Mouse organic solute transporter alpha deficiency alters FGF15 expression and bile acid metabolism

Journal of Hepatology

Volumn 57, Issue 2, 2012, Pages 359-365

  Lan, Tian ^a   Rao, Anuradha ^a   Haywood, Jamie ^a   Kock, Nancy D ^a   Dawson, Paul A ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

Bile acids; Cholesterol; Cyp7a1; Enterohepatic circulation; FXR; Transporters

Indexed keywords

CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; FARNESOID X RECEPTOR; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 15; MEMBRANE PROTEIN; MESSENGER RNA; ORGANIC SOLUTE TRANSPORTER ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CHOLESTEROL METABOLISM; CONTROLLED STUDY; EPITHELIUM CELL; FEMALE; GENE EXPRESSION; ILEUM; MALE; MORPHOLOGY; NONHUMAN; ORGAN WEIGHT; PHENOTYPE; PRIORITY JOURNAL; SMALL INTESTINE; WILD TYPE;

ANIMALS; BILE ACIDS AND SALTS; CHOLESTEROL; CHOLESTEROL 7-ALPHA-HYDROXYLASE; FIBROBLAST GROWTH FACTORS; INTESTINE, SMALL; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, INBRED C57BL; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RNA, MESSENGER;

EID: 84863986239     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2012.03.025     Document Type: Article

References (33)

1. J.Y. Chiang Bile acids: regulation of synthesis J Lipid Res 50 2009 1955 1966
2. T.T. Lu, M. Makishima, J.J. Repa, K. Schoonjans, T.A. Kerr, and J. Auwerx Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors Mol Cell 6 2000 507 515
3. B. Goodwin, S.A. Jones, R.R. Price, M.A. Watson, D.D. McKee, and L.B. Moore A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis Mol Cell 6 2000 517 526
4. T. Inagaki, M. Choi, A. Moschetta, L. Peng, C.L. Cummins, and J.G. McDonald Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis Cell Metab 2 2005 217 225
5. T. Lundasen, C. Galman, B. Angelin, and M. Rudling Circulating intestinal fibroblast growth factor 19 has a pronounced diurnal variation and modulates hepatic bile acid synthesis in man J Intern Med 260 2006 530 536
6. H. Kurosu, M. Choi, Y. Ogawa, A.S. Dickson, R. Goetz, and A.V. Eliseenkova Tissue-specific expression of betaKlotho and fibroblast growth factor (FGF) receptor isoforms determines metabolic activity of FGF19 and FGF21 J Biol Chem 282 2007 26687 26695
7. P.A. Dawson, T. Lan, and A. Rao Bile acid transporters J Lipid Res 50 2009 2340 2357
8. P.A. Dawson, M. Hubbert, J. Haywood, A.L. Craddock, N. Zerangue, and W.V. Christian The heteromeric organic solute transporter alpha-beta, Ostalpha-Ostbeta, is an ileal basolateral bile acid transporter J Biol Chem 280 2005 6960 6968
9. A. Rao, J. Haywood, A.L. Craddock, M.G. Belinsky, G.D. Kruh, and P.A. Dawson The organic solute transporter alpha-beta, Ostalpha-Ostbeta, is essential for intestinal bile acid transport and homeostasis Proc Natl Acad Sci U S A 105 2008 3891 3896
10. N. Ballatori, F. Fang, W.V. Christian, N. Li, and C.L. Hammond Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver Am J Physiol Gastrointest Liver Physiol 295 2008 G179 G186
11. A.F. Hofmann Bile acid malabsorption caused by ileal resection Arch Intern Med 130 1972 597 605
12. P. Oelkers, L.C. Kirby, J.E. Heubi, and P.A. Dawson Primary bile acid malabsorption caused by mutations in the ileal sodium-dependent bile acid transporter gene (SLC10A2) J Clin Invest 99 1997 1880 1887
13. D. Jung, T. Inagaki, R.D. Gerard, P.A. Dawson, S.A. Kliewer, and D.J. Mangelsdorf FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption J Lipid Res 48 2007 2693 2700
14. P.A. Dawson, J. Haywood, A.L. Craddock, M. Wilson, M. Tietjen, and K. Kluckman Targeted deletion of the ileal bile acid transporter eliminates enterohepatic cycling of bile acids in mice J Biol Chem 278 2003 33920 33927
15. D. Haussinger 21st international bile acid meeting. Preface Dig Dis 29 2011 5
16. T. Lan, J. Haywood, A. Rao, and P.A. Dawson Molecular mechanisms of altered bile acid homeostasis in organic solute transporter-alpha knockout mice Dig Dis 29 2011 18 22
17. M.J. Potthoff, J. Boney-Montoya, M. Choi, T. He, N.E. Sunny, and S. Satapati FGF15/19 regulates hepatic glucose metabolism by inhibiting the CREB-PGC-1alpha pathway Cell Metab 13 2011 729 738
18. M.G. Belinsky, P.A. Dawson, I. Shchaveleva, L.J. Bain, R. Wang, and V. Ling Analysis of the in vivo functions of Mrp3 Mol Pharmacol 68 2005 160 168
19. D.M. Heuman Quantitative estimation of the hydrophilic-hydrophobic balance of mixed bile salt solutions J Lipid Res 30 1989 719 730
20. E. Beuling, I.M. Kerkhof, G.A. Nicksa, M.J. Giuffrida, J. Haywood, and D.J. aan de Kerk Conditional Gata4 deletion in mice induces bile acid absorption in the proximal small intestine Gut 59 2010 888 895
21. D.L. Williams, T.C. Newman, G.S. Shelness, and D.A. Gordon Measurement of apolipoprotein mRNA by DNA-excess solution hybridization with single-stranded probes Methods Enzymol 128 1986 671 689
22. J.M. Timmins, J.Y. Lee, E. Boudyguina, K.D. Kluckman, L.R. Brunham, and A. Mulya Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I J Clin Invest 115 2005 1333 1342
23. D.Q. Wang, S. Tazuma, D.E. Cohen, and M.C. Carey Feeding natural hydrophilic bile acids inhibits intestinal cholesterol absorption: studies in the gallstone-susceptible mouse Am J Physiol Gastrointest Liver Physiol 285 2003 G494 G502
24. G. Lambert, M.J. Amar, G. Guo, H.B. Brewer Jr., F.J. Gonzalez, and C.J. Sinal The farnesoid X-receptor is an essential regulator of cholesterol homeostasis J Biol Chem 278 2003 2563 2570
25. I. Kim, S.H. Ahn, T. Inagaki, M. Choi, S. Ito, and G.L. Guo Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine J Lipid Res 48 2007 2664 2672
26. J. Li-Hawkins, M. Gafvels, M. Olin, E.G. Lund, U. Andersson, and G. Schuster Cholic acid mediates negative feedback regulation of bile acid synthesis in mice J Clin Invest 110 2002 1191 1200
27. W.F. Balistreri, J.E. Heubi, and F.J. Suchy Bile acid metabolism: relationship of bile acid malabsorption and diarrhea J Pediatr Gastroenterol Nutr 2 1983 105 121
28. H.J. Weis, and J.M. Dietschy Adaptive responses in hepatic and intestinal cholesterogenesis following ileal resection in the rat Eur J Clin Invest 4 1974 33 41
29. J.E. Akerlund, E. Reihner, B. Angelin, M. Rudling, S. Ewerth, and I. Bjorkhem Hepatic metabolism of cholesterol in Crohn's disease. Effect of partial resection of ileum Gastroenterology 100 1991 1046 1053
30. C.J. Soroka, H. Velazquez, A. Mennone, N. Ballatori, and J.L. Boyer Ostalpha depletion protects liver from oral bile acid load Am J Physiol Gastrointest Liver Physiol 301 2011 G574 G579
31. J. Sinha, F. Chen, T. Miloh, R.C. Burns, Z. Yu, and B.L. Shneider Beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes Am J Physiol Gastrointest Liver Physiol 295 2008 G996 G1003
32. J.R. Walters, A.M. Tasleem, O.S. Omer, W.G. Brydon, T. Dew, and C.W. le Roux A new mechanism for bile acid diarrhea: defective feedback inhibition of bile acid biosynthesis Clin Gastroenterol Hepatol 7 2009 1189 1194
33. Z.R. Vlahcevic, C.C. Bell Jr., I. Buhac, J.T. Farrar, and L. Swell Diminished bile acid pool size in patients with gallstones Gastroenterology 59 1970 165 173