A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 278, Issue 1 41-1, 2000, Pages

  König, Jörg ^a   Cui, Yunhai ^a   Nies, Anne T ^a   Keppler, Dietrich ^a  

^a GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

17 glucuronosyl estradiol; Bilirubin conjugates; Hepatic transport; SLC21A6; Sulfobromophthalein

Indexed keywords

17BETA GLUCURONOSYL ESTRADIOL; BILIRUBIN; BROMSULFOPHTHALEIN; MONOGLUCURONOSYL BILIRUBIN; ORGANIC ANION TRANSPORTING POLYPEPTIDE; RECOMBINANT PROTEIN; STERYL SULFATASE; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL CELL; ANION TRANSPORT; ARTICLE; BASOLATERAL MEMBRANE; CELLULAR DISTRIBUTION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; HUMAN; HUMAN CELL; LIVER CELL; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; TISSUE DISTRIBUTION;

EID: 0037733365     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.278.1.g156     Document Type: Article

References (42)

1. Abe, T., M. Kakyo, H. Sakagami, T. Tokui, T. Nishio, M. Tanemoto, H. Nomura, S. C. Hebert, S. Matsuno, H. Kondo, and H. Yawo. Molecular characterization and tissue distribution of a new organic anion transporter subtype (oatp3) that transports thyroid hormones and taurocholate and comparison with oatp2. J. Biol. Chem. 273: 22395-22401, 1998.
2. Abe, T., M. Kakyo, T. Tokui, R. Nakagomi, T. Nishio, D. Nakai, H. Nomura, M. Unno, M. Suzuki, T. Naitoh, S. Matsuno, and H. Yawo. Identification of a novel gene family encoding human liver specific organic anion transporter LST-1. J. Biol. Chem. 274: 17159-17163, 1999.
3. Alpini, G., S. Roberts, S. M. Kuntz, Y. Ueno, S. Gubba, P. V. Podila, G. LeSage, and N. F. LaRusso. Morphological, molecular, and functional heterogeneity of cholangiocytes from normal rat liver. Gastroenterology 110: 1636-1643, 1996.
4. Angeletti, R. H., P. M. Novikoff, S. R. Juvvadi, J. M. Fritschy, P. J. Meier, and A. W. Wolkoff. The choroid plexus epithelium is the site of the organic anion transport protein in the brain. Proc. Natl. Acad. Sci. USA 94: 283-286, 1997.
5. Bergwerk, A. J., X. Shi, A. C. Ford, N. Kanai, E. Jacquemin, R. D. Burk, S. Bai, P. M. Novikoff, B. Stieger, P. J. Meier, V. L. Schuster, and A. W. Wolkoff. Immunologic distribution of an organic anion transport protein in rat liver and kidney. Am. J. Physiol. Gastrointest. Liver Physiol. 271: G231-G238, 1996.
6. Böhme, M., M. Müller, I. Leier, G. Jedlitschky, and D. Keppler. Cholestasis caused by inhibition of the adenosine triphosphate-dependent bile salt transport in rat liver. Gastroenterology 107: 255-265, 1994.
7. Bossuyt, X., M. Müller, B. Hagenbuch, and P. J. Meier. Polyspecific drug and steroid clearance by an organic anion transporter of mammalian liver. J. Pharmacol. Exp. Ther. 276: 891-896, 1996.
8. Brewer, C. B. Cytomegalovirus plasmid vectors for permanent lines of polarized epithelial cells. Methods Cell Biol. 43: 233-245, 1994.
9. Cui, Y., J. König, U. Buchholz, H. Spring, I. Leier, and D. Keppler. Drug resistance and ATP-dependent conjugate transport mediated by the apical multidrug resistance protein, MRP2, permanently expressed in human and canine cells. Mol. Pharmacol. 55: 929-937, 1999.
10. Devereux, J., P. Haeberli, and O. Smithies. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12: 387-395, 1984.
11. Eckhardt, U., A. Schroeder, B. Stieger, M. Hochli, L. Landmann, R. Tynes, P. J. Meier, and B. Hagenbuch. Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am. J. Physiol. Gastrointest. Liver Physiol. 276: G1037-G1042, 1999.
12. +/bile acid cotransporter. J. Clin. Invest. 93: 1326-1331, 1994.
13. +/bile acid cotransport system. Proc. Natl. Acad. Sci. USA 88: 10629-10633, 1991.
14. Hubbard, A. L., V. A. Barr, and L. J. Scott. Hepatocyte surface polarity. In: The Liver, Biology and Pathobiology, edited by I. M. Arias, J. L. Boyer, N. Fausto, W. B. Jakoby, D. A. Schachter, and D. A. Shafritz. New York: Raven, 1994, p. 189-213.
15. Jacquemin, E., B. Hagenbuch, B. Stieger, A. W. Wolkoff, and P. J. Meier. Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc. Natl. Acad. Sci. USA 91: 133-137, 1994.
16. Jedlitschky, G., I. Leier, U. Buchholz, J. Hummel-Eisenbeiss, B. Burchell, and D. Keppler. ATP-dependent transport of bilirubin glucuronides by the multidrug resistance protein MRP1 and its hepatocyte canalicular isoform MRP2. Biochem. J. 327: 305-310, 1997.
17. Kakyo, M., H. Sakagami, T. Nishio, D. Nakai, R. Nakagomi, T. Tokui, T. Naitoh, S. Matsuno, T. Abe, and H. Yawo. Immunohistochemical distribution and functional characterization of an organic anion transporting polypeptide 2 (oatp2). FEBS Lett. 445: 343-346, 1999.
18. Kamisako, T., I. Leier, Y. Cui, J. König, U. Buchholz, J. Hummel-Eisenbeiss, and D. Keppler. Transport of monoglucuronosyl and bisglucuronosyl bilirubin by recombinant human and rat multidrug resistance protein 2. Hepatology 30: 485-490, 1999.
19. Kanai, N., R. Lu, Y. Bao, A. W. Wolkoff, and V. L. Schuster. Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 270: F319-F325, 1996.
20. Kanai, N., R. Lu, Y. Bao, A. W. Wolkoff, M. Vore, and V. L. Schuster. Estradiol 17β-D-glucuronide is a high-affinity substrate for oatp organic anion transporter. Am. J. Physiol. Renal Fluid Electrolyte Physiol. 270: F326-F331, 1996.
21. Kanai, N., R. Lu, J. A. Satriano, Y. Bao, A. W. Wolkoff, and V. L. Schuster. Identification and characterization of a prostaglandin transporter. Science 268: 866-869, 1995.
22. Keppler, D., and I. M. Arias. Hepatic canalicular membrane. Introduction: transport across the hepatocyte canalicular membrane. FASEB J. 11: 15-18, 1997.
23. Kontaxi, M., U. Echkardt, B. Hagenbuch, B. Stieger, P. J. Meier, and E. Petzinger. Uptake of the mycotoxin ochratoxin A in liver cells occurs via the cloned organic anion transporting polypeptide. J. Pharmacol. Exp. Ther. 279: 1507-1513, 1996.
24. Kool, M., M. van der Linden, M. de Haas, G. L. Scheffer, J. M. de Vree, A. J. Smith, G. Jansen, G. J. Peters, N. Ponne, R. J. Scheper, R. P. Elferink, F. Baas, and P. Borst. MRP3, an organic anion transporter able to transport anti-cancer drugs. Proc. Natl. Acad. Sci. USA 96: 6914-6919, 1999.
25. König, J., D. Rost, Y. Cui, and D. Keppler. Characterization of the human multidrug resistance protein isoform MRP3 localized to the basolateral hepatocyte membrane. Hepatology 29: 1156-1163, 1999.
26. Kozak, M. Compilation and analysis of sequences upstream from the translational start site in eukaryotic mRNAs. Nucleic Acids Res. 12: 857-872, 1984.
27. Kullak-Ublick, G. A., T. Fisch, M. Oswald, B. Hagenbuch, P. J. Meier, U. Beuers, and G. Paumgartner. Dehydroepiandrosterone sulfate (DHEAS): identification of a carrier protein in human liver and brain. FEBS Lett. 424: 173-176, 1998.
28. Kullak-Ublick, G. A., B. Hagenbuch, B. Stieger, C. D. Schteingart, A. F. Hofmann, A. W. Wolkoff, and P. J. Meier. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 109: 1274-1282, 1995.
29. Kullak-Ublick, G. A., B. Hagenbuch, B. Stieger, A. W. Wolkoff, and P. J. Meier. Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology 20: 411-416, 1994.
30. Lineweaver, H., and D. Burk. The determination of enzyme dissociation constants. J. Am. Chem. Soc. 56: 658-666, 1934.
31. Lu, R., N. Kanai, Y. Bao, and V. L. Schuster. Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J. Clin. Invest. 98: 1142-1149, 1996.
32. Lu, R., and V. L. Schuster. Molecular cloning of the gene for the human prostaglandin transporter hPGT: gene organization, promoter activity, and chromosomal localization. Biochem. Biophys. Res. Commun. 246: 805-812, 1998.
33. Masuda, S., K. Ibaramoto, A. Takeuchi, H. Saito, Y. Hashimoto, and K. I. Inui. Cloning and functional characterization of a new multispecific organic anion transporter, OAT-K2, in rat kidney. Mol. Pharmacol. 55: 743-752, 1999.
34. Meier, P. J., U. Eckhardt, A. Schroeder, B. Hagenbuch, and B. Stieger. Substrate specificity of sinusoidal bile acid and organic anion uptake systems in rat and human liver. Hepatology 26: 1667-1677, 1997.
35. Noe, B., B. Hagenbuch, B. Stieger, and P. J. Meier. Isolation of a multispecific organic anion and cardiac glycoside transporter from rat brain. Proc. Natl. Acad. Sci. USA 94: 10346-10350, 1997.
36. Saito, H., S. Masuda, and K. I. Inui. Cloning and functional characterization of a novel rat organic anion transporter mediating basolateral uptake of methotrexate in the kidney. J. Biol. Chem. 271: 20719-20725, 1996.
37. Sanger, F., A. R. Coulson, B. G. Barrell, A. J. Smith, and B. A. Roe. Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J. Mol. Biol. 143: 161-178, 1980.
38. Senger, M., K. H. Glatting, O. Ritter, and S. Suhai. X-HUSAR, an X-based graphical interface for the analysis of genomic sequences. Comput. Methods Programs Biomed. 46: 131-141, 1995.
39. Shi, X., S. Bai, A. C. Ford, R. D. Burk, E. Jacquemin, B. Hagenbuch, P. J. Meier, and A. W. Wolkoff. Stable inducible expression of a functional rat liver organic anion transport protein in HeLa cells. J. Biol. Chem. 270: 25591-25595, 1995.
40. Sonnhammer, E. L., G. von Heijne, and A. Krogh. A hidden Markov model for predicting transmembrane helices in protein sequences. Ismb 6: 175-182, 1998.
41. Stieger, B., and P. J. Meier. Bile acid and xenobiotic transporters in liver. Curr. Opin. Cell Biol. 10: 462-467, 1998.
42. Volz, B., G. Orberger, S. Porwoll, H. P. Hauri, and R. Tauber. Selective reentry of recycling cell surface glycoproteins to the biosynthetic pathway in human hepatocarcinoma HepG2 cells. J. Cell Biol. 130: 537-551, 1995.