Genetic analysis of a complex trait in the Utah Genetic Reference Project: A major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p

Human Genetics

Volumn 112, Issue 5-6, 2003, Pages 567-572

  Drayna, Dennis ^b   Coon, Hilary ^a   Kim, Un Kyung ^b   Elsner, Tami ^a   Cromer, Kevin ^a   Otterud, Brith ^a   Baird, Lisa ^a   Peiffer, Andy P ^c   Leppert, Mark ^a  

^a UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTES OF HEALTH   (United States)

^c UNIVERSITY OF UTAH HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PHENYLTHIOUREA;

AGE; ARTICLE; CHROMOSOME 10; CHROMOSOME 16P; CHROMOSOME 3; CHROMOSOME 7Q; FAMILIAL INCIDENCE; FEMALE; GENDER; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC TRAIT; GENOTYPE; GENOTYPE PHENOTYPE CORRELATION; HUMAN; HUMAN EXPERIMENT; MALE; PRIORITY JOURNAL; QUALITATIVE ANALYSIS; QUANTITATIVE ANALYSIS; RECESSIVE INHERITANCE; TASTE ACUITY; UNITED STATES; ADOLESCENT; ADULT; AGED; CHROMOSOME 16; CHROMOSOME 7; GENETIC LINKAGE; GENETICS; METABOLISM; MIDDLE AGED; PHYSIOLOGY; QUANTITATIVE TRAIT LOCUS; TASTE;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CHROMOSOMES, HUMAN, PAIR 16; CHROMOSOMES, HUMAN, PAIR 7; HUMANS; LOD SCORE; MIDDLE AGED; PHENYLTHIOUREA; QUANTITATIVE TRAIT LOCI; TASTE; UTAH;

EID: 0038121048     PISSN: 03406717     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00439-003-0911-y     Document Type: Article

References (35)

1. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJP, Zuker CS (2000) A novel family of mammalian taste receptors. Cell 100:693-702
2. Almasy L, Blangero J (1998) Multipoint quantitative-trait linkage analysis in general pedigrees. Am J Hum Genet 62:1198-1211
3. Anonymous (1931) Tasteblindness. Science 73 (Suppl):14
4. Blakeslee AF, Salmon TN (1935) Genetics of sensory thresholds: Individual taste reactions for different substances. Proc Nat Acad Sci USA 21:84-90
5. Blangero J, Almasy L (1997) Multipoint oligogenic linkage analysis of quantitative traits. Genet Epidemiol 14:959-964
6. Blangero J, Williams JT, Almasy L (2000) Robust LOD scores for variance component-based linkage analysis. Genet Epidemiol 19:S8-S14
7. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ (2000) T2Rs function as bitter taste receptors. Cell 100:703-711
8. Chautard-Freire-Maia EA (1974) Linkage relationships between 22 autosomal markers. Ann Hum Genet 38:191-198
9. Cherry JL, Young H, Di Sera LJ, Ferguson FM, Kimball AW, Dunn DM, Gesteland RF, Weiss RB (1994) Enzyme-linked fluorescent detection for automated multiplex DNA sequencing. Genomics 20:68-74
10. Conneally PM, Dumont-Driscoll M, Huntzinger RS, Nance WE, Jackson CE (1976) Linkage relations of the loci for Kell and phenylthiocarbamide taste sensitivity. Hum Hered 26:267-271
11. Coon H, Leppert MF, Eckfeldt JH, Oberman A, Myers RH, Peacock JM, Province MA, Hopkins PN, Heiss G (2001) Genomewide linkage analysis of lipids in the HyperGEN Blood Pressure Study. Arterioscler Thromb Vasc Biol 21:1969-1976
12. Crandall BF, Spence MA (1974) Linkage relations of the phenylthiocarbamide locus (PTC). Hum Hered 24:247-252
13. Dausset J, Cann H, Cohen D, Lathrop M, Lalouel J-M, White R (1990) Program description - Centre d'Etude du Polymorphisme Humain (CEPH) - Collaborative mapping of the human genome. Genomics 6:575-577
14. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millaseau P, Marc S, Hazan J, Seboun E, Lathrop M, Gyapay G, Morissette J, Weissenbach JA (1996) A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380:152-154
15. Enoch M-A, Harris CR, Goldman D (2001) Does a reduced sensitivity to bitter taste increase the risk of becoming nicotine addicted? Addict Behav 26:399-404
16. Green BG, Shaffer GS, Gilmore M (1993) Derivation and evaluation of a semantic scale of oral sensation magnitude with apparent ratio properties. Chem Senses 18:683-702
17. Guo S-W, Reed D (2001) The genetics of phenylthiocarbamide perception. Ann Hum Biol 28:111-142
18. Hall MA, Norman PJ, Thiel B, Tiwari H, Peiffer A, Vaughan RW, Prescott S, Leppert M, Schork NJ, Lanchbury JS (2002) Quantitative trait loci on chromosomes 1, 2, 3, 4, 8, 9, 11, 12, and 18 control variation in levels of T and B lymphocyte subpopulations. Am J Hum Genet 70:1172-1182
19. Harris H, Kalmus H (1949) The measurement of taste sensitivity to phenylthiourea (PTC). Ann Eugenics (Lond) 15:24-31
20. Holt HA, Thompson JS, Sanger R, Race RR (1952) Linkage relations of the blood group genes of man. Heredity 6:213-216
21. Kalmus H (1958) Improvements in the classification of the taster genotypes. Ann Hum Genet 22:222-230
22. Kruglyak L, Daly MJ, Reeve-Daly MP, Lander ES (1996) Parametric and nonparametric linkage analysis: A unified multipoint approach. Am J Hum Genet 58:1347-1363
23. Lander E, Kruglyak (1995) Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247
24. Lange K, Little RJA, Taylor JMG (1989) Robust statistical modeling using the t distribution. J Am Stat Assoc 84:881-896
25. NIH/CEPH Collaborative Mapping Group (1992) A comprehensive genetic linkage map of the human genome. Science 258: 67-86
26. Olson JM, Boehnke M, Neiswanger K, Roche AF, Siervogel RM (1989) Alternative genetics models for the inheritance of the phenylthiocarbamide taste deficiency. Genet Epidemiol 6:423-434
27. Prodi DA, Drayna D, Angius A, Forabosco P, Piras D, Palmas MA, Pirastu M (2002) Genetics of bitter taste: Identification of a Ch7q35 locus in a Sardinian genetic isolate. Am J Hum Genet 71[Suppl]:464
28. Reddy BM, Rao DC (1989) Phenylthiocarbamide taste sensitivity revisited; Complete sorting test supports residual family resemblance. Genet Epidemiol 6:413-421
29. Reed D, Nanthakumar E, North M, Bell C, Bartoshuk L, Price RA (1999) Localization of a gene for bitter taster perception to human chromosome 5p15. Am J Hum Genet 64:1478-1480
30. Spence MA, Falk CT, Neiswanger K, Field LL, Marazita ML, Allen FH, Siervogel RM, Roche AF, Crandall BF, Sparkes RS (1984) Estimating the recombination frequency for the PTC-Kell linkage. Hum Genet 67:183-186
31. Tepper B (1998) 6-n-Propylthiouracil: A genetic marker for taste, with implications for food preference and dietary habits. Am J Hum Genet 63:1271-1276
32. Utah Marker Development Group (1995) A collection of ordered tetranucleotide-repeat markers from the human genome. The Utah Marker Development Group. Am J Hum Genet 57:619-628
33. Weber JL, Broman KW (2001) Genotyping for human whole-genome scans: Past, present, and future. Adv Genet 42:77-96
34. White R, Leppert M, Bishop DT, Barker D, Berkowitz J, Brown C, Callahan P, Holm T, Jerominski L (1985) Construction of linkage maps with DNA markers for human chromosomes. Nature 313:101-105
35. Zhang W, Tapper W, Collins A, Jacobs KB, Elston RC, Morton NE (2001) A tournament of linkage tests in complex inheritance. Hum Hered 52:140-148