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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 12, 2012, Pages 3962-3966

E297G mutated bile salt export pump (BSEP) function enhancers derived from GW4064: Structural development study and separation from farnesoid X receptor-agonistic activity

(5) Misawa, Takashi a Hayashi, Hisamitsu a Makishima, Makoto b Sugiyama, Yuichi a Hashimoto, Yuichi a

a UNIVERSITY OF TOKYO (Japan)

b NIHON UNIVERSITY (Japan)

Author keywords

Bile acid; Bile salt export pump; Farnesoid X receptor; Mutant

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ABC TRANSPORTER; BILE SALT EXPORT PUMP; CARBOXYLIC ACID DERIVATIVE; HORMONE RECEPTOR STIMULATING AGENT; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION;

ANIMALS; ATP-BINDING CASSETTE TRANSPORTERS; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELL LINE; DOGS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; ISOXAZOLES; MUTATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84861572217 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2012.04.099 Document Type: Article

Times cited : (8)

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