch to bamboo. Mol Biol Evol 2010; 27: 2669-73.
66. Li R, Fan W, Tian G, et al. The sequence and de novo assembly of the giant panda genome. Nature 2010; 463: 311-7.
67. Sato JJ, Wolsan M. Loss or major reduction of umami taste sensation in pinnipeds. Naturwissenschaften 2012; 99: 655-9.
68. Zhao H, Xu D, Zhang S, Zhang J. Genomic and genetic evidence for the loss of umami taste in bats. Genome Biol Evol 2011; 4: 73-9.
69. Lagerstrom MC, Hellstrom AR, Gloriam DE, et al. The G proteincoupled receptor subset of the chicken genome. PLoS Comput Biol 2006; 2: e54.
70. Zhao H, Zhou Y, Pinto CM, et al. Evolution of the sweet taste receptor gene Tas1r2 in bats. Mol Biol Evol 2010; 27: 2642-50.
71. Daly K, Al-Rammahi M, Arora DK, et al. Expression of sweet receptor components in equine small intestine: relevance to intestinal glucose transport. Am J Physiol Regul Integr Comp Physiol 2012; 303: R199-208.
72. Li X, Li W, Wang H, et al. Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet 2005; 1: 27-35.
73. Jiang P, Josue J, Li X, et al. Major taste loss in carnivorous mammals. Proc Natl Acad Sci USA 2012; 109: 4956-61.
74. Grace J, Russek M. The influence of previous experience on the taste behavior of dogs toward sucrose and saccharin. Physiol Behav 1969; 4: 553-558.
75. Ferrell F. Preference for sugars and nonnutritive sweeteners in young beagles. Neurosci Biobehav Rev 1984; 8: 199-203.
76. Martinez del Rio C, Stevens BR, Daneke DE, Andreadis PT. Physiological correlates of preference and aversion for sugars in three species of birds. Physiol Zool 1988; 61: 222-229.
77. Matson KD, Millam JR, Klasing KC. Thresholds for sweet, salt, and sour taste stimuli in cockatiels (Nymphicus hollandicus). Zoo Biol. 2001; 20: 1-13.
78. Stiles FG. Taste preferences, color preferences, and flower choice in humminbirds. The Condor 1976; 78: 10-26.
79. Thompson JD, Elias DJ, Shumake SA, Gaddis SE. Taste preferences of the common vampire bat (Desmodus rotundus). J Chem Ecol 1982; 8: 715-721.
80. Danilova V, Hellekant G, Tinti JM, Nofre C. Gustatory responses of the hamster Mesocricetus auratus to various compounds considered sweet by humans. J Neurophysiol 1998; 80: 2102-2112.
81. Bachmanov AA, Tordoff MG, Beauchamp GK. Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem Senses 2001; 26: 905-913.
82. Inoue M, McCaughey SA, Bachmanov AA, Beauchamp GK. Whole-nerve chorda tympani responses to sweeteners in C57BL/6ByJ and 129P3/J mice. Chem Senses 2001; 26: 915-923.
83. Winnig M, Bufe B, Meyerhof W. Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci 2005; 6: 22.
84. Jiang P, Ji Q, Liu Z, et al. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J Biol Chem 2004; 279: 45068-75.
85. Xu H, Staszewski L, Tang H, et al. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci USA 2004; 101: 14258-63.
86. Jiang P, Cui M, Ji Q, et al. Molecular mechanisms of sweet receptor function. Chem Senses 2005; 30 Suppl 1: i17-i18.
87. Zhang Y, Hoon MA, Chandrashekar J, et al. Coding of sweet, bitter, and umami tastes. Different receptor cells sharing similar signaling pathways. Cell 2003; 112: 293-301.
88. Jiang P, Cui M, Zhao B, et al. Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem 2005; 280: 34296-305.
89. Jiang P, Cui M, Zhao B, et al. Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem 2005; 280: 15238-46.
90. Li X, Bachmanov AA, Maehashi K, et al. Sweet Taste Receptor Gene Variation and Aspartame Taste in Primates and Other Species. Chem Senses 2011; 36: 453-475.
91. Liu B, Ha M, Meng XY, et al. Molecular Mechanism of Species-Dependent Sweet Taste toward Artificial Sweeteners. J Neurosci 2011; 31: 11070-6.
92. Kim UK, Wooding S, Riaz N, Jorde LB, Drayna D. Variation in the human TAS1R taste receptor genes. Chem Senses 2006; 31: 599-611.
93. Lu K, McDaniel AH, Tordoff MG, et al. No relationship between sequence variation in protein coding regions of the Tas1r3 gene and saccharin preference in rats. Chem Senses 2005; 30: 231-40.
94. Reed DR, Li S, Li X, et al. Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J Neurosci 2004; 24: 938-46.
95. Reed DR, McDaniel AH. The human sweet tooth. BMC Oral Health 2006; 6 Suppl 1: S17.
96. Reed DR, Li X, Bachmanov AA, Mascioli K, Beauchamp GK. The molecular basis of the mammalian sweet tooth. In: Medeiros-Neto G, Halpern A, Bouchard C, eds., Progress in Obesity Research. John Libbey Eurotext Ltd.: London 2003; pp. 304-306.
97. Reed DR, Bachmanov AA, Beauchamp GK, Tordoff MG, Price RA. Heritable variation in food preferences and their contribution to obesity. Behav Genet 1997; 27: 373-387.
98. Reed DR, Tanaka T, McDaniel AH. Diverse tastes: Genetics of sweet and bitter perception. Physiol Behav 2006; 88: 215-26.
99. Drayna D. Human taste genetics. Annu Rev Genomics Hum Genet 2005; 6: 217-35.
100. Kim UK, Breslin PA, Reed D, Drayna D. Genetics of human taste perception. J Dent Res 2004; 83: 448-53.
101. Lugaz O, Pillias AM, Faurion A. A new specific ageusia: some humans cannot taste L-glutamate. Chem Senses 2002; 27: 105-15.
102. Fushan AA, Simons CT, Slack JP, Manichaikul A, Drayna D. Allelic polymorphism within the TAS1R3 promoter is associated with human taste sensitivity to sucrose. Curr Biol 2009; 19: 1288-93.
103. Eny KM, Wolever TM, Corey PN, El-Sohemy A. Genetic variation in TAS1R2 (Ile191Val) is associated with consumption of sugars in overweight and obese individuals in 2 distinct populations. Am J Clin Nutr 2010; 92: 1501-10.
104. Chen QY, Alarcon S, Tharp A, et al. Perceptual variation in umami taste and polymorphisms in TAS1R taste receptor genes. Am J Clin Nutr 2009; 90: 770S-779S.
105. Raliou M, Boucher Y, Wiencis A, et al. Tas1R1-Tas1R3 taste receptor variants in human fungiform papillae. Neurosci Lett 2009; 451: 217-21.
106. Shigemura N, Shirosaki S, Sanematsu K, Yoshida R, Ninomiya Y. Genetic and molecular basis of individual differences in human umami taste perception. PLoS One 2009; 4: e6717.
107. Fuller JL. Single-locus control of saccharin preference in mice. J Hered 1974; 65: 33-36.
108. Lush IE. The genetics of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet Res 1989; 53: 95-99.
109. Lush IE, Hornigold N, King P, Stoye JP. The genetics of tasting in mice. VII. Glycine revisited, and the chromosomal location of Sac and Soa. Genet Res 1995; 66: 167-174.
110. Belknap JK, Crabbe JC, Plomin R, et al. Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: Some methodological implications for RI strain analysis. Behav Genet 1992; 22: 81-100.
111. Bachmanov AA, Li X, Reed DR, et al. Positional cloning of the mouse saccharin preference (Sac) locus. Chem Senses 2001; 26: 925-933.
112. Li X, Bachmanov AA, Li S, et al. Genetic, physical and comparative map of the subtelomeric region of mouse chromosome 4. Mamm Genome 2002; 13: 5-19.
113. Nie Y, Vigues S, Hobbs JR, Conn GL, Munger SD. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr Biol 2005; 15: 1948-52.
114. Inoue M, Reed DR, Li X, et al. Allelic variation of the Tas1r3 taste receptor gene selectively affects behavioral and neural taste responses to sweeteners in the F2 hybrids between C57BL/6ByJ and 129P3/J mice. J Neurosci 2004; 24: 2296-303.
115. Inoue M, Glendinning JI, Theodorides ML, et al. Allelic variation of the Tas1r3 taste receptor gene selectively affects taste responses to sweeteners: evidence from 129. B6-Tas1r3 congenic mice. Physiol Genomics 2007; 32: 82-94.
116. Zukerman S, Glendinning JI, Margolskee RF, Sclafani A. T1R3 taste receptor is critical for sucrose but not Polycose taste. Am J Physiol Regul Integr Comp Physiol 2009; 296: R866-76.
117. Treesukosol Y, Blonde GD, Spector AC. T1R2 and T1R3 subunits are individually unnecessary for normal affective licking responses to Polycose: implications for saccharide taste receptors in mice. Am J Physiol Regul Integr Comp Physiol 2009; 296: R855-65.
118. Sclafani A. The sixth taste? Appetite 2004; 43: 1-3.
119. Glendinning JI. Is the bitter rejection response always adaptive? Physiol Behav 1994; 56: 1217-27.
120. Adler E, Hoon MA, Mueller KL, et al. A novel family of mammalian taste receptors. Cell 2000; 100: 693-702.
121. Chandrashekar J, Mueller KL, Hoon MA, et al. T2Rs function as bitter taste receptors. Cell 2000; 100: 703-711.
122. Matsunami H, Montmayeur JP, Buck LB. A family of candidate taste receptors in human and mouse. Nature 2000; 404: 601-604.
123. Mueller KL, Hoon MA, Erlenbach I, et al. The receptors and coding logic for bitter taste. Nature 2005; 434: 225-9.
124. Chandrashekar J, Hoon MA, Ryba NJ, Zuker CS. The receptors and cells for mammalian taste. Nature 2006; 444: 288-94.
125. Behrens M, Foerster S, Staehler F, Raguse JD, Meyerhof W. Gustatory expression pattern of the human TAS2R bitter receptor gene family reveals a heterogenous population of bitter responsive taste receptor cells. J Neurosci 2007; 27: 12630-40.
126. Spector AC, Kopka SL. Rats fail to discriminate quinine from denatonium: implications for the neural coding of bitter-tasting compounds. J Neurosci 2002; 22: 1937-41.
127. Aspen J, Gatch MB, Woods JH. Training and characterization of a quinine taste discrimination in rhesus monkeys. Psychopharmacology (Berl) 1999; 141: 251-7.
128. Chan CY, Yoo JE, Travers SP. Diverse bitter stimuli elicit highly similar patterns of Fos-like immunoreactivity in the nucleus of the solitary tract. Chem Senses 2004; 29: 573-81.
129. Scott TR, Giza BK, Yan J. Gustatory neural coding in the cortex of the alert cynomolgus macaque: the quality of bitterness. J Neurophysiol 1999; 81: 60-71.
130. Caicedo A, Roper SD. Taste receptor cells that discriminate between bitter stimuli. Science 2001; 291: 1557-60.
131. Dahl M, Erickson RP, Simon SA. Neural responses to bitter compounds in rats. Brain Res 1997; 756: 22-34.
132. Frank ME, Bouverat BP, MacKinnon BI, Hettinger TP. The distinctiveness of ionic and nonionic bitter stimuli. Physiol Behav 2004; 80: 421-31.
133. Meyerhof W, Batram C, Kuhn C, et al. The molecular receptive ranges of human TAS2R bitter taste receptors. Chem Senses 2010; 35: 157-70.
134. Behrens M, Meyerhof W. Bitter taste receptors and human bitter taste perception. Cell Mol Life Sci 2006; 63: 1501-9.
135. Kim UK, Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clin Genet 2005; 67: 275-80.
136. Kim U, Wooding S, Ricci D, Jorde LB, Drayna D. Worldwide haplotype diversity and coding sequence variation at human bitter taste receptor loci. Hum Mutat 2005; 26: 199-204.
137. Meyerhof W. Elucidation of mammalian bitter taste. Rev Physiol Biochem Pharmacol 2005; 154: 37-72.
138. Sawano S, Seto E, Mori T, Hayashi Y. G-protein-dependent and-independent pathways in denatonium signal transduction. Biosci Biotechnol Biochem 2005; 69: 1643-51.
139. Lindemann B. Taste reception. Physiol Rev 1996; 76: 719-766.
140. Rosenzweig S, Yan W, Dasso M, Spielman AI. Possible novel mechanism for bitter taste mediated through cGMP. J Neurophysiol 1999; 81: 1661-5.
141. Takeuchi H, Tsunenari T, Kurahashi T, Kaneko A. Physiology of morphologically identified cells of the bullfrog fungiform papilla. Neuroreport 2001; 12: 2957-62.
142. Jacobs WW. Taste responses in wild and domestic guinea pigs. Physiol Behav 1978; 20: 579-588.
143. Glendinning JI. Is the bitter rejection response always adaptive? Physiol Behav 1994; 56: 1217-1227.
144. Nolte DL, Mason JR, Lewis SL. Tolerance of bitter compounds by an herbivore, Cavia porcellus. J Chem Ecol 1994; 20: 303-308.
145. Field KL, Bachmanov AA, Mennella JA, Beauchamp GK, Kimball BA. Protein hydrolysates are avoided by herbivores but not by omnivores in two-choice preference tests. PLoS One 2009; 4: e4126.
146. Field KL, Beauchamp GK, Kimball BA, Mennella JA, Bachmanov AA. Bitter avoidance in guinea pigs (Cavia porcellus) and mice (Mus musculus and Peromyscus leucopus). J Comp Psychol 2010; 124: 455-9.
147. Nelson TM, Munger SD, Boughter JD, Jr. Taste sensitivities to PROP and PTC vary independently in mice. Chem Senses 2003; 28: 695-704.
148. Bachmanov AA, Beauchamp GK. Taste Receptor Genes. Annu Rev Nutr 2007; 27: 389-414.
149. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to betaglucopyranosides. Nat Genet 2002; 32: 397-401.
150. Bufe B, Breslin PA, Kuhn C, et al. The molecular basis of individual differences in phenylthiocarbamide and propylthiouracil bitterness perception. Curr Biol 2005; 15: 322-7.
151. Wooding S, Bufe B, Grassi C, et al. Independent evolution of bitter-taste sensitivity in humans and chimpanzees. Nature 2006; 440: 930-4.
152. Go Y. Lineage-specific expansions and contractions of the bitter taste receptor gene repertoire in vertebrates. Mol Biol Evol 2006; 23: 964-72.
153. Shi P, Zhang J, Yang H, Zhang YP. Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol 2003; 20: 805-14.
154. Conte C, Ebeling M, Marcuz A, Nef P, Andres-Barquin PJ. Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiol Genomics 2003; 14: 73-82.
155. Liman ER. Use it or lose it: molecular evolution of sensory signaling in primates. Pflugers Arch 2006; 453: 125-31.
156. Ueda T, Ugawa S, Ishida Y, et al. Identification of coding singlenucleotide polymorphisms in human taste receptor genes involving bitter tasting. Biochem Biophys Res Commun 2001; 285: 147-51.
157. Wang X, Thomas SD, Zhang J. Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes. Hum Mol Genet 2004; 13: 2671-8.
158. Guo SW, Reed DR. The genetics of phenylthiocarbamide perception. Ann Hum Biol 2001; 28: 111-42.
159. Kim UK, Jorgenson E, Coon H, et al. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003; 299: 1221-5.
160. Drayna D, Coon H, Kim UK, et al. Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum Genet 2003; 112: 567-72.
161. Prodi DA, Drayna D, Forabosco P, et al. Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chem Senses 2004; 29: 697-702.
162. Mennella JA, Pepino MY, Reed DR. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005; 115: e216-22.
163. Duffy VB, Davidson AC, Kidd JR, et al. Bitter receptor gene (TAS2R38), 6-n-propylthiouracil (PROP) bitterness and alcohol intake. Alcohol Clin Exp Res 2004; 28: 1629-37.
164. Sandell MA, Breslin PA. Variability in a taste-receptor gene determines whether we taste toxins in food. Curr Biol 2006; 16: R792-4.
165. Wooding S, Kim UK, Bamshad MJ, et al. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am J Hum Genet 2004; 74: 637-46.
166. Soranzo N, Bufe B, Sabeti PC, et al. Positive selection on a highsensitivity allele of the human bitter-taste receptor TAS2R16. Curr Biol 2005; 15: 1257-65.
167. Roudnitzky N, Bufe B, Thalmann S, et al. Genomic, genetic and functional dissection of bitter taste responses to artificial sweeteners. Hum Mol Genet 2011; 20: 3437-49.
168. Reed DR, Zhu G, Breslin PA, et al. The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12. Hum Mol Genet 2010; 19: 4278-85.
169. Nelson TM, Munger SD, Boughter JD, Jr. Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice. BMC Genet 2005; 6: 32.
170. Boughter JD, Jr., Raghow S, Nelson TM, Munger SD. Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli. BMC Genet 2005; 6: 36.
171. Fitzsimons JT. The Physiology of Thirst and Sodium Appetite. Cambridge University Press: Cambridge 1979.
172. Denton D. The hunger for salt: An anthropological, physiological and medical analysis. Springer-Verlag: Berlin 1984.
173. Beauchamp GK, Stein LJ. Salt Taste. In: Firestein S, Beauchamp GK, eds., Olfaction and Taste. Elsevier/Academic Press: San Diego 2008; pp. 401-408.
174. Schiffman S, Lockhead E, Mars F. Amiloride reduces the taste intensity of Na+ and Li+ salts and sweeteners. Proc Natl Acad Sci USA 1983; 80: 6136-6140.
175. Heck GL, Mierson S, DeSimone JA. Salt taste transduction occurs through an amiloride-sensitive sodium transport pathway. Science 1984; 223: 403-405.
176. Brand J, Teeter J, Silver W. Inhibition by amiloride of chorda tympani responses evoked by monovalent salts. Brain Res 1985; 334: 207-214.
177. Kellenberger S, Schild L. Epithelial sodium channel/degenerin family of ion channels: a variety of functions for a shared structure. Physiol Rev 2002; 82: 735-67.
178. Bachmanov AA, Li X, Reed DR, et al. Positional cloning of the mouse saccharin preference (Sac) locus. Chem Senses 2001; 26: 925-33.
179. Li XJ, Blackshaw S, Snyder SH. Expression and localization of amiloride-sensitive sodium channel indicate a role for non-taste cells in taste perception. Proc Natl Acad Sci USA 1994; 91: 1814-8.
180. Lindemann B, Barbry P, Kretz O, Bock R. Occurrence of ENaC subunit mRNA and immunocytochemistry of the channel subunits in taste buds of the rat vallate papilla. Ann N Y Acad Sci 1998; 855: 116-27.
181. Kretz O, Barbry P, Bock R, Lindemann B. Differential expression of RNA and protein of the three pore-forming subunits of the amiloride-sensitive epithelial sodium channel in taste buds of the rat. J Histochem Cytochem 1999; 47: 51-64.
182. Lin W, Finger TE, Rossier BC, Kinnamon SC. Epithelial Na+ channel subunits in rat taste cells: localization and regulation by aldosterone. J Comp Neurol 1999; 405: 406-20.
183. Lindemann B. Sodium taste. Curr Opin Nephrol Hypertens 1997; 6: 425-9.
184. Halpern BP. Amiloride and vertebrate gustatory responses to NaCl. Neurosci Biobehav Rev 1998; 23: 5-47.
185. Boughter JD, Jr., Gilbertson TA. From channels to behavior: an integrative model of NaCl taste. Neuron 1999; 22: 213-5.
186. Bosak N, Inoue M, Nelson T, et al. Epithelial sodium channel (ENaC) is involved in reception of sodium taste: evidence from mice with a tissue-specific conditional targeted mutation of the ENaCa gene (Abstract). AChemS XXXII Annual Meeting; 2010 April 21-25; St. Petersburg (FL). Chem Senses 2010; 35: doi:10.1093/chemse/bjq071.
187. Chandrashekar J, Kuhn C, Oka Y, et al. The cells and peripheral representation of sodium taste in mice. Nature 2010; 464: 297-301.
188. Ye Q, Heck GL, DeSimone JA. Voltage dependence of the rat chorda tympani response to Na+ salts: implications for the functional organization of taste receptor cells. J Neurophysiol 1993; 70: 167-78.
189. Mierson S, Olson MM, Tietz AE. Basolateral amiloride-sensitive Na+ transport pathway in rat tongue epithelium. J Neurophysiol 1996; 76: 1297-309.
190. Yoshida R, Horio N, Murata Y, et al. NaCl responsive taste cells in the mouse fungiform taste buds. Neuroscience 2009; 159: 795-803.
191. Formaker BK, Hill DL. An analysis of residual NaCl taste response after amiloride. Am J Physiol 1988; 255: R1002-7.
192. Elliott EJ, Simon SA. The anion in salt taste: a possible role of paracellular pathways. Brain Res 1990; 535: 9-17.
193. Rehnberg BG, MacKinnon BI, Hettinger TP, Frank ME. Anion modulation of taste responses in sodium-sensitive neurons of the hamster chorda tympani nerve. J Gen Physiol 1993; 101: 453-65.
194. Oka Y, Butnaru M, von Buchholtz L, Ryba NJ, Zuker CS. High salt recruits aversive taste pathways. Nature 2013; 494: 472-475.
195. Caterina MJ, Schumacher MA, Tominaga M, et al. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-824.
196. Lyall V, Heck GL, Vinnikova AK, et al. The mammalian amiloride-insensitive non-specific salt taste receptor is a vanilloid receptor-1 variant. J Physiol 2004; 558: 147-59.
197. Ruiz C, Gutknecht S, Delay E, Kinnamon S. Detection of NaCl and KCl in TRPV1 knockout mice. Chem Senses 2006; 31: 813-20.
198. Treesukosol Y, Lyall V, Heck GL, DeSimone JA, Spector AC. A psychophysical and electrophysiological analysis of salt taste in Trpv1 null mice. Am J Physiol Regul Integr Comp Physiol 2007; 292: R1799-809.
199. Breza JM, Contreras RJ. Anion size modulates salt taste in rats. J Neurophysiol 2012; 107: 1632-48.
200. Smith KR, Treesukosol Y, Paedae AB, Contreras RJ, Spector AC. Contribution of the TRPV1 channel to salt taste quality in mice as assessed by conditioned taste aversion generalization and chorda tympani nerve responses. Am J Physiol Regul Integr Comp Physiol 2012; 303: R1195-205.
201. Kido MA, Muroya H, Yamaza T, Terada Y, Tanaka T. Vanilloid receptor expression in the rat tongue and palate. J Dent Res 2003; 82: 393-7.
202. Ishida Y, Ugawa S, Ueda T, Murakami S, Shimada S. Vanilloid receptor subtype-1 (VR1) is specifically localized to taste papillae. Brain Res Mol Brain Res 2002; 107: 17-22.
203. Moon YW, Lee JH, Yoo SB, Jahng JW. Capsaicin receptors are colocalized with sweet/bitter receptors in the taste sensing cells of circumvallate papillae. Genes Nutr 2010; 5: 251-5.
204. Riera CE, Vogel H, Simon SA, le Coutre J. Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. Am J Physiol Regul Integr Comp Physiol 2007; 293: R626-34.
205. Moyer B, Zlotnik A, Hevezi P, et al. Identification of TRPML3 (MCOLN3) as a Salty Taste Receptor and Use in Assays for Identifying Taste (Salty) Modulators and/or Therapeutics that Modulate Sodium Transport, Absorption or Excretion and/or Aldosterone and/or Vasopressin Production or Release. 2009 Patent Pub. No.: WO/2009/008950.
206. Castiglioni AJ, Remis NN, Flores EN, Garcia-Anoveros J. Expression and vesicular localization of mouse Trpml3 in stria vascularis, hair cells, and vomeronasal and olfactory receptor neurons. J Comp Neurol 2011; 519: 1095-114.
207. Ossebaard CA, Polet IA, Smith DV. Amiloride effects on taste quality: comparison of single and multiple response category procedures. Chem Senses 1997; 22: 267-75.
208. Huque T, Cowart BJ, Dankulich-Nagrudny L, et al. Sour ageusia in two individuals implicates ion channels of the ASIC and PKD families in human sour taste perception at the anterior tongue. PLoS One 2009; 4: e7347.
209. Stähler F, Riedel K, Demgensky S, et al. A role of the epithelial sodium channel in human salt taste transduction? Chemosensory Perception 2008; 1: 78-90.
210. Brand JG, Huque T. Human salty taste receptor and methods of modulating salty taste perception. 2008 Patent Pub. No.: WO2008051447 A2.
211. Ji HL, Zhao RZ, Chen ZX, et al. delta ENaC: a novel divergent amiloride-inhibitable sodium channel. Am J Physiol Lung Cell Mol Physiol 2012; 303: L1013-26.
212. Giraldez T, Rojas P, Jou J, Flores C, Alvarez de la Rosa D. The epithelial sodium channel delta-subunit: new notes for an old song. Am J Physiol Renal Physiol 2012; 303: F328-38.
213. Hellekant G, Ninomiya Y, Danilova V. Taste in chimpanzees II: single chorda tympani fibers. Physiol Behav 1997; 61: 829-41.
214. Danilova V, Danilov Y, Roberts T, et al. Sense of taste in a new world monkey, the common marmoset: recordings from the chorda tympani and glossopharyngeal nerves. J Neurophysiol 2002; 88: 579-94.
215. Eylam S, Spector AC. Oral amiloride treatment decreases taste sensitivity to sodium salts in C57BL/6J and DBA/2J mice. Chem Senses 2003; 28: 447-58.
216. Liu L, Leonard AS, Motto DG, et al. Contribution of Drosophila DEG/ENaC genes to salt taste. Neuron 2003; 39: 133-46.
217. Ishiwatari Y, Bachmanov AA. NaCl taste thresholds in 13 inbred mouse strains. Chem Senses 2012; 37: 497-508.
218. Shigemura N, Ohkuri T, Sadamitsu C, et al. Amiloride-sensitive NaCl taste responses are associated with genetic variation of ENaC-subunit in mice Am J Physiol Regul Integr Comp Physiol 2008; 294: R66-R75.
219. Dias AG, Rousseau D, Duizer L, et al. Genetic variation in putative salt taste receptors and salt taste perception in humans. Chem Senses 2013; 38: 137-45.
220. Nelson TM, Lopezjimenez ND, Tessarollo L, et al. Taste function in mice with a targeted mutation of the Pkd1l3 gene. Chem Senses 2010; 35: 565-77.
221. Ishimaru Y, Inada H, Kubota M, et al. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc Natl Acad Sci USA 2006; 103: 12569-74.
222. Huang AL, Chen X, Hoon MA, et al. The cells and logic for mammalian sour taste detection. Nature 2006; 442: 934-8.
223. LopezJimenez ND, Sainz E, Cavenagh MM, et al. Two novel genes, Gpr113, which encodes a family 2 G-protein-coupled receptor, and Trcg1, are selectively expressed in taste receptor cells. Genomics 2005; 85: 472-82.
224. Horio N, Yoshida R, Yasumatsu K, et al. Sour taste responses in mice lacking PKD channels. PLoS One 2011; 6: e20007.
225. Wise PM, Hansen JL, Reed DR, Breslin PA. Twin study of the heritability of recognition thresholds for sour and salty taste. Chem Senses 2007; 32: 749-54.
226. Bachmanov AA, Tordoff MG, Beauchamp GK. Acid acceptance in 28 mouse strains (Abstract). Chem Senses 2000; 25: 600.
227. Gilbertson TA, Baquero AF, Spray-Watson KJ. Water taste: the importance of osmotic sensing in the oral cavity. J Water Health 2006; 4 Suppl 1: 35-40.
228. Gilbertson TA, Kim I, Siears NL, Zhang H, Liu L. The water response in taste cells: expression of aquaporin-1,-2 and-5 and the characterization of hypoosmic-induced currents in mammalian taste cells (Abstract). Chem Senses 1999; 24: 596.
229. Bartoshuk LM. NaCl thresholds in man: thresholds for water taste or NaCl taste? J Comp Physiol Psychol 1974; 87: 310-25.
230. Bartoshuk LM. Water taste in mammals. In: Weijnen JAWM, Mendelson J, eds., Drinking behavior: oral stimulation, reinforcement, and preference. Plenum Press: New York 1977; pp. 317-339.
231. Bartoshuk LM, McBurney DH, Pfaffmann C. Taste of sodium chloride solutions after adaptation to sodium chloride: implications for the "water taste". Science 1964; 143: 967-8.
232. McBurney DH, Bartoshuk LM. Water taste in mammals. In: Schneider D, ed., Olfaction and Taste IV. Proceedings of the Fourth International Symposium held in Starnberg, Germany, August 2-4 1971. Wissenschaftlische Verlagsgesellschaft MBH: Stuttgart 1972; pp. 329-335.
233. DuBois GE. Unraveling the biochemistry of sweet and umami tastes. Proc Natl Acad Sci USA 2004; 101: 13972-3.
234. Galindo-Cuspinera V, Winnig M, Bufe B, Meyerhof W, Breslin PA. A TAS1R receptor-based explanation of sweet 'water-taste'. Nature 2006; 441: 354-7.
235. Bachmanov AA, Kiefer SW, Molina JC, et al. Chemosensory factors influencing alcohol perception, preferences, and consumption. Alcohol Clin Exp Res 2003; 27: 220-31.
236. Bachmanov AA, Reed DR, Li X, et al. Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross. Genome Res 2002; 12: 1257-68.
237. Hinrichs AL, Wang JC, Bufe B, et al. Functional variant in a bittertaste receptor (hTAS2R16) influences risk of alcohol dependence. Am J Hum Genet 2006; 78: 103-11.
238. Dunkel A, Koster J, Hofmann T. Molecular and sensory characterization of gamma-glutamyl peptides as key contributors to the kokumi taste of edible beans (Phaseolus vulgaris L.). J Agric Food Chem 2007; 55: 6712-9.
239. Ueda Y, Yonemitsu M, Tsubuku T, Sakaguchi M, Miyajima R. Flavor characteristics of glutathione in raw and cooked foodstuffs. Biosci Biotechnol Biochem 1997; 61: 1977-80.
240. Ohsu T, Amino Y, Nagasaki H, et al. Involvement of the calciumsensing receptor in human taste perception. J Biol Chem 2010; 285: 1016-22.
241. San Gabriel A, Uneyama H, Maekawa T, Torii K. The calciumsensing receptor in taste tissue. Biochem Biophys Res Commun 2009; 378: 414-8.
242. Maruyama Y, Yasuda R, Kuroda M, Eto Y. Kokumi substances, enhancers of basic tastes, induce responses in calcium-sensing receptor expressing taste cells. PLoS One 2012; 7: e34489.
243. Tordoff MG. Calcium: taste, intake, and appetite. Physiol Rev 2001; 81: 1567-97.
244. Tordoff MG, Shao H, Alarcon LK, et al. Involvement of T1R3 in calcium-magnesium taste. Physiol Genomics 2008; 34: 338-48.
245. Tordoff MG, Alarcon LK, Valmeki S, Jiang P. T1R3: a human calcium taste receptor. Sci Rep 2012; 2: 496.
246. Fukuwatari T, Kawada T, Tsuruta M, et al. Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats. FEBS Lett 1997; 414: 461-4.
247. Zhang X, Fitzsimmons RL, Cleland LG, et al. CD36/fatty acid translocase in rats: distribution, isolation from hepatocytes, and comparison with the scavenger receptor SR-B1. Lab Invest 2003; 83: 317-32.
248. Laugerette F, Passilly-Degrace P, Patris B, et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest 2005; 115: 3177-84.
249. Cartoni C, Yasumatsu K, Ohkuri T, et al. Taste preference for fatty acids is mediated by GPR40 and GPR120. J Neurosci 2010; 30: 8376-82.
250. Matsumura S, Mizushige T, Yoneda T, et al. GPR expression in the rat taste bud relating to fatty acid sensing. Biomed Res 2007; 28: 49-55.
251. Gaillard D, Laugerette F, Darcel N, et al. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J 2008; 22: 1458-68.
252. El-Yassimi A, Hichami A, Besnard P, Khan NA. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. J Biol Chem 2008; 283: 12949-59.
253. Sclafani A, Ackroff K, Abumrad NA. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. Am J Physiol Regul Integr Comp Physiol 2007; 293: R1823-32.
254. Galindo MM, Voigt N, Stein J, et al. G protein-coupled receptors in human fat taste perception. Chem Senses 2012; 37: 123-39.
255. Pepino MY, Love-Gregory L, Klein S, Abumrad NA. The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects. J Lipid Res 2012; 53: 561-6.
256. Keller KL, Liang LC, Sakimura J, et al. Common variants in the CD36 gene are associated with oral fat perception, fat preferences, and obesity in African Americans. Obesity (Silver Spring) 2012; 20: 1066-73.
257. Bachmanov AA. Genetic architecture of sweet taste. In: Weerasinghe DK, DuBois GE, eds., Sweetness and Sweeteners: Biology, Chemistry and Psychophysics. American Chemical Society: Washington, D.C. 2008; pp. 18-47.
258. Shi P, Zhang J. Extraordinary diversity of chemosensory receptor gene repertoires among vertebrates. Results Probl Cell Differ 2009; 47: 57-75.
259. Dong D, Jones G, Zhang S. Dynamic evolution of bitter taste receptor genes in vertebrates. BMC Evol Biol 2009; 9: 12.
260. Davis JK, Lowman JJ, Thomas PJ, et al. Evolution of a bitter taste receptor gene cluster in a New World sparrow. Genome Biol Evol 2010; 2: 358-70.
261. Zhou Y, Dong D, Zhang S, Zhao H. Positive selection drives the evolution of bat bitter taste receptor genes. Biochem Genet 2009; 47: 207-15.
262. Oike H, Nagai T, Furuyama A, et al. Characterization of ligands for fish taste receptors. J Neurosci 2007; 27: 5584-92.
263. Kusuhara Y, Yoshida R, Ohkuri T, Yasumatsu K, Voigt A, Hubner S, Maeda K, Boehm U, Meyerhof W, Ninomiya Y. Taste responses in mice lacking taste receptor subunit T1R1. J Physiol 2013; 591: 1967-1985.
264. Ohmoto M, Okada S, Nakamura S, Abe K, Matsumoto I. Mutually exclusive expression of Gaia and Ga14 reveales diversification of taste receptor cells in zebrafish. J Comp Neurol 2011; 519: 1616-1629.