메뉴 건너뛰기




Volumn 36, Issue SUPPL.1, 2012, Pages

Ursodeoxycholic acid and bile-acid mimetics as therapeutic agents for cholestatic liver diseases: An overview of their mechanisms of action

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; CHENODEOXYCHOLIC ACID; FARNESOID X RECEPTOR; HORMONE RECEPTOR STIMULATING AGENT; NORURSODEOXYCHOLIC ACID; OBETICHOLIC ACID; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG; URSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID DERIVATIVE;

EID: 84868698756     PISSN: 22107401     EISSN: 2210741X     Source Type: Journal    
DOI: 10.1016/S2210-7401(12)70015-3     Document Type: Article
Times cited : (192)

References (117)
  • 3
    • 0033026760 scopus 로고    scopus 로고
    • Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
    • Wang H., Chen J., Hollister K., Sowers L.C., Forman B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999, 3:543-553.
    • (1999) Mol Cell , vol.3 , pp. 543-553
    • Wang, H.1    Chen, J.2    Hollister, K.3    Sowers, L.C.4    Forman, B.M.5
  • 6
    • 0021739393 scopus 로고
    • Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem
    • Hofmann A.F., Roda A. Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem. J Lipid Res 1984, 25:1477-1489.
    • (1984) J Lipid Res , vol.25 , pp. 1477-1489
    • Hofmann, A.F.1    Roda, A.2
  • 7
    • 0026623067 scopus 로고
    • Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions
    • Hofmann A.F., Mysels K.J. Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions. J Lipid Res 1992, 33:617-626.
    • (1992) J Lipid Res , vol.33 , pp. 617-626
    • Hofmann, A.F.1    Mysels, K.J.2
  • 8
    • 0343648748 scopus 로고
    • Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile
    • Holsti P. Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile. Acta Pathol Microbiol Scand Suppl 1956, 39:1-66.
    • (1956) Acta Pathol Microbiol Scand Suppl , vol.39 , pp. 1-66
    • Holsti, P.1
  • 9
    • 0025247125 scopus 로고
    • Hepatic injury induced by bile salts: correlation between biochemical and morphological events
    • Schmucker D.L., Ohta M., Kanai S., Sato Y., Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology 1990, 12:1216-1221.
    • (1990) Hepatology , vol.12 , pp. 1216-1221
    • Schmucker, D.L.1    Ohta, M.2    Kanai, S.3    Sato, Y.4    Kitani, K.5
  • 10
    • 33847082573 scopus 로고    scopus 로고
    • Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation
    • Becker S., Reinehr R., Graf D., vom Dahl S., Haussinger D. Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. Cell Physiol Biochem 2007, 19:89-98.
    • (2007) Cell Physiol Biochem , vol.19 , pp. 89-98
    • Becker, S.1    Reinehr, R.2    Graf, D.3    vom Dahl, S.4    Haussinger, D.5
  • 12
    • 78650793157 scopus 로고    scopus 로고
    • Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis
    • Allen K., Jaeschke H., Copple B.L. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 2011, 178:175-186.
    • (2011) Am J Pathol , vol.178 , pp. 175-186
    • Allen, K.1    Jaeschke, H.2    Copple, B.L.3
  • 14
    • 0027932658 scopus 로고
    • Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes
    • Hillaire S., Boucher E., Calmus Y., Gane P., Ballet F., Franco D., Moukthar M., et al. Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes. Gastroenterology 1994, 107:781-788.
    • (1994) Gastroenterology , vol.107 , pp. 781-788
    • Hillaire, S.1    Boucher, E.2    Calmus, Y.3    Gane, P.4    Ballet, F.5    Franco, D.6    Moukthar, M.7
  • 15
    • 0027282029 scopus 로고
    • Immunogenicity of rat hepatocytes in vivo: effect of cholestasis-induced changes in major histocompatibility complex expression
    • Arvieux C., Calmus Y., Gane P., Legendre C., Mariani P., Delelo R., Poupon R., et al. Immunogenicity of rat hepatocytes in vivo: effect of cholestasis-induced changes in major histocompatibility complex expression. J Hepatol 1993, 18:335-341.
    • (1993) J Hepatol , vol.18 , pp. 335-341
    • Arvieux, C.1    Calmus, Y.2    Gane, P.3    Legendre, C.4    Mariani, P.5    Delelo, R.6    Poupon, R.7
  • 16
    • 0026657890 scopus 로고
    • Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes
    • Calmus Y., Guechot J., Podevin P., Bonnefis M.T., Giboudeau J., Poupon R. Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes. Hepatology 1992, 16:719-723.
    • (1992) Hepatology , vol.16 , pp. 719-723
    • Calmus, Y.1    Guechot, J.2    Podevin, P.3    Bonnefis, M.T.4    Giboudeau, J.5    Poupon, R.6
  • 17
    • 0028958795 scopus 로고
    • Effect of cholestasis and bile acids on interferoninduced 2',5'-adenylate synthetase and NK cell activities
    • Podevin P., Calmus Y., Bonnefis M.T., Veyrunes C., Chereau C., Poupon R. Effect of cholestasis and bile acids on interferoninduced 2',5'-adenylate synthetase and NK cell activities. Gastroenterology 1995, 108:1192-1198.
    • (1995) Gastroenterology , vol.108 , pp. 1192-1198
    • Podevin, P.1    Calmus, Y.2    Bonnefis, M.T.3    Veyrunes, C.4    Chereau, C.5    Poupon, R.6
  • 20
    • 0023125182 scopus 로고
    • Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?
    • Poupon R., Chretien Y., Poupon R.E., Ballet F., Calmus Y., Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?. Lancet 1987, 1:834-836.
    • (1987) Lancet , vol.1 , pp. 834-836
    • Poupon, R.1    Chretien, Y.2    Poupon, R.E.3    Ballet, F.4    Calmus, Y.5    Darnis, F.6
  • 21
    • 0028294206 scopus 로고
    • Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group
    • Poupon R.E., Poupon R., Balkau B. Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group. N Engl J Med 1994, 330:1342-1347.
    • (1994) N Engl J Med , vol.330 , pp. 1342-1347
    • Poupon, R.E.1    Poupon, R.2    Balkau, B.3
  • 22
    • 0030852495 scopus 로고    scopus 로고
    • Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis
    • Poupon R.E., Lindor K.D., Cauch-Dudek K., Dickson E.R., Poupon R., Heathcote E.J. Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1997, 113:884-890.
    • (1997) Gastroenterology , vol.113 , pp. 884-890
    • Poupon, R.E.1    Lindor, K.D.2    Cauch-Dudek, K.3    Dickson, E.R.4    Poupon, R.5    Heathcote, E.J.6
  • 25
    • 0019976525 scopus 로고
    • Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part II
    • Bachrach W.H., Hofmann A.F. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part II. Dig Dis Sci 1982, 27:833-856.
    • (1982) Dig Dis Sci , vol.27 , pp. 833-856
    • Bachrach, W.H.1    Hofmann, A.F.2
  • 26
    • 0042508785 scopus 로고    scopus 로고
    • Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration
    • Lanzini A., De Tavonatti M.G., Panarotto B., Scalia S., Mora A., Benini F., Baisini O., et al. Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration. Gut 2003, 52:1371-1375.
    • (2003) Gut , vol.52 , pp. 1371-1375
    • Lanzini, A.1    De Tavonatti, M.G.2    Panarotto, B.3    Scalia, S.4    Mora, A.5    Benini, F.6    Baisini, O.7
  • 27
    • 0030482271 scopus 로고    scopus 로고
    • Ileal absorption of bile acids in patients with chronic cholestasis: SeHCAT test results and effect of ursodeoxycholic acid (UDCA)
    • Chazouilleres O., Marteau P., Haniche M., Jian R., Poupon R. Ileal absorption of bile acids in patients with chronic cholestasis: SeHCAT test results and effect of ursodeoxycholic acid (UDCA). Dig Dis Sci 1996, 41:2417-2422.
    • (1996) Dig Dis Sci , vol.41 , pp. 2417-2422
    • Chazouilleres, O.1    Marteau, P.2    Haniche, M.3    Jian, R.4    Poupon, R.5
  • 28
    • 0028882410 scopus 로고
    • Intestinal absorption of bile acids: effect of ursodeoxycholic acid treatment
    • Stiehl A. Intestinal absorption of bile acids: effect of ursodeoxycholic acid treatment. Ital J Gastroenterol 1995, 27:193-195.
    • (1995) Ital J Gastroenterol , vol.27 , pp. 193-195
    • Stiehl, A.1
  • 30
    • 0026596936 scopus 로고
    • Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease
    • Beuers U., Spengler U., Zwiebel F.M., Pauletzki J., Fischer S., Paumgartner G. Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease. Hepatology 1992, 15:603-608.
    • (1992) Hepatology , vol.15 , pp. 603-608
    • Beuers, U.1    Spengler, U.2    Zwiebel, F.M.3    Pauletzki, J.4    Fischer, S.5    Paumgartner, G.6
  • 31
    • 0028933933 scopus 로고
    • Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children
    • Poupon R., Poupon R.E. Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children. Pharmacol Ther 1995, 66:1-15.
    • (1995) Pharmacol Ther , vol.66 , pp. 1-15
    • Poupon, R.1    Poupon, R.E.2
  • 32
    • 0037370065 scopus 로고    scopus 로고
    • Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes
    • Spirli C., Fabris L., Duner E., Fiorotto R., Ballardini G., Roskams T., Larusso N.F., et al. Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. Gastroenterology 2003, 124:737-753.
    • (2003) Gastroenterology , vol.124 , pp. 737-753
    • Spirli, C.1    Fabris, L.2    Duner, E.3    Fiorotto, R.4    Ballardini, G.5    Roskams, T.6    Larusso, N.F.7
  • 34
    • 0027325467 scopus 로고
    • Abnormal expression of anion exchanger genes in primary biliary cirrhosis
    • Prieto J., Qian C., Garcia N., Diez J., Medina J.F. Abnormal expression of anion exchanger genes in primary biliary cirrhosis. Gastroenterology 1993, 105:572-578.
    • (1993) Gastroenterology , vol.105 , pp. 572-578
    • Prieto, J.1    Qian, C.2    Garcia, N.3    Diez, J.4    Medina, J.F.5
  • 36
    • 38849104576 scopus 로고    scopus 로고
    • Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells
    • Arenas F., Hervias I., Uriz M., Joplin R., Prieto J., Medina J.F. Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. J Clin Invest 2008, 118:695-709.
    • (2008) J Clin Invest , vol.118 , pp. 695-709
    • Arenas, F.1    Hervias, I.2    Uriz, M.3    Joplin, R.4    Prieto, J.5    Medina, J.F.6
  • 37
    • 1642338852 scopus 로고    scopus 로고
    • Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease
    • vi
    • Paumgartner G., Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. Clin Liver Dis 2004, 8:67-81. vi.
    • (2004) Clin Liver Dis , vol.8 , pp. 67-81
    • Paumgartner, G.1    Beuers, U.2
  • 38
    • 83455221623 scopus 로고    scopus 로고
    • Ursodeoxycholic acid is conjugated with taurine to promote secretinstimulated biliary hydrocholeresis in the normal rat
    • Uriz M., Saez E., Prieto J., Medina J.F., Banales J.M. Ursodeoxycholic acid is conjugated with taurine to promote secretinstimulated biliary hydrocholeresis in the normal rat. PLoS One 2011, 6:e28717.
    • (2011) PLoS One , vol.6
    • Uriz, M.1    Saez, E.2    Prieto, J.3    Medina, J.F.4    Banales, J.M.5
  • 40
  • 41
    • 0031950282 scopus 로고    scopus 로고
    • Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
    • Rodrigues C.M., Fan G., Wong P.Y., Kren B.T., Steer C.J. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med 1998, 4:165-178.
    • (1998) Mol Med , vol.4 , pp. 165-178
    • Rodrigues, C.M.1    Fan, G.2    Wong, P.Y.3    Kren, B.T.4    Steer, C.J.5
  • 43
    • 0033740305 scopus 로고    scopus 로고
    • Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease
    • Ljubuncic P., Tanne Z., Bomzon A. Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease. Dig Dis Sci 2000, 45:1921-1928.
    • (2000) Dig Dis Sci , vol.45 , pp. 1921-1928
    • Ljubuncic, P.1    Tanne, Z.2    Bomzon, A.3
  • 44
    • 0036109728 scopus 로고    scopus 로고
    • Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats
    • Rodriguez-Ortigosa C.M., Cincu R.N., Sanz S., Ruiz F., Quiroga J., Prieto J. Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats. Gut 2002, 50:701-706.
    • (2002) Gut , vol.50 , pp. 701-706
    • Rodriguez-Ortigosa, C.M.1    Cincu, R.N.2    Sanz, S.3    Ruiz, F.4    Quiroga, J.5    Prieto, J.6
  • 45
    • 0036129525 scopus 로고    scopus 로고
    • Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate
    • Bernstein C., Payne C.M., Bernstein H., Garewal H. Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate. Pharmacology 2002, 65:2-9.
    • (2002) Pharmacology , vol.65 , pp. 2-9
    • Bernstein, C.1    Payne, C.M.2    Bernstein, H.3    Garewal, H.4
  • 47
    • 77954101086 scopus 로고    scopus 로고
    • Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
    • Kawata K., Kobayashi Y., Souda K., Kawamura K., Sumiyoshi S., Takahashi Y., Noritake H., et al. Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. Antioxid Redox Signal 2010, 13:259-268.
    • (2010) Antioxid Redox Signal , vol.13 , pp. 259-268
    • Kawata, K.1    Kobayashi, Y.2    Souda, K.3    Kawamura, K.4    Sumiyoshi, S.5    Takahashi, Y.6    Noritake, H.7
  • 48
    • 68949114163 scopus 로고    scopus 로고
    • Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications
    • Yang H., Ramani K., Xia M., Ko K.S., Li T.W., Oh P., Li J., et al. Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications. Hepatology 2009, 49:1982-1991.
    • (2009) Hepatology , vol.49 , pp. 1982-1991
    • Yang, H.1    Ramani, K.2    Xia, M.3    Ko, K.S.4    Li, T.W.5    Oh, P.6    Li, J.7
  • 49
    • 59749083235 scopus 로고    scopus 로고
    • Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells
    • Arisawa S., Ishida K., Kameyama N., Ueyama J., Hattori A., Tatsumi Y., Hayashi H., et al. Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells. Biochem Pharmacol 2009, 77:858-866.
    • (2009) Biochem Pharmacol , vol.77 , pp. 858-866
    • Arisawa, S.1    Ishida, K.2    Kameyama, N.3    Ueyama, J.4    Hattori, A.5    Tatsumi, Y.6    Hayashi, H.7
  • 50
  • 51
    • 0031005366 scopus 로고    scopus 로고
    • Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis
    • Koga H., Sakisaka S., Ohishi M., Sata M., Tanikawa K. Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis. Hepatology 1997, 25:1077-1084.
    • (1997) Hepatology , vol.25 , pp. 1077-1084
    • Koga, H.1    Sakisaka, S.2    Ohishi, M.3    Sata, M.4    Tanikawa, K.5
  • 52
    • 33846699177 scopus 로고    scopus 로고
    • T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis
    • Allina J., Hu B., Sullivan D.M., Fiel M.I., Thung S.N., Bronk S.F., Huebert R.C., et al. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun 2006, 27:232-241.
    • (2006) J Autoimmun , vol.27 , pp. 232-241
    • Allina, J.1    Hu, B.2    Sullivan, D.M.3    Fiel, M.I.4    Thung, S.N.5    Bronk, S.F.6    Huebert, R.C.7
  • 53
    • 0036725164 scopus 로고    scopus 로고
    • Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation
    • Xie Q., Khaoustov V.I., Chung C.C., Sohn J., Krishnan B., Lewis D.E., Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 2002, 36:592-601.
    • (2002) Hepatology , vol.36 , pp. 592-601
    • Xie, Q.1    Khaoustov, V.I.2    Chung, C.C.3    Sohn, J.4    Krishnan, B.5    Lewis, D.E.6    Yoffe, B.7
  • 54
    • 0036211298 scopus 로고    scopus 로고
    • Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes
    • Qiao L., Yacoub A., Studer E., Gupta S., Pei X.Y., Grant S., Hylemon P.B., et al. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 2002, 35:779-789.
    • (2002) Hepatology , vol.35 , pp. 779-789
    • Qiao, L.1    Yacoub, A.2    Studer, E.3    Gupta, S.4    Pei, X.Y.5    Grant, S.6    Hylemon, P.B.7
  • 55
  • 56
    • 3142580336 scopus 로고    scopus 로고
    • Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes
    • Sola S., Castro R.E., Kren B.T., Steer C.J., Rodrigues C.M. Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. Biochemistry 2004, 43:8429-8438.
    • (2004) Biochemistry , vol.43 , pp. 8429-8438
    • Sola, S.1    Castro, R.E.2    Kren, B.T.3    Steer, C.J.4    Rodrigues, C.M.5
  • 58
    • 0025098908 scopus 로고
    • Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid
    • Calmus Y., Gane P., Rouger P., Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990, 11:12-15.
    • (1990) Hepatology , vol.11 , pp. 12-15
    • Calmus, Y.1    Gane, P.2    Rouger, P.3    Poupon, R.4
  • 59
    • 0030043423 scopus 로고    scopus 로고
    • Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway
    • Tanaka H., Makino Y., Miura T., Hirano F., Okamoto K., Komura K., Sato Y., et al. Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway. J Immunol 1996, 156:1601-1608.
    • (1996) J Immunol , vol.156 , pp. 1601-1608
    • Tanaka, H.1    Makino, Y.2    Miura, T.3    Hirano, F.4    Okamoto, K.5    Komura, K.6    Sato, Y.7
  • 60
    • 84863167924 scopus 로고    scopus 로고
    • Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis
    • Takahashi T., Miura T., Nakamura J., Yamada S., Miura T., Yanagi M., Matsuda Y., et al. Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis. Hepatology 2012, 55:846-855.
    • (2012) Hepatology , vol.55 , pp. 846-855
    • Takahashi, T.1    Miura, T.2    Nakamura, J.3    Yamada, S.4    Miura, T.5    Yanagi, M.6    Matsuda, Y.7
  • 61
    • 65449131223 scopus 로고    scopus 로고
    • Ursodeoxycholic acid reduces CpG-induced IgM production in patients with primary biliary cirrhosis
    • Kikuchi K., Hsu W., Hosoya N., Moritoki Y., Kajiyama Y., Kawai T., Takai A., et al. Ursodeoxycholic acid reduces CpG-induced IgM production in patients with primary biliary cirrhosis. Hepatol Res 2009, 39:448-454.
    • (2009) Hepatol Res , vol.39 , pp. 448-454
    • Kikuchi, K.1    Hsu, W.2    Hosoya, N.3    Moritoki, Y.4    Kajiyama, Y.5    Kawai, T.6    Takai, A.7
  • 63
    • 36549034307 scopus 로고    scopus 로고
    • Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-alpha and macrophage inflammatory protein-2 production
    • Ishizaki K., Iwaki T., Kinoshita S., Koyama M., Fukunari A., Tanaka H., Tsurufuji M., et al. Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-alpha and macrophage inflammatory protein-2 production. Eur J Pharmacol 2008, 578:57-64.
    • (2008) Eur J Pharmacol , vol.578 , pp. 57-64
    • Ishizaki, K.1    Iwaki, T.2    Kinoshita, S.3    Koyama, M.4    Fukunari, A.5    Tanaka, H.6    Tsurufuji, M.7
  • 64
    • 79955592279 scopus 로고    scopus 로고
    • Plant lectins are novel Toll-like receptor agonists
    • Unitt J., Hornigold D. Plant lectins are novel Toll-like receptor agonists. Biochem Pharmacol 2011, 81:1324-1328.
    • (2011) Biochem Pharmacol , vol.81 , pp. 1324-1328
    • Unitt, J.1    Hornigold, D.2
  • 65
    • 84856079186 scopus 로고    scopus 로고
    • Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression
    • Tu C.T., Han B., Yao Q.Y., Zhang Y.A., Liu H.C., Zhang S.C. Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression. Int Immunopharmacol 2012, 12:151-157.
    • (2012) Int Immunopharmacol , vol.12 , pp. 151-157
    • Tu, C.T.1    Han, B.2    Yao, Q.Y.3    Zhang, Y.A.4    Liu, H.C.5    Zhang, S.C.6
  • 66
    • 24144465889 scopus 로고    scopus 로고
    • Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
    • Ogawa S., Lozach J., Benner C., Pascual G., Tangirala R.K., Westin S., Hoffmann A., et al. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 2005, 122:707-721.
    • (2005) Cell , vol.122 , pp. 707-721
    • Ogawa, S.1    Lozach, J.2    Benner, C.3    Pascual, G.4    Tangirala, R.K.5    Westin, S.6    Hoffmann, A.7
  • 68
    • 32944464959 scopus 로고    scopus 로고
    • Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogenassociated molecular patterns
    • Sadeghi K., Wessner B., Laggner U., Ploder M., Tamandl D., Friedl J., Zugel U., et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogenassociated molecular patterns. Eur J Immunol 2006, 36:361-370.
    • (2006) Eur J Immunol , vol.36 , pp. 361-370
    • Sadeghi, K.1    Wessner, B.2    Laggner, U.3    Ploder, M.4    Tamandl, D.5    Friedl, J.6    Zugel, U.7
  • 70
    • 0030056154 scopus 로고    scopus 로고
    • Ursodeoxycholic acid corrects defective natural killer activity by inhibiting prostaglandin E2 production in primary biliary cirrhosis
    • Nishigaki Y., Ohnishi H., Moriwaki H., Muto Y. Ursodeoxycholic acid corrects defective natural killer activity by inhibiting prostaglandin E2 production in primary biliary cirrhosis. Dig Dis Sci 1996, 41:1487-1493.
    • (1996) Dig Dis Sci , vol.41 , pp. 1487-1493
    • Nishigaki, Y.1    Ohnishi, H.2    Moriwaki, H.3    Muto, Y.4
  • 71
    • 0028804229 scopus 로고
    • Role of hepatocytes in direct clearance of lipopolysaccharide in rats
    • Mimura Y., Sakisaka S., Harada M., Sata M., Tanikawa K. Role of hepatocytes in direct clearance of lipopolysaccharide in rats. Gastroenterology 1995, 109:1969-1976.
    • (1995) Gastroenterology , vol.109 , pp. 1969-1976
    • Mimura, Y.1    Sakisaka, S.2    Harada, M.3    Sata, M.4    Tanikawa, K.5
  • 73
    • 0032171526 scopus 로고    scopus 로고
    • Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
    • Sasatomi K., Noguchi K., Sakisaka S., Sata M., Tanikawa K. Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. J Hepatol 1998, 29:409-416.
    • (1998) J Hepatol , vol.29 , pp. 409-416
    • Sasatomi, K.1    Noguchi, K.2    Sakisaka, S.3    Sata, M.4    Tanikawa, K.5
  • 74
    • 77953749477 scopus 로고    scopus 로고
    • Biliary innate immunity in the pathogenesis of biliary diseases
    • Harada K., Nakanuma Y. Biliary innate immunity in the pathogenesis of biliary diseases. Inflamm Allergy Drug Targets 2010, 9:83-90.
    • (2010) Inflamm Allergy Drug Targets , vol.9 , pp. 83-90
    • Harada, K.1    Nakanuma, Y.2
  • 75
    • 67650668741 scopus 로고    scopus 로고
    • Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
    • Harada K., Shimoda S., Sato Y., Isse K., Ikeda H., Nakanuma Y. Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol 2009, 157:261-270.
    • (2009) Clin Exp Immunol , vol.157 , pp. 261-270
    • Harada, K.1    Shimoda, S.2    Sato, Y.3    Isse, K.4    Ikeda, H.5    Nakanuma, Y.6
  • 76
    • 84863837341 scopus 로고    scopus 로고
    • Cholangiopathy with respect to biliary innate immunity
    • Harada K., Nakanuma Y. Cholangiopathy with respect to biliary innate immunity. Int J Hepatol 2012, 2012:793569.
    • (2012) Int J Hepatol , vol.2012 , pp. 793569
    • Harada, K.1    Nakanuma, Y.2
  • 77
    • 0030782580 scopus 로고    scopus 로고
    • Increased serum IgM class anti-lipid A antibody and therapeutic effect of ursodeoxycholic acid in primary biliary cirrhosis
    • Ide T., Sata M., Nakano H., Suzuki H., Tanikawa K. Increased serum IgM class anti-lipid A antibody and therapeutic effect of ursodeoxycholic acid in primary biliary cirrhosis. Hepatogastroenterology 1997, 44:1569-1573.
    • (1997) Hepatogastroenterology , vol.44 , pp. 1569-1573
    • Ide, T.1    Sata, M.2    Nakano, H.3    Suzuki, H.4    Tanikawa, K.5
  • 78
    • 1342329687 scopus 로고    scopus 로고
    • Immune response to lipopolysaccharide in primary biliary cirrhosis and autoimmune diseases
    • Ballot E., Bandin O., Chazouilleres O., Johanet C., Poupon R. Immune response to lipopolysaccharide in primary biliary cirrhosis and autoimmune diseases. J Autoimmun 2004, 22:153-158.
    • (2004) J Autoimmun , vol.22 , pp. 153-158
    • Ballot, E.1    Bandin, O.2    Chazouilleres, O.3    Johanet, C.4    Poupon, R.5
  • 79
    • 80053580862 scopus 로고    scopus 로고
    • Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-kappaB-mediated inflammatory response in mice
    • 1508 e1491-5
    • Fiorotto R., Scirpo R., Trauner M., Fabris L., Hoque R., Spirli C., Strazzabosco M. Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-kappaB-mediated inflammatory response in mice. Gastroenterology 2011, 141:1498-1508. 1508 e1491-5.
    • (2011) Gastroenterology , vol.141 , pp. 1498-1508
    • Fiorotto, R.1    Scirpo, R.2    Trauner, M.3    Fabris, L.4    Hoque, R.5    Spirli, C.6    Strazzabosco, M.7
  • 80
    • 0021710273 scopus 로고
    • Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action
    • Hagmann W., Denzlinger C., Keppler D. Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action. Circ Shock 1984, 14:223-235.
    • (1984) Circ Shock , vol.14 , pp. 223-235
    • Hagmann, W.1    Denzlinger, C.2    Keppler, D.3
  • 81
    • 0028091402 scopus 로고
    • Ursodeoxycholic acid modifies gut-derived endotoxemia in neonatal rats
    • Schwarzenberg S.J., Bundy M. Ursodeoxycholic acid modifies gut-derived endotoxemia in neonatal rats. Pediatr Res 1994, 35:214-217.
    • (1994) Pediatr Res , vol.35 , pp. 214-217
    • Schwarzenberg, S.J.1    Bundy, M.2
  • 82
    • 0031050208 scopus 로고    scopus 로고
    • Protective effect of the intravenous administration of ursodeoxycholic acid against endotoxemia in rats with obstructive jaundice
    • Hori Y., Ohyanagi H. Protective effect of the intravenous administration of ursodeoxycholic acid against endotoxemia in rats with obstructive jaundice. Surg Today 1997, 27:140-144.
    • (1997) Surg Today , vol.27 , pp. 140-144
    • Hori, Y.1    Ohyanagi, H.2
  • 83
    • 0035861563 scopus 로고    scopus 로고
    • Functional modulation of the glucocorticoid receptor and suppression of NF-kappaBdependent transcription by ursodeoxycholic acid
    • Miura T., Ouchida R., Yoshikawa N., Okamoto K., Makino Y., Nakamura T., Morimoto C., et al. Functional modulation of the glucocorticoid receptor and suppression of NF-kappaBdependent transcription by ursodeoxycholic acid. J Biol Chem 2001, 276:47371-47378.
    • (2001) J Biol Chem , vol.276 , pp. 47371-47378
    • Miura, T.1    Ouchida, R.2    Yoshikawa, N.3    Okamoto, K.4    Makino, Y.5    Nakamura, T.6    Morimoto, C.7
  • 86
    • 8544233530 scopus 로고    scopus 로고
    • Partial characterization of cytoprotective mechanisms of lecithin against bile salt-induced bile duct damage
    • Tsuboi K., Tazuma S., Nishioka T., Chayama K. Partial characterization of cytoprotective mechanisms of lecithin against bile salt-induced bile duct damage. J Gastroenterol 2004, 39:955-960.
    • (2004) J Gastroenterol , vol.39 , pp. 955-960
    • Tsuboi, K.1    Tazuma, S.2    Nishioka, T.3    Chayama, K.4
  • 87
    • 0029084190 scopus 로고
    • Biliary secretion of bile acids and lipids in primary sclerosing cholangitis. Influence of cholestasis and effect of ursodeoxycholic acid treatment
    • Stiehl A., Rudolph G., Sauer P., Theilmann L. Biliary secretion of bile acids and lipids in primary sclerosing cholangitis. Influence of cholestasis and effect of ursodeoxycholic acid treatment. J Hepatol 1995, 23:283-289.
    • (1995) J Hepatol , vol.23 , pp. 283-289
    • Stiehl, A.1    Rudolph, G.2    Sauer, P.3    Theilmann, L.4
  • 88
    • 7344246553 scopus 로고    scopus 로고
    • Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones
    • Kano M., Shoda J., Irimura T., Ueda T., Iwasaki R., Urasaki T., Kawauchi Y., et al. Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones. Hepatology 1998, 28:302-313.
    • (1998) Hepatology , vol.28 , pp. 302-313
    • Kano, M.1    Shoda, J.2    Irimura, T.3    Ueda, T.4    Iwasaki, R.5    Urasaki, T.6    Kawauchi, Y.7
  • 89
    • 34547382615 scopus 로고    scopus 로고
    • Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene
    • Rosmorduc O., Poupon R. Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene. Orphanet J Rare Dis 2007, 2:29.
    • (2007) Orphanet J Rare Dis , vol.2 , pp. 29
    • Rosmorduc, O.1    Poupon, R.2
  • 91
    • 32044467118 scopus 로고    scopus 로고
    • 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
    • Fickert P., Wagner M., Marschall H.U., Fuchsbichler A., Zollner G., Tsybrovskyy O., Zatloukal K., et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 2006, 130:465-481.
    • (2006) Gastroenterology , vol.130 , pp. 465-481
    • Fickert, P.1    Wagner, M.2    Marschall, H.U.3    Fuchsbichler, A.4    Zollner, G.5    Tsybrovskyy, O.6    Zatloukal, K.7
  • 92
    • 78049492335 scopus 로고    scopus 로고
    • Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver
    • Denk G.U., Maitz S., Wimmer R., Rust C., Invernizzi P., Ferdinandusse S., Kulik W., et al. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver. Hepatology 2010, 52:1758-1768.
    • (2010) Hepatology , vol.52 , pp. 1758-1768
    • Denk, G.U.1    Maitz, S.2    Wimmer, R.3    Rust, C.4    Invernizzi, P.5    Ferdinandusse, S.6    Kulik, W.7
  • 93
    • 33748809238 scopus 로고    scopus 로고
    • Nuclear receptors in human immune cells: expression and correlations
    • Schote A.B., Turner J.D., Schiltz J., Muller C.P. Nuclear receptors in human immune cells: expression and correlations. Mol Immunol 2007, 44:1436-1445.
    • (2007) Mol Immunol , vol.44 , pp. 1436-1445
    • Schote, A.B.1    Turner, J.D.2    Schiltz, J.3    Muller, C.P.4
  • 94
    • 20344399619 scopus 로고    scopus 로고
    • Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor
    • Campana G., Pasini P., Roda A., Spampinato S. Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor. Biochem Pharmacol 2005, 69:1755-1763.
    • (2005) Biochem Pharmacol , vol.69 , pp. 1755-1763
    • Campana, G.1    Pasini, P.2    Roda, A.3    Spampinato, S.4
  • 95
    • 57349124804 scopus 로고    scopus 로고
    • Beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes
    • Sinha J., Chen F., Miloh T., Burns R.C., Yu Z., Shneider B.L. beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. Am J Physiol Gastrointest Liver Physiol 2008, 295:G996-G1003.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.295
    • Sinha, J.1    Chen, F.2    Miloh, T.3    Burns, R.C.4    Yu, Z.5    Shneider, B.L.6
  • 96
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005, 2:217-225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5    McDonald, J.G.6    Luo, G.7
  • 97
    • 0033637121 scopus 로고    scopus 로고
    • A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
    • Goodwin B., Jones S.A., Price R.R., Watson M.A., McKee D.D., Moore L.B., Galardi C., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000, 6:517-526.
    • (2000) Mol Cell , vol.6 , pp. 517-526
    • Goodwin, B.1    Jones, S.A.2    Price, R.R.3    Watson, M.A.4    McKee, D.D.5    Moore, L.B.6    Galardi, C.7
  • 99
    • 0035800772 scopus 로고    scopus 로고
    • Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
    • Ananthanarayanan M., Balasubramanian N., Makishima M., Mangelsdorf D.J., Suchy F.J. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 2001, 276:28857-28865.
    • (2001) J Biol Chem , vol.276 , pp. 28857-28865
    • Ananthanarayanan, M.1    Balasubramanian, N.2    Makishima, M.3    Mangelsdorf, D.J.4    Suchy, F.J.5
  • 100
    • 0346690402 scopus 로고    scopus 로고
    • Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
    • Liu Y., Binz J., Numerick M.J., Dennis S., Luo G., Desai B., MacKenzie K.I., et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest 2003, 112:1678-1687.
    • (2003) J Clin Invest , vol.112 , pp. 1678-1687
    • Liu, Y.1    Binz, J.2    Numerick, M.J.3    Dennis, S.4    Luo, G.5    Desai, B.6    MacKenzie, K.I.7
  • 101
    • 0037169551 scopus 로고    scopus 로고
    • Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
    • Kast H.R., Goodwin B., Tarr P.T., Jones S.A., Anisfeld A.M., Stoltz C.M., Tontonoz P., et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 2002, 277:2908-2915.
    • (2002) J Biol Chem , vol.277 , pp. 2908-2915
    • Kast, H.R.1    Goodwin, B.2    Tarr, P.T.3    Jones, S.A.4    Anisfeld, A.M.5    Stoltz, C.M.6    Tontonoz, P.7
  • 102
    • 6944234902 scopus 로고    scopus 로고
    • Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene
    • Gnerre C., Blattler S., Kaufmann M.R., Looser R., Meyer U.A. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 2004, 14:635-645.
    • (2004) Pharmacogenetics , vol.14 , pp. 635-645
    • Gnerre, C.1    Blattler, S.2    Kaufmann, M.R.3    Looser, R.4    Meyer, U.A.5
  • 103
    • 0038281429 scopus 로고    scopus 로고
    • FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity
    • Barbier O., Torra I.P., Sirvent A., Claudel T., Blanquart C., Duran-Sandoval D., Kuipers F., et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology 2003, 124:1926-1940.
    • (2003) Gastroenterology , vol.124 , pp. 1926-1940
    • Barbier, O.1    Torra, I.P.2    Sirvent, A.3    Claudel, T.4    Blanquart, C.5    Duran-Sandoval, D.6    Kuipers, F.7
  • 104
    • 0035834769 scopus 로고    scopus 로고
    • Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor
    • Song C.S., Echchgadda I., Baek B.S., Ahn S.C., Oh T., Roy A.K., Chatterjee B. Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. J Biol Chem 2001, 276:42549-42556.
    • (2001) J Biol Chem , vol.276 , pp. 42549-42556
    • Song, C.S.1    Echchgadda, I.2    Baek, B.S.3    Ahn, S.C.4    Oh, T.5    Roy, A.K.6    Chatterjee, B.7
  • 105
    • 0042825756 scopus 로고    scopus 로고
    • Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
    • Wagner M., Fickert P., Zollner G., Fuchsbichler A., Silbert D., Tsybrovskyy O., Zatloukal K., et al. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology 2003, 125:825-838.
    • (2003) Gastroenterology , vol.125 , pp. 825-838
    • Wagner, M.1    Fickert, P.2    Zollner, G.3    Fuchsbichler, A.4    Silbert, D.5    Tsybrovskyy, O.6    Zatloukal, K.7
  • 106
    • 84856159269 scopus 로고    scopus 로고
    • Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
    • e351-4
    • Modica S., Petruzzelli M., Bellafante E., Murzilli S., Salvatore L., Celli N., Di Tullio G., et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 2012, 142:355-365. e351-4.
    • (2012) Gastroenterology , vol.142 , pp. 355-365
    • Modica, S.1    Petruzzelli, M.2    Bellafante, E.3    Murzilli, S.4    Salvatore, L.5    Celli, N.6    Di Tullio, G.7
  • 107
    • 80053334403 scopus 로고    scopus 로고
    • Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/-(Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO(-)(3) output
    • Baghdasaryan A., Claudel T., Gumhold J., Silbert D., Adorini L., Roda A., Vecchiotti S., et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/-(Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO(-)(3) output. Hepatology 2011, 54:1303-1312.
    • (2011) Hepatology , vol.54 , pp. 1303-1312
    • Baghdasaryan, A.1    Claudel, T.2    Gumhold, J.3    Silbert, D.4    Adorini, L.5    Roda, A.6    Vecchiotti, S.7
  • 108
    • 29444434655 scopus 로고    scopus 로고
    • The human Na+- taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism
    • Eloranta J.J., Jung D., Kullak-Ublick G.A. The human Na+- taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. Mol Endocrinol 2006, 20:65-79.
    • (2006) Mol Endocrinol , vol.20 , pp. 65-79
    • Eloranta, J.J.1    Jung, D.2    Kullak-Ublick, G.A.3
  • 109
    • 33644867569 scopus 로고    scopus 로고
    • Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
    • Inagaki T., Moschetta A., Lee Y.K., Peng L., Zhao G., Downes M., Yu R.T., et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 2006, 103:3920-3925.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 3920-3925
    • Inagaki, T.1    Moschetta, A.2    Lee, Y.K.3    Peng, L.4    Zhao, G.5    Downes, M.6    Yu, R.T.7
  • 110
    • 56149085041 scopus 로고    scopus 로고
    • X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
    • Farnesoid
    • Wang Y.D., Chen W.D., Wang M., Yu D., Forman B.M., Huang W., Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 2008, 48:1632-1643.
    • (2008) Hepatology , vol.48 , pp. 1632-1643
    • Wang, Y.D.1    Chen, W.D.2    Wang, M.3    Yu, D.4    Forman, B.M.5    Huang, W.6
  • 111
    • 77952674868 scopus 로고    scopus 로고
    • The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
    • Mencarelli A., Renga B., Migliorati M., Cipriani S., Distrutti E., Santucci L., Fiorucci S. The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 2009, 183:6657-6666.
    • (2009) J Immunol , vol.183 , pp. 6657-6666
    • Mencarelli, A.1    Renga, B.2    Migliorati, M.3    Cipriani, S.4    Distrutti, E.5    Santucci, L.6    Fiorucci, S.7
  • 112
    • 24144461617 scopus 로고    scopus 로고
    • VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium
    • Chignard N., Mergey M., Barbu V., Finzi L., Tiret E., Paul A., Housset C. VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium. Hepatology 2005, 42:549-557.
    • (2005) Hepatology , vol.42 , pp. 549-557
    • Chignard, N.1    Mergey, M.2    Barbu, V.3    Finzi, L.4    Tiret, E.5    Paul, A.6    Housset, C.7
  • 114
    • 0037101810 scopus 로고    scopus 로고
    • 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
    • Pellicciari R., Fiorucci S., Camaioni E., Clerici C., Costantino G., Maloney P.R., Morelli A., et al. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 2002, 45:3569-3572.
    • (2002) J Med Chem , vol.45 , pp. 3569-3572
    • Pellicciari, R.1    Fiorucci, S.2    Camaioni, E.3    Clerici, C.4    Costantino, G.5    Maloney, P.R.6    Morelli, A.7
  • 116
    • 80053334535 scopus 로고    scopus 로고
    • An international study evaluating the farnesoid X receptor agonist obeticholic acid as monotherapy in PBC
    • 55, 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); 2011 Mar 30-Apr 3
    • Kowdley K.V., Jones D., Luketic V., Chapman R., Burroughs A., Hirschfield G., Poupon R., et al. An international study evaluating the farnesoid X receptor agonist obeticholic acid as monotherapy in PBC. J Hepatol 2011, S13. 55.
    • (2011) J Hepatol
    • Kowdley, K.V.1    Jones, D.2    Luketic, V.3    Chapman, R.4    Burroughs, A.5    Hirschfield, G.6    Poupon, R.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.