The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions

Clinical Pharmacology and Therapeutics

Volumn 69, Issue 4, 2001, Pages 223-231

  Fattinger, Karin ^a,b,c   Funk, Christoph ^a,b,c   Pantze, Michael ^a,b,c   Weber, Cornelia ^a,b,c   Reichen, Jürg ^a,b,c   Stieger, Bruno ^a,b,c   Meier, Peter J ^a,b,c  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^b F Hoffmann La Roche Zurich Ltd   (Switzerland)

^c UNIVERSITY OF BERN   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; BILE SALT; BOSENTAN; DRUG METABOLITE; GLIBENCLAMIDE; TAUROCHOLIC ACID;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CYTOTOXICITY; DOSE RESPONSE; DRUG EFFECT; DRUG INDUCED DISEASE; DRUG INHIBITION; DRUG POTENTIATION; DRUG SAFETY; HUMAN; INTRAHEPATIC CHOLESTASIS; LIVER CELL DAMAGE; LIVER INJURY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; ANTIHYPERTENSIVE AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; BILE CANALICULI; CHOLESTASIS, INTRAHEPATIC; CLINICAL TRIALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; GLYBURIDE; HUMANS; HYPERTENSION; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; RECEPTORS, ENDOTHELIN; SULFONAMIDES; TAUROCHOLIC ACID;

EID: 0035036050     PISSN: 00099236     EISSN: None     Source Type: Journal    
DOI: 10.1067/mcp.2001.114667     Document Type: Article

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