24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice

Gastroenterology

Volumn 130, Issue 2, 2006, Pages 465-481

  Fickert, Peter ^a   Wagner, Martin ^a   Marschall, Hanns Ulrich ^b   Fuchsbichler, Andrea ^a   Zollner, Gernot ^a   Tsybrovskyy, Oleksiy ^a   Zatloukal, Kurt ^a   Liu, Jie ^c   Waalkes, Michael P ^c   Cover, Cathleen ^d   Denk, Helmut ^a   Hofmann, Alan F ^e   Jaeschke, Hartmut ^d   Trauner, Michael ^a  

^a MEDICAL UNIVERSITY OF GRAZ   (Austria)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

^d UNIVERSITY OF ARIZONA   (United States)

^e UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

24 NORURSODEOXYCHOLIC ACID; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; BILE ACID; ENZYME; HYDROXYPROLINE; MULTIDRUG RESISTANCE PROTEIN 2; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID DERIVATIVE;

ACID SECRETION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; BILE ACID METABOLISM; CONTROLLED STUDY; DISEASE MARKER; DRUG GLUCURONIDATION; DRUG HYDROXYLATION; DRUG MECHANISM; DRUG METABOLISM; DRUG SULFATION; ENZYME INDUCTION; FEEDING; HYDROPHILICITY; INFLAMMATION; KNOCKOUT MOUSE; LIVER; LIVER CELL; LIVER FIBROSIS; LIVER HISTOLOGY; MOUSE; NEUTROPHIL COUNT; NONHUMAN; PRIORITY JOURNAL; SCLEROSING CHOLANGITIS; SERUM; URINE;

EID: 32044467118     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2005.10.018     Document Type: Article

References (42)

1. P. Fickert, G. Zollner, A. Fuchsbichler Ursodeoxycholic acid aggravates bile infarcts in bile duct-ligated and Mdr2 knockout mice via disruption of cholangioles Gastroenterology 123 2002 1238 1251
2. P. Fickert, A. Fuchsbichler, M. Wagner Regurgitation of bile acids from leaky bile ducts causes sclerosing cholangitis in Mdr2 (Abcb4) knockout mice Gastroenterology 127 2004 261 274
3. P.L. Jansen, E. Sturm Genetic cholestasis, causes and consequences for hepatobiliary transport Liver Int 23 2003 315 322
4. G. Paumgartner, U. Beuers Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease Clin Liver Dis 8 2004 67 81
5. M. Trauner, I.W. Graziadei Review article mechanisms of action and therapeutic applications of ursodeoxycholic acid in chronic liver diseases Aliment Pharmacol Ther 13 1999 979 996
6. E. Jacquemin Progressive familial intrahepatic cholestasis. Genetic basis and treatment Clin Liver Dis 4 2000 753 763
7. H. Ismail, P. Kalicinski, M. Markiewicz Treatment of progressive familial intrahepatic cholestasis liver transplantation or partial external biliary diversion Pediatr Transplant 3 1999 219 224
8. J.A. Talwalkar, K.D. Lindor Primary sclerosing cholangitis Inflamm Bowel Dis 11 2005 62 72
9. Y.B. Yoon, L.R. Hagey, A.F. Hofmann, D. Gurantz, E.L. Michelotti, J.H. Steinbach Effect of side-chain shortening on the physiologic properties of bile acids hepatic transport and effect on biliary secretion of 23-nor- ursodeoxycholate in rodents Gastroenterology 90 1986 837 852
10. B.I. Cohen, A.F. Hofmann, E.H. Mosbach Differing effects of nor-ursodeoxycholic or ursodeoxycholic acid on hepatic histology and bile acid metabolism in the rabbit Gastroenterology 91 1986 189 197
11. A.F. Hofmann The continuing importance of bile acids in liver and intestinal disease Arch Intern Med 159 1999 2647 2658
12. C.D. Schteingart, A.F. Hofmann Synthesis of 24-nor-5 beta-cholan-23-oic acid derivatives a convenient and efficient one-carbon degradation of the side chain of natural bile acids J Lipid Res 29 1988 1387 1395
13. P. Fickert, M. Trauner, A. Fuchsbichler, C. Stumptner, K. Zatloukal, H. Denk Mallory body formation in primary biliary cirrhosis is associated with increased amounts and abnormal phosphorylation and ubiquitination of cytokeratins J Hepatol 38 2003 387 394
14. H. Jaeschke, A. Farhood, M.A. Fisher, C.W. Smith Sequestration of neutrophils in the hepatic vasculature during endotoxemia is independent of beta 2 integrins and intercellular adhesion molecule-1 Shock 6 1996 351 356
15. I.S. Jamall, V.N. Finelli, S.S. Que Hee A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues Anal Biochem 112 1981 70 75
16. M. Wagner, P. Fickert, G. Zollner Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice Gastroenterology 125 2003 825 838
17. P. Fickert, G. Zollner, A. Fuchsbichler Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver Gastroenterology 121 2001 170 183
18. H.U. Marschall, U. Broome, C. Einarsson, G. Alvelius, H.G. Thomas, S. Matern Isoursodeoxycholic acid metabolism and therapeutic effects in primary biliary cirrhosis J Lipid Res 42 2001 735 742
19. H.U. Marschall, H. Matern, H. Wietholtz, B. Egestad, S. Matern, J. Sjovall Bile acid N-acetylglucosaminidation. In vivo and in vitro evidence for a selective conjugation reaction of 7 beta-hydroxylated bile acids in humans J Clin Invest 89 1992 1981 1987
20. K. Bodin, L. Bretillon, Y. Aden Antiepileptic drugs increase plasma levels of 4beta-hydroxycholesterol in humans evidence for involvement of cytochrome p450 3A4 J Biol Chem 276 2001 38685 38689
21. N. Blanckaert Analysis of bilirubin and bilirubin Biochem J 185 1980 115 128
22. C.M. Van Nieuwkerk, R.P. Elferink, A.K. Groen Effects of ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene Gastroenterology 111 1996 165 171
23. M. Trauner, M. Arrese, C.J. Soroka The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis Gastroenterology 113 1997 255 264
24. K.N. Lazaridis, M. Strazzabosco, N.F. LaRusso The cholangiopathies disorders of biliary epithelia Gastroenterology 127 2004 1565 1577
25. E. Pikarsky, R.M. Porat, I. Stein NF-kappaB functions as a tumour promoter in inflammation-associated cancer Nature 431 2004 461 466
26. C.D. Schteingart, L.R. Hagey, K.D. Setchell, A.F. Hofmann 5 Beta-hydroxylation by the liver. Identification of 3,5,7-trihydroxy nor-bile acids as new major biotransformation products of 3,7-dihydroxy nor-bile acids in rodents J Biol Chem 268 1993 11239 11246
27. J.S. Gujral, J. Liu, A. Farhood, J.A. Hinson, H. Jaeschke Functional importance of ICAM-1 in the mechanism of neutrophil-induced liver injury in bile duct-ligated mice Am J Physiol Gastrointest Liver Physiol 286 2004 G499 G507
28. J.S. Gujral, J.A. Hinson, H. Jaeschke Chlorotyrosine protein adducts are reliable biomarkers of neutrophil-induced cytotoxicity in vivo Comp Hepatol 3 Suppl 1 2004 48 52
29. J.S. Gujral, A. Farhood, M.L. Bajt, H. Jaeschke Neutrophils aggravate acute liver injury during obstructive cholestasis in bile duct-ligated mice Hepatology 38 2003 355 363
30. J.S. Gujral, J. Liu, A. Farhood, H. Jaeschke Reduced oncotic necrosis in Fas receptor-deficient C57BL/6J-lpr mice after bile duct ligation Hepatology 40 2004 998 1007
31. P. Fickert, M. Trauner, A. Fuchsbichler Oncosis represents the main type of cell death in mouse models of cholestasis J Hepatol 42 2005 378 385
32. U. Bolder, N.V. Trang, L.R. Hagey Sulindac is excreted into bile by a canalicular bile salt pump and undergoes a cholehepatic circulation in rats Gastroenterology 117 1999 962 971
33. G. Zollner, P. Fickert, A. Fuchsbichler Role of nuclear bile acid receptor, FXR, in adaptive ABC transporter regulation by cholic and ursodeoxycholic acid in mouse liver, kidney and intestine J Hepatol 39 2003 480 488
34. E.G. Schuetz, S. Strom, K. Yasuda Disrupted bile acid homeostasis reveals an unexpected interaction among nuclear hormone receptors, transporters, and cytochrome P450 J Biol Chem 276 2001 39411 39418
35. N. Zelcer, G. Reid, P. Wielinga Steroid and bile acid conjugates are substrates of human multidrug-resistance protein (MRP) 4 (ATP-binding cassette C4) Biochem J 371 Pt 2 2003 361 367
36. M. Rius, A.T. Nies, J. Hummel-Eisenbeiss, G. Jedlitschky, D. Keppler Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane Hepatology 38 2003 374 384
37. J. Lee, F. Azzaroli, L. Wang Adaptive regulation of bile salt transporters in kidney and liver in obstructive cholestasis in the rat Gastroenterology 121 2001 1473 1484
38. A. Schmassmann, A.F. Hofmann, M.A. Angellotti Prevention of ursodeoxycholate hepatotoxicity in the rabbit by conjugation with N-methyl amino acids Hepatology 11 1990 989 996
39. R.B. Kirkpatrick, M.D. Green, L.R. Hagey, A.F. Hofmann, T.R. Tephly Effect of side chain length on bile acid conjugation glucuronidation, sulfation and coenzyme A formation of nor-bile acids and their natural C24 homologs by human and rat liver fractions Hepatology 8 1988 353 357
40. A.F. Hofmann, S.F. Zakko, M. Lira, C. Clerici, L.R. Hagey, K.K. Lambert, J.H. Steinbach, C.D. Schteingart, P. Olinga, G.M. Groothuis Novel biotransformation and physiological properties of norursodeoxycholic acid in man Hepatology 42 2005 1391 1398
41. S.N. Marcus, C.D. Schteingart, M.L. Marquez, A.F. Hofmann, Y. Xia, J.H. Steinbach, H.T. Ton-Nu, J. Lillienau, M.A. Angelotti, A. Schassmann Active absorption of conjugated bile acids in vivo kinetic parameters and molecular specificity of the ileal transport system in the rat Gastroenterology 100 1991 212 221
42. C. Handschin, U.A. Meyer Induction of drug metabolism the role of nuclear receptors Pharmacol Rev 55 2003 649 673