Genetics and Evolution of Taste

The Senses: A Comprehensive Reference

Volumn 4, Issue , 2008, Pages 371-390

  Boughter, J D ^a   Bachmanov, A A ^b  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

^b MONELL CHEMICAL SENSES CENTER   (United States)

Author keywords

Behavior; Bitter; Evolution; Genetics; Human; Mouse; QTL; Receptor; Strain; Sweet; Taste; Umami

Indexed keywords

EID: 84882562776     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012370880-9.00092-X     Document Type: Chapter

References (225)

1. Adler E., Hoon M.A., Mueller K.L., Chandrashekar J., Ryba N.J.P., Zuker C.S. A novel family of mammalian taste receptors. Cell 2000, 100:693-702.
2. Anliker J.A., Bartoshuk L., Ferris A.M., Hooks L.D. Children's food preferences and genetic sensitivity to the bitter taste of 6- n-propylthiouracil (PROP). Am. J. Clin. Nutr. 1991, 54:316-320.
3. Bachmanov A.A. Genetic Architecture of Sweet Taste. Sweetness and Sweeteners: Biology, Chemistry and Psychophysics. ACS Symposium Series 2008, Oxford University Press. D.K. Weerasinghe, G.E. Dubois (Eds.).
4. 4Cl solutions by 28 mouse strains. Behav. Genet. 2002, 32:445-457.
5. Bachmanov A.A., Li X., Li S., Neira M., Beauchamp G.K., Azen E.A. High-resolution genetic mapping of the sucrose octaacetate taste aversion (Soa) locus on mouse Chromosome 6. Mamm. Genome 2001, 12:695-699.
6. Bachmanov A.A., Li X., Reed D.R., Ohmen J.D., Li S., Chen Z., Tordoff M.G., De Jong P.J., Wu C., West D.B., Chatterjee A., Ross D.A., Beauchamp G.K. Positional cloning of the mouse saccharin preference (Sac) locus. Chem. Senses 2001, 26:925-933.
7. Bachmanov A.A., Reed D.R., Li X., Beauchamp G.K. Genetics of sweet taste preferences. Pure Appl. Chem. 2002, 74:1135-1140.
8. Bachmanov A.A., Reed D.R., Ninomiya Y., Inoue M., Tordoff M.G., Price R.A., Beauchamp G.K. Sucrose consumption in mice: major influence of two genetic loci affecting peripheral sensory responses. Mamm. Genome 1997, 8:545-548.
9. Bachmanov A.A., Reed D.R., Tordoff M.G., Price R.A., Beauchamp G.K. Intake of ethanol, sodium chloride, sucrose, citric acid, and quinine hydrochloride solutions by mice: a genetic analysis. Behav. Genet. 1996, 26:563-573.
10. Bachmanov A.A., Reed D.R., Tordoff M.G., Price R.A., Beauchamp G.K. Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice. Physiol. Behav. 2001, 72:603-613.
11. Bachmanov A.A., Tordoff M.G., Beauchamp G.K. Ethanol consumption and taste preferences in C57BL/6ByJ and 129/J mice. Alcoholism: Clin. Exp. Res. 1996, 20:201-206.
12. Bachmanov A.A., Tordoff M.G., Beauchamp G.K. Voluntary sodium chloride consumption by mice: Differences among five inbred strains. Behav. Genet. 1998, 28:117-124.
13. Bachmanov A.A., Tordoff M.G., Beauchamp G.K. Intake of umami-tasting solutions by mice: a genetic analysis. J. Nutr. 2000, 130:935S-941S.
14. Bachmanov A.A., Tordoff M.G., Beauchamp G.K. Sweetener preference of C57BL/6ByJ and 129P3/J mice. Chem. Senses 2001, 26:905-913.
15. Barnicot N., Harris H., Kalmus H. Taste thresholds of further eighteen compounds and their correlation with PTC thresholds. Ann. Eugenics 1951, 16:119-128.
16. Bartoshuk L. Influence of chemoreception and psychologic state on food selection. Int. J. Obesity 1980, 4:351-355.
17. Bartoshuk L.M., Duffy V.B., Hayes J.E., Moskowitz H.R., Snyder D.J. Psychophysics of sweet and fat perception in obesity: problems, solutions and new perspectives. Phil. Trans. R. Soc. Lond. B Biol. Sci. 2006, 361:1137-1148.
18. Bartoshuk L.M., Duffy V.B., Miller I.J. PTC/PROP tasting: anatomy, psychophysics, and sex effects. Physiol. Behav. 1994, 56:1165-1171.
19. Bartoshuk L.M., Jacobs H.L., Nichols T.L., Hoff L.A., Ryckman J.J. Taste rejection of nonnutritive sweeteners in cats. J. Comp. Physiol. Psychol. 1975, 89:971-975.
20. Beauchamp G.K. Genetic control over salt preference in inbred strains of mice. Chem. Senses 1990, 15:551.
21. Beauchamp G.K., Maller O., Rogers J.G. Flavor preferences in cats (Felis catus and Panthera sp.). J. Comp. Physiol. Psychol. 1977, 91:1118-1127.
22. Behrens M., Brockhoff A., Kuhn C., Bufe B., Winnig M., Meyerhof W. The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. Biochem. Biophys. Res. Commun. 2004, 319:479-485.
23. Belknap J.K., Crabbe J.C., Plomin R., Mcclearn G.E., Sampson K.E., O'Toole L.A., Gora-Maslak G. Single-locus control of saccharin intake in BXD/Ty recombinant inbred (RI) mice: some methodological implications for RI strain analysis. Behav. Genet. 1992, 22:81-100.
24. Belknap J.K., Crabbe J.C., Young E.R. Voluntary consumption of ethanol in 15 inbred mouse strains. Psychopharmacology (Berl.) 1993, 112:503-510.
25. Bjarnadottir T.K., Fredriksson R., Schioth H.B. The gene repertoire and the common evolutionary history of glutamate, pheromone (V2R), taste(1) and other related G protein-coupled receptors. Gene 2005, 362:70-84.
26. Blednov Y.A., Walker D., Martinez M., Levine M., Damak S., Margolskee R.F. Perception of sweet taste is important for voluntary alcohol consumption in mice. Genes Brain Behav. 2007, 10.1111/j.1601-183X.2007.00309.X.
27. Blizard D.A., Kotlus B., Frank M.E. Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice. Chem. Senses 1999, 24:373-385.
28. Bloomgarden Z.T. Gut hormones and related concepts. Diabetes Care 2006, 29:2319-2324.
29. Boughter J.D., Gilbertson T.A. From channels to behavior: an integrative model of NaCl taste. Neuron 1999, 22:213-215.
30. a heterozygous congenic taster mice. Behav. Genet. 1995, 25:233-237.
31. Boughter J.D., Whitney G. Behavioral specificity of the bitter taste gene Soa. Physiol. Behav. 1998, 63:101-108.
32. Boughter J.D., Harder D.B., Capeless C.G., Whitney G. Polygenic determination of quinine sensitivity among mice. Chem. Senses 1992, 17:427-434.
33. Boughter J.D., Raghow S., Nelson T.M., Munger S.D. Inbred mouse strains C57BL/6J and DBA/2J vary in sensitivity to a subset of bitter stimuli. BMC Genet. 2005, 6:36.
34. Boughter J.D., St. John S.J., Noel D.T., Ndubuizu O., Smith D.V. A brief-access test for bitter taste in mice. Chem. Senses 2002, 27:133-142.
35. Bufe B., Hofmann T., Krautwurst D., Raguse J.D., Meyerhof W. The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat. Genet. 2002, 32:397-401.
36. Butt C.M., King N.M., Hutton S.R., Collins A.C., Stitzel J.A. Modulation of nicotine but not ethanol preference by the mouse Chrna4 A529T polymorphism. Behav. Neurosci. 2005, 119:26-37.
37. Capeless C.G., Whitney G. The genetic basis of preference for sweet substances among inbred strains of mice: preference ratio phenotypes and the alleles of the Sac and dpa loci. Chem. Senses 1995, 20:291-298.
38. Capeless C.G., Whitney G., Azen E.A. Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice. Behav. Genet. 1992, 22:655-663.
39. Carstens E., Kuenzler N., Handwerker H.O. Activation of neurons in rat trigeminal subnucleus caudalis by different irritant chemicals applied to oral or ocular mucosa. J. Neurophysiol. 1998, 80:465-492.
40. Chandrashekar J., Hoon M.A., Ryba N.J., Zuker C.S. The receptors and cells for mammalian taste. Nature. 2006, 444:288-294.
41. Chandrashekar J., Mueller K.L., Hoon M.A., Adler E., Feng L., Guo W., Zuker C.S., Ryba J.P. T2Rs function as bitter taste receptors. Cell 2000, 100:703-711.
42. Chaudhari N., Landin A.M., Roper S.D. A metabotropic glutamate receptor variant functions as a taste receptor. Nat. Neurosci. 2000, 3:113-119.
43. Chyb S., Dahanukar A., Wickens A., Carlson J.R. Drosophila Gr5a encodes a taste receptor tuned to trehalose. Proc. Natl. Acad. Sci. U. S. A. 2003, 100(Suppl. 2):14526-14530.
44. Conte C., Ebeling M., Marcuz A., Andres-Barquin P.J. Identification of the T2R repertoire of taste receptor genes in the rat genome sequence. Genome Lett. 2003, 2:155-161.
45. Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J. Identification and characterization of human taste receptor genes belonging to the TAS2R family. Gene Mapp. Clon. Seq. 2002, 98:45-53.
46. Conte C., Ebeling M., Marcuz A., Nef P., Andres-Barquin P.J. Evolutionary relationships of the Tas2r receptor gene families in mouse and human. Physiol. Genomics 2003, 14:73-82.
47. Conte C., Guarin E., Marcuz A., Andres-Barquin P.J. Functional expression of mammalian bitter taste receptors in Caenorhabditis elegans. Biochimie. 2006, 88:801-806.
48. Dahanukar A., Foster K., Van der Goes Van Naters W.M., Carlson J.R. A Gr receptor is required for response to the sugar trehalose in taste neurons of Drosophila. Nat. Neurosci. 2001, 4:1182-1186.
49. Damak S., Rong M., Yasumatsu K., Kokrashvili Z., Varadarajan V., Zou S., Jiang P., Ninomiya Y., Margolskee R.F. Detection of sweet and umami taste in the absence of taste receptor T1r3. Science 2003, 301:850-853.
50. Delay E.R., Hernandez N.P., Bromley K., Margolskee R.F. Sucrose and monosodium glutamate taste thresholds and discrimination ability of T1R3 knockout mice. Chem. Senses. 2006, 31:351-357.
51. Dess N.K., Badia-Elder N.E., Thiele T.E., Kiefer S.W., Blizard D.A. Ethanol consumption in rats selectively bred for differential saccharin intake. Alcohol 1998, 16:275-278.
52. Dinehart M.E., Hayes J.E., Bartoshuk L.M., Lanier S.L., Duffy V.B. Bitter taste markers explain variability in vegetable sweetness, bitterness, and intake. Physiol. Behav. 2006, 87:304-313.
53. Drewnowski A., Henderson S.A., Barratt-Fornell A. Genetic sensitivity to 6- n-propylthiouracil and sensory responses to sugar and fat mixtures. Physiol. Behav. 1998, 63:771-777.
54. Drewnowski A.J., Brunzell J.D., Sande K., Iverius P.H., Greenwood M.R. Sweet tooth reconsidered: taste responsiveness in human obesity. Physiol. Behav. 1985, 35:617-622.
55. Duffy V.B., Bartoshuk L.M. Food acceptance and genetic variation in taste. J. Am. Dietetic Assoc. 2000, 100:647-655.
56. Duffy V.B., Davidson A.C., Kidd J.R., Kidd K.K., Speed W.C., Pakstis A.J., Reed D.R., Snyder D.J., Bartoshuk L.M. Bitter receptor gene (TAS2R38), 6- n-propylthiouracil (PROP) bitterness and alcohol intake. Alcoholism: Clin. Exp. Res. 2004, 28:1629-1637.
57. Enoch M.A., Harris C.R., Goldman D. Does a reduced sensitivity to bitter taste increase the risk of becoming nicotine addicted?. Addictive Behav. 2001, 26:399-404.
58. Eylam S., Spector A.C. Oral amiloride treatment decreases taste sensitivity to sodium salts in C57BL/6J and DBA/2J mice. Chem. Senses 2003, 28:447-458.
59. Eylam S., Spector A.C. Stimulus processing of glycine is dissociable from that of sucrose and glucose based on behaviorally measured taste signal detection in Sac 'taster' and 'non-taster' mice. Chem. Senses 2004, 29:639-649.
60. Eylam S., Spector A.C. Taste discrimination between NaCl and KCl is disrupted by amiloride in inbred mice with amiloride-insensitive chorda tympani nerves. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2005, 288:R1361-R1368.
61. Fischer A., Gilad Y., Man O., Paabo S. Evolution of bitter taste receptors in humans and apes. Mol. Biol. Evol. 2005, 22:432-436.
62. Fischer R.A., Ford E.B., Huxley J. Taste testing the anthropoid apes. Nature 1939, 144:750.
63. Flaherty L. Congenic Strains. The Mouse in Biomedical Research. Vol. 1. History, Genetics, and Wild Mice 1981, 215-222. Academic Press. H.L. Foster, J.D. Small, J.G. Fox (Eds.).
64. Fox A.L. Six in ten "tasteblind" to bitter chemical. Sci. News Lett. 1931, 9:249.
65. Fox A.L. The relationship between chemical constituion and taste. Proc. Natl. Acad. Sci. U. S. A. 1932, 18:115-120.
66. Fredriksson R., Lagerstrom M.C., Lundin L.G., Schioth H.B. The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints. Mol. Pharmacol. 2003, 63:1256-1272.
67. Fuller J.L. Single-locus control of saccharin preference in mice. J. Heredity 1974, 65:33-36.
68. Ganchrow J.R., Steiner J.E., Bartana A. Behavioral reactions to gustatory stimuli in young chicks (Gallus gallus domesticus). Dev. Psychobiol. 1990, 23:103-117.
69. Gannon K., Contreras R.J. Sodium intake linked to amiloride-sensitive gustatory transduction in C57BL/6J and 129/J mice. Physiol. Behav. 1993, 57:231-239.
70. Gent J.F., Bartoshuk L.M. Sweetness of sucrose, neohesperidin dihydrochalcone, and saccharin is related to genetic ability to taste the bitter substance 6- n-propylthiouracil. Chem. Senses 1983, 7:265-272.
71. Gilbertson T.A., Boughter J.D. Taste transduction: appetizing times in gustation. NeuroReport 2003, 14:905-911.
72. Gilbertson T.A., Avenet P., Kinnamon S.C., Roper S.D. Proton currents through amiloride-sensitive Na channels in hamster taste cells: role in acid transduction. J. Gen. Physiol. 1992, 100:803-824.
73. Gilbertson T.A., Damak S., Margolskee R.F. The molecular physiology of taste transduction. Curr. Opin. Neurobiol. 2000, 10:519-527.
74. Glendinning J.I. Is the bitter rejection response always adaptive?. Physiol. Behav. 1994, 56:1217-1227.
75. Glendinning J.I., Hills T.T. Electrophysiological evidence for two transduction pathways within a bitter-sensitive taste receptor. J. Neurophysiol. 1997, 78:734-745.
76. Glendinning J.I., Gresack J., Spector A.C. A high-throughput screening procedure for identifying mice with aberrant taste and oromotor function. Chem. Senses 2002, 27:461-474.
77. Glendinning J.I., Valcic S., Timmermann B.N. Maxillary palps can mediate taste rejection of plant allelochemicals by caterpillars. J. Comp. Physiol. A 1998, 183:35-43.
78. Go Y. Lineage-specific expansions and contractions of the bitter taste receptor gene repertoire in vertebrates. Mol. Biol. Evol. 2006, 23:964-972.
79. Go Y., Satta Y., Takenaka O., Takahata N. Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates. Genetics 2005, 170:313-1326.
80. Goodwin F.L., Amit Z. Do taste factors contribute to the mediation of ethanol intake? Ethanol and saccharin-quinine intake in three rat strains. Alcoholism: Clin. Exp. Res. 1998, 22:837-844.
81. Grace J., Russek M. The influence of previous experience on the taste behavior of dogs toward sucrose and saccharin. Physiol. Behav. 1969, 4:553-558.
82. Greene L.S., Desor J.A., Maller O. Heredity and experience: their relative importance in the development of taste preference in man. J. Comp. Physiol. Psychol. 1975, 89:279-284.
83. Hall M.J., Bartoshuk L.M., Cain W.S., Stevens J.C. PTC taste blindness and the taste of caffeine. Nature 1975, 253:442-443.
84. Hallem E.A., Dahanukar A., Carlson J.R. Insect odor and taste receptors. Annu. Rev. Entomol. 2006, 51:113-135.
85. Halpern B.P. Gustatory nerve responses in the chicken. Am. J. Physiol. 1962, 203:541-544.
86. Harder D.B., Whitney G. A common polygenic basis for quinine and PROP avoidance in mice. Chem. Senses 1998, 23:327-332.
87. Harder D.B., Azen E.A., Whitney G. Sucrose octaacetate avoidance in nontaster mice is not enhanced by two type-A Prp transgenes from taster mice. Chem. Senses 2000, 25:39-45.
88. Harder D.B., Capeless C.G., Maggio J.C., Boughter J.D., Gannon K.S., Whitney G., Azen E.A. Intermediate sucrose octa-acetate sensitivity suggests a third allele at mouse bitter taste locus Soa and Soa-Rua identity. Chem. Senses 1992, 17:391-401.
89. Harder D.B., Maggio J.C., Whitney G. Assessing gustatory detection capabilities using preference procedures. Chem. Senses 1989, 14:547-564.
90. Harris H., Kalmus H. The measurement of taste sensitivity to phenylthiourea (P.T.C.). Ann. Eugenics 1949, 15:24-31.
91. Hoon M.A., Adler E., Lindemeier J., Battey J.F., Ryba N.J., Zuker C.S. Putative mammalian taste receptors: a class of taste-specific GPCRs with distinct topographic selectivity. Cell 1999, 96:541-551.
92. Hoshishima K., Yokoyama S., Seto K. Taste sensitivity in various strains of mice. Am. J. Physiol. 1962, 202:1200-1204.
93. Huang A.L., Chen X., Hoon M.A., Chandrashekar J., Guo W., Trankner D., Ryba N.J., Zuker C.S. The cells and logic for mammalian sour taste detection. Nature 2006, 442:934-938.
94. Inomata N., Goto H., Itoh M., Isono K. A single-amino-acid change of the gustatory receptor gene, Gr5a, has a major effect on trehalose sensitivity in a natural population of Drosophila melanogaster. Genetics 2004, 167:1749-1758.
95. Inoue M., Beauchamp G.K., Bachmanov A.A. Gustatory neural responses to umami taste stimuli in C57BL/6ByJ and 129P3/J mice. Chem. Senses 2004, 29:789-795.
96. Inoue M., Li X., Mccaughey S.A., Beauchamp G.K., Bachmanov A.A. Soa genotype selectively affects mouse gustatory neural responses to sucrose octaacetate. Physiol. Genomics 2001, 5:181-186.
97. Inoue M., McCaughey S.A., Bachmanov A.A., Beauchamp G.K. Whole nerve chorda tympani responses to sweeteners in C57BL/6ByJ and 129P3/J mice. Chem. Senses 2001, 26:915-923.
98. 2 hybrids between C57BL/6ByJ and 129P3/J mice. J. Neurosci. 2004, 24:2296-2303.
99. Ishimaru Y., Inada H., Kubota M., Zhuang H., Tominaga M., Matsunami H. Transient receptor potential family members PKD1L3 and PKD2L1 form a candidate sour taste receptor. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:12569-12574.
100. Ishimaru Y., Okada S., Naito H., Nagai T., Yasuoka A., Matsumoto I., Abe K. Two families of candidate taste receptors in fishes. Mech. Dev. 2005, 122:1310-1321.
101. Isono K., Morita H., Kohatsu S., Ueno K., Matsubayashi H., Yamamoto M.T. Trehalose sensitivity of the gustatory receptor neurons expressing wild-type, mutant and ectopic Gr5a in Drosophila. Chem. Senses 2005, 30(Suppl.1):i275-i276.
102. Jiang P., Cui M., Ji Q., Snyder L., Liu Z., Benard L., Margolskee R.F., Osman R., Max M. Molecular mechanisms of sweet receptor function. Chem. Senses 2005, 30(Suppl. 1):i17-i18.
103. Jiang P., Cui M., Zhao B., Snyder L.A., Benard L.M., Osman R., Max M., Margolskee R.F. Identification of the cyclamate interaction site within the transmembrane domain of the human sweet taste receptor subunit T1R3. J. Biol. Chem. 2005, 280:34296-34305.
104. Jiang P., Ji Q., Liu Z., Snyder L.A., Benard L.M., Margolskee R.F., Max M. The cysteine-rich region of T1R3 determines responses to intensely sweet proteins. J. Biol. Chem. 2004, 279:45068-45075.
105. Kachele D.L., Lasiter P.S. Murine strain differences in taste responsivity and organization of the rostral nucleus of the solitary tract. Brain Res. Bull. 1990, 24:239-247.
106. Kalmus H. Genetics of Taste. Handbook of Sensory Physiology 1971, 165-179. Springer. L.M. Beidler (Ed.).
107. Kampov-Polevoy A.B., Eick C., Boland G., Khalitov E., Crews F.T. Sweet liking, novelty seeking, and gender predict alcoholic status. Alcoholism: Clin. Exp. Res. 2004, 28:1291-1298.
108. Kampov-Polevoy A., Garbutt J.C., Janowsky D. Evidence of preference for a high-concentration sucrose solution in alcoholic men. Am. J. Psychiatry 1997, 154:269-270.
109. Kampov-Polevoy A.B., Garbutt J.C., Khalitov E. Family history of alcoholism and response to sweets. Alcoholism: Clin. Exp. Res. 2003, 27:1743-1749.
110. Kare M.R. Comparative Aspects of the Sense of Taste. Physiological and Behavioral Aspects of Taste 1961, The University of Chicago Press. M.R. Kare, B.P. Halpern (Eds.).
111. Khan G.J., Mehmood R., Salah Ud D., Ihtesham Ul H. Effects of long-term use of tobacco on taste receptors and salivary secretion. J. Ayub Med. College Abbottabad 2003, 15(15):37-39.
112. Kim U.K., Drayna D. Genetics of individual differences in bitter taste perception: lessons from the PTC gene. Clin. Genet. 2005, 67:275-280.
113. Kim U.K., Breslin P.A., Reed D., Drayna D. Genetics of human taste perception. J. Dental Res. 2004, 83:448-453.
114. Kim U.K., Jorgenson E., Coon H., Leppert M., Risch N., Drayna D. Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003, 299:1221-1225.
115. Kim U.K., Wooding S., Riaz N., Jorde L.B., Drayna D. Variation in the human TAS1R taste receptor genes. Chem. Senses 2006, 31:599-611.
116. Kitagawa M., Kusakabe Y., Miura H., Ninomiya Y., Hino A. Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem. Biophys. Res. Commun. 2001, 283:236-242.
117. Klein T.W., Defries J.C. Similar polymorphism of taste sensitivity to PTC in mice and men. Nature 1970, 225:555-557.
118. Kuhn C., Bufe B., Winnig M., Hofmann T., Frank O., Behrens M., Lewtschenko T., Slack J.P., Ward C.D., Meyerhof W. Bitter taste receptors for saccharin and acesulfame K. J. Neurosci. 2004, 24:10260-10265.
119. Lagerstrom M.C., Hellstrom A.R., Gloriam D.E., Larsson T.P., Schioth H.B., Fredriksson R. The G protein-coupled receptor subset of the chicken genome. PLoS Comput. Biol. 2006, 2:e54.
120. Lanier S.A., Hayes J.E., Duffy V.B. Sweet and bitter tastes of alcoholic beverages mediate alcohol intake in of-age undergraduates. Physiol. Behav. 2005, 83:821-831.
121. Le Roy I., Pager J., Roubertoux P.L. Genetic dissection of gustatory sensitivity to bitterness (sucrose octaacetate) in mice. C. R. Acad. Sci. Série III 1999, 322:831-836.
122. Lemon C.H., Brasser S.M., Smith D.V. Alcohol activates a sucrose-responsive gustatory neural pathway. J. Neurophysiol. 2004, 92:536-544.
123. Li X., Bachmanov A.A., Li S., Chen Z., Tordoff M.G., Beauchamp G.K., De Jong P.J., Wu C., Chen L., West D.B., Ross D.A., Ohmen J.D., Reed D.R. Genetic, physical, and comparative map of the subtelomeric region of mouse Chromosome 4. Mamm. Genome 2002, 13:5-19.
124. Li X., Inoue M., Reed D.R., Huque T., Puchalski R.B., Tordoff M.G., Ninomiya Y., Beauchamp G.K., Bachmanov A.A. High-resolution genetic mapping of the saccharin preference locus (Sac) and the putative sweet taste receptor (T1R1) gene (Gpr70) to mouse distal Chromosome 4. Mamm. Genome 2001, 12:13-16.
125. Li X., Li W., Wang H., Cao J., Maehashi K., Huang L., Bachmanov A.A., Reed D.R., Legrand-Defretin V., Beauchamp G.K., Brand J.G. Pseudogenization of a sweet-receptor gene accounts for cats' indifference toward sugar. PLoS Genet. 2005, 1:27-35.
126. Li X., Staszewski L., Xu H., Durick K., Zoller M., Adler E. Human receptors for sweet and umami taste. Proc. Natl. Acad. Sci. U. S. A. 2002, 99:4692-4696.
127. Liao J., Schultz P.G. Three sweet receptor genes are clustered in human chromosome 1. Mamm. Genome 2003, 14:291-301.
128. Liman E.R. Use it or lose it: molecular evolution of sensory signaling in primates. Pflugers Arch. 2006, 453:125-131.
129. Lindemann B. A taste for umami. Nat. Neurosci. 2000, 3:99-100.
130. Lugaz O., Pillias A.M., Faurion A. A new specific ageusia: some humans cannot taste l-glutamate. Chem. Senses 2002, 27:105-115.
131. Lush I.E. The genetics of tasting in mice. I. Sucrose octaacetate. Genet. Res. 1981, 38:93-95.
132. Lush I.E. The genetics of tasting in mice. II. Strychnine. Chem. Senses 1982, 7:93-98.
133. Lush I.E. The genetics of tasting in mice. III. Quinine. Genet. Res. 1984, 44:151-160.
134. Lush I.E. The genetics of tasting in mice. IV. The acetates of raffinose, galactose and beta-lactose. Genet. Res. 1986, 47:117-123.
135. Lush I.E. The genetics of tasting in mice. VI. Saccharin, acesulfame, dulcin and sucrose. Genet. Res. 1989, 53:95-99.
136. Lush I.E. The Genetics of Bitterness, Sweetness, and Saltiness in Strains of Mice. Genetics of Perception and Communication 1991, Dekker. C.J. Wysocki, M.R. Kare (Eds.).
137. Lush I.E., Holland G. The genetics of tasting in mice. V. Glycine and cycloheximide. Genet. Res. 1988, 52:207-212.
138. Lush I.E., Hornigold N., King P., Stoye J.P. The genetics of tasting in mice. VII. Glycine revisited, and the chromosomal location of Sac and Soa. Genet. Res. 1995, 66:167-174.
139. Manita S., Bachmanov A.A., Li X., Beauchamp G.K., Inoue M. Is glycine "sweet" to mice? Mouse strain differences in perception of glycine taste. Chem. Senses 2006, 31:785-793.
140. Maruyama Y., Pereira E., Margolskee R.F., Chaudhari N., Roper S.D. Umami responses in mouse taste cells indicate more than one receptor. J. Neurosci. 2006, 26:2227-2234.
141. Matson K.D., Millam J.R., Klasing K.C. Taste threshold determination and side-preference in captive cockatiels (Nymphicus hollandicus). Appl. Anim. Behav. Sci. 2000, 69:313-326.
142. Matson K.D., Millam J.R., Klasing K.C. Thresholds for sweet, salt, and sour taste stimuli in cockatiels (Nymphicus hollandicus). Zoo Biol. 2001, 20:1-13.
143. Matsunami H., Montmayeur J.P., Buck L.B. A family of candidate taste receptors in human and mouse. Nature 2000, 404:601-604.
144. Mattes R.D. Influences on acceptance of bitter foods and beverages. Physiol. Behav. 1994, 56:1229-1236.
145. Max M., Shanker Y.G., Huang L., Rong M., Liu Z., Campagne F., Weinstein H., Damak S., Margolskee R.F. Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat. Genet. 2001, 28:58-63.
146. McCaughey S.A. Taste-evoked responses to sweeteners in the nucleus of the solitary tract differ between C57BL/6ByJ and 129P3/J mice. J. Neurosci. 2007, 27:35-45.
147. McClearn G.E., Rodgers D. Genetic factors in alcohol preference of laboratory mice. J. Comp. Physiol. Psychol. 1961, 54:116-119.
148. McClearn G.E., Rodgers D.A. Differences in alcohol preference among inbred strains of mice. Q. J. Stud. Alcohol 1959, 20:691-695.
149. Mela D.J. Gustatory function and dietary habits in users and nonusers of smokeless tobacco. Am. J. Clin. Nutr. 1989, 49:482-489.
150. Mela D.J., Mattes R.D., Tanimura S., Garcia-Medina M.R. Relationships between ingestion and gustatory perception of caffeine. Pharmacol. Biochem. Behav. 1992, 43:513-521.
151. Mennella J.A., Pepino M.Y., Reed D.R. Genetic and environmental determinants of bitter perception and sweet preferences. Pediatrics 2005, 115:e216-e222.
152. Meyerhof W. Elucidation of mammalian bitter taste. Rev. Physiol. Biochem. Pharmacol. 2005, 154:37-72.
153. Midkiff E.E., Bernstein I.L., Fitts D.A., Simpson J.B. Salt preference and salt appetite of Fischer-344 rats. Chem. Senses 1985, 10:446.
154. Miyamoto T., Fujiyama R., Okada Y., Sato T. Strain difference in amiloride-sensitivity of salt-induced responses in mouse non-dissociated taste cells. Neurosci. Lett. 1999, 277:13-16.
155. Montmayeur J.P., Liberles S.D., Matsunami H., Buck L.B. A candidate taste receptor gene near a sweet taste locus. Nat. Neurosci. 2001, 4:492-498.
156. Moon S.J., Kottgen M., Jiao Y., Xu H., Montell C. A taste receptor required for the caffeine response in vivo. Curr. Biol. 2006, 16:1812-1817.
157. Mueller K.L., Hoon M.A., Erlenbach I., Chandrashekar J., Zuker C.S., Ryba N.J.P. The receptors and coding logic for bitter taste. Nature 2005, 434:225-229.
158. Nelson G., Chandrashekar J., Hoon M.A., Feng L., Zhao G., Ryba N.J., Zuker C.S. An amino-acid taste receptor. Nature 2002, 416:199-202.
159. Nelson G., Hoon M.A., Chandrashekar J., Zhang Y., Ryba N.J., Zuker C.S. Mammalian sweet taste receptors. Cell 2001, 106:381-390.
160. Nelson T.M., Munger S.D., Boughter J.D. Taste sensitivities to PROP and PTC vary independently in mice. Chem. Senses 2003, 28:695-704.
161. Nelson T.M., Munger S.D., Boughter J.D. Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice. BMC Genet. 2005, 6:32.
162. Nie Y., Vigues S., Hobbs J.R., Conn G.L., Munger S.D. Distinct contributions of T1R2 and T1R3 taste receptor subunits to the detection of sweet stimuli. Curr. Biol. 2005, 15:1948-1952.
163. Ninomiya Y. Salt taste responses of mouse chorda tympani neurons: evidence for existence of two different amiloride-sensitive receptor components for NaCl with different temperature dependencies. J. Neurophysiol. 1996, 76:3550-3554.
164. Ninomiya Y., Funakoshi M. Behavioural discrimination between glutamate and the four basic taste substances in mice. Comp. Biochem. Physiol. 1989, 92:365-370.
165. Ninomiya Y., Higashi T., Mizukoshi T., Funakoshi M. Genetics of the ability to perceive sweetness of d-phenylalanine in mice. Ann. N. Y. Acad. Sci. 1987, 510:527-529.
166. Ninomiya Y., Mizukoshi T., Higashi T., Katsukawa H., Funakoshi M. Gustatory neural responses in three different strains of mice. Brain Res. 1984, 302:305-314.
167. Ninomiya Y., Nomura T., Katsukawa H. Genetically variable taste sensitivity to d-amino acids in mice. Brain Res. 1992, 596:349-352. Dekker.
168. Ninomiya Y., Sako N., Funakoshi M. Strain differences in amiloride inhibition of NaCl responses in mice, Mus musculus. J. Comp. Physiol. 1989, 166:1-5.
169. Ninomiya Y., Sako N., Katsukawa H., Funakoshi M. Taste Receptor Mechanisms Influenced by a Gene on Chromosome 4 in Mice. Genetics of Perception and Communication 1991, 267-278. C.J. Wysocki, M.R. Kare (Eds.).
170. Overstreet D.H., Kampov-Polevoy A.B., Rezvani A.H., Murelle L., Halikas J.A., Janowsky D.S. Saccharin intake predicts ethanol intake in genetically heterogeneous rats as well as different rat strains. Alcoholism: Clin. Exp. Res. 1993, 17:366-369.
171. Parry C.M., Erkner A., Le Coutre J. Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:14830-14834.
172. Peirce J.L., Lu L., Gu J., Silver L.M., Williams R.W. A new set of BXD recombinant inbred lines from advanced intercross populations in mice. BMC Genet. 2004, 5:7.
173. Pelz W.E., Whitney G., Smith J.C. Genetic influences on saccharin preference of mice. Physiol. Behav. 1973, 10:263-265.
174. Phillips T.J., Crabbe J.C., Metten P., Belknap J.K. Localization of genes affecting alcohol drinking in mice. Alcoholism: Clin. Exp. Res. 1994, 18:931-941.
175. Pomerleau C.S., Marks J.L., Pomerleau O.F., Snedecor S.M. Relationship between early experiences with tobacco and early experiences with alcohol. Addictive Behav. 2004, 29:1245-1251.
176. Ramirez I., Fuller J.L. Genetic influence on water and sweetened water consumption in mice. Physiol. Behav. 1976, 16:163-168.
177. Reed D.R., Bachmanov A.A., Beauchamp G.K., Tordoff M.G., Price R.A. Heritable variation in food preferences and their contribution to obesity. Behav. Genet. 1997, 27:373-387.
178. Reed D.R., Li S., Li X., Huang L., Tordoff M.G., Starling-Roney R., Taniguchi K., West D.B., Ohmen J.D., Beauchamp G.K., Bachmanov A.A. Polymorphisms in the taste receptor gene (Tas1r3) region are associated with saccharin preference in 30 mouse strains. J. Neurosci. 2004, 24:938-946.
179. Reed D.R., McDaniel A.H. The human sweet tooth. BMC Oral Health 2006, 6(Suppl. 1):S17.
180. Richter C. Mineral appetite of parathyroidectomized rats. Am. J. Med. Sci. 1932, 9:9.
181. Richter T.A., Clisby K.H. Phenylthiocarbamide taste thresholds of rats and human beings. Am. J. Physiol. 1941, 134:157-164.
182. Robinson S.F., Marks M.J., Collins A.C. Inbred mouse strains vary in oral self-selection of nicotine. Psychopharmacology (Berl.) 1996, 124:332-339.
183. Rodgers D.A., McClearn G.E. Mouse strain differences in preference for various concentrations of alcohol. Q. J. Stud. Alcohol 1962, 23:26-33.
184. Sainz E., Korley J.N., Battey J.F., Sullivan S.L. Identification of a novel member of the T1R family of putative taste receptors. J. Neurochem. 2001, 77:896-903.
185. Salbe A.D., Delparigi A., Pratley R.E., Drewnowski A., Tataranni P.A. Taste preferences and body weight changes in an obesity-prone population. Am. J. Clin. Nutr. 2004, 79:372-378.
186. Sandell M.A., Breslin P.A. Variability in a taste-receptor gene determines whether we taste toxins in food. Current Biol. 2006, 16:R792-R794.
187. Sato K., Endo S., Tomita H. Sensitivity of three loci on the tongue and soft palate to four basic tastes in smokers and non-smokers. Acta Otolaryngol. 2002, 2002:74-82.
188. Scott T.R. The role of taste in feeding. Appetite 2001, 37:111-113.
189. Shi P., Zhang J. Contrasting modes of evolution between vertebrate sweet/umami receptor genes and bitter receptor genes. Mol. Biol. Evol. 2006, 23:292-300.
190. Shi P., Zhang J., Yang H., Zhang Y.P. Adaptive diversification of bitter taste receptor genes in mammalian evolution. Mol. Biol. Evol. 2003, 20:805-814.
191. Shigemura N., Yasumatsu K., Yoshida R., Sako N., Katsukawa H., Nakashima K., Imoto T., Ninomiya Y. The role of the dpa locus in mice. Chem. Senses 2005, 30(Suppl. 1):i84-i85.
192. Shingai T., Beidler L.M. Interstrain differences in bitter taste responses in mice. Chem. Senses 1985, 10:51-55.
193. Snedecor S.M., Pomerleau C.S., Mehringer A.M., Ninowski R., Pomerleau O.F. Differences in smoking-related variables based on phenylthiocarbamide "taster" status. Addictive Behav. 2006, 31:2309-2312.
194. Sollars S.I., Midkiff E.E., Bernstein I.L. Genetic transmission of NaCl aversion in the Fisher-344 rat. Chem. Senses 1990, 15:521-527.
195. Soranzo N., Bufe B., Sabeti P.C., Wilson J.F., Weale M.E., Marguerie R., Meyerhof W., Goldstein D.B. Positive selection on a high-sensitivity allele of the human bitter-taste receptor TAS2R16. Curr. Biol. 2005, 15:1257-1265.
196. Spielman A.I., Huque T., Whitney G., Brand J.G. The diversity of bitter taste signal transduction mechanisms. Soc. Gen. Physiol. Ser. 1992, 47:307-324.
197. St John S.J., Pour L., Boughter J.D. Phenylthiocarbamide produces conditioned taste aversions in mice. Chem. Senses 2005, 30:377-382.
198. Stewart R.B., Bice P., Foroud T., Lumeng L., Li T.K., Carr L.G. Correlation of saccharin and ethanol intake in the F2 progeny of HAD2 and LAD2 crosses. Alcoholism: Clin. Exp. Res. 2003, 27:49A.
199. Tichansky D.S., Boughter J.D., Madan A.K. Taste change after laparoscopic Roux-en-Y gastric bypass and laparoscopic adjustable gastric banding. Surg. Obes. Relat. Dis. 2006, 2:440-444.
200. Tordoff M.G., Bachmanov A.A. Mouse taste preference tests: why only two bottles? Chem. Senses 2003, 28:315-324.
201. Tordoff M.G., Bachmanov A.A., Reed D.R. Forty mouse strain survey of water and sodium intake. Physiol. Behav. 2007, Apr. 1 (Epub ahead of print).
202. Ueno K., Ohta M., Morita H., Mikuni Y., Nakajima S., Yamamoto K., Isono K. Trehalose sensitivity in Drosophila correlates with mutations in and expression of the gustatory receptor gene Gr5a. Curr. Biol. 2001, 11:1451-1455.
203. Wang X., Thomas S.D., Zhang J. Relaxation of selective constraint and loss of function in the evolution of human bitter taste receptor genes. Hum. Mol. Genet. 2004, 13:2671-2678.
204. Warren R.P., Lewis R.C. Taste polymorphism in mice involving a bitter sugar derivative. Nature 1970, 227:77-78.
205. Whitney G., Harder D.B. PTC preference among laboratory mice: understanding of a previously "unreplicated" report. Behav. Genet. 1986, 16:409-416.
206. Whitney G., Harder D.B. Single locus control of sucrose octaacetate tasting among mice. Behav. Genet. 1986, 16:559-574.
207. Whitney G., Harder D.B. Genetics of bitter perception in mice. Physiol. Behav. 1994, 56:1141-1147.
208. Whitney G., Harder D.B., Gannon K.S. The B6.SW bilineal congenic sucrose octaacetate (SOA)-taster mice. Behav. Genet. 1989, 19:409-416.
209. Winnig M., Bufe B., Meyerhof W. Valine 738 and lysine 735 in the fifth transmembrane domain of rTas1r3 mediate insensitivity towards lactisole of the rat sweet taste receptor. BMC Neurosci. 2005, 6:22.
210. Wooding S. Phenylthiocarbamide: a 75-year adventure in genetics and natural selection. Genetics 2006, 172:2015-2023.
211. Wooding S., Kim U.K., Bamshad M.J., Larsen J., Jorde L.B., Drayna D. Natural selection and molecular evolution in PTC, a bitter-taste receptor gene. Am. J. Hum. Genet. 2004, 74:637-646.
212. Wu S.V., Chen M.C., Rozengurt E. Genomic organization, expression, and function of bitter taste receptors (T2R) in mouse and rat. Physiol. Genomics 2005, 22:139-149.
213. Xu H., Staszewski L., Tang H., Adler E., Zoller M., Li X. Different functional roles of T1R subunits in the heteromeric taste receptors. Proc. Natl. Acad. Sci. U. S. A. 2004, 101:14258-14263.
214. Yamamoto M.E., Block G.D., Ishii E. Food patterns among adolescents: influence of alcohol consumption. Alcoholism: Clin. Exp. Res. 1991, 15:359.
215. Zhao G.Q., Zhang Y., Hoon M.A., Chandrashekar J., Erlenbach I., Ryba N.J., Zuker C.S. The receptors for mammalian sweet and umami taste. Cell 2003, 115:255-266.
216. - Ensemble browser of sequenced genomes. http://www.ensembl.org.
217. - Entrez (National Center for Biotechnology Information cross-database search). http://www.ncbi.nlm.nih.gov/gquery.
218. - GenBank. http://www.ncbi.nlm.nih.gov/Genbank.
219. - Human Genome Database. http://gdbwww.gdb.org/gdb.
220. - Monell Mouse Taste Phenotyping Project. http://www.monell.org/MMTPP.
221. - Mouse Genome Database. http://www.informatics.jax.org.
222. - Mouse Phenome Database. http://www.jax.org/phenome.
223. - National Center for Biotechnology Information browser of sequenced genomes. http://www.ncbi.nlm.nih.gov/mapview.
224. - Rat Genome Database. http://rgd.mcw.edu.
225. - University of California Santa Cruz browser of sequenced genomes. http://genome.ucsc.edu.