Lactisole interacts with the transmembrane domains of human T1R3 to inhibit sweet taste

Journal of Biological Chemistry

Volumn 280, Issue 15, 2005, Pages 15238-15246

  Jiang, Peihua ^a   Cui, Meng ^a   Zhao, Baohua ^a   Liu, Zhan ^a,b   Snyder, Lenore A ^a   Benard, Lumie M J ^a,b   Osman, Roman ^a   Margolskee, Robert F ^a,b   Max, Marianna ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTIFICIAL SWEETNERS; BINDING POCKETS; SWEET-TASTING COMPOUNDS; TRANSMEMBRANE REGIONS;

ENZYME INHIBITION; MATHEMATICAL MODELS; NEUROLOGY; PROTEINS; SENSITIVITY ANALYSIS; SUGARS;

LIVING SYSTEMS STUDIES;

CARBOXYLIC ACID DERIVATIVE; LACTISOLE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHIMERA; CONTROLLED STUDY; HUMAN; HUMAN CELL; MEMBRANE BINDING; MEMBRANE TRANSPORT; MOLECULAR DYNAMICS; MOLECULAR MODEL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SUBSTITUTION REACTION; SWEETNESS;

ALANINE; ANIMALS; BENZENE DERIVATIVES; BINDING SITES; CELL LINE; CELL MEMBRANE; CYSTEINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; LIGANDS; MICE; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTATION; POINT MUTATION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, G-PROTEIN-COUPLED; RECOMBINANT FUSION PROTEINS; TASTE; TRYPTOPHAN;

PRIMATES; RODENTIA; RUMEX;

EID: 17644389240     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M414287200     Document Type: Article

References (43)

1. Lindemann, B. (2001) Nature 413, 219-225
2. Li, X., Staszewski, L., Xu, H., Durick, K., Zoller, M., and Adler, E. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 4692-4696
3. Nelson, G., Hoon, M. A., Chandrashekar, J., Zhang, Y., Ryba, N. J., and Zuker, C. S. (2001) Cell 106, 381-390
4. Zhao, G. Q., Zhang, Y., Hoon, M. A., Chandrashekar, J., Erlenbach, I., Ryba, N. J., and Zuker, C. S. (2003) Cell 115, 255-266
5. Damak, S., Rong, M., Yasumatsu, K., Kokrashvili, Z., Varadarajan, V., Zou, S., Jiang, P., Ninomiya, Y., and Margolskee, R. F. (2003) Science 301, 850-853
6. Hoon, M. A., Adler, E., Lindemeier, J., Battey, J. F., Ryba, N. J., and Zuker, C. S. (1999) Cell 96, 541-551
7. Bachmanov, A. A., Li, X., Reed, D. R., Ohmen, J. D., Li, S., Chen, Z., Tordoff, M. G., de Jong, P. J., Wu, C., West, D. B., Chatterjee, A., Ross, D. A., and Beauchamp, G. K. (2001) Chem. Senses 26, 925-933
8. Montmayeur, J. P., Liberles, S. D., Matsunami, H., and Buck, L. B. (2001) Nat. Neurosci. 4, 492-498
9. Max, M., Shanker, Y. G., Huang, L., Rong, M., Liu, Z., Campagne, F., Weinstein, H., Damak, S., and Margolskee, R. F. (2001) Nat. Genet. 28, 58-63
10. Kitagawa, M., Kusakabe, Y., Miura, H., Ninomiya, Y., and Hino, A. (2001) Biochem. Biophys. Res. Commun. 283, 236-242
11. Kunishima, N., Shimada, Y., Tsuji, Y., Sato, T., Yamamoto, M., Kumasaka, T., Nakauishi, S., Jingami, H., and Morikawa, K. (2000) Nature 407, 971-977
12. Binet, V., Brajon, C., Le Corre, L., Acher, F., Pin, J. P., and Prezeau, L. (2004) J. Biol. Chem. 279, 29085-29091
13. Malherbe, P., Kratochwil, N., Knoflach, F., Zenner, M. T., Kew, J. N., Kratzeisen, C., Maerki, H. P., Adam, G., and Mutel, V. (2003) J. Biol. Chem. 278, 8340-8347
14. Pagano, A., Ruegg, D., Litschig, S., Stoehr, N., Stierlin, C., Heinrich, M., Floersheim, P., Prezeau, L., Carroll, F., Pin, J. P., Cambria, A., Vranesic, I., Flor, P. J., Gasparini, F., and Kuhn, R. (2000) J. Biol. Chem. 275, 33750-33758
15. Petrel, C., Kessler, A., Maslah, F., Dauban, P., Dodd, R. H., Rognan, D., and Ruat, M. (2003) J. Biol. Chem. 278, 49487-49494
16. Petrel, C., Kessler, A., Dauban, P., Dodd, R. H., Rognan, D., and Ruat, M. (2004) J. Biol. Chem. 279, 18990-18997
17. Jiang, P., Ji, Q., Liu, Z., Snyder, L. A., Benard, L. M., Margolskee, R. F., and Max, M. (2004) J. Biol. Chem. 279, 45068-45075
18. Xu, H., Staszewski, L., Tang, H., Adler, E., Zoller, M., and Li, X. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 14258-14263
19. Jiang, P., Cui, M., Ji, Q., Snyder, L., Lui, Z., Benard, L., Margolskee, R., Osman, R., and Max, M. (2005) Chem. Senses 30, Suppl. 1, 117-118
20. Sclafani, A., and Perez, C. (1997) Physiol. Behav. 61, 25-29
21. Ballesteros, J. A., and Weinstein, H. (1995) Methods Neurosci. 25, 366-428
22. Ueda, T., Ugawa, S., Yamamura, H., Imaizumi, Y., and Shimada, S. (2003) J. Neurosci. 23, 7376-7380
23. Thompson, J. D., Higgins, D. G., and Gibson, T. J. (1994) Nucleic Acids Res. 22, 4673-4680
24. Fiser, A., Do, R. K., and Sali, A. (2000) Protein Sci. 9, 1753-1773
25. Fiser, A., and Sali, A. (2003) Bioinformatics 19, 2500-2501
26. Marti-Renom, M. A., Stuart, A. C., Fiser, A., Sanchez, R., Melo, F., and Sali, A. (2000) Annu. Rev. Biophys. Biomol. Struct. 29, 291-325
27. Sali, A., and Blundell, T. L. (1993) J. Mol. Biol. 234, 779-815
28. Brooks, B. R., Bruccoleri, R. E., Olafson, B. D., States, D. J., Swaminathan, S., and Karplus, M. (1983) J. Comp. Chem. 4, 187-217
29. Frisch, M. J., Trucks, G. W., Schlegel, H. B., Scuseria, G. E., Robb, M. A., Cheeseman, J. R., Zakrzewski, Montgomery, V. G., Jr., Stratmann, R. E., Burant, J. C., Dapprich, S., Millam, J. M., Daniels, A. D., Kudin, K. N., Strain, M. C., Farkas, O., Tomasi, J., Barone, V., Cossi, M., Cammi, R., Mennucci, B., Pomelli, C., Adamo, C., Clifford, S., Ochterski, J., Petersson, G. A., Ayala, P. Y., Cui, Q., Morokuma, K., Malick, D. K., Rabuck, A. D., Raghavachari, K., Foresman, J. B., Cioslowski, J., Ortiz, J. V., Baboul, A. G., Stefanov, B. B., Liu, G., Liashenko, A., Piskorz, P., Komaromi, I., Gomperts, R., Martin, R. L., Fox, D. J., Keith, T., Al-Laham, M. A., Peng, C. Y., Nanayakkara, A., Gonzalez, C., Challacombe, M., Gill, P. M. W., Johnson, B. G., Chen, M., Wong, W., Andres, J. L., Head-Gordon, M., Replogle, E. S., and Pople, J. A. (1998) Gaussian 98 (Revision A.x), Gaussian Inc., Pittsburgh, PA
30. Breneman, C. M., and Wiberg, K. B. (1990) J. Comp. Chem. 11, 361-373
31. Morris, G. M., Goodsell, D. S., Halliday, P. S., Huey, R., Hart, W. E., Belew, R. K., and Olson, A. J. (1998) J. Comp. Chem. 19, 1639-1662
32. Schiffman, S. S., Booth, B. J., Sattely-Miller, E. A., Graham, B. G., and Gibes, K. M. (1999) Chem. Senses 24, 439-447
33. Johnson, C., Birch, G. G., and MacDougall, D. B. (1994) Chem. Senses 19, 349-358
34. Malherbe, P., Knoflach, F., Broger, C., Ohresser, S., Kratzeisen, C., Adam, G., Stadler, H., Kemp, J. A., and Mutel, V. (2001) Mol. Pharmacol. 60, 944-954
35. Palczewski, K., Kumasaka, T., Hori, T., Behnke, C. A., Motoshima, H., Fox, B. A., Trong, I. L., Teller, D. C., Okada, T., Stenkamp, R. E., Yamamoto, M., and Miyano, M. (2000) Science 289, 739-745
36. Strader, C. D., and Dixon, R. A. (1991) Adv. Exp. Med. Biol. 287, 209-220
37. Perlman, J. H., Thaw, C. N., Laakkonen, L., Bowers, C. Y., Osman, R., and Gershengorn, M. C. (1994) J. Biol. Chem. 269, 1610-1613
38. Perlman, J. H., Laakkonen, L. J., Guarnieri, F., Osman, R., and Gershengorn, M. C. (1996) Biochemistry 35, 7643-7650
39. Manivet, P., Schneider, B., Smith, J. C., Choi, D. S., Maroteaux, L., Kellermann, O., and Launay, J. M. (2002) J. Biol. Chem. 277, 17170-17178
40. Schmidt, C., Li, B., Bloodworth, L., Erlenbach, I., Zeng, F. Y., and Wess, J. (2003) J. Biol. Chem. 278, 30248-30260
41. Farrens, D. L., Altenbach, C., Yang, K., Hubbell, W. L., and Khorana, H. G. (1996) Science 274, 768-770
42. Ward, S. D., Hamdan, F. F., Bloodworth, L. M., and Wess, J. (2002) J. Biol. Chem. 277, 2247-2257
43. Ghanouni, P., Steenhuis, J. J., Farrens, D. L., and Kobilka, B. K. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5997-6002