The fatty acid translocase gene CD36 and lingual lipase influence oral sensitivity to fat in obese subjects

Journal of Lipid Research

Volumn 53, Issue 3, 2012, Pages 561-566

  Pepino, Marta Yanina ^a   Love Gregory, Latisha ^a   Klein, Samuel ^a   Abumrad, Nada A ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Diet and dietary lipids; Fat oral sensitivity; Genetics; Lipids; Obesity; Taste perception; Triglycerides

Indexed keywords

CD36 ANTIGEN; FATTY ACID; OLEIC ACID; TETRAHYDROLIPSTATIN; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; TRIOLEIN;

ADULT; ANTIGEN EXPRESSION; ARTICLE; BODY MASS; CALORIC INTAKE; CLINICAL ARTICLE; CONTROLLED STUDY; EMULSION; FAT INTAKE; FEMALE; FOOD INTAKE; FOOD PREFERENCE; GENOTYPE; HETEROZYGOSITY; HOMOZYGOSITY; HUMAN; LIPID ANALYSIS; MALE; OBESITY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; TASTE; TASTE ACUITY; TASTE DISCRIMINATION;

ADULT; ANTIGENS, CD36; DIETARY FATS; FEMALE; FOOD PREFERENCES; GENOTYPE; HUMANS; LIPASE; MALE; OBESITY; OLEIC ACID; POLYMORPHISM, SINGLE NUCLEOTIDE; TASTE; TRIOLEIN;

EID: 84857749426     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M021873     Document Type: Article

References (50)

1. Drewnowski, A., C. Kurth, J. Holden-Wiltse, and J. Saari. 1992. Food preferences in human obesity: carbohydrates versus fats. Appetite. 18: 207-221.
2. Rolls, B. J. 1995. Carbohydrates, fats, and satiety. Am. J. Clin. Nutr. 61: 960S-967S.
3. Bray, G. A., and B. M. Popkin. 1998. Dietary fat intake does affect obesity! Am. J. Clin. Nutr. 68: 1157-1173. (Pubitemid 28550944)
4. Swinburn, B. A., G. Sacks, S. K. Lo, K. R. Westerterp, E. C. Rush, M. Rosenbaum, A. Luke, D. A. Schoeller, J. P. DeLany, N. F. Butte, et al. 2009. Estimating the changes in energy flux that characterize the rise in obesity prevalence. Am. J. Clin. Nutr. 89: 1723-1728.
5. Drewnowski, A. 1985. Food perceptions and preferences of obese adults: a multidimensional approach. Int. J. Obes. 9: 201-212. (Pubitemid 15016779)
6. White, M. A., B. L. Whisenhunt, D. A. Williamson, F. L. Greenway, and R. G. Netemeyer. 2002. Development and validation of the food-craving inventory. Obes. Res. 10: 107-114. (Pubitemid 135687498)
7. Pepino, M. Y., S. Finkbeiner, and J. A. Mennella. 2009. Similarities in food cravings and mood states between obese women and women who smoke tobacco. Obesity (Silver Spring). 17: 1158-1163.
8. Miller, W. C., A. K. Lindeman, J. Wallace, and M. Niederpruem. 1990. Diet composition, energy intake, and exercise in relation to body fat in men and women. Am. J. Clin. Nutr. 52: 426-430.
9. Chalé-Rush, A., J. R. Burgess, and R. D. Mattes. 2007. Multiple routes of chemosensitivity to free fatty acids in humans. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G1206-G1212. (Pubitemid 47084653)
10. Mattes, R. D. 2001. Oral exposure to butter, but not fat replacers elevates postprandial triacylglycerol concentration in humans. J. Nutr. 131: 1491-1496. (Pubitemid 32422972)
11. Mattes, R. D. 2005. Fat taste and lipid metabolism in humans. Physiol. Behav. 86: 691-697. (Pubitemid 41728987)
12. Gilbertson, T. A., D. T. Fontenot, L. Liu, H. Zhang, and W. T. Monroe. 1997. Fatty acid modulation of K+ channels in taste receptor cells: gustatory cues for dietary fat. Am. J. Physiol. 272:C1203-C1210.
13. Sclafani, A., K. Ackroff, and N. A. Abumrad. 2007. CD36 gene deletion reduces fat preference and intake but not post-oral fat conditioning in mice. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293:R1823-R1832. (Pubitemid 350085658)
14. Fukuwatari, T., K. Shibata, K. Iguchi, T. Saeki, A. Iwata, K. Tani, E. Sugimoto, and T. Fushiki. 2003. Role of gustation in the recognition of oleate and triolein in anosmic rats. Physiol. Behav. 78:579-583. (Pubitemid 36628084)
15. Gaillard, D., F. Laugerette, N. Darcel, A. El-Yassimi, P. Passilly- Degrace, A. Hichami, N. A. Khan, J. P. Montmayeur, and P. Besnard. 2008. The gustatory pathway is involved in CD36-mediated orosensory perception of long-chain fatty acids in the mouse. FASEB J. 22:1458-1468. (Pubitemid 351656786)
16. Stewart, J. E., R. V. Seimon, B. Otto, R. S. Keast, P. M. Clifton, and C. Feinle-Bisset. 2011. Marked differences in gustatory and gastrointestinal sensitivity to oleic acid between lean and obese men. Am. J. Clin. Nutr. 93: 703-711.
17. Mattes, R. D. 2011. Accumulating evidence supports a taste component for free fatty acids in humans. Physiol. Behav. 104: 624 -6 31.
18. Stewart, J. E., C. Feinle-Bisset, M. Golding, C. Dealhunty, P. M. Clifton, and R. S. Keast. 2010. Oral sensitivity to fatty acids, food consumption and BMI in human subjects. Br. J. Nutr. 104: 145-152.
19. Mattes, R. D. 2009. Oral detection of short-, medium-, and long-chain free fatty acids in humans. Chem. Senses. 34: 145-150.
20. Stewart J. E., R. S. Keast. Recent fat intake modulates fat taste sensitivity in lean and overweight subjects. Int. J. Obes. (Lond). Epub ahead of print. August 9, 2011; doi:10.1038/ijo.2011.155.
21. Mattes, R. D. 2011. Oral fatty acid signaling and intestinal lipid processing: support and supposition. Physiol. Behav. 105: 27-35.
22. Kawai, T., and T. Fushiki. 2003. Importance of lipolysis in oral cavity for orosensory detection of fat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 285: R447-R454. (Pubitemid 36898913)
23. Matsumura, S., A. Eguchi, T. Mizushige, N. Kitabayashi, S. Tsuzuki, K. Inoue, and T. Fushiki. 2009. Colocalization of GPR120 with phospholipase-Cbeta2 and alpha-gustducin in the taste bud cells in mice. Neurosci. Lett. 450: 186-190.
24. Cartoni, C., K. Yasumatsu, T. Ohkuri, N. Shigemura, R. Yoshida, N. Godinot, J. le Coutre, Y. Ninomiya, and S. Damak. 2010. Taste preference for fatty acids is mediated by GPR40 and GPR120. J. Neurosci. 30: 8376-8382.
25. Laugerette F., P. Passilly-Degrace, B. Patris, I. Niot, M. Febbraio, J. P. Montmayeur, P. Besnard. 2005. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J. Clin. Invest. 115: 3177-3184. (Pubitemid 41567582)
26. Su, X., and N. A. Abumrad. 2009. Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol. Metab. 20: 72-77.
27. Fukuwatari, T., T. Kawada, M. Tsuruta, T. Hiraoka, T. Iwanaga, E. Sugimoto, and T. Fushiki. 1997. Expression of the putative membrane fatty acid transporter (FAT) in taste buds of the circumvallate papillae in rats. FEBS Lett. 414: 461-464. (Pubitemid 27389417)
28. Simons, P. J., J. A. Kummer, J. J. Luiken, and L. Boon. 2011. Apical CD36 immunolocalization in human and porcine taste buds from circumvallate and foliate papillae. Acta Histochem. 113: 839-843.
29. El-Yassimi, A., A. Hichami, P. Besnard, and N. A. Khan. 2008. Linoleic acid induces calcium signaling, Src kinase phosphorylation, and neurotransmitter release in mouse CD36-positive gustatory cells. J. Biol. Chem. 283: 12949-12959.
30. Love-Gregory, L., R. Sherva, T. Schappe, J. S. Qi, J. McCrea, S. Klein, M. A. Connelly, and N. A. Abumrad. 2011. Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. Hum. Mol. Genet. 20: 193-201.
31. Ghosh, A., G. Murugesan, K. Chen, L. Zhang, Q. Wang, M. Febbraio, R. M. Anselmo, K. Marchant, J. Barnard, and R. L. Silverstein. 2011. Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. Blood. 117: 6355-6366.
32. Mojet, J., E. Christ-Hazelhof, and J. Heidema. 2001. Taste perception with age: generic or specific losses in threshold sensitivity to the five basic tastes? Chem. Senses. 26: 845-860. (Pubitemid 32899104)
33. Kutyavin, I. V., I. A. Afonina, A. Mills, V. V. Gorn, E. A. Lukhtanov, E. S. Belousov, M. J. Singer, D. K. Walburger, S. G. Lokjpv, A. A. Gall, et al. 2000. 3′-minor groove binder-DNA probes increase sequence specificity at PCR extension temperatures. Nucleic Acids Res. 28: 655-661. (Pubitemid 30058009)
34. Ledikwe, J. H., J. Ello-Martin, C. L. Pelkman, L. L. Birch, M. L. Mannino, and B. J. Rolls. 2007. A reliable, valid questionnaire indicates that preference for dietary fat declines when following a reduced-fat diet. Appetite. 49: 74-83. (Pubitemid 46754522)
35. Patterson, B. W., G. Zhao, N. Elias, D. L. Hachey, and S. Klein. 1999. Validation of a new procedure to determine plasma fatty acid concentration and isotopic enrichment. J. Lipid Res. 40: 2118-2124. (Pubitemid 29523438)
36. Pribitkin, E., M. D. Rosenthal, and B. J. Cowart. 2003. Prevalence and causes of severe taste loss in a chemosensory clinic population. Ann. Otol. Rhinol. Laryngol. 112: 971-978. (Pubitemid 37429642)
37. ASTM. 2004. Standard test method E1885-04. In Standard Test Method for Sensory Analysis-Triangle Test WC, PA: ASTM International.).
38. Martin, C., P. Passilly-Degrace, D. Gaillard, J. F. Merlin, M. Chevrot, and P. Besnard. 2011. The lipid-sensor candidates CD36 and GPR120 are differentially regulated by dietary lipids in mouse taste buds: impact on spontaneous fat preference. PLoS ONE. 6: e24014.
39. Sclafani, A., S. Zukerman, J. I. Glendinning, and R. F. Margolskee. 2007. Fat and carbohydrate preferences in mice: the contribution of alpha-gustducin and Trpm5 taste-signaling proteins. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293: R1504-R1513. (Pubitemid 47535768)
40. Khan, N. A., and P. Besnard. 2009. Oro-sensory perception of dietary lipids: new insights into the fat taste transduction. Biochim. Biophys. Acta. 1791: 149-155.
41. Fushan, A. A., C. T. Simons, J. P. Slack, and D. Drayna. 2010. Association between common variation in genes encoding sweet taste signaling components and human sucrose perception. Chem. Senses. 35: 579-592.
42. Little, T. J., and C. Feinle-Bisset. 2011. Effects of dietary fat on appetite and energy intake in health and obesity-oral and gastrointestinal sensory contributions. Physiol. Behav. 104: 613-620.
43. Schwartz, G. J. 2011. Gut fat sensing in the negative feedback control of energy balance-recent advances. Physiol. Behav. 104: 621-623.
44. Galindo, M. M., N. Voigt, J. Stein, J. van Lengerich, J. D. Raguse, T. Hofmann, W. Meyerhof, and M. Behrens. 2011. G protein-coupled receptors in human fat taste perception. Chem. Senses. Epub ahead of print. August 25, 2011; doi: 10.1093/chemse/bjr069.
45. Brennan, I. M., R. V. Seimon, N. D. Luscombe-Marsh, B. Otto, M. Horowitz, and C. Feinle-Bisset. 2011. Effects of acute dietary restriction on gut motor, hormone and energy intake responses to duodenal fat in obese men. Int J Obes (Lond). 35: 448-456.
46. Zhang X.J., L. H. Zhou, X. Ban, D.X. Liu, W. Jiang, X. M. Liu. 2011. Decreased expression of CD36 in circumvallate taste buds of high-fat diet induced obese rats. Acta Histochem. 113: 663-667.
47. Covasa, M., J. Grahn, and R. C. Ritter. 2000. Reduced hindbrain and enteric neuronal response to intestinal oleate in rats maintained on high-fat diet. Auton. Neurosci. 84: 8-18.
48. Valeri, D., and A. J. A. Meirelles. 1997. Viscosities of fatty acids, triglycerides, and their binary mixtures. J. Am. Oil Chem. Soc. 74: 1221-1226. (Pubitemid 127555278)
49. Brand, G. 2006. Olfactory/trigeminal interactions in nasal chemoreception. Neurosci. Biobehav. Rev. 30: 908-917. (Pubitemid 44292851)
50. Gilbertson, T. A., T. Yu, and B. P. Shah. 2010. Gustatory Mechanisms for Fat Detection. In Fat Detection: Taste, Texture, and Post Ingestive Effects. J. P. Montmayeur, J. le Coutre editors. CRC Press Boca Raton, FL. 83-97.