Pleiotropic functions of the organic solute transporter Ostα-Ostβ

Digestive Diseases

Volumn 29, Issue 1, 2011, Pages 13-17

  Ballatori, Nazzareno ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Bile acids; Fxr; Neurosteroids; Ost Ost ; Ost mice

Indexed keywords

BILE ACID; CYCLIC AMP DEPENDENT PROTEIN KINASE; FARNESOID X RECEPTOR; MEMBRANE PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NEUROSTEROID; ORGANIC SOLUTE TRANSPORTER ALPHA BETA; PREGNANE X RECEPTOR; PROTEIN KINASE C; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

BILE ACID METABOLISM; BILE ACID SYNTHESIS; CONFERENCE PAPER; ENZYME ACTIVATION; ENZYME SPECIFICITY; HUMAN; INTESTINE ABSORPTION; INTESTINE CELL; NONHUMAN; PLEIOTROPY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; TISSUE DISTRIBUTION;

ANIMALS; BILE ACIDS AND SALTS; HUMANS; MEMBRANE TRANSPORT PROTEINS; ORGAN SPECIFICITY; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STEROLS;

EID: 79959524834     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000324123     Document Type: Conference Paper

References (38)

1. Ballatori N: Biology of a novel organic solute and steroid transporter, OST alpha-OST beta. Exp Biol Med 2005; 230: 689-698. (Pubitemid 41565937)
2. Ballatori N, Li N, Fang F, Boyer JL, Christian WV, Hammond CL: OST alpha-OST beta: a key membrane transporter of bile acids and conjugated steroids. Front Biosci 2009; 14: 2829-2844.
3. Dawson PA, Hubbert M, Haywood J, Craddock AL, Zerangue N, Christian WV, Ballatori N: The heteromeric organic solute transporter alpha-beta, Ost alpha-Ost beta, is an ileal basolateral bile acid transporter. J Biol Chem 2005; 280:6960-6968. (Pubitemid 40341252)
4. Ballatori N, Fang F, Christian WV, Li N, Hammond CL: Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol 2008; 295:G179-G186.
5. Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA: The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci USA 2008; 105:3891-3896. (Pubitemid 351723495)
6. Wang W, Seward DJ, Li L, Boyer JL, Ballatori N: Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate. Proc Natl Acad Sci USA 2001; 98:9431-9436. (Pubitemid 32743934)
7. Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OST alpha-OST beta. J Biol Chem 2003; 278: 27473-27482. (Pubitemid 36899930)
8. Li N, Cui Z, Fang F, Lee JY, Ballatori N: Heterodimerization, trafficking, and membrane topology of the two proteins, Ost alpha and Ost beta, that constitute the organic solute and steroid transporter. Biochem J 2007; 407: 363-372. (Pubitemid 350058470)
9. Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, Madejczyk MS, Li N: OSTalpha-OSTbeta: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. Hepatology 2005; 42:1270-1279. (Pubitemid 43260029)
10. Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Moustafa T, Zollner G, Lee JY, Ballatori N: Upregulation of a basolateral FXR-dependent bile acid efflux transporter OST-alpha-OSTbeta in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 2006; 290: G1124-G1130. (Pubitemid 43788293)
11. Soroka CJ, Mennone A, Hagey LR, Ballatori N, Boyer JL: Mouse organic solute transporter alpha deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology 2010; 51: 181-190.
12. Soroka CJ, Ballatori N, Boyer JL: Organic solute transporter, OSTalpha-OSTbeta: its role in bile acid transport and cholestasis. Semin Liver Dis 2010; 30:178-185.
13. Dawson PA, Hubbert ML, Rao A: Getting the mOST from OST: Role of organic solute transporter, OSTalpha-OSTbeta, in bile acid and steroid metabolism. Biochim Biophys Acta 2010; 1801: 994-1004.
14. Ogundare M, Theofilopoulos S, Lockhart A, Hall LJ, Arenas E, Sjövall J, Brenton AG, Wang Y, Griffiths WJ: Cerebrospinal fluid steroidomics: are bioactive bile acids present in brain? J Biol Chem 2010; 285:4666-4679.
15. Smith LP, Nierstenhoefer M, Yoo SW, Penzias AS, Tobiasch E, Usheva A: The bile acid synthesis pathway is present and functional in the human ovary. PLoS One 2009; 4:e7333.
16. Fang F, Christian WV, Gorman SG, Cui M, Huang J, Tieu K, Ballatori N: Neurosteroid transport by the organic solute transporter OSTα-OSTβ. J Neurochem 2010; 115:220-233.
17. Wang YD, Chen WD, Moore DD, Huang W: FXR: a metabolic regulator and cell protector. Cell Res 2008; 18: 1087-1095.
18. Modica S, Bellafante E, Moschetta A: Master regulation of bile acid and xenobiotic metabolism via the FXR, PXR and CAR trio. Front Biosci 2009; 14:4719-4745.
19. Lefebvre P, Cariou B, Lien F, Kuipers F, Staels B: Role of bile acids and bile acidreceptors in metabolic regulation. Physiol Rev 2009; 89: 147-191.
20. Trauner M, Claudel T, Fickert P, Moustafa T, Wagner M: Bile acids as regulators of hepatic lipid and glucose metabolism. Dig Dis 2010; 28:220-224.
21. Hylemon PB, Zhou H, Pandak WM, Ren S, Gil G, Dent P: Bile acids as regulatory molecules. J Lipid Res 2009; 50:1509-1520.
22. Fiorucci S, Cipriani S, Mencarelli A, Renga B, Distrutti E, Baldelli F: Counter-regulatory role of bile acid activated receptors in immunity and inflammation. Curr Mol Med 2010; 10:579-595.
23. Verreault M, Kaeding J, Caron P, Trottier J, Grosse L, Houssin E, Pâquet S, Perreault M, Barbier O: Regulation of endobiotics glucuronidation by ligand-activated transcription factors: physiological function and therapeutic potential. Drug Metab Rev 2010; 42: 106-118.
24. Poole DP, Godfrey C, Cattaruzza F, Cottrell GS, Kirkland JG, Pelayo JC, Bunnett NW, Corvera CU: Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system. Neurogastroenterol Motil 2010; 22: 814-825.
25. Kassam A, Miao B, Young PR, Mukherjee R: Retinoid X receptor (RXR) agonist-induced antagonism of farnesoid X receptor (FXR) activity due to absence of coactivator recruitment and decreased DNA binding. J Biol Chem 2003; 278: 10028-10032. (Pubitemid 36800256)
26. Zhao A, Yu J, Lew JL, Huang L, Wright SD, Cui J: Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. DNA Cell Biol 2004; 23: 519-526. (Pubitemid 39050558)
27. Nishimaki-Mogami T, Kawahara Y, Tamehiro N, Yoshida T, Inoue K, Ohno Y, Nagao T, Une M: 5Alpha-bile alcohols function as farnesoid X receptor antagonists. Biochem Biophys Res Commun 2006; 339:386-391. (Pubitemid 41697562)
28. Cai SY, Xiong L, Wray CG, Ballatori N, Boyer JL: The farnesoid X receptor FXRalpha/NR1H4 acquired ligand specificity for bile salts late in vertebrate evolution. Am J Physiol Regul Integr Comp Physiol 2007; 293: R1400-R1409. (Pubitemid 47358967)
29. Cai SY, He H, Nguyen T, Mennone A, Boyer JL: Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR-dependent and independent mechanisms. J Lipid Res 2010; 51: 2265-2274.
30. Kaimal R, Song X, Yan B, King R, Deng R: Differential modulation of farnesoid X receptor signaling pathway by the thiazolidinediones. J Pharmacol Exp Ther 2009; 330: 125-134.
31. Iguchi Y, Yamaguchi M, Sato H, Kihira K, Nishimaki-Mogami T, Une M: Bile alcohols function as the ligands of membrane-type bile acid-activated G protein-coupled receptor. J Lipid Res 2010; 51: 1432-1441.
32. Iguchi Y, Kihira K, Nishimaki-Mogami T, Une M: Structure-activity relationship of bile alcohols as human farnesoid X receptor agonist. Steroids 2010; 75: 95-100.
33. Keitel V, Görg B, Bidmon HJ, Zemtsova I, Spomer L, Zilles K, Häussinger D: The bile acid receptor TGR5 (Gpbar-1) acts as a neurosteroid receptor in brain. Glia 2010; 15: 1794-1805.
34. Liu W, Wong C: Oleanolic acid is a selective farnesoid X receptor modulator. Phytother Res 2010; 24:369-373.
35. Herbert MR, Siegel DL, Staszewski L, Cayanan C, Banerjee U, Dhamija S, Anderson J, Fan A, Wang L, Rix P, Shiau AK, Rao TS, Noble SA, Heyman RA, Bischoff E, Guha M, Kabakibi A, Pinkerton AB: Synthesis and SAR of 2-aryl-3-aminomethylquinolines as agonists of the bile acid receptor TGR5. Bioorg Med Chem Lett 2010; 20:5718-5721.
36. Budzik BW, Evans KA, Wisnoski DD, Jin J, Rivero RA, Szewczyk GR, Jayawickreme C, Moncol DL, Yu H: Synthesis and structure-activity relationships of a series of 3-aryl-4-isoxazolecarboxamides as a new class of TGR5 agonists. Bioorg Med Chem Lett 2010; 20: 1363-1367.
37. Genet C, Strehle A, Schmidt C, Boudjelal G, Lobstein A, Schoonjans K, Souchet M, Auwerx J, Saladin R, Wagner A: Structure-activity relationship study of betulinic acid, a novel and selective TGR5 agonist, and its synthetic derivatives: potential impact in diabetes. J Med Chem 2010; 53: 178-190.
38. Hwang JH, Parton A, Czechanski A, Ballatori N, Barnes D: Arachidonic acid-induced expression of the organic solute and steroid transporter-beta (Ost-beta) in a cartilaginous fish cell line. Comp Biochem Physiol C Toxicol Pharmacol 2008; 148:39 - 47.