Cloning and characterization of a novel mGluR1 variant from vallate papillae that functions as a receptor for L-glutamate stimuli

Chemical Senses

Volumn 30 SUPPL. 1, Issue , 2005, Pages

  San Gabriel, Ana ^a   Uneyama, H ^a   Yoshie, S ^b   Torii, K ^a  

^a AJINOMOTO CO INC   (Japan)

^b NIPPON DENTAL UNIVERSITY   (Japan)

Author keywords

5 RACE PCR; L glutamate; Metabotropic; Rat foliate papillae; Rat taste receptors; Soft palate; Xenopus oocytes

Indexed keywords

CALCIUM; METABOTROPIC RECEPTOR 1;

5' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; CALCIUM CELL LEVEL; CALCIUM MOBILIZATION; CONFERENCE PAPER; DOWNSTREAM PROCESSING; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; OOCYTE; OPEN READING FRAME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN VARIANT; RAT; RAT STRAIN; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SENSITIVITY ANALYSIS; SENSORY STIMULATION; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY; SOFT PALATE; STOP CODON; TASTE BUD; VOLTAGE CLAMP; XENOPUS;

ANIMALS; CHEMORECEPTORS; GLUTAMIC ACID; MODELS, BIOLOGICAL; OOCYTES; OPEN READING FRAMES; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, METABOTROPIC GLUTAMATE; TASTE BUDS; XENOPUS;

ANIMALIA;

EID: 33644552461     PISSN: 0379864X     EISSN: 14643553     Source Type: Journal    
DOI: 10.1093/chemse/bjh095     Document Type: Conference Paper

References (12)

1. Chaudhari, N., Landin, A.M. and Roper, S.D. (2000) A metabotropic glutamate receptor variant functions as a taste receptor. Nat. Neurosci., 3, 113-119.
2. Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Vardarajan, V., Zou, S., Jiang, P., Ninomiya, Y. and Margolskee R.F. (2003) Detection of sweet and umami taste in the absence of taste receptor T1r3. Science, 301, 850-853.
3. Hoon, M.A., Adler, E., Lindemeier, J., Battey, J.F., Ryba, N.J. and Zuker, C.S. (1999) Putative mammalian taste receptors: A class of taste-specific GPCRs with distinct topographic selectivity. Cell, 96, 541-551.
4. Kim, M.R., Kusakabe Y., Miura H., Shindo Y., Ninomiya, Y. and Hino, A. (2003) Regional expression patterns of taste receptors and gustducin in the mouse tongue. Biochem. Biophys. Res. Commun., 312, 500-506.
5. Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M. and Adler, E. (2002) Human receptors for sweet and umami taste. Proc. Natl Acad. Sci. USA, 99, 4692-4696.
6. Masu, M., Tanabe, Y., Tsuchida, K., Shigemoto, R. and Nakanishi, S. (1991) Sequence and expression of a metabotropic glutamate receptor. Nature, 349, 760-765.
7. Nelson, G., Chandrashekar, J., Hoon, M.A., Feng, L., Zhao, G., Ryba, N.J. and Zuker, C.S. (2002) An amino-acid taste receptor. Nature, 416, 199-202.
8. Ninomiya, Y., Nakashima, K., Fukuda, A., Nishino, H., Sugimura, T., Hino, A., Danilova, V. and Hellekant, G. (2000) Responses to umami substances in taste bud cells innervated by the chorda tympani and glossopharyngeal nerves. J. Nutr., 130, 950S-953S.
9. Takahashi, K., Tsuchida, K., Tanabe, Y., Masu, M. and Nakanishi, S. (1993) Role of the large extracellular domain of metabotropic glutamate receptors in agonist selectivity determination. J. Biol. Chem., 268, 19341-19345.
10. Toyono, T., Seta, Y., Kataoka, S., Kawano, S., Shigemoto, R. and Toyoshima, K. (2003) Expression of metabotropic glutamate receptor group I in rat gustatory papillae. Cell Tissue Res., 313, 29-35.
11. Yamaguchi, S. and Nakanishi, S. (1998) Regional expression and regulation of alternative forms of mRNAs derived from two distinct transcripts initiation sites of the rat mGluR5 gene. J. Neurochem., 71, 60-68.
12. Zhao, G.Q., Zhang, Y., Hoon, M.A., Chandrashekar, J., Erlenbach, I., Ryba, N.J. and Zuker, C.S. (2003) The receptors for mammalian sweet and umami taste Cell, 115, 255-266.