Estrogen receptor α mediates 17α-ethynylestradiol causing hepatotoxicity

Journal of Biological Chemistry

Volumn 281, Issue 24, 2006, Pages 16625-16631

  Yamamoto, Yukio ^a   Moore, Rick ^a   Hess, Holly A ^a   Guo, Grace L ^c   Gonzalez, Frank J ^c   Korach, Kenneth S ^a   Maronpot, Robert R ^b   Negishi, Masahiko ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^c NATIONAL CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; BIOSYNTHESIS; ENZYMES; GENES; GYNECOLOGY; HORMONES; MOLECULAR BIOLOGY; PROTEINS; TOXICITY;

BILE ACIDS; HEPATOTOXICITY; HOMEOSTASIS; ORAL CONTRACEPTIVES;

ENDOCRINOLOGY;

ALKALINE PHOSPHATASE; BETA MURICHOLIC ACID; BILE ACID; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID DERIVATIVE; COTRANSPORTER; CYTOCHROME P450; CYTOCHROME P450 7B1; CYTOCHROME P450 8B1; ESTROGEN RECEPTOR ALPHA; ETHINYLESTRADIOL; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID BLOOD LEVEL; BILE SECRETION; CONTROLLED STUDY; ENZYME ACTIVITY; FEMALE; GENE EXPRESSION; HEPATITIS; HEPATOMEGALY; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; WILD TYPE;

ANIMALS; BILE; BILE ACIDS AND SALTS; CELL LINE; CHOLESTEROL; ESTROGEN RECEPTOR ALPHA; ETHINYL ESTRADIOL; GENE EXPRESSION REGULATION; HUMANS; LIPIDS; LIVER; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MODELS, BIOLOGICAL;

EID: 33745187361     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M602723200     Document Type: Article

References (43)

1. Schreiber, A. J., and Simon, F. R. (1983) Hepatology 3, 607-613
2. Reyes, H. (1997) J. Gastroenterol. Hepatol. 12, 211-216
3. Riely, C. A., and Bacq, Y. (2004) Clin. Liver Dis. 8, 167-176
4. Rodriguez-Garay, E. A. (2003) Ann. Hepatol. 2, 150-158
5. Lee, J. M., Trauner, M., Soroka, C. J., Stieger, B., Meier, P. J., and Boyer, J. L. (2000) Gastroenterology 118, 163-172
6. Simon, F. R., Fortune, J., Iwahashi, M., Gartung, C., Wolkoff, A., and Sutherland, E. (1996) Am. J. Physiol. 271, G1043-G1052
7. Koopen, N. R., Post, S. M., Wolters, H., Havinga, R., Stellaard, F., Boverhof, R., Kuipers, F., and Princen, H. M. (1999) J. Lipid Res. 40, 100-108
8. Karpen, S. J. (2002) J. Hepatol. 36, 832-850
9. Francis, G. A., Fayard, E., Picard, F., and Auwerx, J. (2003) Annu. Rev. Physiol. 65, 261-311
10. Guo, G. L., Lambert, G., Negishi, M., Ward, J. M., Brewer, H. B., Jr., Kliewer, S. A., Gonzalez, F. J., and Sinal, C. J. (2003) J. Biol. Chem. 278, 45062-45071
11. Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., and Gonzalez, F. J. (2000) Cell 102, 731-744
12. Goodwin, B., Jones, S. A., Price, R. R., Watson, M. A., McKee, D. D., Moore, L. B., Galardi, C., Wilson, J. G., Lewis, M. C., Roth, M. E., Maloney, P. R., Willson, T. M., and Kliewer, S. A. (2000) Mol. Cell 6, 517-526
13. Lu, T. T., Makishima, M., Repa, J. J., Schoonjans, K., Kerr, T. A., Auwerx, J., and Mangelsdorf, D. J. (2000) Mol. Cell 6, 507-515
14. Ananthanarayanan, M., Balasubramanian, N., Makishima, M., Mangelsdorf, D. J., and Suchy, F. J. (2001) J. Biol. Chem. 276, 28857-28865
15. Staudinger, J. L., Goodwin, B., Jones, S. A., Hawkins-Brown, D., MacKenzie, K. I., LaTour, A., Liu, Y., Klaassen, C. D., Brown, K. K., Reinhard, J., Willson, T. M., Koller, B. H., and Kliewer, S. A. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3369-3374
16. Xie, W., Radominska-Pandya, A., Shi, Y., Simon, C. M., Nelson, M. C., Ong, E. S., Waxman, D. J., and Evans, R. M. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 3375-3380
17. Assem, M., Schuetz, E. G., Leggas, M., Sun, D., Yasuda, K., Reid, G., Zelcer, N., Adachi, M., Strom, S., Evans, R. M., Moore, D. D., Borst, P., and Schuetz, J. D. (2004) J. Biol. Chem. 279, 22250-22257
18. Zhang, J., Huang, W., Qatanani, M., Evans, R. M., and Moore, D. D. (2004) J. Biol. Chem. 279, 49517-49522
19. Uppal, H., Toma, D., Saini, S. P., Ren, S., Jones, T. J., and Xie, W. (2005) Hepatology 41, 168-176
20. Stedman, C. A., Liddle, C., Coulter, S. A., Sonoda, J., Alvarez, J. G., Moore, D. D., Evans, R. M., and Downes, M. (2005) Proc. Natl. Acad. Sci. U. S. A. 102, 2063-2068
21. Couse, J. F., and Korach, K. S. (1999) Endocr. Rev. 20, 358-417
22. Ueda, A., Hamadeh, H. K., Webb, H. K., Yamamoto, Y., Sueyoshi, T., Afshari, C. A., Lehmann, J. M., and Negishi, M. (2002) Mol. Pharmacol. 61, 1-6
23. Inoue, Y., Yu, A. M., Inoue, J., and Gonzalez, F. J. (2004) J. Biol. Chem. 279, 2480-2489
24. Yamamoto, Y., Kawamoto, T., and Negishi, M. (2003) Arch. Biochem. Biophys. 409, 207-211
25. Kitada, H., Miyata, M., Nakamura, T., Tozawa, A., Honma, W., Shimada, M., Nagata, K., Sinal, C. J., Guo, G. L., Gonzalez, F. J., and Yamazoe, Y. (2003) J. Biol. Chem. 278, 17838-17844
26. Pettersson, K., Grandien, K., Kuiper, G. G., and Gustafsson, J. A. (1997) Mol. Endocrinol. 11, 1486-1496
27. Couse, J. F., Lindzey, J., Grandien, K., Gustafsson, J. A., and Korach, K. S. (1997) Endocrinology 138, 4613-4621
28. Repa, J. J., and Mangelsdorf, D. J. (2000) Annu. Rev. Cell Dev. Biol. 16, 459-481
29. Russell, D. W. (2003) Annu. Rev. Biochem. 72, 137-174
30. Jansen, P. L., Muller, M., and Sturm, E. (2001) Hepatology 34, 1067-1074
31. Zollner, G., Fickert, P., Zenz, R., Fuchsbichler, A., Stumptner, C., Kenner, L., Ferenci, P., Stauber, R. E., Krejs, G. J., Denk, H., Zatloukal, K., and Trauner, M. (2001) Hepatology 33, 633-646
32. Yu, L., Hammer, R. E., Li-Hawkins, J., Von Bergmann, K., Lutjohann, D., Cohen, J. C., and Hobbs, H. H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 16237-16242
33. Grodstein, F., Colditz, G. A., Hunter, D. J., Manson, J. E., Willett, W. C., and Stampfer, M. J. (1994) Obstet. Gynecol. 84, 207-214
34. Wang, H. H., Afdhal, N. H., and Wang, D. Q. (2004) Gastroenterology 127, 239-249
35. Hayhurst, G. P., Lee, Y. H., Lambert, G., Ward, J. M., and Gonzalez, F. J. (2001) Mol. Cell. Biol. 21, 1393-1403
36. Pauli-Magnus, C., Lang, T., Meier, Y., Zodan-Marin, T., Jung, D., Breymann, C., Zimmermann, R., Kenngott, S., Beuers, U., Reichel, C., Kerb, R., Penger, A., Meier, P. J., and Kullak-Ublick, G. A. (2004) Pharmacogenetics 14, 91-102
37. Savander, M., Ropponen, A., Avela, K., Weerasekera, N., Cormand, B., Hirvioja, M. L., Riikonen, S., Ylikorkala, O., Lehesjoki, A. E., Williamson, C., and Aittomaki, K. (2003) Gut 52, 1025-1029
38. Wang, R., Salem, M., Yousef, I. M., Tuchweber, B., Lam, P., Childs, S. J., Helgason, C. D., Ackerley, C., Phillips, M. J., and Ling, V. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 2011-2016
39. Invernizzi, P., Alvaro, D., Crosignani, A., Gaudio, E., and Podda, M. (2004) Hepatology 39, 1175-1176
40. Reddy, A., Prince, M., James, O. F., Jain, S., and Bassendine, M. F. (2004) Liver Int. 24, 194-197
41. Liu, Y., Binz, J., Numerick, M. J., Dennis, S., Luo, G., Desai, B., MacKenzie, K. I., Mansfield, T. A., Kliewer, S. A., Goodwin, B., and Jones, S. A. (2003) J. Clin. Investig. 112, 1678-1687
42. Moschetta, A., Bookout, A. L., and Mangelsdorf, D. J. (2004) Nat. Med. 10, 1352-1358
43. Lammert, F., Marschall, H. U., and Matern, S. (2003) Curr. Treat. Options Gastroenterol. 6, 123-132