Identification of a chemical tool for the orphan nuclear receptor FXR

Journal of Medicinal Chemistry

Volumn 43, Issue 16, 2000, Pages 2971-2974

  Maloney, P R ^a   Parks, D J ^a   Haffner, C D ^a   Fivush, A M ^a   Chandra, G ^a   Plunket, K D ^a   Creech, K L ^a   Moore, L B ^a   Wilson, J G ^a   Lewis, M C ^a   Jones, S A ^a   Willson, T M ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; BILE ACID; CELL NUCLEUS RECEPTOR; CHOLESTEROL; ISOXAZOLE DERIVATIVE; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; CATALYSIS; CHOLESTEROL METABOLISM; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; LETTER; LIVER METABOLISM; MULTIGENE FAMILY; NONHUMAN; RAT; TRANSCRIPTION REGULATION;

ANIMALS; BIOLOGICAL AVAILABILITY; CELL LINE; CELL-FREE SYSTEM; COMBINATORIAL CHEMISTRY TECHNIQUES; DNA-BINDING PROTEINS; HUMANS; ISOXAZOLES; MICE; RATS; RATS, INBRED F344; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSFECTION; TRIGLYCERIDES;

EID: 0034632762     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0002127     Document Type: Letter

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