Compensatory induction of liver efflux transporters in response to ANIT-induced liver injury is impaired in FXR-Null mice

Toxicological Sciences

Volumn 110, Issue 1, 2009, Pages 47-60

  Cui, Yue J ^a   Aleksunes, Lauren M ^a   Tanaka, Yuji ^a   Goedken, Michael J ^b   Klaassen, Curtis D ^a  

^a UNIVERSITY OF KANSAS SCHOOL OF MEDICINE   (United States)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

ANIT; Bile acids; FXR; Liver; PXR; Transporters

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; 3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATASE 8B1; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; BILE ACID; BILE ACID CONJUGATE; BILE SALT EXPORT PUMP; BILIRUBIN; FARNESOID X RECEPTOR; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 1A1; ORGANIC ANION TRANSPORTER 1A4; ORGANIC ANION TRANSPORTER 1B2; ORGANIC ANION TRANSPORTER ALPHA; ORGANIC ANION TRANSPORTER BETA; PREGNANE X RECEPTOR; TAUROCHOLIC ACID; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; C57BL 6 MOUSE; CONTROLLED STUDY; GENE EXPRESSION; GENOTYPE; HISTOPATHOLOGY; LIVER CELL; LIVER INJURY; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION;

1-NAPHTHYLISOTHIOCYANATE; ALANINE TRANSAMINASE; ANIMALS; ASPARTATE AMINOTRANSFERASES; BILE ACIDS AND SALTS; BIOLOGICAL MARKERS; BRANCHED DNA SIGNAL AMPLIFICATION ASSAY; CARRIER PROTEINS; CHOLESTASIS, INTRAHEPATIC; FLUORESCENT ANTIBODY TECHNIQUE; HEPATITIS, TOXIC; ISOXAZOLES; LIVER; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA;

MUS; RODENTIA;

EID: 67649208211     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfp094     Document Type: Article

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