Molecular mechanism of species-dependent sweet taste toward artificial sweeteners

Journal of Neuroscience

Volumn 31, Issue 30, 2011, Pages 11070-11076

  Liu, Bo ^a,b   Ha, Matthew ^a   Meng, Xuan Yu ^a   Kaur, Tanno ^a   Khaleduzzaman, Mohammed ^a   Zhang, Zhe ^a   Jiang, Peihua ^c   Li, Xia ^c   Cui, Meng ^a  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b QILU UNIVERSITY OF TECHNOLOGY   (China)

^c MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTAME; G PROTEIN COUPLED RECEPTOR; G PROTEIN COUPLED RECEPTOR TAS1R2; NEOTAME; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CHIMERA; CONTROLLED STUDY; HAPLORHINI; HUMAN; LIGAND BINDING; MOLECULAR MODEL; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; RESIDUE ANALYSIS; SPECIES DIFFERENCE; SWEETNESS;

ANIMALS; ASPARTAME; DIPEPTIDES; FEMALE; HEK293 CELLS; HUMANS; MALE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS; MUTANT CHIMERIC PROTEINS; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; SAIMIRI; SEQUENCE ALIGNMENT; SPECIES SPECIFICITY; SWEETENING AGENTS;

EID: 79960969598     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0791-11.2011     Document Type: Article

References (33)

1. Bassoli A, Drew MG, Merlini L, Morini G (2002) General pseudoreceptor model for sweet compounds: a semiquantitative prediction of binding affinity for sweet-tasting molecules. J Med Chem 45:4402-4409.
2. Bowie JU, Luthy R, Eisenberg D (1991) A method to identify protein sequences that fold into a known three-dimensional structure. Science 253:164-170.
3. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M (2010) CHARMM: a program for macromolecular energy, minimization, and dynamics calculations. J Comput Chem 4:187-217.
4. Cui M, Jiang P, Maillet E, Max M, Margolskee RF, Osman R (2006) The het-erodimeric sweet taste receptor has multiple potential ligand binding sites. Curr Pharm Des 12:4591-4600.
5. Cui M, Jiang P, Maillet E, Max M, Margolskee RF, Osman R (2008) Molecular models of sweet taste receptors provide insights into function. In: Sweetness and sweeteners: biology, chemistry, and psychophysics (Weerasinghe DK, DuBois GE, eds), pp 117-132. Washington, DC: American Chemical Society.
6. Garbow JR, Likos JJ, Schroeder SA (2001) Structure, dynamics, and stability of beta-cyclodextrin inclusion complexes of aspartame and neotame. J Agric Food Chem 49:2053-2060.
7. Glaser D, Tinti JM, Nofre C (1995) Evolution of the sweetness receptor in primates. I. Why does alitame taste sweet in all prosimians and simians, and aspartame only in Old World simians? Chem Senses 20:573-584.
8. Hellekant G, Danilova V (1996) Species differences toward sweeteners. Food Chem 56:323-328.
9. Humphrey W, Dalke A, Schulten K (1996) VMD-visual molecular dynamics. J Mol Graphics 14:33-38.
10. Jiang P, Ji Q, Liu Z, Snyder LA, Benard LM, Margolskee RF, Max M (2004) The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J Biol Chem 279:45068-45075.
11. Jiang P, Cui M, Ji Q, Snyder L, Liu Z, Benard L, Margolskee RF, Osman R, Max M (2005a) Molecular mechanisms of sweet receptor function. Chem Senses 30 [Suppl 1]:i17-i18.
12. Jiang P, Cui M, Zhao B, Liu Z, Snyder LA, Benard LM, Osman R, Margolskee RF, Max M (2005b) Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste. J Biol Chem 280:15238-15246.
13. Jiang P, Cui M, Zhao B, Snyder LA, Benard LM, Osman R, Max M, Margolskee RF (2005c) Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J Biol Chem 280:34296-34305.
14. Kier LB (1972) A molecular theory of sweet taste. J Pharm Sci 61:1394-1397.
15. Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, Morikawa K (2000) Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407:971-977.
16. Li X, Glaser D, Li W, Johnson WE, O'Brien SJ, Beauchamp GK, Brand JG (2009) Analyses of sweet receptor gene (Tas1r2) and preference for sweet stimuli in species of Carnivora. J Hered 100 [Suppl 1]:S90-S100.
17. Li X, Bachmanov AA, Maehashi K, Li W, Lim R, Brand JG, Beauchamp GK, Reed DR, Thai C, Floriano WB (2011) Sweet taste receptor gene variation and aspartame taste in primates and other species. Chem Senses 36:453-475.
18. Luthy R, Bowie JU, Eisenberg D (1992) Assessment of protein models with three-dimensional profiles. Nature 356:83-85.
19. Martí-Renom MA, Stuart AC, Fiser A, Sanchez R, Melo F, Sali A (2000) Comparative protein structure modeling of genes and genomes. Annu Rev Biophys Biomol Struct 29:291-325.
20. Meguro T, Kashiwagi T, Satow Y (2000) Crystal structure of the low-humidity form of aspartame sweetener. J Pept Res 56:97-104.
21. Morris GM, Goodsell DS, Halliday RS, Huey R, Hart WE, Belew RK, Olson AJ (1998) Automated docking using a Lamarckian genetic algorithm and an empirical binding free energy function. J Comput Chem 19:1639-1662.
22. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS (2001) Mammalian sweet taste receptors. Cell 106:381-390.
23. Nie Y, Vigues S, Hobbs JR, Conn GL, Munger SD (2005) Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr Biol 15:1948-1952.
24. Nofre C, Tinti JM, Glaser D (1996) Evolution of the sweetness receptor in primates. II. Gustatory responses of non-human primates to nine compounds known to be sweet in man. Chem Senses 21:747-762.
25. Sali A, Blundell TL (1993) Comparative protein modelling by satisfaction of spatial restraints. J Mol Biol 234:779-815.
26. Shallenberger RS, Acree TE (1967) Molecular theory of sweet taste. Nature 216:480-482.
27. Thompson JD, Higgins DG, Gibson TJ (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res 22:4673-4680.
28. Tinti JM, Nofre C (1991) Why does a sweetener taste sweet? A new model. In: Sweeteners: discovery, molecular design, and chemoreception (DuBois GE, ed), pp 206-213. Washington DC: American Chemical Society.
29. Ueda T, Ugawa S, Yamamura H, Imaizumi Y, Shimada S (2003) Functional interaction between T2R taste receptors and G-protein a subunits expressed in taste receptor cells. J Neurosci 23:7376-7380.
30. Winnig M, Bufe B, Meyerhof W (2005) Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci 6:22.
31. Winnig M, Bufe B, Kratochwil NA, Slack JP, Meyerhof W (2007) The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. BMC Struct Biol 7:66.
32. Xu H, Staszewski L, Tang H, Adler E, Zoller M, Li X (2004) Different functional roles of T1R subunits in the heteromeric taste receptors. Proc Natl Acad Sci USA 101:14258-14263.
33. Zhang F, Klebansky B, Fine RM, Liu H, Xu H, Servant G, Zoller M, Tachdjian C, Li X (2010) Molecular mechanism of the sweet taste enhancers. Proc Natl Acad Sci USA 107:4752-4757.