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Volumn 41, Issue 4, 2000, Pages 514-520

Peroxisome proliferator-activated receptor α (PPARα) and agonist inhibit cholesterol 7α-hydroxylase gene (CYP7A1) transcription

Author keywords

Bile acid synthesis; Cytochrome P450; Gallstones; HNF 4; Hypolipidemic drugs; Peroxisome proliferators

Indexed keywords

ANTILIPEMIC AGENT; BILE ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; COMPLEMENTARY DNA; CYTOCHROME P450; FIBRIC ACID DERIVATIVE; NUCLEAR FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIRINIXIC ACID; RETINOID X RECEPTOR;

EID: 0033999108     PISSN: 00222275     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (167)

References (33)
  • 1
    • 0032054839 scopus 로고    scopus 로고
    • Consensus for the use of fibrates in the treatment of dyslipoproteinemia and corollary heart disease. Fibrate Consensus
    • Fruchart, J. C., H. B. Brewer, Jr., and E. Leitersdorf. 1998. Consensus for the use of fibrates in the treatment of dyslipoproteinemia and corollary heart disease. Fibrate Consensus. Am. J. Cardiol. 81: 912-917.
    • (1998) Am. J. Cardiol. , vol.81 , pp. 912-917
    • Fruchart, J.C.1    Brewer H.B., Jr.2    Leitersdorf, E.3
  • 3
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ
    • Forman, B. M., J. Chen, and R. M. Evans. 1997. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl. Acad. Sci. USA. 94: 4312-4317.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 4
    • 0029994543 scopus 로고    scopus 로고
    • Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
    • Schoonjans, K., B. Staels, and J. Auwerx. 1996. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J. Lipid Res. 37: 907-925.
    • (1996) J. Lipid Res. , vol.37 , pp. 907-925
    • Schoonjans, K.1    Staels, B.2    Auwerx, J.3
  • 5
    • 0030766476 scopus 로고    scopus 로고
    • Alterations in lipoprotein metaboism in peroxisome proliferator-activated receptor α-deficient mice
    • Peters, J. M., N. Hennuyer, B. Stales, J-C. Fruchart, C. Fievet, F. J. Gonzalez, and J. Auwerx. 1997. Alterations in lipoprotein metaboism in peroxisome proliferator-activated receptor α-deficient mice. J. Biol. Chem. 272: 27307-27312.
    • (1997) J. Biol. Chem. , vol.272 , pp. 27307-27312
    • Peters, J.M.1    Hennuyer, N.2    Stales, B.3    Fruchart, J.-C.4    Fievet, C.5    Gonzalez, F.J.6    Auwerx, J.7
  • 6
    • 0032491614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis
    • Costet, P., C. Legendre, J. More, A. Edgar, P. Galtier, and T. Pineau. 1998. Peroxisome proliferator-activated receptor alpha-isoform deficiency leads to progressive dyslipidemia with sexually dimorphic obesity and steatosis. J. Biol. Chem. 273: 29577-29585.
    • (1998) J. Biol. Chem. , vol.273 , pp. 29577-29585
    • Costet, P.1    Legendre, C.2    More, J.3    Edgar, A.4    Galtier, P.5    Pineau, T.6
  • 7
    • 0028997684 scopus 로고
    • Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisime proliferators
    • Lee, S., T. Pineau, J. Drago, E. Lee, J. Owens, D. Kroetz, P. Fernandez-Salguero, H. Westphal, and F. Gonzalez. 1995. Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisime proliferators. Mol. Cell. Biol. 15: 3012-3022.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3012-3022
    • Lee, S.1    Pineau, T.2    Drago, J.3    Lee, E.4    Owens, J.5    Kroetz, D.6    Fernandez-Salguero, P.7    Westphal, H.8    Gonzalez, F.9
  • 8
    • 0002450306 scopus 로고
    • Hyperlipoproteinemia, hypolipidemic treatment, and gallstone disease
    • Einarsson, K., and B. Angelin. 1986. Hyperlipoproteinemia, hypolipidemic treatment, and gallstone disease. Atheroscler. Rev. 15: 67-97.
    • (1986) Atheroscler. Rev. , vol.15 , pp. 67-97
    • Einarsson, K.1    Angelin, B.2
  • 9
    • 0000778664 scopus 로고    scopus 로고
    • Regulation of bile acid synthesis
    • Chiang, J. Y. L. 1998. Regulation of bile acid synthesis. Front. Biosci. 3: D176-D193.
    • (1998) Front. Biosci. , vol.3
    • Chiang, J.Y.L.1
  • 10
    • 0025894157 scopus 로고
    • Regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by taurocholate and cholestetol in the chronic biliary diverted rat
    • Pandak, W. M., Y. C. Li, J. Y. L. Chiang, E. L. Studer, E. C. Gurley, D. M. Heuman, Z. R. Vlahcevic, and P. B. Hylemon. 1991. Regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by taurocholate and cholestetol in the chronic biliary diverted rat. J. Biol. Chem. 266: 3416-3421.
    • (1991) J. Biol. Chem. , vol.266 , pp. 3416-3421
    • Pandak, W.M.1    Li, Y.C.2    Chiang, J.Y.L.3    Studer, E.L.4    Gurley, E.C.5    Heuman, D.M.6    Vlahcevic, Z.R.7    Hylemon, P.B.8
  • 11
    • 0029834337 scopus 로고    scopus 로고
    • Transcriptional regulation of the human cholesterol 7α-hydroxylase gene (CYPZA) in HepG2 cells
    • Wang, D. P., D. Stroup, M. Marrapodi, M. Crestani, G. Galli, and J. Y. L. Chiang. 1996. Transcriptional regulation of the human cholesterol 7α-hydroxylase gene (CYPZA) in HepG2 cells, J. Lipid Res. 37: 1831-1841.
    • (1996) J. Lipid Res. , vol.37 , pp. 1831-1841
    • Wang, D.P.1    Stroup, D.2    Marrapodi, M.3    Crestani, M.4    Galli, G.5    Chiang, J.Y.L.6
  • 12
    • 0024316516 scopus 로고
    • Effects of treatment with clofibrate, bezafibrate, and ciprofibrale on the metabolism of cholesterol in rat liver microsomes
    • Stahlberg, D., B. Angelin, and K. Einarsson. 1989. Effects of treatment with clofibrate, bezafibrate, and ciprofibrale on the metabolism of cholesterol in rat liver microsomes. J. Lipid Res. 30: 953-958.
    • (1989) J. Lipid Res. , vol.30 , pp. 953-958
    • Stahlberg, D.1    Angelin, B.2    Einarsson, K.3
  • 13
    • 84991145406 scopus 로고
    • Influence of bezafibrate on hepatic cholesterol metabolisrn in gallstone patients: Reduced activity of cholesterol 7alpha-hydroxylase
    • Stahlberg, D., E. Reihner, M. Rudling, L. Berglund, K. Einarsson, and B. Angelin. 1995. Influence of bezafibrate on hepatic cholesterol metabolisrn in gallstone patients: reduced activity of cholesterol 7alpha-hydroxylase. Hepatology. 21: 1025-1230.
    • (1995) Hepatology , vol.21 , pp. 1025-1230
    • Stahlberg, D.1    Reihner, E.2    Rudling, M.3    Berglund, L.4    Einarsson, K.5    Angelin, B.6
  • 14
    • 0029143455 scopus 로고
    • Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric acid derivatives on the rates of cholesterol 7alpha-hydroxylation in humans
    • Bertolotti, M., M. Concari, P. Loria, N. Abate, A. Pinetti, M. E. Guicciardi, and N. Carulli. 1995. Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric acid derivatives on the rates of cholesterol 7alpha-hydroxylation in humans. Arterioscler. Thromb. Vasc. Biol. 15: 1064-1069.
    • (1995) Arterioscler. Thromb. Vasc. Biol. , vol.15 , pp. 1064-1069
    • Bertolotti, M.1    Concari, M.2    Loria, P.3    Abate, N.4    Pinetti, A.5    Guicciardi, M.E.6    Carulli, N.7
  • 15
    • 0025865551 scopus 로고
    • Gemfibrozil in familial combined hyperlipidaemia: Effect of added low-dose cholestyramine on plasma and biliary lipids
    • Odman, B., S. Ericsson, M. Lindmark, L. Berglund, and B. Angelin. 1991. Gemfibrozil in familial combined hyperlipidaemia: effect of added low-dose cholestyramine on plasma and biliary lipids. Eur. J. Clin. Invest. 21: 344-349.
    • (1991) Eur. J. Clin. Invest. , vol.21 , pp. 344-349
    • Odman, B.1    Ericsson, S.2    Lindmark, M.3    Berglund, L.4    Angelin, B.5
  • 16
    • 0031751631 scopus 로고    scopus 로고
    • Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors
    • Crestani, M., A. Sadeghpour, D. Stroup, G. Gali, and J. Y. L. Chiang. 1998. Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors. J. Lipid Res. 39: 2192-2200.
    • (1998) J. Lipid Res. , vol.39 , pp. 2192-2200
    • Crestani, M.1    Sadeghpour, A.2    Stroup, D.3    Gali, G.4    Chiang, J.Y.L.5
  • 17
    • 0031023181 scopus 로고    scopus 로고
    • Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7α-hydroxylase gene
    • Cooper, A. D., J. Chen, M. J. Botelho-Yetkinler, Y. Cao, T. Taniguchi, and B. Levy-Wilson. 1997. Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7α-hydroxylase gene. J. Biol. Chem. 272: 3444-3452.
    • (1997) J. Biol. Chem. , vol.272 , pp. 3444-3452
    • Cooper, A.D.1    Chen, J.2    Botelho-Yetkinler, M.J.3    Cao, Y.4    Taniguchi, T.5    Levy-Wilson, B.6
  • 18
    • 0029113123 scopus 로고
    • Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors
    • Jiang, G., L. Nepomuceno, K. Hopkins, and F. M. Sladek. 1995. Exclusive homodimerization of the orphan receptor hepatocyte nuclear factor 4 defines a new subclass of nuclear receptors. Mol. Cell. Biol. 15: 5131-5143.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 5131-5143
    • Jiang, G.1    Nepomuceno, L.2    Hopkins, K.3    Sladek, F.M.4
  • 19
    • 0030870025 scopus 로고    scopus 로고
    • Identification of a bile acid response element in the choleslerol 7α-hydroxylase gene (CYP7A)
    • Stroup, D., M. Crestani, and J. Y. L. Chiang. 1997. Identification of a bile acid response element in the choleslerol 7α-hydroxylase gene (CYP7A). Am. J. Physiol. 273:G508-G517.
    • (1997) Am. J. Physiol. , vol.273
    • Stroup, D.1    Crestani, M.2    Chiang, J.Y.L.3
  • 22
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang, H., J. Chen, K. Hollister, L. C. Sowers, and B. M. Forman. 1999. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol. Cell. 3: 543-553.
    • (1999) Mol. Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 23
    • 0040979121 scopus 로고    scopus 로고
    • Transcriptional regulation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptor bound to the bile acid response elements (BARE)
    • G. Paumgartner, A. Stiehl, W. Gerok, D. Keppler, and U. Leuschner, editors. Kluwer Academic Publishers, Norwell, MA
    • Chiang, J. Y. L., D. Stroup, M. Crestani, and A. Sadeghpour. 1999. Transcriptional regulation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptor bound to the bile acid response elements (BARE). In Bile Acids and Cholestasis. G. Paumgartner, A. Stiehl, W. Gerok, D. Keppler, and U. Leuschner, editors. Kluwer Academic Publishers, Norwell, MA. 51-58.
    • (1999) Bile Acids and Cholestasis , pp. 51-58
    • Chiang, J.Y.L.1    Stroup, D.2    Crestani, M.3    Sadeghpour, A.4
  • 24
    • 0023655038 scopus 로고
    • Isolation and structural characterization of the rat acyl-CoA oxidase gene
    • Osumi, T., N. Ishii, S. Miyazawa, and T. Hashimoto. 1987. Isolation and structural characterization of the rat acyl-CoA oxidase gene. J. Biol. Chem. 262: 8138-8143.
    • (1987) J. Biol. Chem. , vol.262 , pp. 8138-8143
    • Osumi, T.1    Ishii, N.2    Miyazawa, S.3    Hashimoto, T.4
  • 25
    • 0028868818 scopus 로고
    • Hormonal regulation of the cholesterol 7α-hydroxylase gene (CYP7A)
    • Crestani, M., D. Stroup, and J. Y. L. Chiang. 1995. Hormonal regulation of the cholesterol 7α-hydroxylase gene (CYP7A). J. Lipid Res. 36: 2419-2432.
    • (1995) J. Lipid Res. , vol.36 , pp. 2419-2432
    • Crestani, M.1    Stroup, D.2    Chiang, J.Y.L.3
  • 27
    • 0032524459 scopus 로고    scopus 로고
    • Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-I, PPAR, RAR and RXR through common response elements
    • Nakshatri, H., and P. Bhat-Nakshatri. 1998. Multiple parameters determine the specificity of transcriptional response by nuclear receptors HNF-4, ARP-I, PPAR, RAR and RXR through common response elements. Nucleic Acids Res. 26: 2491-2499.
    • (1998) Nucleic Acids Res. , vol.26 , pp. 2491-2499
    • Nakshatri, H.1    Bhat-Nakshatri, P.2
  • 28
    • 0033954261 scopus 로고    scopus 로고
    • HNF4 and COUP-TFII interact to modulate transcription of the choleslerol 7α-hydroxylase gene (CYP7A)
    • Stroup, D., and J. Y. L. Chiang. 2000. HNF4 and COUP-TFII interact to modulate transcription of the choleslerol 7α-hydroxylase gene (CYP7A). J. Lipid Res. 41: 1-11.
    • (2000) J. Lipid Res. , vol.41 , pp. 1-11
    • Stroup, D.1    Chiang, J.Y.L.2
  • 29
    • 1842295133 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepresors
    • DiRenzo, J., M. Soderstrom, R. Kurokawa, M. H. Ogliastro, M. Ricote, S. Ingrey, A. Horlein, M. G. Rosenfeld, and C. K. Glass. 1997. Peroxisome proliferator-activated receptors and retinoic acid receptors differentially control the interactions of retinoid X receptor heterodimers with ligands, coactivators, and corepresors. Mol. Cell. Biol. 17: 2166-2176.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 2166-2176
    • DiRenzo, J.1    Soderstrom, M.2    Kurokawa, R.3    Ogliastro, M.H.4    Ricote, M.5    Ingrey, S.6    Horlein, A.7    Rosenfeld, M.G.8    Glass, C.K.9
  • 30
    • 0028998129 scopus 로고
    • Mode of artion of peroxisome proliferators as hypolipidemic drugs
    • Hertz, R., J. Bishara-Shieban, and J. Bar-Tana. 1995. Mode of artion of peroxisome proliferators as hypolipidemic drugs. J. Biol. Chem. 270: 13470-13475.
    • (1995) J. Biol. Chem. , vol.270 , pp. 13470-13475
    • Hertz, R.1    Bishara-Shieban, J.2    Bar-Tana, J.3
  • 31
    • 0030058106 scopus 로고    scopus 로고
    • Transcriptional suppression of the transferrin gene by hypolipidemic peroxisome proliferators
    • Hertz, R., M. Seckbach, M. M. Zakin, and J. Bar-Tana. 1996. Transcriptional suppression of the transferrin gene by hypolipidemic peroxisome proliferators. J. Biol. Chem. 271: 218-224.
    • (1996) J. Biol. Chem. , vol.271 , pp. 218-224
    • Hertz, R.1    Seckbach, M.2    Zakin, M.M.3    Bar-Tana, J.4
  • 32
    • 0032475854 scopus 로고    scopus 로고
    • The nuclear receptors peroxisome proliferator-activated receptor alpha and Reverbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates
    • Vu-Dac, N., S. Chopin-Delannoy, P. Gervois, E. Bonnelye, G. Martin, J. G. Fruchart, V. Laudet, and B. Staels. 1998. The nuclear receptors peroxisome proliferator-activated receptor alpha and Reverbalpha mediate the species-specific regulation of apolipoprotein A-I expression by fibrates. J. Biol Chem. 273: 25713-25720.
    • (1998) J. Biol Chem. , vol.273 , pp. 25713-25720
    • Vu-Dac, N.1    Chopin-Delannoy, S.2    Gervois, P.3    Bonnelye, E.4    Martin, G.5    Fruchart, J.G.6    Laudet, V.7    Staels, B.8


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