Regulation of MRP2/ABCC2 and BSEP/ABCB11 expression in sandwich cultured human and rat hepatocytes exposed to inflammatory cytokines TNF-α, IL-6, and IL-1β

Journal of Biological Chemistry

Volumn 285, Issue 41, 2010, Pages 31185-31192

  Diao, Lei ^a,b   Li, Na ^a,c   Brayman, Timothy G ^a   Hotz, Kathy J ^a   Lai, Yurong ^a  

^a PFIZER INC   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^c BD Biosciences Discovery Labware2 ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LAWS AND LEGISLATION; RATS;

CYTOKINES; DIFFERENTIAL EFFECT; HEPATOCYTES; HUMAN HEPATOCYTES; IN-VITRO; IN-VIVO; INFLAMMATORY CYTOKINES; LIPOPOLYSACCHARIDES; LPS TREATMENT; MRNA LEVEL; POST TREATMENT; PROINFLAMMATORY CYTOKINES; PROTEIN LEVEL; RAT HEPATOCYTES;

PROTEINS;

ABC TRANSPORTER; ABC TRANSPORTER B11; CYTOKINE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ABCB11 PROTEIN, HUMAN; ABCB11 PROTEIN, RAT; ABCC2 PROTEIN, RAT; IL6 PROTEIN, HUMAN; LIPOPOLYSACCHARIDE; MULTIDRUG RESISTANCE PROTEIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEIN 2;

ANIMAL CELL; ANIMAL CELL CULTURE; ARTICLE; CONTROLLED STUDY; CULTURE TECHNIQUE; CYTOKINE RELEASE; DOWN REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; RAT; REGULATORY MECHANISM; ACUTE PHASE RESPONSE; ANIMAL; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; METABOLISM; PHYSIOLOGY; TIME;

RATTUS;

ACUTE-PHASE REACTION; ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; CELLS, CULTURED; DOWN-REGULATION; HEPATOCYTES; HUMANS; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MODELS, BIOLOGICAL; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; RATS; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 77957786509     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.107805     Document Type: Article

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