Probenecid inhibits the human bitter taste receptor TAS2R16 and suppresses bitter perception of salicin

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Greene, Tiffani A ^a   Alarcon, Suzanne ^b   Thomas, Anu ^a   Berdougo, Eli ^a   Doranz, Benjamin J ^a   Breslin, Paul A S ^b,c   Rucker, Joseph B ^a  

^a Integral Molecular Inc   (United States)

^b RUTGERS UNIVERSITY   (United States)

^c MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 SULFAMOYLBENZOIC ACID; ALOIN; CHLOROQUINE; ETEBENECID; G PROTEIN COUPLED RECEPTOR; INDOMETACIN; PHENYLTHIOUREA; PROBENECID; PROPYLTHIOURACIL; SACCHARIN; SALICIN; UNCLASSIFIED DRUG; BENZYL ALCOHOL DERIVATIVE; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; CXCR4 PROTEIN, HUMAN; GLUCOSIDE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 1; TASTE RECEPTORS, TYPE 2;

ARTICLE; BITTER TASTE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CALCIUM TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFICACY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IC 50; PSEUDOGENE; TAS2R16 GENE; TAS2R38 GENE; TAS2R43 GENE; TASTE ACUITY; TASTE BUD; CELL STRAIN HEK293; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; METABOLISM; SIGNAL TRANSDUCTION;

BENZYL ALCOHOLS; GLUCOSIDES; HEK293 CELLS; HUMANS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROBENECID; RECEPTORS, CCR5; RECEPTORS, CXCR4; RECEPTORS, G-PROTEIN-COUPLED; SIGNAL TRANSDUCTION;

EID: 79956347958     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0020123     Document Type: Article

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