Functional Modulation of the Glucocorticoid Receptor and Suppression of NF-κB-dependent Transcription by Ursodeoxycholic Acid

Journal of Biological Chemistry

Volumn 276, Issue 50, 2001, Pages 47371-47378

  Miura, Takanori ^a   Ouchida, Rika ^b   Yoshikawa, Noritada ^a,b   Okamoto, Kensaku ^a   Makino, Yuichi ^b   Nakamura, Tetsuya ^b   Morimoto, Chikao ^b   Makino, Isao ^a   Tanaka, Hirotoshi ^b  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BIOASSAY; BIOLOGICAL ORGANS; DISEASES; DNA; GENES;

IMMUNOMODULATOR;

ORGANIC ACIDS;

DEXAMETHASONE; GLUCOCORTICOID RECEPTOR; GLUCOCORTICOID RECEPTOR AGONIST; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SYNAPTOTAGMIN; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; CHOLAGOGUE; DNA; GLUCOCORTICOID; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LIGAND; NF KAPPA B P65; NF-KAPPA B P65; PHOTOPROTEIN;

ANIMAL CELL; ARTICLE; BILIARY CIRRHOSIS; CELL PROTECTION; CONTROLLED STUDY; DRUG SAFETY; IMMUNOSUPPRESSIVE TREATMENT; LIGAND BINDING; LIVER DISEASE; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RECEPTOR UPREGULATION; SPECIES DIFFERENTIATION; TRANSCRIPTION REGULATION; ACTIVE TRANSPORT; ANIMAL; CELL STRAIN COS1; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HELA CELL; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; NUCLEOTIDE SEQUENCE; PLASMID; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; PROTEIN TRANSPORT; REPORTER GENE; SERODIAGNOSIS; SIGNAL TRANSDUCTION; TIME; TRANSACTIVATION; WESTERN BLOTTING;

ANIMALIA;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMAL; BLOTTING, WESTERN; CHOLAGOGUES AND CHOLERETICS; COS CELLS; DEXAMETHASONE; DNA; DNA MUTATIONAL ANALYSIS; GENE EXPRESSION REGULATION; GENES, REPORTER; GLUCOCORTICOIDS, TOPICAL; HELA CELLS; HUMAN; IMMUNOHISTOCHEMISTRY; LIGANDS; LUMINESCENT PROTEINS; NF-KAPPA B; PLASMIDS; PRECIPITIN TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; RECEPTORS, GLUCOCORTICOID; RECOMBINANT FUSION PROTEINS; SIGNAL TRANSDUCTION; SUPPORT, NON-U.S. GOV'T; TIME FACTORS; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION, GENETIC; TRANSFECTION; URSODEOXYCHOLIC ACID;

EID: 0035861563     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M107098200     Document Type: Article

References (62)

1. Makino, I., and Tanaka, H. (1998) J. Gastroenterol. Hepatol. 13, 659-664
2. Gershwin, M. E., Ansari, A. A., Mackay, I. R., Nakanuma, Y., Nishio, A., Rowley, M. J., and Coppel, R. L. (2000) Immunol. Rev. 174, 210-225
3. Heathcote, E. J. (2000) Hepatology 31, 1005-1013
4. Lacaille, F., and Paradis, K. (1993) Hepatology 18, 165-172
5. Nishigaki, Y., Ohnishi, H., Moriwaki, H., and Muto, Y. (1996) Dig. Dis. Sci. 41, 1487-1493
6. Yamazaki, K., Suzuki, K., Nakamura, A., Sato, S., Lindor, K. D., Batts, K. P., Tarara, J. E., Kephart, G. M., Kita, H., and Gleich, G. J. (1999) Hepatology 30, 71-78
7. Yoshikawa, M., Tsujii, T., Matsumura, K., Yamao, J., Matsumura, Y., Kubo, R., Fukui, H., and Ishizaka, S. (1992) Hepatology 16, 358-364
8. Calmus, Y., Guechot, J., Podevin, P., Bonnefis, M. T., Giboudeau, J., and Poupon, R. (1992) Hepatology 16, 719-723
9. Hirano, F., Tanaka, H., Makino, Y., Okamoto, K., and Makino, I. (1996) J. Gastroenterol. 31, 55-60
10. Botla, R., Spivey, J. R., Aguilar, H., Bronk, S. F., and Gores, G. J. (1995) J. Pharmacol. Exp. Ther. 272, 930-938
11. Rodrigues, C. M., Fan, G., Ma, X., Kren, B. T., and Steer, C. J. (1998) J. Clin. Invest. 101, 2790-2799
12. Gustafsson, J. A., Carlstedt-Duke, J., Poellinger, L., Okret, S., Wikstrom, A. C., Bronnegard, M., Gillner, M., Dong, Y., Fuxe, K., and Cintra, A. (1987) Endocr. Rev. 8, 185-234
13. Reichardt, H. M., Tronche, F., Berger, S., Kellendonk, C., and Schutz, G. (2000) Adv. Pharmacol. 47, 1-21
14. Boumpas, D. T., Chrousos, G. P., Wilder, R. L., Cupps, T. R., and Balow, J. E. (1993) Ann. Intern. Med. 119, 1198-1208
15. Lee, K. C., and Lee Kraus, W. (2001) Trends Endocrinol. Metab. 12, 191-197
16. Evans, R. M. (1989) Recent Prog. Horm. Res. 45, 1-22
17. Kumar, R., and Thompson, E. B. (1999) Steroids 64, 310-319
18. Picard, D., Kumar, V., Chambon, P., and Yamamoto, K. R. (1990) Cell Regul. 1, 291-299
19. Gottlicher, M., Heck, S., and Herrlich, P. (1998) J. Mol. Med. 76, 480-489
20. Barnes, P. J., and Karin, M. (1997) N. Engl. J. Med. 336, 1066-1071
21. Ghosh, S., May, M. J., and Kopp, E. B. (1998) Annu. Rev. Immunol. 16, 225-260
22. Baldwin, A. S., Jr. (2001) J. Clin. Invest. 107, 3-6
23. Karin, M. (1999) Oncogene 18, 6867-6874
24. Ghosh, S. (1999) Immunol. Res. 19, 183-189
25. Uranishi, H., Tetsuka, T., Yamashita, M., Asamitsu, K., Shimizu, M., Itoh, M., and Okamoto, T. (2001) J. Biol. Chem. 276, 13395-13401
26. Hiramoto, M., Shimizu, N., Sugimoto, K., Tang, J., Kawakami, Y., Ito, M., Aizawa, S., Tanaka, H., Makino, I., and Handa, H. (1998) J. Immunol. 160, 810-819
27. Shimizu, N., Sugimoto, K., Tang, J., Nishi, T., Sato, I., Hiramoto, M., Aizawa, S., Hatakeyama, M., Ohba, R., Hatori, H., Yoshikawa, T., Suzuki, F., Oomori, A., Tanaka, H., Kawaguchi, H., Watanabe, H., and Handa, H. (2000) Nat. Biotechnol. 18, 877-881
28. Auphan, N., DiDonato, J. A., Rosette, C., Helmberg, A., and Karin, M. (1995) Science 270, 286-290
29. Scheinman, R. I., Gualberto, A., Jewell, C. M., Cidlowski, J. A., and Baldwin, A. S., Jr. (1995) Mol. Cell. Biol. 15, 943-953
30. Liden, J., Delaunay, F., Rafter, I., Gustafsson, J., and Okret, S. (1997) J. Biol. Chem. 272, 21467-21472
31. De Bosscher, K., Vanden Berghe, W., Vermeulen, L., Plaisance, S., Boone, E., and Haegeman, G. (2000) Proc. Natl. Acad. Sci. U. S. A. 97, 3919-3924
32. Nissen, R. M., and Yamamoto, K. R. (2000) Genes Dev. 14, 2314-2329
33. Adcock, I. M., Nasuhara, Y., Stevens, D. A., and Barnes, P. J. (1999) Br. J. Pharmacol. 127, 1003-1011
34. Vayssiere, B. M., Dupont, S., Choquart, A., Petit, F., Garcia, T., Marchandeau, C., Gronemeyer, H., and Resche-Rigon, M. (1997) Mol. Endocrinol. 11, 1245-1255
35. Hofmann, T. G., Hehner, S. P., Bacher, S., Droge, W., and Schmitz, M. L. (1998) FEBS Lett. 441, 441-446
36. Belvisi, M. G., Wicks, S. L., Battram, C. H., Bottoms, S. E., Redford, J. E., Woodman, P., Brown, T. J., Webber, S. E., and Foster, M. L. (2001) J. Immunol. 166, 1975-1982
37. Tanaka, H., Makino, Y., Miura, T., Hirano, F., Okamoto, K., Komura, K., Sato, Y., and Makino, I. (1996) J. Immunol. 156, 1601-1608
38. Makino, Y., Okamoto, K., Yoshikawa, N., Aoshima, M., Hirota, K., Yodoi, J., Umesono, K., Makino, I., and Tanaka, H. (1996) J. Clin. Invest. 98, 2469-2477
39. Okamoto, K., Tanaka, H., Ogawa, H., Makino, Y., Eguchi, H., Hayashi, S., Yoshikawa, N., Poellinger, L., Umesono, K., and Makino, I. (1999) J. Biol. Chem. 274, 10363-10371
40. Hong, H., Kohli, K., Garabedian, M. J., and Stallcup, M. R. (1997) Mol. Cell. Biol. 17, 2735-2744
41. Htun, H., Barsony, J., Renyi, I., Gould, D. L., and Hager, G. L. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 4845-4850
42. Baumann, C. T., Ma, H., Wolford, R., Reyes, J. C., Maruvada, P., Lim, C., Yen, P. M., Stallcup, M. R., and Hager, G. L. (2001) Mol. Endocrinol. 15, 485-500
43. Poupon, R., Chazouilleres, O., Balkau, B., and Poupon, R. E. (1999) J. Hepatol. 30, 408-412
44. Parks, D. J., Blanchard, S. G., Bledsoe, R. K., Chandra, G., Consler, T. G., Kliewer, S. A., Stimmel, J. B., Willson, T. M., Zavacki, A. M., Moore, D. D., and Lehmann, J. M. (1999) Science 284, 1365-1368
45. Makishima, M., Okamoto, A. Y., Repa, J. J., Tu, H., Learned, R. M., Luk, A., Hull, M. V., Lustig, K. D., Mangelsdorf, D. J., and Shan, B. (1999) Science 284, 1362-1365
46. Wang, H., Chen, J., Hollister, K., Sowers, L. C., and Forman, B. M. (1999) Mol. Cell 3, 543-553
47. Sinal, C. J., Tohkin, M., Miyata, M., Ward, J. M., Lambert, G., and Gonzalez, F. J. (2000) Cell 102, 731-744
48. Tu, H., Okamoto, A. Y., and Shan, B. (2000) Trends Cardiovasc. Med. 10, 30-35
49. Bouscarel, B., Fromm, H., and Nussbaum, R. (1993) Am. J. Physiol. 264, G243-G251
50. Sanchez, E. R. (1992) J. Biol. Chem. 267, 17-20
51. Galigniana, M. D., Scruggs, J. L., Herrington, J., Welsh, M. J., Carter-Su, C., Housley, P. R., and Pratt, W. B. (1998) Mol. Endocrinol. 12, 1903-1913
52. Hollenberg, S. M., and Evans, R. M. (1988) Cell 55, 899-906
53. Gustafsson, J. A., Dahlman-Wright, K., Stromstedt, P. E., Wright, T., and Carlstedt-Duke, J. (1990) Princess Takamatsu Symp. 21, 137-155
54. Wan, Y., Coxe, K. K., Thackray, V. G., Housley, P. R., and Nordeen, S. K. (2001) Mol. Endocrinol. 15, 17-31
55. Sheldon, L. A., Smith, C. L., Bodwell, J. E., Munck, A. U., and Hager, G. L. (1999) Mol. Cell. Biol. 19, 8146-8157
56. Roux, S., Terouanne, B., Couette, B., Rafestin-Oblin, M. E., and Nicolas, J. C. (1999) J. Biol. Chem. 274, 10059-10065
57. Prima, V., Depoix, C., Masselot, B., Formstecher, P., and Lefebvre, P. (2000) J. Steroid Biochem. Mol. Biol. 72, 1-12
58. Vanden Berghe, W., Francesconi, E., De Bosscher, K., Resche-Rigon, M., and Haegeman, G. (1999) Mol. Pharmacol. 56, 797-806
59. Ozaki, S., Tashiro, A., Makino, I., Nakagawa, S., and Yoshizawa, I. (1979) J. Lipid Res. 20, 240-245
60. Lianidou, E. S., Papastathopoulos, D. S., and Siskos, P. A. (1989) Anal. Biochem. 179, 341-346
61. Ewerth, S., Angelin, B., Einarsson, K., Nilsell, K., and Bjorkhem, I. (1985) Gastroenterology 88, 126-133
62. Setchell, K. D. R., Rodrigues, C. M. P., Clerici, C., Solinas, A., Morelli, A., Gartung, C., and Boyer, J. (1997) Gastroenterology 112, 226-235