Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid x receptor ligand, in estrogen-induced cholestasis

Journal of Pharmacology and Experimental Therapeutics

Volumn 313, Issue 2, 2005, Pages 604-612

  Fiorucci, Stefano ^a,d   Clerici, Carlo ^a   Antonelli, Elisabetta ^a   Orlandi, Stefano ^a   Goodwin, Bryan ^b   Sadeghpour, Bahman M ^a   Sabatino, Giuseppe ^a   Russo, Giuseppe ^a   Castellani, Danilo ^a   Willson, Timothy M ^b   Pruzanski, Mark ^c   Pellicciari, Roberto ^a   Morelli, Antonio ^a  

^a UNIVERSITY OF PERUGIA   (Italy)

^b GLAXOSMITHKLINE   (United States)

^c INTERCEPT PHARMACEUTICALS   (United States)

^d POLICLINICO MONTELUCE   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; 6 ETHYL CHENODEOXYCHOLIC ACID; BILE ACID; CHENODEOXYCHOLIC ACID; CHOLESTEROL 7ALPHA MONOOXYGENASE; CHOLIC ACID; CYTOCHROME P450; CYTOCHROME P450 8B1; ESTROGEN; ETHINYLESTRADIOL; FARNESOID X RECEPTOR; INT 747; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MURICHOLIC ACID; OXYSTEROL; OXYSTEROL 12BETA HYDROXYLASE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE SHP; SODIUM ION; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE FLOW; CHOLESTASIS; CONTROLLED STUDY; DRUG EFFICACY; DRUG MECHANISM; IN VIVO STUDY; LIVER CELL; LIVER PROTECTION; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TRANSPORT; RAT;

ANIMALS; CHENODEOXYCHOLIC ACID; CHOLESTASIS; DNA-BINDING PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTROGENS; HEPATOCYTES; LIGANDS; MALE; RATS; RATS, WISTAR; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 20944450029     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.079665     Document Type: Article

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