Hepatocyte nuclear factor-1α is an essential regulator of bile acid and plasma cholesterol metabolism

Nature Genetics

Volumn 27, Issue 4, 2001, Pages 375-382

  Shih, David Q ^a   Bussen, Markus ^a   Sehayek, Ephraim ^a   Ananthanarayanan, Meenakshisundaram ^b   Shneider, Benjamin L ^b   Suchy, Frederick J ^b   Shefer, Sarah ^c   Bollileni, Jaya S ^c   Gonzalez, Frank J ^d   Breslow, Jan L ^a   Stoffel, Markus ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF MEDICINE AND DENTISTRY OF NEW JERSEY   (United States)

^d NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NUCLEAR FACTOR I; SCATTER FACTOR;

AMINO ACID METABOLISM; ANIMAL CELL; ARTICLE; BASOLATERAL MEMBRANE; BILE SECRETION; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL METABOLISM; ESTERIFICATION; GLUCOSE HOMEOSTASIS; HYPERCHOLESTEROLEMIA; INSULIN RELEASE; MATURITY ONSET DIABETES MELLITUS; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION; UNINDEXED SEQUENCE;

ANIMALS; BASE SEQUENCE; BILE ACIDS AND SALTS; CHOLESTEROL; DNA PRIMERS; DNA-BINDING PROTEINS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; ILEUM; KIDNEY; MICE; MICE, KNOCKOUT; NUCLEAR PROTEINS; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0035072875     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/86871     Document Type: Article

References (43)

1. Hepatocyte nuclear factor-1 (HNF1) and liver gene expression
2. Mutations in the hepatocyte nuclear factor-1α, gene in maturity-onset diabetes of the young
3. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome
4. Laron dwarfism and non-insulin-dependent diabetes mellitus in the Hnf-1α knockout mouse
5. The SREBP pathway: Regulation of cholesterol metabolism by proteolysis by proteolysis of a membrane bound transcription factor
6. Molecular aspects of hepatobiliary transport
7. Don't know much bile-ology
8. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver
9. Bile acid and xenobiotic transporters in liver
10. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis
11. Regulation of bile acid synthesis
12. An oxysterol signaling pathway mediated by the nuclear receptor LXRa
13. Cholesterol and bile acid metabolisms are impaired in mice lacking the nuclear oxysterol receptor LXR α
14. Identification of a nuclear receptor for bile acids
15. Bile acids: Natural ligands for an orphan nuclear receptor
16. CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7a-hydroxylase gene
17. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
18. Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
19. Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
20. HNF1 activates transcription of the human gene for insulin-like growth factor binding protein-1
21. Expression cloning and characterization of the hamster ileal sodium-dependent bile acid transporter
22. Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum
23. Massive xanthomatosis and atherosclerosis in cholesterol-fed low density lipoprotein receptor-negative mice
24. Secretion of lipoprotein-X by perfused livers of rats with cholestasis
25. Formation of lipoprotein-X. Its relationship to bile compounds
26. Plasma lipoproteins in familial lecithin: Cholesterol acyltransferase deficiency: Physical and chemical of low and high-density lipoproteins
27. Cryo-electron microscopy of low-density lipoprotein and reconstituted discoidal high density lipoprotein: Imaging of the apolipoprotein moiety
28. The lipid bilayer structure of the abnormal human plasma lipoprotein X. An X-ray small-angle-scattering study
29. Small, dense low-density lipoproteins, the insulin resistance syndrome and noninsulin-dependent diabetes
30. Mild dyslipidemia in mice following targeted inactivation of the hepatic lipase gene
31. Cholesteryl ester transfer protein corrects dysfunctional high density lipoproteins and reduces aortic atherosclerosis in lecithin cholesterol acyltransferase transgenic mice
32. Swine lipoproteins and atherosclerosis. Changes in the plasma lipoproteins and apoproteins induced by cholesterol feeding
33. cDNA cloning of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family
34. The maturity-onset diabetes of the young (MODY1) transcription factor HNF4α regulates expression of genes required for glucose transport and metabolism
35. An ontogenically regulated 48-kDa protein is a component of the Na(+)-bile acid cotransporter of rat liver
36. Immunologic distribution of an organic anion transport protein in rat liver and kidney
37. HNF-1 α and HNF-1 β (vHNF-1) share dimerization and homeo domains, but not activation domains, and form heterodimers in vitro
38. General methods for the analysis of metabolic profiles of bile acids and related compounds in feces
39. 22-Ursodeoxycholic acid, a unique metabolite of administered ursodeoxycholic acid in rats, indicating partial β-oxidation as a major pathway for bile acid metabolism
40. Intestinal expression of human apolipoprotein A-IV in transgenic mice fails to influence dietary lipid absorption or feeding behavior
41. Biliary cholesterol excretion: A novel mechanism that regulates dietary cholesterol absorption
42. Automated measurements of mouse apolipoprotein B: Convenient screening tool for mouse models of atherosclerosis
43. Cloning and characterization of a novel peptidase from rat and human ileum