Clinical application of transcriptional activators of bile salt transporters

Molecular Aspects of Medicine

Volumn 37, Issue , 2014, Pages 57-76

  Baghdasaryan, Anna ^a,b   Chiba, Peter ^a   Trauner, Michael ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b MEDICAL UNIVERSITY OF GRAZ   (Austria)

Author keywords

ATB binding cassette transporters; Cholestasis; Nuclear receptors

Indexed keywords

ABC TRANSPORTER; BILE SALT; BILE SALT EXPORT PUMP; CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; FARNESOID X RECEPTOR; ORGANIC SOLUTE TRANSPORTER ALPHA; ORGANIC SOLUTE TRANSPORTER BETA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREGNANE X RECEPTOR; SODIUM BILE ACID COTRANSPORTER; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID DERIVATIVE; VITAMIN D RECEPTOR; ABCB11 PROTEIN, HUMAN; BILE ACID; COTRANSPORTER; ORGANIC ANION TRANSPORTER; ORGANIC SOLUTE TRANSPORTER ALPHA, HUMAN; ORGANIC SOLUTE TRANSPORTER BETA, HUMAN; SODIUM-BILE ACID COTRANSPORTER;

ANTICHOLESTATIC ACTIVITY; CELL DEATH; CELL MEMBRANE; CELL ORGANELLE; CHOLESTASIS; CHOLESTATIC HEPATITIS; CONCENTRATION (PARAMETERS); DRUG ACTIVITY; DRUG MECHANISM; ENTEROHEPATIC CIRCULATION; FIBROSIS; HOMEOSTASIS; HUMAN; INFLAMMATION; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN TARGETING; REVIEW; TRANSCRIPTION REGULATION; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PATHOLOGY; TRANSCRIPTION INITIATION; TRANSPORT AT THE CELLULAR LEVEL;

ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CHOLESTASIS; GENE EXPRESSION REGULATION; HUMANS; MEMBRANE TRANSPORT PROTEINS; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; SYMPORTERS; TRANSCRIPTIONAL ACTIVATION;

EID: 84901234820     PISSN: 00982997     EISSN: 18729452     Source Type: Journal    
DOI: 10.1016/j.mam.2013.12.001     Document Type: Review

References (346)

1. U. Abel, T. Schluter, A. Schulz, E. Hambruch, C. Steeneck, M. Hornberger, T. Hoffmann, S. Perovic-Ottstadt, O. Kinzel, and M. Burnet et al. Synthesis and pharmacological validation of a novel series of non-steroidal FXR agonists Bioorg. Med. Chem. Lett. 20 2010 4911 4917
2. S. Abramovitch, L. Dahan-Bachar, E. Sharvit, Y. Weisman, A. Ben Tov, E. Brazowski, and S. Reif Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats Gut 60 2011 1728 1737
3. H. Akita, H. Suzuki, K. Ito, S. Kinoshita, N. Sato, H. Takikawa, and Y. Sugiyama Characterization of bile acid transport mediated by multidrug resistance associated protein 2 and bile salt export pump Biochim. Biophys. Acta 1511 2001 7 16
4. K. Allen, H. Jaeschke, and B.L. Copple Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis Am. J. Pathol. 178 2010 175 186
5. D. Alvaro, A. Gigliozzi, L. Marucci, G. Alpini, B. Barbaro, R. Monterubbianesi, L. Minetola, M.G. Mancino, J.F. Medina, A.F. Attili, and A. Benedetti Corticosteroids modulate the secretory processes of the rat intrahepatic biliary epithelium Gastroenterology 122 2002 1058 1069
6. M. Ananthanarayanan, O.C. Ng, J.L. Boyer, and F.J. Suchy Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies Am. J. Physiol. 267 1994 G637 G643
7. M. Ananthanarayanan, N. Balasubramanian, M. Makishima, D.J. Mangelsdorf, and F.J. Suchy Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor J. Biol. Chem. 276 2001 28857 28865
8. M. Ananthanarayanan, S. Li, N. Balasubramaniyan, F.J. Suchy, and M.J. Walsh Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1 J. Biol. Chem. 279 2004 54348 54357
9. M. Ananthanarayanan, Y. Li, S. Surapureddi, N. Balasubramaniyan, J. Ahn, J.A. Goldstein, and F.J. Suchy Histone H3K4 trimethylation by MLL3 as part of ASCOM complex is critical for NR activation of bile acid transporter genes and is downregulated in cholestasis Am. J. Physiol. Gastrointest. Liver Physiol. 300 2011 G771 G781
10. P. Angulo, R.A. Jorgensen, J.C. Keach, E.R. Dickson, C. Smith, and K.D. Lindor Oral budesonide in the treatment of patients with primary biliary cirrhosis with a suboptimal response to ursodeoxycholic acid Hepatology 31 2000 318 323
11. F. Arenas, I. Hervias, M. Uriz, R. Joplin, J. Prieto, and J.F. Medina Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells J. Clin. Invest. 118 2008 695 709
12. +/taurocholate cotransporting polypeptide during pregnancy in the rat J. Hepatol. 38 2003 148 155
13. M. Arrese, R.I. Macias, O. Briz, M.J. Perez, and J.J. Marin Molecular pathogenesis of intrahepatic cholestasis of pregnancy Expert Rev. Mol. Med. 10 2008 e9
14. L. Bachs, A. Pares, M. Elena, C. Piera, and J. Rodes Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis Lancet 1 1989 574 576
15. L. Bachs, A. Pares, M. Elena, C. Piera, and J. Rodes Effects of long-term rifampicin administration in primary biliary cirrhosis Gastroenterology 102 1992 2077 2080
16. Y. Bacq, L. Sentilhes, H.B. Reyes, A. Glantz, J. Kondrackiene, T. Binder, P.L. Nicastri, A. Locatelli, A. Floreani, I. Hernandez, and V. Di Martino Efficacy of ursodeoxycholic acid in treating intrahepatic cholestasis of pregnancy: a meta-analysis Gastroenterology 143 2012 1492 1501
17. A. Baghdasaryan, P. Fickert, A. Fuchsbichler, D. Silbert, J. Gumhold, G. Horl, C. Langner, T. Moustafa, E. Halilbasic, T. Claudel, and M. Trauner Role of hepatic phospholipids in development of liver injury in Mdr2 (Abcb4) knockout mice Liver Int. 28 2008 948 958
18. -/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation Gut 59 2010 521 530
19. -/-) mouse cholangiopathy model by promoting biliary HCO output Hepatology 54 2011 1303 1312
20. N. Balasubramaniyan, M. Ananthanarayanan, and F.J. Suchy Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes Am. J. Physiol. Gastrointest. Liver Physiol. 302 2012 G937 G947
21. N. Ballatori Pleiotropic functions of the organic solute transporter Ostalpha-Ostbeta Dig. Dis. 29 2011 13 17
22. N. Ballatori, W.V. Christian, J.Y. Lee, P.A. Dawson, C.J. Soroka, J.L. Boyer, M.S. Madejczyk, and N. Li OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia Hepatology 42 2005 1270 1279
23. N. Ballatori, F. Fang, W.V. Christian, N. Li, and C.L. Hammond Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver Am. J. Physiol. Gastrointest. Liver Physiol. 295 2008 G179 G186
24. O. Barbier, D. Duran-Sandoval, I. Pineda-Torra, V. Kosykh, J.C. Fruchart, and B. Staels Peroxisome proliferator-activated receptor alpha induces hepatic expression of the human bile acid glucuronidating UDP-glucuronosyltransferase 2B4 enzyme J. Biol. Chem. 278 2003 32852 32860
25. O. Barbier, I.P. Torra, A. Sirvent, T. Claudel, C. Blanquart, D. Duran-Sandoval, F. Kuipers, V. Kosykh, J.C. Fruchart, and B. Staels FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity Gastroenterology 124 2003 1926 1940
26. I. Barchetta, S. Carotti, G. Labbadia, U.V. Gentilucci, A.O. Muda, F. Angelico, G. Silecchia, F. Leonetti, A. Fraioli, and A. Picardi et al. Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus Hepatology 56 2012 2180 2187
27. A. Barth, G. Klinger, and M. Rost Influence of ethinyloestradiol propanolsulphonate on serum bile acids in healthy volunteers Exp. Toxicol. Pathol. 54 2003 381 386
28. E.S. Baskin-Bey, W. Huang, N. Ishimura, H. Isomoto, S.F. Bronk, K. Braley, R.W. Craig, D.D. Moore, and G.J. Gores Constitutive androstane receptor (CAR) ligand, TCPOBOP, attenuates Fas-induced murine liver injury by altering Bcl-2 proteins Hepatology 44 2006 252 262
29. A.P. Beigneux, A.H. Moser, J.K. Shigenaga, C. Grunfeld, and K.R. Feingold The acute phase response is associated with retinoid X receptor repression in rodent liver J. Biol. Chem. 275 2000 16390 16399
30. A.P. Beigneux, A.H. Moser, J.K. Shigenaga, C. Grunfeld, and K.R. Feingold Reduction in cytochrome P-450 enzyme expression is associated with repression of CAR (constitutive androstane receptor) and PXR (pregnane X receptor) in mouse liver during the acute phase response Biochem. Biophys. Res. Commun. 293 2002 145 149
31. M. Bertolotti, C. Gabbi, C. Anzivino, N. Mitro, C. Godio, E. De Fabiani, M. Crestani, M. Del Puppo, M. Ricchi, and L. Carulli et al. Decreased hepatic expression of PPAR-gamma coactivator-1 in cholesterol cholelithiasis Eur. J. Clin. Invest. 36 2006 170 175
32. U. Beuers, M. Bilzer, A. Chittattu, G.A. Kullak-Ublick, D. Keppler, G. Paumgartner, and F. Dombrowski Tauroursodeoxycholic acid inserts the apical conjugate export pump, Mrp2, into canalicular membranes and stimulates organic anion secretion by protein kinase C-dependent mechanisms in cholestatic rat liver Hepatology 33 2001 1206 1216
33. J.R. Bloomer, and J.L. Boyer Phenobarbital effects in cholestatic liver diseases Ann. Intern. Med. 82 1975 310 317
34. R. Bossard, B. Stieger, B. O'Neill, G. Fricker, and P.J. Meier Ethinylestradiol treatment induces multiple canalicular membrane transport alterations in rat liver J. Clin. Invest. 91 1993 2714 2720
35. J.L. Boyer, M. Trauner, A. Mennone, C.J. Soroka, S.Y. Cai, T. Moustafa, G. Zollner, J.Y. Lee, and N. Ballatori Upregulation of a basolateral FXR-dependent bile acid efflux transporter OSTalpha-OSTbeta in cholestasis in humans and rodents Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G1124 G1130
36. D. Brites Intrahepatic cholestasis of pregnancy: changes in maternal-fetal bile acid balance and improvement by ursodeoxycholic acid Ann. Hepatol. 1 2002 20 28
37. J.A. Byrne, S.S. Strautnieks, G. Mieli-Vergani, C.F. Higgins, K.J. Linton, and R.J. Thompson The human bile salt export pump: characterization of substrate specificity and identification of inhibitors Gastroenterology 123 2002 1649 1658
38. E.L. Cancado, R.M. Leitao, F.J. Carrilho, and A.A. Laudanna Unexpected clinical remission of cholestasis after rifampicin therapy in patients with normal or slightly increased levels of gamma-glutamyl transpeptidase Am. J. Gastroenterol. 93 1998 1510 1517
39. J. Cao, P.M. Gowri, T.C. Ganguly, M. Wood, J.F. Hyde, F. Talamantes, and M. Vore PRL, placental lactogen, and GH induce NA(+)/taurocholate-cotransporting polypeptide gene expression by activating signal transducer and activator of transcription-5 in liver cells Endocrinology 142 2001 4212 4222
40. +/ taurocholate cotransporting polypeptide in liver cells through estrogen receptor-alpha and signal transducers and activators of transcription 5a Endocrinology 145 2004 1739 1749
41. F.X. Caroli-Bosc, P. Le Gall, P. Pugliese, B. Delabre, C. Caroli-Bosc, J.F. Demarquay, J.P. Delmont, P. Rampal, and J.C. Montet Role of fibrates and HMG-CoA reductase inhibitors in gallstone formation: epidemiological study in an unselected population Dig. Dis. Sci. 46 2001 540 544
42. B.A. Carter, and R.J. Shulman Mechanisms of disease: update on the molecular etiology and fundamentals of parenteral nutrition associated cholestasis Nat. Clin. Pract. Gastroenterol. Hepatol. 4 2007 277 287
43. J. Chai, D. Luo, X. Wu, H. Wang, Y. He, Q. Li, Y. Zhang, L. Chen, Z.H. Peng, and T. Xiao et al. Changes of organic anion transporter MRP4 and related nuclear receptors in human obstructive cholestasis J. Gastrointest. Surg. 15 2011 996 1004
44. C. Chen, J.L. Staudinger, and C.D. Klaassen Nuclear receptor, pregname X receptor, is required for induction of UDP-glucuronosyltranferases in mouse liver by pregnenolone-16 alpha-carbonitrile Drug Metab. Dispos. 31 2003 908 915
45. Y. Chen, S.S. Ferguson, M. Negishi, and J.A. Goldstein Identification of constitutive androstane receptor and glucocorticoid receptor binding sites in the CYP2C19 promoter Mol. Pharmacol. 64 2003 316 324
46. Y. Chen, S.S. Ferguson, M. Negishi, and J.A. Goldstein Induction of human CYP2C9 by rifampicin, hyperforin, and phenobarbital is mediated by the pregnane X receptor J. Pharmacol. Exp. Ther. 308 2004 495 501
47. Y. Chen, X. Song, L. Valanejad, A. Vasilenko, V. More, X. Qiu, W. Chen, Y. Lai, A. Slitt, and M. Stoner et al. Bile salt export pump is dysregulated with altered farnesoid X receptor isoform expression in patients with hepatocellular carcinoma Hepatology 57 2012 1530 1541
48. N. Chignard, M. Mergey, V. Barbu, L. Finzi, E. Tiret, A. Paul, and C. Housset VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium Hepatology 42 2005 549 557
49. S. Childs, R.L. Yeh, E. Georges, and V. Ling Identification of a sister gene to P-glycoprotein Cancer Res. 55 1995 2029 2034
50. M.K. Choi, H.J. Shin, Y.L. Choi, J.W. Deng, J.G. Shin, and I.S. Song Differential effect of genetic variants of Na(+)-taurocholate co-transporting polypeptide (NTCP) and organic anion-transporting polypeptide 1B1 (OATP1B1) on the uptake of HMG-CoA reductase inhibitors Xenobiotica 41 2011 24 34
51. A.R. Chopra, R. Kommagani, P. Saha, J.F. Louet, C. Salazar, J. Song, J. Jeong, M. Finegold, B. Viollet, and F. DeMayo et al. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption Cell Metab. 13 2011 35 43
52. W.V. Christian, N. Li, P.M. Hinkle, and N. Ballatori Beta-Subunit of the Ostalpha-Ostbeta organic solute transporter is required not only for heterodimerization and trafficking but also for function J. Biol. Chem. 287 2012 21233 21243
53. D.E. Cohen, M.R. Leonard, and M.C. Carey In vitro evidence that phospholipid secretion into bile may be coordinated intracellularly by the combined actions of bile salts and the specific phosphatidylcholine transfer protein of liver Biochemistry 33 1994 9975 9980
54. F.A. Crocenzi, A.D. Mottino, J. Cao, L.M. Veggi, E.J. Pozzi, M. Vore, R. Coleman, and M.G. Roma Estradiol-17beta-d-glucuronide induces endocytic internalization of Bsep in rats Am. J. Physiol. Gastrointest. Liver Physiol. 285 2003 G449 G459
55. Y.J. Cui, L.M. Aleksunes, Y. Tanaka, M.J. Goedken, and C.D. Klaassen Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-null mice Toxicol. Sci. 110 2009 47 60
56. E. D''Aldebert, M.J. Biyeyeme Bi Mve, M. Mergey, D. Wendum, D. Firrincieli, A. Coilly, L. Fouassier, C. Corpechot, R. Poupon, C. Housset, and N. Chignard Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium Gastroenterology 136 2009 1435 1443
57. P.A. Dawson, M. Hubbert, J. Haywood, A.L. Craddock, N. Zerangue, W.V. Christian, and N. Ballatori The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter J. Biol. Chem. 280 2005 6960 6968
58. P.A. Dawson, M.L. Hubbert, and A. Rao Getting the mOST from OST: role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism Biochim. Biophys. Acta 1801 2010 994 1004
59. G.U. Denk, C.J. Soroka, Y. Takeyama, W.S. Chen, J.D. Schuetz, and J.L. Boyer Multidrug resistance-associated protein 4 is up-regulated in liver but down-regulated in kidney in obstructive cholestasis in the rat J. Hepatol. 40 2004 585 591
60. L.A. Denson, E. Sturm, W. Echevarria, T.L. Zimmerman, M. Makishima, D.J. Mangelsdorf, and S.J. Karpen The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp Gastroenterology 121 2001 140 147
61. U. Deuschle, J. Schuler, A. Schulz, T. Schluter, O. Kinzel, U. Abel, and C. Kremoser FXR controls the tumor suppressor NDRG2 and FXR agonists reduce liver tumor growth and metastasis in an orthotopic mouse xenograft model PLoS ONE 7 2012 e43044
62. L. Diao, N. Li, T.G. Brayman, K.J. Hotz, and Y. Lai Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-{alpha}, IL-6, and IL-1{beta} J. Biol. Chem. 285 2010 31185 31192
63. P.H. Dixon, S.W. van Mil, J. Chambers, S. Strautnieks, R.J. Thompson, F. Lammert, R. Kubitz, V. Keitel, A. Glantz, and L.A. Mattsson et al. Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy Gut 58 2009 537 544
64. F. Dombrowski, B. Stieger, and U. Beuers Tauroursodeoxycholic acid inserts the bile salt export pump into canalicular membranes of cholestatic rat liver Lab. Invest. 86 2006 166 174
65. M.G. Donner, S. Schumacher, U. Warskulat, J. Heinemann, and D. Haussinger Obstructive cholestasis induces TNF-alpha- and IL-1-mediated periportal downregulation of Bsep and zonal regulation of Ntcp, Oatp1a4, and Oatp1b2 Am. J. Physiol. Gastrointest. Liver Physiol. 293 2007 G1134 G1146
66. M.L. Eloranta, T. Hakli, M. Hiltunen, S. Helisalmi, K. Punnonen, and S. Heinonen Association of single nucleotide polymorphisms of the bile salt export pump gene with intrahepatic cholestasis of pregnancy Scand. J. Gastroenterol. 38 2003 648 652
67. +-taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism Mol. Endocrinol. 20 2006 65 79
68. L. Fan, X. Tu, Y. Zhu, L. Zhou, T. Pfeiffer, R. Feltens, W. Stoecker, and R. Zhong Genetic association of vitamin D receptor polymorphisms with autoimmune hepatitis and primary biliary cirrhosis in the Chinese J. Gastroenterol. Hepatol. 20 2005 249 255
69. H.L. Fang, S.C. Strom, H. Cai, C.N. Falany, T.A. Kocarek, and M. Runge-Morris Regulation of human hepatic hydroxysteroid sulfotransferase gene expression by the peroxisome proliferator-activated receptor alpha transcription factor Mol. Pharmacol. 67 2005 1257 1267
70. K. Fattinger, C. Funk, M. Pantze, C. Weber, J. Reichen, B. Stieger, and P.J. Meier The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: a potential mechanism for hepatic adverse reactions Clin. Pharmacol. Ther. 69 2001 223 231
71. W.A. Faubion, M.E. Guicciardi, H. Miyoshi, S.F. Bronk, P.J. Roberts, P.A. Svingen, S.H. Kaufmann, and G.J. Gores Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas J. Clin. Invest. 103 1999 137 145
72. E. Fayard, J. Auwerx, and K. Schoonjans LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis Trends Cell Biol. 14 2004 250 260
73. S.S. Ferguson, Y. Chen, E.L. LeCluyse, M. Negishi, and J.A. Goldstein Human CYP2C8 is transcriptionally regulated by the nuclear receptors constitutive androstane receptor, pregnane X receptor, glucocorticoid receptor, and hepatic nuclear factor 4alpha Mol. Pharmacol. 68 2005 747 757
74. P. Fickert, G. Zollner, A. Fuchsbichler, C. Stumptner, C. Pojer, R. Zenz, F. Lammert, B. Stieger, P.J. Meier, and K. Zatloukal et al. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver Gastroenterology 121 2001 170 183
75. P. Fickert, M. Wagner, H.U. Marschall, A. Fuchsbichler, G. Zollner, O. Tsybrovskyy, K. Zatloukal, J. Liu, M.P. Waalkes, and C. Cover et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice Gastroenterology 130 2006 465 481
76. S. Fiorucci, C. Clerici, E. Antonelli, S. Orlandi, B. Goodwin, B.M. Sadeghpour, G. Sabatino, G. Russo, D. Castellani, and T.M. Willson et al. Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis J. Pharmacol. Exp. Ther. 313 2005 604 612
77. L. Fouassier, N. Kinnman, G. Lefevre, E. Lasnier, C. Rey, R. Poupon, R.P. Elferink, and C. Housset Contribution of mrp2 in alterations of canalicular bile formation by the endothelin antagonist bosentan J. Hepatol. 37 2002 184 191
78. T. Frankenberg, A. Rao, F. Chen, J. Haywood, B.L. Shneider, and P.A. Dawson Regulation of the mouse organic solute transporter alpha-beta, Ostalpha-Ostbeta, by bile acids Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G912 G922
79. D. Fu, Y. Wakabayashi, Y. Ido, J. Lippincott-Schwartz, and I.M. Arias Regulation of bile canalicular network formation and maintenance by AMP-activated protein kinase and LKB1 J. Cell Sci. 123 2010 3294 3302
80. C. Funk, C. Ponelle, G. Scheuermann, and M. Pantze Cholestatic potential of troglitazone as a possible factor contributing to troglitazone-induced hepatotoxicity: in vivo and in vitro interaction at the canalicular bile salt export pump (Bsep) in the rat Mol. Pharmacol. 59 2001 627 635
81. R.M. Gadaleta, B. Oldenburg, E.C. Willemsen, M. Spit, S. Murzilli, L. Salvatore, L.W. Klomp, P.D. Siersema, K.J. van Erpecum, and S.W. van Mil Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappaB signaling in the intestine Biochim. Biophys. Acta 1812 2011 851 858
82. T.C. Ganguly, M.L. O'Brien, S.J. Karpen, J.F. Hyde, F.J. Suchy, and M. Vore Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5 J. Clin. Invest. 99 1997 2906 2914
83. +/bile acid cotransporter in extrahepatic cholestasis Gastroenterology 110 1996 199 209
84. A. Geier, C.G. Dietrich, T. Gerloff, J. Haendly, G.A. Kullak-Ublick, B. Stieger, P.J. Meier, S. Matern, and C. Gartung Regulation of basolateral organic anion transporters in ethinylestradiol-induced cholestasis in the rat Biochim. Biophys. Acta 1609 2003 87 94
85. A. Geier, C.G. Dietrich, S. Voigt, S.K. Kim, T. Gerloff, G.A. Kullak-Ublick, J. Lorenzen, S. Matern, and C. Gartung Effects of proinflammatory cytokines on rat organic anion transporters during toxic liver injury and cholestasis Hepatology 38 2003 345 354
86. A. Geier, C.G. Dietrich, S. Voigt, M. Ananthanarayanan, F. Lammert, A. Schmitz, M. Trauner, H.E. Wasmuth, D. Boraschi, and N. Balasubramaniyan et al. Cytokine-dependent regulation of hepatic organic anion transporter gene transactivators in mouse liver Am. J. Physiol. Gastrointest. Liver Physiol. 289 2005 G831 G841
87. A. Geier, G. Zollner, C.G. Dietrich, M. Wagner, P. Fickert, H. Denk, N. van Rooijen, S. Matern, C. Gartung, and M. Trauner Cytokine-independent repression of rodent Ntcp in obstructive cholestasis Hepatology 41 2005 470 477
88. A. Geier, I.V. Martin, C.G. Dietrich, N. Balasubramaniyan, S. Strauch, F.J. Suchy, C. Gartung, C. Trautwein, and M. Ananthanarayanan Hepatocyte nuclear factor-4alpha is a central transactivator of the mouse Ntcp gene Am. J. Physiol. Gastrointest. Liver Physiol. 295 2008 G226 G233
89. S. Gerbal-Chaloin, M. Daujat, J.M. Pascussi, L. Pichard-Garcia, M.J. Vilarem, and P. Maurel Transcriptional regulation of CYP2C9 gene. Role of glucocorticoid receptor and constitutive androstane receptor J. Biol. Chem. 277 2002 209 217
90. T. Gerloff, B. Stieger, B. Hagenbuch, J. Madon, L. Landmann, J. Roth, A.F. Hofmann, and P.J. Meier The sister of P-glycoprotein represents the canalicular bile salt export pump of mammalian liver J. Biol. Chem. 273 1998 10046 10050
91. T. Gerloff, A. Geier, I. Roots, P.J. Meier, and C. Gartung Functional analysis of the rat bile salt export pump gene promoter Eur. J. Biochem. 269 2002 3495 3503
92. N.S. Ghonem, and J.L. Boyer Fibrates as adjuvant therapy for chronic cholestatic liver disease - it's time has come Hepatology 57 2013 1691 1693
93. R. Ghose, J. Mulder, R.J. von Furstenberg, S. Thevananther, F. Kuipers, and S.J. Karpen Rosiglitazone attenuates suppression of RXRalpha-dependent gene expression in inflamed liver J. Hepatol. 46 2007 115 123
94. A. Glantz, H.U. Marschall, F. Lammert, and L.A. Mattsson Intrahepatic cholestasis of pregnancy: a randomized controlled trial comparing dexamethasone and ursodeoxycholic acid Hepatology 42 2005 1399 1405
95. A. Glantz, S.J. Reilly, L. Benthin, F. Lammert, L.A. Mattsson, and H.U. Marschall Intrahepatic cholestasis of pregnancy: amelioration of pruritus by UDCA is associated with decreased progesterone disulphates in urine Hepatology 47 2008 544 551
96. C. Gnerre, S. Blattler, M.R. Kaufmann, R. Looser, and U.A. Meyer Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene Pharmacogenetics 14 2004 635 645
97. J.A. Goldstein, and S.M. de Morais Biochemistry and molecular biology of the human CYP2C subfamily Pharmacogenetics 4 1994 285 299
98. B. Goodwin, E. Hodgson, and C. Liddle The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module Mol. Pharmacol. 56 1999 1329 1339
99. B. Goodwin, E. Hodgson, D.J. D'Costa, G.R. Robertson, and C. Liddle Transcriptional regulation of the human CYP3A4 gene by the constitutive androstane receptor Mol. Pharmacol. 62 2002 359 365
100. D. Graf, A.K. Kurz, R. Fischer, R. Reinehr, and D. Haussinger Taurolithocholic acid-3 sulfate induces CD95 trafficking and apoptosis in a c-Jun N-terminal kinase-dependent manner Gastroenterology 122 2002 1411 1427
101. R.M. Green, D. Beier, and J.L. Gollan Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents Gastroenterology 111 1996 193 198
102. M.E. Guicciardi, and G.J. Gores Ursodeoxycholic acid cytoprotection: dancing with death receptors and survival pathways Hepatology 35 2002 971 973
103. +/bile acid cotransport system Proc. Natl. Acad. Sci. USA 88 1991 10629 10633
104. -/- mice Hepatology 49 2009 1972 1981
105. B. Halmos, F. Szalay, T. Cserniczky, E. Nemesanszky, P. Lakatos, S. Barlage, G. Schmitz, L. Romics, and A. Csaszar Association of primary biliary cirrhosis with vitamin D receptor BsmI genotype polymorphism in a Hungarian population Dig. Dis. Sci. 45 2000 1091 1095
106. S.K. Hansen, M. Parrizas, M.L. Jensen, S. Pruhova, J. Ek, S.F. Boj, A. Johansen, M.A. Maestro, F. Rivera, and H. Eiberg et al. Genetic evidence that HNF-1alpha-dependent transcriptional control of HNF-4alpha is essential for human pancreatic beta cell function J. Clin. Invest. 110 2002 827 833
107. K. Harada, and Y. Nakanuma Biliary innate immunity: function and modulation Mediators Inflamm. 2010 2010 10.1155/2010/373878
108. K. Harada, K. Isse, T. Kamihira, S. Shimoda, and Y. Nakanuma Th1 cytokine-induced downregulation of PPARgamma in human biliary cells relates to cholangitis in primary biliary cirrhosis Hepatology 41 2005 1329 1338
109. G. Hartmann, A.K. Cheung, and M. Piquette-Miller Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia J. Pharmacol. Exp. Ther. 303 2002 273 281
110. H. Hayashi, T. Takada, H. Suzuki, R. Onuki, A.F. Hofmann, and Y. Sugiyama Transport by vesicles of glycine- and taurine-conjugated bile salts and taurolithocholate 3-sulfate: a comparison of human BSEP with rat Bsep Biochim. Biophys. Acta 1738 2005 54 62
111. G.P. Hayhurst, Y.H. Lee, G. Lambert, J.M. Ward, and F.J. Gonzalez Hepatocyte nuclear factor 4alpha (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis Mol. Cell. Biol. 21 2001 1393 1403
112. S. Hazra, T. Miyahara, R.A. Rippe, and H. Tsukamoto PPAR gamma and hepatic stellate cells Comp. Hepatol. 3 Suppl. 1 2004 S7
113. S. Hazra, S. Xiong, J. Wang, R.A. Rippe, V. Krishna, K. Chatterjee, and H. Tsukamoto Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells J. Biol. Chem. 279 2004 11392 11401
114. W. Hempfling, F. Grunhage, K. Dilger, C. Reichel, U. Beuers, and T. Sauerbruch Pharmacokinetics and pharmacodynamic action of budesonide in early- and late-stage primary biliary cirrhosis Hepatology 38 2003 196 202
115. A.S. Henkel, M.H. Kavesh, M.S. Kriss, A.M. Dewey, M.E. Rinella, and R.M. Green Hepatic overexpression of abcb11 promotes hypercholesterolemia and obesity in mice Gastroenterology 141 2011 1404 1411 1411 e1401-1402
116. Hirschfield, G.M., Mason, A.L., Gordon, S.C., Luketic, V.A., Mayo, M., Vincent, V., Lindor, K.D., Pares, A., Kowdley, K.V., Trauner, M., et al. (2011). A long term safety extension trial of the farnesoid X receptor (FXR) agonist obeticholic acid (OCA) and UDCA in primary biliary cirrhosis (PBC). In: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 54, 429A (Hepatology Supplement).
117. +-taurocholate cotransporting polypeptide (SLC10A1) reveals a domain critical for bile acid substrate recognition J. Biol. Chem. 279 2004 7213 7222
118. R.H. Ho, B.F. Leake, D.M. Kilkenny, Zu. Meyer, H.E. Schwabedissen, H. Glaeser, D.L. Kroetz, and R.B. Kim Polymorphic variants in the human bile salt export pump (BSEP; ABCB11): functional characterization and interindividual variability Pharmacogenet. Genomics 20 2010 45 57
119. A.F. Hofmann Pharmacology of ursodeoxycholic acid, an enterohepatic drug Scand. J. Gastroenterol. Suppl. 204 1994 1 15
120. A.F. Hofmann Bile acids: the good, the bad, and the ugly News Physiol. Sci. 14 1999 24 29
121. Y. Hojo, A. Shiraki, T. Tsuchiya, K. Shimamoto, Y. Ishii, K. Suzuki, M. Shibutani, and K. Mitsumori Liver tumor promoting effect of etofenprox in rats and its possible mechanism of action J. Toxicol. Sci. 37 2012 297 306
122. A. Honda, T. Ikegami, M. Nakamuta, T. Miyazaki, J. Iwamoto, T. Hirayama, Y. Saito, H. Takikawa, M. Imawari, and Y. Matsuzaki Anticholestatic effects of bezafibrate in patients with primary biliary cirrhosis treated with ursodeoxycholic acid Hepatology 57 2013 1931 1941
123. Y. Honjo, S. Sasaki, Y. Kobayashi, H. Misawa, and H. Nakamura 1,25-Dihydroxyvitamin D3 and its receptor inhibit the chenodeoxycholic acid-dependent transactivation by farnesoid X receptor J. Endocrinol. 188 2006 635 643
124. P. Honkakoski, I. Zelko, T. Sueyoshi, and M. Negishi The nuclear orphan receptor CAR-retinoid X receptor heterodimer activates the phenobarbital- responsive enhancer module of the CYP2B gene Mol. Cell. Biol. 18 1998 5652 5658
125. W. Huang, J. Zhang, S.S. Chua, M. Qatanani, Y. Han, R. Granata, and D.D. Moore Induction of bilirubin clearance by the constitutive androstane receptor (CAR) Proc. Natl. Acad. Sci. USA 100 2003 4156 4161
126. W. Huang, J. Zhang, and D.D. Moore A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR J. Clin. Invest. 113 2004 137 143
127. W. Huang, J. Zhang, M. Washington, J. Liu, J.M. Parant, G. Lozano, and D.D. Moore Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor Mol. Endocrinol. 19 2005 1646 1653
128. W. Huang, K. Ma, J. Zhang, M. Qatanani, J. Cuvillier, J. Liu, B. Dong, X. Huang, and D.D. Moore Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration Science 312 2006 233 236
129. J. Itakura, N. Izumi, Y. Nishimura, K. Inoue, K. Ueda, H. Nakanishi, K. Tsuchiya, K. Hamano, Y. Asahina, and M. Kurosaki et al. Prospective randomized crossover trial of combination therapy with bezafibrate and UDCA for primary biliary cirrhosis Hepatol. Res. 29 2004 216 222
130. K. Itoh, T. Chiba, S. Takahashi, T. Ishii, K. Igarashi, Y. Katoh, T. Oyake, N. Hayashi, K. Satoh, and I. Hatayama et al. An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements Biochem. Biophys. Res. Commun. 236 1997 313 322
131. P.L. Jansen, S.S. Strautnieks, E. Jacquemin, M. Hadchouel, E.M. Sokal, G.J. Hooiveld, J.H. Koning, A. De Jager-Krikken, F. Kuipers, and F. Stellaard et al. Hepatocanalicular bile salt export pump deficiency in patients with progressive familial intrahepatic cholestasis Gastroenterology 117 1999 1370 1379
132. T. Janvilisri, S. Shahi, H. Venter, L. Balakrishnan, and H.W. van Veen Arginine-482 is not essential for transport of antibiotics, primary bile acids and unconjugated sterols by the human breast cancer resistance protein (ABCG2) Biochem. J. 385 2005 419 426
133. R.P. Jazrawi, J.S. de Caestecker, P.M. Goggin, A.J. Britten, A.E. Joseph, J.D. Maxwell, and T.C. Northfield Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid Gastroenterology 106 1994 134 142
134. D. Jung, and G.A. Kullak-Ublick Hepatocyte nuclear factor 1 alpha: a key mediator of the effect of bile acids on gene expression Hepatology 37 2003 622 631
135. D. Jung, M. Fried, and G.A. Kullak-Ublick Human apical sodium-dependent
136. D. Jung, A.C. Fantin, U. Scheurer, M. Fried, and G.A. Kullak-Ublick Human ileal bile acid transporter gene ASBT (SLC10A2) is transactivated by the glucocorticoid receptor Gut 53 2004 78 84
137. D. Jung, B. Hagenbuch, M. Fried, P.J. Meier, and G.A. Kullak-Ublick Role of liver-enriched transcription factors and nuclear receptors in regulating the human, mouse, and rat NTCP gene Am. J. Physiol. Gastrointest. Liver Physiol. 286 2004 G752 G761
138. T. Kagawa, N. Watanabe, K. Mochizuki, A. Numari, Y. Ikeno, J. Itoh, H. Tanaka, I.M. Arias, and T. Mine Phenotypic differences in PFIC2 and BRIC2 correlate with protein stability of mutant Bsep and impaired taurocholate secretion in MDCK II cells Am. J. Physiol. Gastrointest. Liver Physiol. 294 2008 G58 G67
139. R. Kaimal, X. Song, B. Yan, R. King, and R. Deng Differential modulation of farnesoid X receptor signaling pathway by the thiazolidinediones J. Pharmacol. Exp. Ther. 330 2009 125 134
140. E. Kanaya, T. Shiraki, and H. Jingami The nuclear bile acid receptor FXR is activated by PGC-1alpha in a ligand-dependent manner Biochem. J. 382 2004 913 921
141. T. Kanda, O. Yokosuka, F. Imazeki, and H. Saisho Bezafibrate treatment: a new medical approach for PBC patients? J. Gastroenterol. 38 2003 573 578
142. S.J. Karpen, A.Q. Sun, B. Kudish, B. Hagenbuch, P.J. Meier, M. Ananthanarayanan, and F.J. Suchy Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter J. Biol. Chem. 271 1996 15211 15221
143. H.R. Kast, B. Goodwin, P.T. Tarr, S.A. Jones, A.M. Anisfeld, C.M. Stoltz, P. Tontonoz, S. Kliewer, T.M. Willson, and P.A. Edwards Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor J. Biol. Chem. 277 2002 2908 2915
144. Y. Kawamata, R. Fujii, M. Hosoya, M. Harada, H. Yoshida, M. Miwa, S. Fukusumi, Y. Habata, T. Itoh, and Y. Shintani et al. A G protein-coupled receptor responsive to bile acids J. Biol. Chem. 278 2003 9435 9440
145. V. Keitel, C. Vogt, D. Haussinger, and R. Kubitz Combined mutations of canalicular transporter proteins cause severe intrahepatic cholestasis of pregnancy Gastroenterology 131 2006 624 629
146. Keitel, V., Reinehr, R., Reich, M., Sommerfeld, A., Cupisti, K., Knoefel, W.T., Haussinger, D. (2011). The membrane-bound bile acid receptor TGR5 (Gpbar-1) is highly expressed in intrahepatic cholangiocarcinoma. In: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 54 (Hepatology Supplement).
147. D. Keppler, J. Konig, and M. Buchler The canalicular multidrug resistance protein, cMRP/MRP2, a novel conjugate export pump expressed in the apical membrane of hepatocytes Adv. Enzyme Regul. 37 1997 321 333
148. T.A. Kerr, S. Saeki, M. Schneider, K. Schaefer, S. Berdy, T. Redder, B. Shan, D.W. Russell, and M. Schwarz Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis Dev. Cell 2 2002 713 720
149. A.A. Khan, E.C. Chow, R.J. Porte, K.S. Pang, and G.M. Groothuis Expression and regulation of the bile acid transporter, OSTalpha-OSTbeta in rat and human intestine and liver Biopharm. Drug Dispos. 30 2009 241 258
150. N. Kiyosawa, J.C. Kwekel, L.D. Burgoon, K.J. Williams, C. Tashiro, B. Chittim, and T.R. Zacharewski O, p′-DDT elicits PXR/CAR-, not ER-, mediated responses in the immature ovariectomized rat liver Toxicol. Sci. 101 2008 350 363
151. A.S. Knisely, and B.C. Portmann Deficiency of BSEP in PFIC with hepatocellular malignancy Pediatr. Transplant. 10 2006 644 645 author reply 646
152. A.S. Knisely, S.S. Strautnieks, Y. Meier, B. Stieger, J.A. Byrne, B.C. Portmann, L.N. Bull, L. Pawlikowska, B. Bilezikci, and F. Ozcay et al. Hepatocellular carcinoma in ten children under five years of age with bile salt export pump deficiency Hepatology 44 2006 478 486
153. J. Kondrackiene, U. Beuers, and L. Kupcinskas Efficacy and safety of ursodeoxycholic acid versus cholestyramine in intrahepatic cholestasis of pregnancy Gastroenterology 129 2005 894 901
154. J. Konig, Y. Cui, A.T. Nies, and D. Keppler A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane Am. J. Physiol. Gastrointest. Liver Physiol. 278 2000 G156 G164
155. Kowdley, K.V., Luketic, V.A., Jones, D.E., Chapman, R.W., Burroughs, A., Hirschfield, G.M., Poupon, R., Schramm, C., Vincent, C., Rust, C., et al. (2011). The first new monotherapy therapeutic PBC study in a decade? An international study evaluating the farnesoid X receptor agonist obeticholic acid in PBC. In: The 62nd Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 54, 416A (Hepatology Supplement).
156. S. Krahenbuhl, C. Talos, S. Fischer, and J. Reichen Toxicity of bile acids on the electron transport chain of isolated rat liver mitochondria Hepatology 19 1994 471 479
157. A.E. Kremer, J.J. Martens, W. Kulik, F. Rueff, E.M. Kuiper, H.R. van Buuren, K.J. van Erpecum, J. Kondrackiene, J. Prieto, and C. Rust et al. Lysophosphatidic acid is a potential mediator of cholestatic pruritus Gastroenterology 139 2010 1008 1018 1018 e1001
158. A.E. Kremer, R. van Dijk, P. Leckie, F.G. Schaap, E.M. Kuiper, T. Mettang, K.S. Reiners, U. Raap, H.R. van Buuren, and K.J. van Erpecum et al. Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions Hepatology 56 2012 1391 1400
159. I.N. Krylova, E.P. Sablin, J. Moore, R.X. Xu, G.M. Waitt, J.A. MacKay, D. Juzumiene, J.M. Bynum, K. Madauss, and V. Montana et al. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1 Cell 120 2005 343 355
160. R. Kubitz, G. Sutfels, T. Kuhlkamp, R. Kolling, and D. Haussinger Trafficking of the bile salt export pump from the golgi to the canalicular membrane is regulated by the p38 MAP kinase Gastroenterology 126 2004 541 553
161. R. Kubitz, V. Keitel, S. Scheuring, K. Kohrer, and D. Haussinger Benign recurrent intrahepatic cholestasis associated with mutations of the bile salt export pump J. Clin. Gastroenterol. 40 2006 171 175
162. J. Kublbeck, J. Jyrkkarinne, F. Molnar, T. Kuningas, J. Patel, B. Windshugel, T. Nevalainen, T. Laitinen, W. Sippl, A. Poso, and P. Honkakoski New in vitro tools to study human constitutive androstane receptor (CAR) biology: discovery and comparison of human CAR inverse agonists Mol. Pharm. 8 2011 2424 2433
163. G.A. Kullak-Ublick, J. Glasa, C. Boker, M. Oswald, U. Grutzner, B. Hagenbuch, B. Stieger, P.J. Meier, U. Beuers, and W. Kramer et al. Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas Gastroenterology 113 1997 1295 1305
164. G.A. Kullak-Ublick, M.G. Ismair, B. Stieger, L. Landmann, R. Huber, F. Pizzagalli, K. Fattinger, P.J. Meier, and B. Hagenbuch Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver Gastroenterology 120 2001 525 533
165. T. Kurihara, A. Niimi, A. Maeda, M. Shigemoto, and K. Yamashita Bezafibrate in the treatment of primary biliary cirrhosis: comparison with ursodeoxycholic acid Am. J. Gastroenterol. 95 2000 2990 2992
166. T. Kurihara, A. Maeda, M. Shigemoto, K. Yamashita, and E. Hashimoto Investigation into the efficacy of bezafibrate against primary biliary cirrhosis, with histological references from cases receiving long term monotherapy Am. J. Gastroenterol. 97 2002 212 214
167. A.K. Kurz, D. Graf, M. Schmitt, S. Vom Dahl, and D. Haussinger Tauroursodesoxycholate-induced choleresis involves p38(MAPK) activation and translocation of the bile salt export pump in rats Gastroenterology 121 2001 407 419
168. F. Lacaille, and K. Paradis The immunosuppressive effect of ursodeoxycholic acid: a comparative in vitro study on human peripheral blood mononuclear cells Hepatology 18 1993 165 172
169. P. Lam, R. Wang, and V. Ling Bile acid transport in sister of P-glycoprotein (ABCB11) knockout mice Biochemistry 44 2005 12598 12605
170. T. Lamireau, G. Bouchard, I.M. Yousef, H. Clouzeau-Girard, J. Rosenbaum, A. Desmouliere, and B. Tuchweber Dietary lecithin protects against cholestatic liver disease in cholic acid-fed Abcb4-deficient mice Pediatr. Res. 61 2007 185 190
171. T. Lan, J. Haywood, A. Rao, and P.A. Dawson Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice Dig. Dis. 29 2011 18 22
172. T. Lan, A. Rao, J. Haywood, N.D. Kock, and P.A. Dawson Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism J. Hepatol. 57 2012 359 365
173. J.F. Landrier, J.J. Eloranta, S.R. Vavricka, and G.A. Kullak-Ublick The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-alpha and -beta genes Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G476 G485
174. C. Lang, Y. Meier, B. Stieger, U. Beuers, T. Lang, R. Kerb, G.A. Kullak-Ublick, P.J. Meier, and C. Pauli-Magnus Mutations and polymorphisms in the bile salt export pump and the multidrug resistance protein 3 associated with drug-induced liver injury Pharmacogenet. Genomics 17 2007 47 60
175. K.N. Lazaridis, G.J. Gores, and K.D. Lindor Ursodeoxycholic acid 'mechanisms of action and clinical use in hepatobiliary disorders' J. Hepatol. 35 2001 134 146
176. M. Le Vee, P. Gripon, B. Stieger, and O. Fardel Down-regulation of organic anion transporter expression in human hepatocytes exposed to the proinflammatory cytokine interleukin 1beta Drug Metab. Dispos. 36 2008 217 222
177. J. Lee, and J.L. Boyer Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders Semin. Liver Dis. 20 2000 373 384
178. Y.K. Lee, H. Dell, D.H. Dowhan, M. Hadzopoulou-Cladaras, and D.D. Moore The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression Mol. Cell. Biol. 20 2000 187 195
179. Y.H. Lee, S.A. Coonrod, W.L. Kraus, M.A. Jelinek, and M.R. Stallcup Regulation of coactivator complex assembly and function by protein arginine methylation and demethylimination Proc. Natl. Acad. Sci. USA 102 2005 3611 3616
180. H. Lee, Y. Zhang, F.Y. Lee, S.F. Nelson, F.J. Gonzalez, and P.A. Edwards FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine J. Lipid Res. 47 2006 201 214
181. Y.K. Lee, D.R. Schmidt, C.L. Cummins, M. Choi, L. Peng, Y. Zhang, B. Goodwin, R.E. Hammer, D.J. Mangelsdorf, and S.A. Kliewer Liver receptor homolog-1 regulates bile acid homeostasis but is not essential for feedback regulation of bile acid synthesis Mol. Endocrinol. 22 2008 1345 1356
182. M. Leuschner, K.P. Maier, J. Schlichting, S. Strahl, G. Herrmann, H.H. Dahm, H. Ackermann, J. Happ, and U. Leuschner Oral budesonide and ursodeoxycholic acid for treatment of primary biliary cirrhosis: results of a prospective double-blind trial Gastroenterology 117 1999 918 925
183. C. Levy, J.A. Peter, D.R. Nelson, J. Keach, J. Petz, R. Cabrera, V. Clark, R.J. Firpi, G. Morelli, C. Soldevila-Pico, and K. Lindor Pilot study: fenofibrate for patients with primary biliary cirrhosis and an incomplete response to ursodeoxycholic acid Aliment. Pharmacol. Ther. 33 2011 235 242
184. D. Li, T.L. Zimmerman, S. Thevananther, H.Y. Lee, J.M. Kurie, and S.J. Karpen Interleukin-1 beta-mediated suppression of RXR:RAR transactivation of the Ntcp promoter is JNK-dependent J. Biol. Chem. 277 2002 31416 31422
185. N. Li, Z. Cui, F. Fang, J.Y. Lee, and N. Ballatori Heterodimerization, trafficking and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter Biochem. J. 407 2007 363 372
186. J. Li, Y.M. Gong, J. Wu, W.J. Wu, and W. Cai Anti-tumor necrosis factor-alpha monoclonal antibody alleviates parenteral nutrition-associated liver disease in mice JPEN J. Parenter. Enteral Nutr. 36 2012 219 225
187. L. Lindblad, K. Lundholm, and T. Schersten Bile acid concentrations in systemic and portal serum in presumably normal man and in cholestatic and cirrhotic conditions Scand. J. Gastroenterol. 12 1977 395 400
188. K.D. Lindor, K.V. Kowdley, V.A. Luketic, M.E. Harrison, T. McCashland, A.S. Befeler, D. Harnois, R. Jorgensen, J. Petz, and J. Keach et al. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis Hepatology 50 2009 808 814
189. Y. Liu, J. Binz, M.J. Numerick, S. Dennis, G. Luo, B. Desai, K.I. MacKenzie, T.A. Mansfield, S.A. Kliewer, B. Goodwin, and S.A. Jones Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis J. Clin. Invest. 112 2003 1678 1687
190. Y. Lu, Z. Zhang, X. Xiong, X. Wang, J. Li, G. Shi, J. Yang, X. Zhang, H. Zhang, and J. Hong et al. Glucocorticoids promote hepatic cholestasis in mice by inhibiting the transcriptional activity of the farnesoid X receptor Gastroenterology 143 1630-1640 2012 e1638
191. M. Makishima, A.Y. Okamoto, J.J. Repa, H. Tu, R.M. Learned, A. Luk, M.V. Hull, K.D. Lustig, D.J. Mangelsdorf, and B. Shan Identification of a nuclear receptor for bile acids Science 284 1999 1362 1365
192. P.R. Maloney, D.J. Parks, C.D. Haffner, A.M. Fivush, G. Chandra, K.D. Plunket, K.L. Creech, L.B. Moore, J.G. Wilson, and M.C. Lewis et al. Identification of a chemical tool for the orphan nuclear receptor FXR J. Med. Chem. 43 2000 2971 2974
193. M. Marrapodi, and J.Y. Chiang Peroxisome proliferator-activated receptor alpha (PPARalpha) and agonist inhibit cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription J. Lipid Res. 41 2000 514 520
194. H.U. Marschall, M. Wagner, G. Zollner, P. Fickert, U. Diczfalusy, J. Gumhold, D. Silbert, A. Fuchsbichler, L. Benthin, and R. Grundstrom et al. Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans Gastroenterology 129 2005 476 485
195. T. Maruyama, Y. Miyamoto, T. Nakamura, Y. Tamai, H. Okada, E. Sugiyama, T. Nakamura, H. Itadani, and K. Tanaka Identification of membrane-type receptor for bile acids (M-BAR) Biochem. Biophys. Res. Commun. 298 2002 714 719
196. Mason, A.L., Luketic, V.A., Lindor, K.D., Hirschfield, G.M., Gordon, S.C., Mayo, M.J., Kowdley, K.V., Pares, A., Trauner, M., Sciacca, C.I., et al. (2010). Farnesoid-X receptor agonists: a new class of drugs for the treatment of PBC? An international study evaluating the addition of obeticholic acid (INT-747) to ursodeoxycholic acid. In: The 61th Annual Meeting of the American Association for the Study of Liver Diseases: The Liver Meeting 52, 357A (Hepatology Supplement).
197. C. Mataki, B.C. Magnier, S.M. Houten, J.S. Annicotte, C. Argmann, C. Thomas, H. Overmars, W. Kulik, D. Metzger, J. Auwerx, and K. Schoonjans Compromised intestinal lipid absorption in mice with a liver-specific deficiency of liver receptor homolog 1 Mol. Cell. Biol. 27 2007 8330 8339
198. T. Matsumoto, H. Miyazaki, Y. Nakahashi, J. Hirohara, T. Seki, K. Inoue, and K. Okazaki Multidrug resistance3 is in situ detected in the liver of patients with primary biliary cirrhosis, and induced in human hepatoma cells by bezafibrate Hepatol. Res. 30 2004 125 136
199. G. Mazzella, N. Rizzo, F. Azzaroli, P. Simoni, L. Bovicelli, A. Miracolo, G. Simonazzi, A. Colecchia, G. Nigro, and C. Mwangemi et al. Ursodeoxycholic acid administration in patients with cholestasis of pregnancy: effects on primary bile acids in babies and mothers Hepatology 33 2001 504 508
200. J.F. Medina Role of the anion exchanger 2 in the pathogenesis and treatment of primary biliary cirrhosis Dig. Dis. 29 2011 103 112
201. J.F. Medina, A. Martinez, J.J. Vazquez, and J. Prieto Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis Hepatology 25 1997 12 17
202. J.F. Mehlmann, M.L. Crawley, J.T.T. Lundquist, R.J. Unwalla, D.C. Harnish, M.J. Evans, C.Y. Kim, J.E. Wrobel, and P.E. Mahaney Pyrrole[2,3-d]azepino compounds as agonists of the farnesoid X receptor (FXR) Bioorg. Med. Chem. Lett. 19 2009 5289 5292
203. P.J. Meier, and B. Stieger Bile salt transporters Annu. Rev. Physiol. 64 2002 635 661
204. Y. Meier, T. Zodan, C. Lang, R. Zimmermann, G.A. Kullak-Ublick, P.J. Meier, B. Stieger, and C. Pauli-Magnus Increased susceptibility for intrahepatic cholestasis of pregnancy and contraceptive-induced cholestasis in carriers of the 1331T>C polymorphism in the bile salt export pump World J. Gastroenterol. 14 2008 38 45
205. -/- mice have an impaired cytoprotective response in obstructive cholestasis Hepatology 43 2006 1013 1021
206. A. Mennone, C.J. Soroka, K.M. Harry, and J.L. Boyer Role of breast cancer resistance protein in the adaptive response to cholestasis Drug Metab. Dispos. 38 2010 1673 1678
207. R.L. Meyers, L.S. Book, M.A. O'Gorman, W.D. Jackson, R.E. Black, D.G. Johnson, and M.E. Matlak High-dose steroids, ursodeoxycholic acid, and chronic intravenous antibiotics improve bile flow after Kasai procedure in infants with biliary atresia J. Pediatr. Surg. 38 2003 406 411
208. P. Milkiewicz, M.G. Roma, E. Elias, and R. Coleman Hepatoprotection with tauroursodeoxycholate and beta muricholate against taurolithocholate induced cholestasis: involvement of signal transduction pathways Gut 51 2002 113 119
209. J.O. Miners, and D.J. Birkett Cytochrome P4502C9: an enzyme of major importance in human drug metabolism Br. J. Clin. Pharmacol. 45 1998 525 538
210. T. Misawa, H. Hayashi, M. Makishima, Y. Sugiyama, and Y. Hashimoto E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: structural development study and separation from farnesoid X receptor-agonistic activity Bioorg. Med. Chem. Lett. 22 2012 3962 3966
211. T. Misawa, H. Hayashi, Y. Sugiyama, and Y. Hashimoto Discovery and structural development of small molecules that enhance transport activity of bile salt export pump mutant associated with progressive familial intrahepatic cholestasis type 2 Bioorg. Med. Chem. 20 2012 2940 2949
212. T. Miura, R. Ouchida, N. Yoshikawa, K. Okamoto, Y. Makino, T. Nakamura, C. Morimoto, I. Makino, and H. Tanaka Functional modulation of the glucocorticoid receptor and suppression of NF-kappaB-dependent transcription by ursodeoxycholic acid J. Biol. Chem. 276 2001 47371 47378
213. S. Modica, M. Petruzzelli, E. Bellafante, S. Murzilli, L. Salvatore, N. Celli, G. Di Tullio, G. Palasciano, T. Moustafa, and E. Halilbasic et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis Gastroenterology 2012
214. R.E. Morgan, M. Trauner, C.J. van Staden, P.H. Lee, B. Ramachandran, M. Eschenberg, C.A. Afshari, C.W. Qualls Jr., R. Lightfoot-Dunn, and H.K. Hamadeh Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development Toxicol. Sci. 118 2010 485 500
215. R. Morita, K. Shimamoto, Y. Ishii, K. Kuwata, B. Ogawa, M. Imaoka, S.M. Hayashi, K. Suzuki, M. Shibutani, and K. Mitsumori Suppressive effect of enzymatically modified isoquercitrin on phenobarbital-induced liver tumor promotion in rats Arch. Toxicol. 85 2011 1475 1484
216. A. Moschetta, A.L. Bookout, and D.J. Mangelsdorf Prevention of cholesterol gallstone disease by FXR agonists in a mouse model Nat. Med. 10 2004 1352 1358
217. R.H. Moseley Sepsis and cholestasis Clin. Liver Dis. 3 1999 465 475
218. R.H. Moseley, W. Wang, H. Takeda, K. Lown, L. Shick, M. Ananthanarayanan, and F.J. Suchy Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis Am. J. Physiol. 271 1996 G137 G146
219. S. Nakai, T. Masaki, K. Kurokohchi, A. Deguchi, and M. Nishioka Combination therapy of bezafibrate and ursodeoxycholic acid in primary biliary cirrhosis: a preliminary study Am. J. Gastroenterol. 95 2000 326 327
220. M.H. Nathanson, and J.L. Boyer Mechanisms and regulation of bile secretion Hepatology 14 1991 551 566
221. D.W. Nebert, and J.E. Jones Regulation of the mammalian cytochrome P1-450 (CYP1A1) gene Int. J. Biochem. 21 1989 243 252
222. T. Nishida, Z. Gatmaitan, M. Che, and I.M. Arias Rat liver canalicular membrane vesicles contain an ATP-dependent bile acid transport system Proc. Natl. Acad. Sci. USA 88 1991 6590 6594
223. Y. Nishigaki, H. Ohnishi, H. Moriwaki, and Y. Muto Ursodeoxycholic acid corrects defective natural killer activity by inhibiting prostaglandin E2 production in primary biliary cirrhosis Dig. Dis. Sci. 41 1996 1487 1493
224. M. Nishimura, M. Yamaguchi, A. Yamauchi, N. Ueda, and S. Naito Role of soybean oil fat emulsion in the prevention of hepatic xenobiotic transporter mRNA up- and down-regulation induced by overdose of fat-free total parenteral nutrition in infant rats Drug Metab. Pharmacokinet. 20 2005 46 54
225. J. Noe, B. Stieger, and P.J. Meier Functional expression of the canalicular bile salt export pump of human liver Gastroenterology 123 2002 1659 1666
226. D.T. Odom, N. Zizlsperger, D.B. Gordon, G.W. Bell, N.J. Rinaldi, H.L. Murray, T.L. Volkert, J. Schreiber, P.A. Rolfe, and D.K. Gifford et al. Control of pancreas and liver gene expression by HNF transcription factors Science 303 2004 1378 1381
227. E. Ogimura, S. Sekine, and T. Horie Bile salt export pump inhibitors are associated with bile acid-dependent drug-induced toxicity in sandwich-cultured hepatocytes Biochem. Biophys. Res. Commun. 416 2011 313 317
228. M. Ogura, S. Nishida, M. Ishizawa, K. Sakurai, M. Shimizu, S. Matsuo, S. Amano, S. Uno, and M. Makishima Vitamin D3 modulates the expression of bile acid regulatory genes and represses inflammation in bile duct-ligated mice J. Pharmacol. Exp. Ther. 328 2009 564 570
229. M. Okuwaki, T. Takada, Y. Iwayanagi, S. Koh, Y. Kariya, H. Fujii, and H. Suzuki LXR alpha transactivates mouse organic solute transporter alpha and beta via IR-1 elements shared with FXR Pharm. Res. 24 2007 390 398
230. E.A. Ortlund, Y. Lee, I.H. Solomon, J.M. Hager, R. Safi, Y. Choi, Z. Guan, A. Tripathy, C.R. Raetz, and D.P. McDonnell et al. Modulation of human nuclear receptor LRH-1 activity by phospholipids and SHP Nat. Struct. Mol. Biol. 12 2005 357 363
231. J. Palma, H. Reyes, J. Ribalta, I. Hernandez, L. Sandoval, R. Almuna, J. Liepins, F. Lira, M. Sedano, and O. Silva et al. Ursodeoxycholic acid in the treatment of cholestasis of pregnancy: a randomized, double-blind study controlled with placebo J. Hepatol. 27 1997 1022 1028
232. C.M. Palmeira, and A.P. Rolo Mitochondrially-mediated toxicity of bile acids Toxicology 203 2004 1 15
233. +-taurocholate co-transporting polypeptide (NTCP) and ileal apical sodium-dependent bile acid transporter (ASBT) and ethnic comparisons of functional variants of NTCP among Asian populations Xenobiotica 41 2011 501 510
234. D.J. Parks, S.G. Blanchard, R.K. Bledsoe, G. Chandra, T.G. Consler, S.A. Kliewer, J.B. Stimmel, T.M. Willson, A.M. Zavacki, D.D. Moore, and J.M. Lehmann Bile acids: natural ligands for an orphan nuclear receptor Science 284 1999 1365 1368
235. J.M. Pascussi, L. Drocourt, J.M. Fabre, P. Maurel, and M.J. Vilarem Dexamethasone induces pregnane X receptor and retinoid X receptor-alpha expression in human hepatocytes: synergistic increase of CYP3A4 induction by pregnane X receptor activators Mol. Pharmacol. 58 2000 361 372
236. J.M. Pascussi, S. Gerbal-Chaloin, J.M. Fabre, P. Maurel, and M.J. Vilarem Dexamethasone enhances constitutive androstane receptor expression in human hepatocytes: consequences on cytochrome P450 gene regulation Mol. Pharmacol. 58 2000 1441 1450
237. J.M. Pascussi, S. Gerbal-Chaloin, L. Pichard-Garcia, M. Daujat, J.M. Fabre, P. Maurel, and M.J. Vilarem Interleukin-6 negatively regulates the expression of pregnane X receptor and constitutively activated receptor in primary human hepatocytes Biochem. Biophys. Res. Commun. 274 2000 707 713
238. D.D. Patel, B.L. Knight, A.K. Soutar, G.F. Gibbons, and D.P. Wade The effect of peroxisome-proliferator-activated receptor-alpha on the activity of the cholesterol 7 alpha-hydroxylase gene Biochem. J. 351 Pt. 3 2000 747 753
239. A.D. Patterson, Y.M. Shah, T. Matsubara, K.W. Krausz, and F.J. Gonzalez Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2 protects against acetaminophen-induced liver toxicity Hepatology 56 2012 281 290
240. C. Pauli-Magnus, T. Lang, Y. Meier, T. Zodan-Marin, D. Jung, C. Breymann, R. Zimmermann, S. Kenngott, U. Beuers, and C. Reichel et al. Sequence analysis of bile salt export pump (ABCB11) and multidrug resistance p-glycoprotein 3 (ABCB4, MDR3) in patients with intrahepatic cholestasis of pregnancy Pharmacogenetics 14 2004 91 102
241. G. Paumgartner, and U. Beuers Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease Clin. Liver Dis. 8 2004 67 81 vi
242. L. Pawlikowska, S. Strautnieks, I. Jankowska, P. Czubkowski, K. Emerick, A. Antoniou, C. Wanty, B. Fischler, E. Jacquemin, and S. Wali et al. Differences in presentation and progression between severe FIC1 and BSEP deficiencies J. Hepatol. 53 2010 170 178
243. R. Pellicciari, S. Fiorucci, E. Camaioni, C. Clerici, G. Costantino, P.R. Maloney, A. Morelli, D.J. Parks, and T.M. Willson 6Alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity J. Med. Chem. 45 2002 3569 3572
244. J.R. Plass, O. Mol, J. Heegsma, M. Geuken, K.N. Faber, P.L. Jansen, and M. Muller Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump Hepatology 35 2002 589 596
245. S.M. Post, H. Duez, P.P. Gervois, B. Staels, F. Kuipers, and H.M. Princen Fibrates suppress bile acid synthesis via peroxisome proliferat or-activated receptor-alpha-mediated downregulation of cholesterol 7alpha-hydroxylase and sterol 27-hydroxylase expression Arterioscler. Thromb. Vasc. Biol. 21 2001 1840 1845
246. R.E. Poupon Ursodeoxycholic acid for primary biliary cirrhosis: lessons from the past-issues for the future J. Hepatol. 32 2000 685 688
247. R. Poupon Treatment of primary biliary cirrhosis with ursodeoxycholic acid, budesonide and fibrates Dig. Dis. 29 2011 85 88
248. R. Poupon Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: an overview of their mechanisms of action Clin. Res. Hepatol. Gastroenterol. 36 Suppl. 1 2012 S3 S12
249. R. Poupon, and R.E. Poupon Treatment of primary biliary cirrhosis Baillieres Best Pract. Res. Clin. Gastroenterol. 14 2000 615 628
250. J. Prieto, C. Qian, N. Garcia, J. Diez, and J.F. Medina Abnormal expression of anion exchanger genes in primary biliary cirrhosis Gastroenterology 105 1993 572 578
251. J. Prieto, N. Garcia, J.M. Marti-Climent, I. Penuelas, J.A. Richter, and J.F. Medina Assessment of biliary bicarbonate secretion in humans by positron emission tomography Gastroenterology 117 1999 167 172
252. M.I. Prince, A.D. Burt, and D.E. Jones Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis Gut 50 2002 436 439
253. A. Rao, J. Haywood, A.L. Craddock, M.G. Belinsky, G.D. Kruh, and P.A. Dawson The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis Proc. Natl. Acad. Sci. USA 105 2008 3891 3896
254. F.M. Rausa, Y. Tan, H. Zhou, K.W. Yoo, D.B. Stolz, S.C. Watkins, R.R. Franks, T.G. Unterman, and R.H. Costa Elevated levels of hepatocyte nuclear factor 3beta in mouse hepatocytes influence expression of genes involved in bile acid and glucose homeostasis Mol. Cell. Biol. 20 2000 8264 8282
255. H. Rautiainen, P. Karkkainen, A.L. Karvonen, H. Nurmi, P. Pikkarainen, H. Nuutinen, and M. Farkkila Budesonide combined with UDCA to improve liver histology in primary biliary cirrhosis: a three-year randomized trial Hepatology 41 2005 747 752
256. R. Reinehr, D. Graf, and D. Haussinger Bile salt-induced hepatocyte apoptosis involves epidermal growth factor receptor-dependent CD95 tyrosine phosphorylation Gastroenterology 125 2003 839 853
257. O. Renner, S. Harsch, A. Strohmeyer, S. Schimmel, and E.F. Stange Reduced ileal expression of OSTalpha-OSTbeta in non-obese gallstone disease J. Lipid Res. 49 2008 2045 2054
258. G. Rizzo, D. Passeri, F. De Franco, G. Ciaccioli, L. Donadio, G. Rizzo, S. Orlandi, B. Sadeghpour, X.X. Wang, and T. Jiang et al. Functional characterization of the semisynthetic bile acid derivative INT-767, a dual farnesoid X receptor and TGR5 agonist Mol. Pharmacol. 78 2010 617 630
259. N. Roglans, M. Vazquez-Carrera, M. Alegret, F. Novell, D. Zambon, E. Ros, J.C. Laguna, and R.M. Sanchez Fibrates modify the expression of key factors involved in bile-acid synthesis and biliary-lipid secretion in gallstone patients Eur. J. Clin. Pharmacol. 59 2004 855 861
260. R. Rosales, M.R. Romero, J. Vaquero, M.J. Monte, P. Requena, O. Martinez-Augustin, F. Sanchez de Medina, and J.J. Marin FXR-dependent and -independent interaction of glucocorticoids with the regulatory pathways involved in the control of bile acid handling by the liver Biochem. Pharmacol. 85 2013 829 838
261. S.P. Saini, J. Sonoda, L. Xu, D. Toma, H. Uppal, Y. Mu, S. Ren, D.D. Moore, R.M. Evans, and W. Xie A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification Mol. Pharmacol. 65 2004 292 300
262. H. Sato, A. Macchiarulo, C. Thomas, A. Gioiello, M. Une, A.F. Hofmann, R. Saladin, K. Schoonjans, R. Pellicciari, and J. Auwerx Novel potent and selective bile acid derivatives as TGR5 agonists: biological screening, structure-activity relationships, and molecular modeling studies J. Med. Chem. 51 2008 1831 1841
263. R.S. Savkur, J.S. Thomas, K.S. Bramlett, Y. Gao, L.F. Michael, and T.P. Burris Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha J. Pharmacol. Exp. Ther. 312 2005 170 178
264. S.I. Sayin, A. Wahlstrom, J. Felin, S. Jantti, H.U. Marschall, K. Bamberg, B. Angelin, T. Hyotylainen, M. Oresic, and F. Backhed Gut microbiota regulates bile acid metabolism by reducing the levels of tauro-beta-muricholic acid, a naturally occurring FXR antagonist Cell Metab. 17 2013 225 235
265. A.O. Scheimann, S.S. Strautnieks, A.S. Knisely, J.A. Byrne, R.J. Thompson, and M.J. Finegold Mutations in bile salt export pump (ABCB11) in two children with progressive familial intrahepatic cholestasis and cholangiocarcinoma J. Pediatr. 150 2007 556 559
266. K.D. Setchell, C.M. Rodrigues, C. Clerici, A. Solinas, A. Morelli, C. Gartung, and J. Boyer Bile acid concentrations in human and rat liver tissue and in hepatocyte nuclei Gastroenterology 112 1997 226 235
267. D.J. Seward, A.S. Koh, J.L. Boyer, and N. Ballatori Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta J. Biol. Chem. 278 2003 27473 27482
268. H. She, S. Xiong, S. Hazra, and H. Tsukamoto Adipogenic transcriptional regulation of hepatic stellate cells J. Biol. Chem. 280 2005 4959 4967
269. R.M. Sheridan, A. Gupta, A. Miethke, A.S. Knisely, and K.E. Bove Multiple dysplastic liver nodules in PFIC2 underscore risk for neoplasia associated with functional BSEP deficiency Am. J. Surg. Pathol. 36 2012 785 786
270. T. Shiao, M. Iwahashi, J. Fortune, L. Quattrochi, S. Bowman, M. Wick, I. Qadri, and F.R. Simon Structural and functional characterization of liver cell-specific activity of the human sodium/taurocholate cotransporter Genomics 69 2000 203 213
271. D.Q. Shih, M. Bussen, E. Sehayek, M. Ananthanarayanan, B.L. Shneider, F.J. Suchy, S. Shefer, J.S. Bollileni, F.J. Gonzalez, J.L. Breslow, and M. Stoffel Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism Nat. Genet. 27 2001 375 382
272. B.L. Shneider, V.L. Fox, K.B. Schwarz, C.L. Watson, M. Ananthanarayanan, S. Thevananther, D.M. Christie, W. Hardikar, K.D. Setchell, and G. Mieli-Vergani et al. Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia Hepatology 25 1997 1176 1183
273. J. Shoda, Y. Inada, A. Tsuji, H. Kusama, T. Ueda, T. Ikegami, H. Suzuki, Y. Sugiyama, D.E. Cohen, and N. Tanaka Bezafibrate stimulates canalicular localization of NBD-labeled PC in HepG2 cells by PPARalpha-mediated redistribution of ABCB4 J. Lipid Res. 45 2004 1813 1825
274. F.R. Simon, J. Fortune, M. Iwahashi, C. Gartung, A. Wolkoff, and E. Sutherland Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters Am. J. Physiol. 271 1996 G1043 G1052
275. F.R. Simon, J. Fortune, M. Iwahashi, I. Qadri, and E. Sutherland Multihormonal regulation of hepatic sinusoidal Ntcp gene expression Am. J. Physiol. Gastrointest. Liver Physiol. 287 2004 G782 G794
276. J.J. Smit, A.H. Schinkel, R.P. Oude Elferink, A.K. Groen, E. Wagenaar, L. van Deemter, C.A. Mol, R. Ottenhoff, N.M. van der Lugt, and M.A. van Roon Homozygous disruption of the murine mdr2 P-glycoprotein gene leads to a complete absence of phospholipid from bile and to liver disease Cell 75 1993 451 462
277. K.L. Snow, and R.H. Moseley Effect of thiazolidinediones on bile acid
278. R.J. Sokol, M. Devereaux, R. Dahl, and E. Gumpricht "Let there be bile"-understanding hepatic injury in cholestasis J. Pediatr. Gastroenterol. Nutr. 43 Suppl. 1 2006 S4 S9
279. C.S. Song, I. Echchgadda, B.S. Baek, S.C. Ahn, T. Oh, A.K. Roy, and B. Chatterjee Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor J. Biol. Chem. 276 2001 42549 42556
280. X. Song, R. Kaimal, B. Yan, and R. Deng Liver receptor homolog 1 transcriptionally regulates human bile salt export pump expression J. Lipid Res. 49 2008 973 984
281. C.J. Soroka, A. Mennone, L.R. Hagey, N. Ballatori, and J.L. Boyer Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis Hepatology 51 2010 181 190
282. C.J. Soroka, H. Velazquez, A. Mennone, N. Ballatori, and J.L. Boyer Ostalpha depletion protects liver from oral bile acid load Am. J. Physiol. Gastrointest. Liver Physiol. 301 2011 G574 G579
283. R.F. Souza, K. Krishnan, and S.J. Spechler Acid, bile, and CDX: the ABCs of making Barrett's metaplasia Am. J. Physiol. Gastrointest. Liver Physiol. 295 2008 G211 G218
284. J. Staudinger, Y. Liu, A. Madan, S. Habeebu, and C.D. Klaassen Coordinate regulation of xenobiotic and bile acid homeostasis by pregnane X receptor Drug Metab. Dispos. 29 2001 1467 1472
285. J.L. Staudinger, B. Goodwin, S.A. Jones, D. Hawkins-Brown, K.I. MacKenzie, A. LaTour, Y. Liu, C.D. Klaassen, K.K. Brown, and J. Reinhard et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Proc. Natl. Acad. Sci. USA 98 2001 3369 3374
286. C. Stedman, C. Liddle, S. Coulter, J. Sonoda, J.G. Alvarez, R.M. Evans, and M. Downes Benefit of farnesoid X receptor inhibition in obstructive cholestasis Proc. Natl. Acad. Sci. USA 103 2006 11323 11328
287. B. Stieger Role of the bile salt export pump, BSEP, in acquired forms of cholestasis Drug Metab. Rev. 42 2010 437 445
288. B. Stieger, and U. Beuers The canalicular bile salt export pump BSEP (ABCB11) as a potential therapeutic target Curr. Drug Targets 12 2011 661 670
289. +/taurocholate cotransporting polypeptide in rat liver Gastroenterology 107 1994 1781 1787
290. B. Stieger, K. Fattinger, J. Madon, G.A. Kullak-Ublick, and P.J. Meier Drug- and estrogen-induced cholestasis through inhibition of the hepatocellular bile salt export pump (Bsep) of rat liver Gastroenterology 118 2000 422 430
291. A. Stiehl, M.M. Thaler, and W.H. Admirand The effects of phenobarbital on bile salts and bilirubin in patients with intrahepatic and extrahepatic cholestasis N. Engl. J. Med. 286 1972 858 861
292. S.S. Strautnieks, L.N. Bull, A.S. Knisely, S.A. Kocoshis, N. Dahl, H. Arnell, E. Sokal, K. Dahan, S. Childs, and V. Ling et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis Nat. Genet. 20 1998 233 238
293. S.S. Strautnieks, J.A. Byrne, L. Pawlikowska, D. Cebecauerova, A. Rayner, L. Dutton, Y. Meier, A. Antoniou, B. Stieger, and H. Arnell et al. Severe bile salt export pump deficiency: 82 different ABCB11 mutations in 109 families Gastroenterology 134 2008 1203 1214
294. H. Su, C. Ma, J. Liu, N. Li, M. Gao, A. Huang, X. Wang, W. Huang, and X. Huang Downregulation of nuclear receptor FXR is associated with multiple malignant clinicopathological characteristics in human hepatocellular carcinoma Am. J. Physiol. Gastrointest. Liver Physiol. 303 2012 G1245 G1253
295. T. Sueyoshi, T. Kawamoto, I. Zelko, P. Honkakoski, and M. Negishi The repressed nuclear receptor CAR responds to phenobarbital in activating the human CYP2B6 gene J. Biol. Chem. 274 1999 6043 6046
296. J. Sugatani, S. Nishitani, K. Yamakawa, K. Yoshinari, T. Sueyoshi, M. Negishi, and M. Miwa Transcriptional regulation of human UGT1A1 gene expression: activated glucocorticoid receptor enhances constitutive androstane receptor/pregnane X receptor-mediated UDP-glucuronosyltransferase 1A1 regulation with glucocorticoid receptor-interacting protein 1 Mol. Pharmacol. 67 2005 845 855
297. A.Q. Sun, N. Balasubramaniyan, K. Xu, C.J. Liu, V.M. Ponamgi, H. Liu, and F.J. Suchy Protein-protein interactions and membrane localization of the human organic solute transporter Am. J. Physiol. Gastrointest. Liver Physiol. 292 2007 G1586 G1593
298. H. Tanaka, and I. Makino Ursodeoxycholic acid-dependent activation of the glucocorticoid receptor Biochem. Biophys. Res. Commun. 188 1992 942 948
299. H. Tanaka, Y. Makino, T. Miura, F. Hirano, K. Okamoto, K. Komura, Y. Sato, and I. Makino Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway J. Immunol. 156 1996 1601 1608
300. A. Tanaka, S. Nezu, S. Uegaki, K. Kikuchi, A. Shibuya, H. Miyakawa, S. Takahashi, I. Bianchi, P. Zermiani, and M. Podda et al. Vitamin D receptor polymorphisms are associated with increased susceptibility to primary biliary cirrhosis in Japanese and Italian populations J. Hepatol. 50 2009 1202 1209
301. S. Teng, and M. Piquette-Miller The involvement of the pregnane X receptor in hepatic gene regulation during inflammation in mice J. Pharmacol. Exp. Ther. 312 2005 841 848
302. S. Teng, and M. Piquette-Miller Hepatoprotective role of PXR activation and MRP3 in cholic aci d-induced cholestasis Br. J. Pharmacol. 151 2007 367 376
303. C. Thomas, R. Pellicciari, M. Pruzanski, J. Auwerx, and K. Schoonjans Targeting bile-acid signalling for metabolic diseases Nat. Rev. Drug Discov. 7 2008 678 693
304. C. Thomas, A. Gioiello, L. Noriega, A. Strehle, J. Oury, G. Rizzo, A. Macchiarulo, H. Yamamoto, C. Mataki, and M. Pruzanski et al. TGR5-mediated bile acid sensing controls glucose homeostasis Cell Metab. 10 2009 167 177
305. M. Trauner, and J.L. Boyer Bile salt transporters: molecular characterization, function, and regulation Physiol. Rev. 83 2003 633 671
306. M. Trauner, M. Arrese, H. Lee, J.L. Boyer, and S.J. Karpen Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors J. Clin. Invest. 101 1998 2092 2100
307. M. Trauner, A. Baghdasaryan, T. Claudel, P. Fickert, E. Halilbasic, T. Moustafa, and G. Zollner Targeting nuclear bile acid receptors for liver disease Dig. Dis. 29 2011 98 102
308. R.Z. Turncliff, X. Tian, and K.L. Brouwer Effect of culture conditions on the expression and function of Bsep, Mrp2, and Mdr1a/b in sandwich-cultured rat hepatocytes Biochem. Pharmacol. 71 2006 1520 1529
309. S.W. van Mil, W.L. van der Woerd, G. van der Brugge, E. Sturm, P.L. Jansen, L.N. Bull, I.E. van den Berg, R. Berger, R.H. Houwen, and L.W. Klomp Benign recurrent intrahepatic cholestasis type 2 is caused by mutations in ABCB11 Gastroenterology 127 2004 379 384
310. A. Vogel, C.P. Strassburg, and M.P. Manns Genetic association of vitamin D receptor polymorphisms with primary biliary cirrhosis and autoimmune hepatitis Hepatology 35 2002 126 131
311. M. Wagner, P. Fickert, G. Zollner, A. Fuchsbichler, D. Silbert, O. Tsybrovskyy, K. Zatloukal, G.L. Guo, J.D. Schuetz, and F.J. Gonzalez et al. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice Gastroenterology 125 2003 825 838
312. M. Wagner, E. Halilbasic, H.U. Marschall, G. Zollner, P. Fickert, C. Langner, K. Zatloukal, H. Denk, and M. Trauner CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice Hepatology 42 2005 420 430
313. M. Wagner, G. Zollner, and M. Trauner Nuclear receptors in liver disease Hepatology 53 2011 1023 1034
314. J. Walkowiak, I. Jankowska, J. Pawlowska, S. Strautnieks, L. Bull, R. Thompson, K.H. Herzig, and J. Socha Exocrine pancreatic function in children with progressive familial intrahepatic cholestasis type 2 J. Pediatr. Gastroenterol. Nutr. 42 2006 416 418
315. H. Wang, J. Chen, K. Hollister, L.C. Sowers, and B.M. Forman Endogenous bile acids are ligands for the nuclear receptor FXR/BAR Mol. Cell 3 1999 543 553
316. R. Wang, M. Salem, I.M. Yousef, B. Tuchweber, P. Lam, S.J. Childs, C.D. Helgason, C. Ackerley, M.J. Phillips, and V. Ling Targeted inactivation of sister of P-glycoprotein gene (spgp) in mice results in nonprogressive but persistent intrahepatic cholestasis Proc. Natl. Acad. Sci. USA 98 2001 2011 2016
317. W. Wang, D.J. Seward, L. Li, J.L. Boyer, and N. Ballatori Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate Proc. Natl. Acad. Sci. USA 98 2001 9431 9436
318. D.Q. Wang, S. Tazuma, D.E. Cohen, and M.C. Carey Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse Am. J. Physiol. Gastrointest. Liver Physiol. 285 2003 G494 G502
319. L. Wang, Y. Han, C.S. Kim, Y.K. Lee, and D.D. Moore Resistance of SHP-null mice to bile acid-induced liver damage J. Biol. Chem. 278 2003 44475 44481
320. Y.D. Wang, W.D. Chen, M. Wang, D. Yu, B.M. Forman, and W. Huang Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response Hepatology 48 2008 1632 1643
321. H.H. Wang, F. Lammert, A. Schmitz, and D.Q. Wang Transgenic overexpression of Abcb11 enhances biliary bile salt outputs, but does not affect cholesterol cholelithogenesis in mice Eur. J. Clin. Invest. 40 2010 541 551
322. U. Warskulat, R. Kubitz, M. Wettstein, B. Stieger, P.J. Meier, and D. Haussinger Regulation of bile salt export pump mRNA levels by dexamethasone and osmolarity in cultured rat hepatocytes Biol. Chem. 380 1999 1273 1279
323. M. Watanabe, S.M. Houten, C. Mataki, M.A. Christoffolete, B.W. Kim, H. Sato, N. Messaddeq, J.W. Harney, O. Ezaki, and T. Kodama et al. Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation Nature 439 2006 484 489
324. J. Weerachayaphorn, S.Y. Cai, C.J. Soroka, and J.L. Boyer Nuclear factor erythroid 2-related factor 2 is a positive regulator of human bile salt export pump expression Hepatology 50 2009 1588 1596
325. H. Wolters, B.M. Elzinga, J.F. Baller, R. Boverhof, M. Schwarz, B. Stieger, H.J. Verkade, and F. Kuipers Effects of bile salt flux variations on the expression of hepatic bile salt transporters in vivo in mice J. Hepatol. 37 2002 556 563
326. W. Xie, J.L. Barwick, M. Downes, B. Blumberg, C.M. Simon, M.C. Nelson, B.A. Neuschwander-Tetri, E.M. Brunt, P.S. Guzelian, and R.M. Evans Humanized xenobiotic response in mice expressing nuclear receptor SXR Nature 406 2000 435 439
327. W. Xie, A. Radominska-Pandya, Y. Shi, C.M. Simon, M.C. Nelson, E.S. Ong, D.J. Waxman, and R.M. Evans An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids Proc. Natl. Acad. Sci. USA 98 2001 3375 3380
328. Y. Yamamoto, R. Moore, T.L. Goldsworthy, M. Negishi, and R.R. Maronpot The orphan nuclear receptor constitutive active/androstane receptor is essential for liver tumor promotion by phenobarbital in mice Cancer Res. 64 2004 7197 7200
329. Y. Yamamoto, R. Moore, H.A. Hess, G.L. Guo, F.J. Gonzalez, K.S. Korach, R.R. Maronpot, and M. Negishi Estrogen receptor alpha mediates 17alpha-ethynylestradiol causing hepatotoxicity J. Biol. Chem. 281 2006 16625 16631
330. Y. Yamanishi, Y. Nosaka, H. Kawasaki, C. Hirayama, and S. Ikawa Sterol and bile acid metabolism after short-term prednisolone treatment in patients with chronic active hepatitis Gastroenterol. Jpn. 20 1985 246 251
331. K. Yamazaki, K. Suzuki, A. Nakamura, S. Sato, K.D. Lindor, K.P. Batts, J.E. Tarara, G.M. Kephart, H. Kita, and G.J. Gleich Ursodeoxycholic acid inhibits eosinophil degranulation in patients with primary biliary cirrhosis Hepatology 30 1999 71 78
332. Y. Yamazaki, R. Moore, and M. Negishi Nuclear receptor CAR (NR1I3) is essential for DDC-induced liver injury and oval cell proliferation in mouse liver Lab. Invest. 91 2011 1624 1633
333. K. Yano, H. Kato, S. Morita, O. Takahara, H. Ishibashi, and R. Furukawa Is bezafibrate histologically effective for primary biliary cirrhosis? Am. J. Gastroenterol. 97 2002 1075 1077
334. B. Yerushalmi, R.J. Sokol, M.R. Narkewicz, D. Smith, and F.M. Karrer Use of rifampin for severe pruritus in children with chronic cholestasis J. Pediatr. Gastroenterol. Nutr. 29 1999 442 447
335. M. Yoshikawa, T. Tsujii, K. Matsumura, J. Yamao, Y. Matsumura, R. Kubo, H. Fukui, and S. Ishizaka Immunomodulatory effects of ursodeoxycholic acid on immune responses Hepatology 16 1992 358 364
336. J. Yu, J.L. Lo, L. Huang, A. Zhao, E. Metzger, A. Adams, P.T. Meinke, S.D. Wright, and J. Cui Lithocholic acid decreases expression of bile salt export pump through farnesoid X receptor antagonist activity J. Biol. Chem. 277 2002 31441 31447
337. N. Zelcer, K. van de Wetering, R. de Waart, G.L. Scheffer, H.U. Marschall, P.R. Wielinga, A. Kuil, C. Kunne, A. Smith, and M. van der Valk et al. Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides J. Hepatol. 44 2006 768 775
338. Y. Zhang, L.W. Castellani, C.J. Sinal, F.J. Gonzalez, and P.A. Edwards Peroxisome proliferator-activated receptor-gamma coactivator 1alpha (PGC-1alpha) regulates triglyceride metabolism by activation of the nuclear receptor FXR Genes Dev. 18 2004 157 169
339. F. Zhang, Y. Lu, and S. Zheng Peroxisome proliferator-activated receptor-gamma cross-regulation of signaling events implicated in liver fibrogenesis Cell. Signal. 24 2012 596 605
340. C. Zimmermann, R.A. van Waterschoot, S. Harmsen, A. Maier, H. Gutmann, and A.H. Schinkel PXR-mediated induction of human CYP3A4 and mouse Cyp3a11 by the glucocorticoid budesonide Eur. J. Pharm. Sci. 36 2009 565 571
341. G. Zollner, P. Fickert, R. Zenz, A. Fuchsbichler, C. Stumptner, L. Kenner, P. Ferenci, R.E. Stauber, G.J. Krejs, and H. Denk et al. Hepatobiliary transporter expression in percutaneous liver biopsies of patients with cholestatic liver diseases Hepatology 33 2001 633 646
342. G. Zollner, P. Fickert, A. Fuchsbichler, D. Silbert, M. Wagner, S. Arbeiter, F.J. Gonzalez, H.U. Marschall, K. Zatloukal, H. Denk, and M. Trauner Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine J. Hepatol. 39 2003 480 488
343. G. Zollner, P. Fickert, D. Silbert, A. Fuchsbichler, H.U. Marschall, K. Zatloukal, H. Denk, and M. Trauner Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis J. Hepatol. 38 2003 717 727
344. G. Zollner, M. Wagner, P. Fickert, A. Geier, A. Fuchsbichler, D. Silbert, J. Gumhold, K. Zatloukal, A. Kaser, and H. Tilg et al. Role of nuclear receptors and hepatocyte-enriched transcription factors for Ntcp repression in biliary obstruction in mouse liver Am. J. Physiol. Gastrointest. Liver Physiol. 289 2005 G798 G805
345. G. Zollner, H.U. Marschall, M. Wagner, and M. Trauner Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations Mol. Pharm. 3 2006 231 251
346. G. Zollner, M. Wagner, T. Moustafa, P. Fickert, D. Silbert, J. Gumhold, A. Fuchsbichler, E. Halilbasic, H. Denk, H.U. Marschall, and M. Trauner Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-alpha/beta in the adaptive response to bile acids Am. J. Physiol. Gastrointest. Liver Physiol. 290 2006 G923 G932