Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-κB signaling in the intestine

Biochimica et Biophysica Acta - Molecular Basis of Disease

Volumn 1812, Issue 8, 2011, Pages 851-858

  Gadaleta, Raffaella M ^a,b   Oldenburg, Bas ^a   Willemsen, Ellen C L ^a   Spit, Maureen ^a   Murzilli, Stefania ^b,c   Salvatore, Lorena ^b   Klomp, Leo W J ^a   Siersema, Peter D ^a   van Erpecum, Karel J ^a   van Mil, Saskia W C ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b Laboratorio Angela Valenti dei Fattori Genetici e Ambientali di Rischio Trombotico   (Italy)

^c Sta Maria Imbaro (Ch)   (Italy)

Author keywords

Farnesoid X Receptor; Inflammatory bowel disease; Mutual inhibition; Nuclear factor B

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; DIMETHYL SULFOXIDE; FARNESOID X RECEPTOR; GLUTATHIONE TRANSFERASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1BETA; OBETICHOLIC ACID; PROTEIN P50; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; CARCINOMA CELL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INHIBITION; FGF15/19 GENE; GENE; GENE TARGETING; HUMAN; HUMAN CELL; IBABP GENE; IN VITRO STUDY; INHIBITION KINETICS; INTERMETHOD COMPARISON; KNOCKOUT MOUSE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; BILE ACIDS AND SALTS; CELL LINE; CYTOKINES; HUMANS; INFLAMMATION MEDIATORS; INTESTINES; MALE; MICE; MICE, INBRED C57BL; NF-KAPPA B; RECEPTORS, CYTOPLASMIC AND NUCLEAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

MUS;

EID: 79958278121     PISSN: 09254439     EISSN: 1879260X     Source Type: Journal    
DOI: 10.1016/j.bbadis.2011.04.005     Document Type: Review

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