Haplotypes at the Tas2r locus on distal chromosome 6 vary with quinine taste sensitivity in inbred mice

BMC Genetics

Volumn 6, Issue , 2005, Pages

  Nelson, Theodore M ^a   Munger, Steven D ^a   Boughter Jr , John D ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; DENATONIUM BENZOATE; G PROTEIN COUPLED RECEPTOR; PROPYLTHIOURACIL; QUININE; SUCROSE; TASTE RECEPTOR 2 PROTEIN; UNCLASSIFIED DRUG;

ALLELE; ANIMAL EXPERIMENT; ARTICLE; BITTER TASTE; CHROMOSOME 6; CONTROLLED STUDY; CORRELATION ANALYSIS; EXON; FEMALE; GENE CLUSTER; GENE LOCUS; HAPLOTYPE; INBRED STRAIN; LINKAGE ANALYSIS; MALE; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PALATE; PHENOTYPIC VARIATION; QUANTITATIVE TRAIT LOCUS MAPPING; RECEPTOR SENSITIVITY; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; STRAIN DIFFERENCE; TASTE BUD; TASTE DISCRIMINATION; TONGUE;

ANIMALIA; CINCHONA PUBESCENS;

EID: 25444459919     PISSN: 14712156     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/1471-2156-6-32     Document Type: Article

References (46)

1. Nelson G, Chandrashekar J, Hoon MA, Feng L, Zhao G, Ryba NJ, Zuker CS: An amino-acid taste receptor. Nature 2002, 416:199-202.
2. Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, Zuker CS: Mammalian sweet taste receptors. Cell 2001, 106:381-390.
3. Max M, Shanker YG, Huang L, Rong M, Liu Z, Campagne F, Weinstein H, Damak S, Margolskee RF: Tas1r3, encoding a new candidate taste receptor, is allelic to the sweet responsiveness locus Sac. Nat Genet 2001, 28:58-63.
4. Montmayeur JP, Liberles SD, Matsunami H, Buck LB: A candidate taste receptor gene near a sweet taste locus. Nat Neurosci 2001, 4:492-498.
5. Bachmanov AA, Li X, Reed DR, Ohmen JD, Li S, Chen Z, Tordoff MG, de Jong PJ, Wu C, West DB, Chatterjee, A, Ross, DA, Beauchamp, GK: Positional cloning of the mouse saccharin preference (Sac) locus. Chem Senses 2001, 26:925-933.
6. Li X, Staszewski L, Xu H, Durick K, Zoller M, Adler E: Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 2002, 99:4692-4696.
7. Sainz E, Korley JN, Battey JF, Sullivan SL: Identification of a novel member of the T1R family of putative taste receptors. J Neurochem 2001, 77:896-903.
8. Kitagawa M, Kusakabe Y, Miura H, Ninomiya Y, Hino A: Molecular genetic identification of a candidate receptor gene for sweet taste. Biochem Biophys Res Commun 2001, 283:236-242.
9. Adler E, Hoon MA, Mueller KL, Chandrashekar J, Ryba NJ, Zuker CS: A novel family of mammalian taste receptors. Cell 2000, 100:693-702.
10. Chandrashekar J, Mueller KL, Hoon MA, Adler E, Feng L, Guo W, Zuker CS, Ryba NJ: T2Rs function as bitter taste receptors. Cell 2000, 100:703-711.
11. Matsunami H, Montmayeur JP, Buck LB: A family of candidate taste receptors in human and mouse. Nature 2000, 404:601-604.
12. Lush IE: The genetics of tasting in mice. III. Quinine. Genet Res 1984, 44:151-160.
13. Lush IE, Holland G: The genetics of tasting in mice. V. Glycine and cycloheximide. Genet Res 1988, 52:207-212.
14. Lush IE, Hornigold N, King P, Stoye JP: The genetics of tasting in mice. VII. Glycine revisited, and the chromosomal location of Sac and Soa. Genet Res 1995, 66:167-174.
15. Capeless CG, Whitney G, Azen EA: Chromosome mapping of Soa, a gene influencing gustatory sensitivity to sucrose octaacetate in mice. Behav Genet 1992, 22:655-663.
16. Harder DB, Whitney G: A common polygenic basis for quinine and PROP avoidance in mice. Chem Senses 1998, 23:327-332.
17. Bachmanov AA, Li X, Li S, Neira M, Beauchamp GK, Azen EA: High-resolution genetic mapping of the sucrose octaacetate taste aversion (Soa) locus on mouse Chromosome 6. Mamm Genome 2001, 12:695-699.
18. Kim UK, Jorgenson E, Coon H, Leppert M, Risch N, Drayna D: Positional cloning of the human quantitative trait locus underlying taste sensitivity to phenylthiocarbamide. Science 2003, 299:1221-1225.
19. Shi P, Zhang J, Yang H, Zhang YP: Adaptive diversification of bitter taste receptor genes in Mammalian evolution. Mol Biol Evol 2003, 20:805-814.
20. Bufe B, Hofmann T, Krautwurst D, Raguse JD, Meyerhof W: The human TAS2R16 receptor mediates bitter taste in response to beta-glucopyranosides. Nat Genet 2002, 32:397-401.
21. Behrens M, Brockhoff A, Kuhn C, Bufe B, Winnig M, Meyerhof W: The human taste receptor hTAS2R14 responds to a variety of different bitter compounds. Biochem Biophys Res Commun 2004, 319:479-485.
22. Kuhn C, Bufe B, Winnig M, Hofmann T, Frank O, Behrens M, Lewtschenko T, Slack JP, Ward CD, Meyerhof W: Bitter taste receptors for saccharin and acesulfame K. J Neurosci 2004, 24:10260-10265.
23. Pronin AN, Tang H, Connor J, Keung W: Identification of ligands for two human bitter T2R receptors. Chem Senses 2004, 29:583-593.
24. Drayna D, Coon H, Kim UK, Elsner T, Cromer K, Otterud B, Baird L, Peiffer AP, Leppert M: Genetic analysis of a complex trait in the Utah Genetic Reference Project: a major locus for PTC taste ability on chromosome 7q and a secondary locus on chromosome 16p. Hum Genet 2003, 112:567-572.
25. Prodi DA, Drayna D, Forabosco P, Palmas MA, Maestrale GB, Piras D, Pirastu M, Angius A: Bitter taste study in a sardinian genetic isolate supports the association of phenylthiocarbamide sensitivity to the TAS2R38 bitter receptor gene. Chem Senses 2004, 29:697-702.
26. Boughter JD, Jr., Harder, DB, Capeless, CG, Whitney, G: Polygenic determination of quinine aversion among mice. Chem Senses 1992, 17:427-434.
27. Whitney G, Harder DB: Genetics of bitter perception in mice. Physiol Behav 1994, 56:1141-1147.
28. Blizard DA, Kotlus B, Frank ME: Quantitative trait loci associated with short-term intake of sucrose, saccharin and quinine solutions in laboratory mice. Chem Senses 1999, 24:373-385.
29. Nelson TM, Munger SD, Boughter JD, Jr.: Taste sensitivities to PROP and PTC vary independently in mice. Chem Senses 2003, 28:695-704.
30. Caicedo A, Pereira E, Margolskee RF, Roper SD: Role of the G-protein subunit alpha-gustducin in taste cell responses to bitter stimuli. J Neurosci 2003, 23:9947-9952.
31. Seto E, Hayashi Y, Mori T: Patch clamp recording of the responses to three bitter stimuli in mouse taste cells. Cell Mol Biol (Noisy-le-grand) 1999, 45:317-325.
32. Chen Y, Herness MS: Electrophysiological actions of quinine on voltage-dependent currents in dissociated rat taste cells. Pflugers Arch 1997, 434:215-226.
33. Rosenzweig S, Yan W, Dasso M, Spielman AI: Possible novel mechanism for bitter taste mediated through cGMP. J Neurophysiol 1999, 81:1661-1665.
34. Cummings TA, Kinnamon SC: Apical K+ channels in Necturus taste cells. Modulation by intracellular factors and taste stimuli. J Gen Physiol 1992, 99:591-613.
35. Naim M, Seifert R, Nurnberg B, Grunbaum L, Schultz G: Some taste substances are direct activators of G-proteins. Biochem J 1994, 297:451-454.
36. Tsunenari T, Hayashi Y, Orita M, Kurahashi T, Kaneko A, Mori T: A quinine-activated cationic conductance in vertebrate taste receptor cells. J Gen Physiol 1996, 108:515-523.
37. Boughter JD, Jr., St John SJ, Noel DT, Ndubuizu O, Smith DV: A brief-access test for bitter taste in mice. Chem Senses 2002, 27:133-142.
38. Manly KF, Cudmore RH, Jr., Meer JM: Map Manager QTX, cross-platform software for genetic mapping. Mamm Genome 2001, 12:930-932.
39. Sheehan S: BXD RI Mapping, direct data submission, MGI:2179770 (2002). In.: Mouse Genome Informatics (MGI; http://www.informatics.jax.org); 2002.
40. Blake JA, Richardson JE, Bult CJ, Kadin JA, Eppig JT: MGD: the Mouse Genome Database. Nucleic Acids Res 2003, 31:193-195.
41. Spielman AI, Huque T, Whitney G, Brand JG: The diversity of bitter taste signal transduction mechanisms. Soc Gen Physiol Ser 1992, 47:307-324.
42. Mombaerts P: Genes and ligands for odorant, vomeronasal and taste receptors. Nat Rev Neurosci 2004, 5:263-278.
43. Parry CM, Erkner A, le Coutre J: Divergence of T2R chemosensory receptor families in humans, bonobos, and chimpanzees. Proc Natl Acad Sci U S A 2004, 101:14830-14834.
44. Fischer A, Gilad Y, Man O, Paabo S: Evolution of Bitter Taste Receptors in Humans and Apes. Mol Biol Evol 2004, 22:432-6.
45. Wang J, Williams RW, Manly KF: WebQTL: web-based complex trait analysis. Neuroinformatics 2003, 1:299-308.
46. Knott SA, Haley CS: Maximum likelihood mapping of quantitative trait loci using full-sib families. Genetics 1992, 132:1211-1222.