FXR Controls the Tumor Suppressor NDRG2 and FXR Agonists Reduce Liver Tumor Growth and Metastasis in an Orthotopic Mouse Xenograft Model

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Deuschle, Ulrich ^a   Schüler, Julia ^b   Schulz, Andreas ^a   Schlüter, Thomas ^a   Kinzel, Olaf ^a   Abel, Ulrich ^c   Kremoser, Claus ^a  

^a PHENEX PHARMACEUTICALS AG   (Germany)

^b CHARLES RIVER LABORATORIES   (United States)

^c MERZ PHARMACEUTICALS GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ANTINEOPLASTIC AGENT; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR AGONIST; MESSENGER RNA; PX 20350; PX 20606; SORAFENIB; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; COLORECTAL CARCINOMA; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; DRUG PROTEIN BINDING; DRUG STRUCTURE; FEMALE; GENE CONTROL; HEPATOMA CELL; HUMAN; HUMAN CELL; INTESTINE CANCER; INTRON; LIVER CELL CARCINOMA; LIVER TUMOR; METASTASIS; MOUSE; N MYC DOWNREGULATED GENE 2; NDRG2 GENE; NONHUMAN; PREVALENCE; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; STRUCTURE ANALYSIS; TRANSCRIPTION REGULATION; TUMOR SUPPRESSOR GENE; TUMOR XENOGRAFT;

ANIMALS; BINDING SITES; BLOTTING, WESTERN; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HEK293 CELLS; HEP G2 CELLS; HUMANS; ISOXAZOLES; LIVER; LIVER NEOPLASMS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, NUDE; NEOPLASM METASTASIS; PROTEIN BINDING; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA INTERFERENCE; TUMOR BURDEN; TUMOR SUPPRESSOR PROTEINS; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84867305638     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043044     Document Type: Article

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