-
1
-
-
0033591297
-
Identification of a nuclear receptor for bile acids
-
Makishima M., Okamoto A.Y., Repa J.J., Tu H., Learned R.M., Luk A., Hull M.V., et al. Identification of a nuclear receptor for bile acids. Science 1999, 284:1362-1365.
-
(1999)
Science
, vol.284
, pp. 1362-1365
-
-
Makishima, M.1
Okamoto, A.Y.2
Repa, J.J.3
Tu, H.4
Learned, R.M.5
Luk, A.6
Hull, M.V.7
-
2
-
-
0033591387
-
Bile acids: natural ligands for an orphan nuclear receptor
-
Parks D.J., Blanchard S.G., Bledsoe R.K., Chandra G., Consler T.G., Kliewer S.A., Stimmel J.B., et al. Bile acids: natural ligands for an orphan nuclear receptor. Science 1999, 284:1365-1368.
-
(1999)
Science
, vol.284
, pp. 1365-1368
-
-
Parks, D.J.1
Blanchard, S.G.2
Bledsoe, R.K.3
Chandra, G.4
Consler, T.G.5
Kliewer, S.A.6
Stimmel, J.B.7
-
3
-
-
0033026760
-
Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
-
Wang H., Chen J., Hollister K., Sowers L.C., Forman B.M. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR. Mol Cell 1999, 3:543-553.
-
(1999)
Mol Cell
, vol.3
, pp. 543-553
-
-
Wang, H.1
Chen, J.2
Hollister, K.3
Sowers, L.C.4
Forman, B.M.5
-
4
-
-
0036432845
-
Identification of membranetype receptor for bile acids (M-BAR)
-
Maruyama T., Miyamoto Y., Nakamura T., Tamai Y., Okada H., Sugiyama E., Nakamura T., et al. Identification of membranetype receptor for bile acids (M-BAR). Biochem Biophys Res Commun 2002, 298:714-719.
-
(2002)
Biochem Biophys Res Commun
, vol.298
, pp. 714-719
-
-
Maruyama, T.1
Miyamoto, Y.2
Nakamura, T.3
Tamai, Y.4
Okada, H.5
Sugiyama, E.6
Nakamura, T.7
-
5
-
-
0003269455
-
A G protein-coupled receptor responsive to bile acids
-
Kawamata Y., Fujii R., Hosoya M., Harada M., Yoshida H., Miwa M., Fukusumi S., et al. A G protein-coupled receptor responsive to bile acids. J Biol Chem 2003, 278:9435-9440.
-
(2003)
J Biol Chem
, vol.278
, pp. 9435-9440
-
-
Kawamata, Y.1
Fujii, R.2
Hosoya, M.3
Harada, M.4
Yoshida, H.5
Miwa, M.6
Fukusumi, S.7
-
6
-
-
0021739393
-
Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem
-
Hofmann A.F., Roda A. Physicochemical properties of bile acids and their relationship to biological properties: an overview of the problem. J Lipid Res 1984, 25:1477-1489.
-
(1984)
J Lipid Res
, vol.25
, pp. 1477-1489
-
-
Hofmann, A.F.1
Roda, A.2
-
7
-
-
0026623067
-
Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions
-
Hofmann A.F., Mysels K.J. Bile acid solubility and precipitation in vitro and in vivo: the role of conjugation, pH, and Ca2+ ions. J Lipid Res 1992, 33:617-626.
-
(1992)
J Lipid Res
, vol.33
, pp. 617-626
-
-
Hofmann, A.F.1
Mysels, K.J.2
-
8
-
-
0343648748
-
Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile
-
Holsti P. Experimental cirrhosis of the liver in rabbits induced by gastric instillation of desiccated whole bile. Acta Pathol Microbiol Scand Suppl 1956, 39:1-66.
-
(1956)
Acta Pathol Microbiol Scand Suppl
, vol.39
, pp. 1-66
-
-
Holsti, P.1
-
9
-
-
0025247125
-
Hepatic injury induced by bile salts: correlation between biochemical and morphological events
-
Schmucker D.L., Ohta M., Kanai S., Sato Y., Kitani K. Hepatic injury induced by bile salts: correlation between biochemical and morphological events. Hepatology 1990, 12:1216-1221.
-
(1990)
Hepatology
, vol.12
, pp. 1216-1221
-
-
Schmucker, D.L.1
Ohta, M.2
Kanai, S.3
Sato, Y.4
Kitani, K.5
-
10
-
-
33847082573
-
Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation
-
Becker S., Reinehr R., Graf D., vom Dahl S., Haussinger D. Hydrophobic bile salts induce hepatocyte shrinkage via NADPH oxidase activation. Cell Physiol Biochem 2007, 19:89-98.
-
(2007)
Cell Physiol Biochem
, vol.19
, pp. 89-98
-
-
Becker, S.1
Reinehr, R.2
Graf, D.3
vom Dahl, S.4
Haussinger, D.5
-
11
-
-
28844489800
-
Bile salt-induced apoptosis involves NADPH oxidase isoform activation
-
Reinehr R., Becker S., Keitel V., Eberle A., Grether-Beck S., Haussinger D. Bile salt-induced apoptosis involves NADPH oxidase isoform activation. Gastroenterology 2005, 129:2009-2031.
-
(2005)
Gastroenterology
, vol.129
, pp. 2009-2031
-
-
Reinehr, R.1
Becker, S.2
Keitel, V.3
Eberle, A.4
Grether-Beck, S.5
Haussinger, D.6
-
12
-
-
78650793157
-
Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis
-
Allen K., Jaeschke H., Copple B.L. Bile acids induce inflammatory genes in hepatocytes: a novel mechanism of inflammation during obstructive cholestasis. Am J Pathol 2011, 178:175-186.
-
(2011)
Am J Pathol
, vol.178
, pp. 175-186
-
-
Allen, K.1
Jaeschke, H.2
Copple, B.L.3
-
13
-
-
0026505862
-
Cholestasis induces major histocompatibility complex class I expression in hepatocytes
-
Calmus Y., Arvieux C., Gane P., Boucher E., Nordlinger B., Rouger P., Poupon R. Cholestasis induces major histocompatibility complex class I expression in hepatocytes. Gastroenterology 1992, 102:1371-1377.
-
(1992)
Gastroenterology
, vol.102
, pp. 1371-1377
-
-
Calmus, Y.1
Arvieux, C.2
Gane, P.3
Boucher, E.4
Nordlinger, B.5
Rouger, P.6
Poupon, R.7
-
14
-
-
0027932658
-
Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes
-
Hillaire S., Boucher E., Calmus Y., Gane P., Ballet F., Franco D., Moukthar M., et al. Effects of bile acids and cholestasis on major histocompatibility complex class I in human and rat hepatocytes. Gastroenterology 1994, 107:781-788.
-
(1994)
Gastroenterology
, vol.107
, pp. 781-788
-
-
Hillaire, S.1
Boucher, E.2
Calmus, Y.3
Gane, P.4
Ballet, F.5
Franco, D.6
Moukthar, M.7
-
15
-
-
0027282029
-
Immunogenicity of rat hepatocytes in vivo: effect of cholestasis-induced changes in major histocompatibility complex expression
-
Arvieux C., Calmus Y., Gane P., Legendre C., Mariani P., Delelo R., Poupon R., et al. Immunogenicity of rat hepatocytes in vivo: effect of cholestasis-induced changes in major histocompatibility complex expression. J Hepatol 1993, 18:335-341.
-
(1993)
J Hepatol
, vol.18
, pp. 335-341
-
-
Arvieux, C.1
Calmus, Y.2
Gane, P.3
Legendre, C.4
Mariani, P.5
Delelo, R.6
Poupon, R.7
-
16
-
-
0026657890
-
Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes
-
Calmus Y., Guechot J., Podevin P., Bonnefis M.T., Giboudeau J., Poupon R. Differential effects of chenodeoxycholic and ursodeoxycholic acids on interleukin 1, interleukin 6 and tumor necrosis factor-alpha production by monocytes. Hepatology 1992, 16:719-723.
-
(1992)
Hepatology
, vol.16
, pp. 719-723
-
-
Calmus, Y.1
Guechot, J.2
Podevin, P.3
Bonnefis, M.T.4
Giboudeau, J.5
Poupon, R.6
-
17
-
-
0028958795
-
Effect of cholestasis and bile acids on interferoninduced 2',5'-adenylate synthetase and NK cell activities
-
Podevin P., Calmus Y., Bonnefis M.T., Veyrunes C., Chereau C., Poupon R. Effect of cholestasis and bile acids on interferoninduced 2',5'-adenylate synthetase and NK cell activities. Gastroenterology 1995, 108:1192-1198.
-
(1995)
Gastroenterology
, vol.108
, pp. 1192-1198
-
-
Podevin, P.1
Calmus, Y.2
Bonnefis, M.T.3
Veyrunes, C.4
Chereau, C.5
Poupon, R.6
-
18
-
-
0033061334
-
Bile acids modulate the interferon signalling pathway
-
Podevin P., Rosmorduc O., Conti F., Calmus Y., Meier P.J., Poupon R. Bile acids modulate the interferon signalling pathway. Hepatology 1999, 29:1840-1847.
-
(1999)
Hepatology
, vol.29
, pp. 1840-1847
-
-
Podevin, P.1
Rosmorduc, O.2
Conti, F.3
Calmus, Y.4
Meier, P.J.5
Poupon, R.6
-
19
-
-
77958004743
-
Counter-regulatory role of bile acid activated receptors in immunity and inflammation
-
Fiorucci S., Cipriani S., Mencarelli A., Renga B., Distrutti E., Baldelli F. Counter-regulatory role of bile acid activated receptors in immunity and inflammation. Curr Mol Med 2010, 10:579-595.
-
(2010)
Curr Mol Med
, vol.10
, pp. 579-595
-
-
Fiorucci, S.1
Cipriani, S.2
Mencarelli, A.3
Renga, B.4
Distrutti, E.5
Baldelli, F.6
-
20
-
-
0023125182
-
Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?
-
Poupon R., Chretien Y., Poupon R.E., Ballet F., Calmus Y., Darnis F. Is ursodeoxycholic acid an effective treatment for primary biliary cirrhosis?. Lancet 1987, 1:834-836.
-
(1987)
Lancet
, vol.1
, pp. 834-836
-
-
Poupon, R.1
Chretien, Y.2
Poupon, R.E.3
Ballet, F.4
Calmus, Y.5
Darnis, F.6
-
21
-
-
0028294206
-
Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group
-
Poupon R.E., Poupon R., Balkau B. Ursodiol for the long-term treatment of primary biliary cirrhosis. The UDCA-PBC Study Group. N Engl J Med 1994, 330:1342-1347.
-
(1994)
N Engl J Med
, vol.330
, pp. 1342-1347
-
-
Poupon, R.E.1
Poupon, R.2
Balkau, B.3
-
22
-
-
0030852495
-
Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis
-
Poupon R.E., Lindor K.D., Cauch-Dudek K., Dickson E.R., Poupon R., Heathcote E.J. Combined analysis of randomized controlled trials of ursodeoxycholic acid in primary biliary cirrhosis. Gastroenterology 1997, 113:884-890.
-
(1997)
Gastroenterology
, vol.113
, pp. 884-890
-
-
Poupon, R.E.1
Lindor, K.D.2
Cauch-Dudek, K.3
Dickson, E.R.4
Poupon, R.5
Heathcote, E.J.6
-
23
-
-
70349263453
-
High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis
-
Lindor K.D., Kowdley K.V., Luketic V.A., Harrison M.E., McCashland T., Befeler A.S., Harnois D., et al. High-dose ursodeoxycholic acid for the treatment of primary sclerosing cholangitis. Hepatology 2009, 50:808-814.
-
(2009)
Hepatology
, vol.50
, pp. 808-814
-
-
Lindor, K.D.1
Kowdley, K.V.2
Luketic, V.A.3
Harrison, M.E.4
McCashland, T.5
Befeler, A.S.6
Harnois, D.7
-
24
-
-
0029922694
-
Clinical pharmacokinetics of therapeutic bile acids
-
Crosignani A., Setchell K.D., Invernizzi P., Larghi A., Rodrigues C.M., Podda M. Clinical pharmacokinetics of therapeutic bile acids. Clin Pharmacokinet 1996, 30:333-358.
-
(1996)
Clin Pharmacokinet
, vol.30
, pp. 333-358
-
-
Crosignani, A.1
Setchell, K.D.2
Invernizzi, P.3
Larghi, A.4
Rodrigues, C.M.5
Podda, M.6
-
25
-
-
0019976525
-
Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part II
-
Bachrach W.H., Hofmann A.F. Ursodeoxycholic acid in the treatment of cholesterol cholelithiasis. Part II. Dig Dis Sci 1982, 27:833-856.
-
(1982)
Dig Dis Sci
, vol.27
, pp. 833-856
-
-
Bachrach, W.H.1
Hofmann, A.F.2
-
26
-
-
0042508785
-
Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration
-
Lanzini A., De Tavonatti M.G., Panarotto B., Scalia S., Mora A., Benini F., Baisini O., et al. Intestinal absorption of the bile acid analogue 75Se-homocholic acid-taurine is increased in primary biliary cirrhosis, and reverts to normal during ursodeoxycholic acid administration. Gut 2003, 52:1371-1375.
-
(2003)
Gut
, vol.52
, pp. 1371-1375
-
-
Lanzini, A.1
De Tavonatti, M.G.2
Panarotto, B.3
Scalia, S.4
Mora, A.5
Benini, F.6
Baisini, O.7
-
27
-
-
0030482271
-
Ileal absorption of bile acids in patients with chronic cholestasis: SeHCAT test results and effect of ursodeoxycholic acid (UDCA)
-
Chazouilleres O., Marteau P., Haniche M., Jian R., Poupon R. Ileal absorption of bile acids in patients with chronic cholestasis: SeHCAT test results and effect of ursodeoxycholic acid (UDCA). Dig Dis Sci 1996, 41:2417-2422.
-
(1996)
Dig Dis Sci
, vol.41
, pp. 2417-2422
-
-
Chazouilleres, O.1
Marteau, P.2
Haniche, M.3
Jian, R.4
Poupon, R.5
-
28
-
-
0028882410
-
Intestinal absorption of bile acids: effect of ursodeoxycholic acid treatment
-
Stiehl A. Intestinal absorption of bile acids: effect of ursodeoxycholic acid treatment. Ital J Gastroenterol 1995, 27:193-195.
-
(1995)
Ital J Gastroenterol
, vol.27
, pp. 193-195
-
-
Stiehl, A.1
-
29
-
-
0028084463
-
Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid
-
Jazrawi R.P., de Caestecker J.S., Goggin P.M., Britten A.J., Joseph A.E., Maxwell J.D., Northfield T.C. Kinetics of hepatic bile acid handling in cholestatic liver disease: effect of ursodeoxycholic acid. Gastroenterology 1994, 106:134-142.
-
(1994)
Gastroenterology
, vol.106
, pp. 134-142
-
-
Jazrawi, R.P.1
de Caestecker, J.S.2
Goggin, P.M.3
Britten, A.J.4
Joseph, A.E.5
Maxwell, J.D.6
Northfield, T.C.7
-
30
-
-
0026596936
-
Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease
-
Beuers U., Spengler U., Zwiebel F.M., Pauletzki J., Fischer S., Paumgartner G. Effect of ursodeoxycholic acid on the kinetics of the major hydrophobic bile acids in health and in chronic cholestatic liver disease. Hepatology 1992, 15:603-608.
-
(1992)
Hepatology
, vol.15
, pp. 603-608
-
-
Beuers, U.1
Spengler, U.2
Zwiebel, F.M.3
Pauletzki, J.4
Fischer, S.5
Paumgartner, G.6
-
31
-
-
0028933933
-
Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children
-
Poupon R., Poupon R.E. Ursodeoxycholic acid therapy of chronic cholestatic conditions in adults and children. Pharmacol Ther 1995, 66:1-15.
-
(1995)
Pharmacol Ther
, vol.66
, pp. 1-15
-
-
Poupon, R.1
Poupon, R.E.2
-
32
-
-
0037370065
-
Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes
-
Spirli C., Fabris L., Duner E., Fiorotto R., Ballardini G., Roskams T., Larusso N.F., et al. Cytokine-stimulated nitric oxide production inhibits adenylyl cyclase and cAMP-dependent secretion in cholangiocytes. Gastroenterology 2003, 124:737-753.
-
(2003)
Gastroenterology
, vol.124
, pp. 737-753
-
-
Spirli, C.1
Fabris, L.2
Duner, E.3
Fiorotto, R.4
Ballardini, G.5
Roskams, T.6
Larusso, N.F.7
-
33
-
-
0034959516
-
Proinflammatory cytokines inhibit secretion in rat bile duct epithelium
-
Spirli C., Nathanson M.H., Fiorotto R., Duner E., Denson L.A., Sanz J.M., Di Virgilio F., et al. Proinflammatory cytokines inhibit secretion in rat bile duct epithelium. Gastroenterology 2001, 121:156-169.
-
(2001)
Gastroenterology
, vol.121
, pp. 156-169
-
-
Spirli, C.1
Nathanson, M.H.2
Fiorotto, R.3
Duner, E.4
Denson, L.A.5
Sanz, J.M.6
Di Virgilio, F.7
-
34
-
-
0027325467
-
Abnormal expression of anion exchanger genes in primary biliary cirrhosis
-
Prieto J., Qian C., Garcia N., Diez J., Medina J.F. Abnormal expression of anion exchanger genes in primary biliary cirrhosis. Gastroenterology 1993, 105:572-578.
-
(1993)
Gastroenterology
, vol.105
, pp. 572-578
-
-
Prieto, J.1
Qian, C.2
Garcia, N.3
Diez, J.4
Medina, J.F.5
-
35
-
-
0033033458
-
Assessment of biliary bicarbonate secretion in humans by positron emission tomography
-
Prieto J., Garcia N., Marti-Climent J.M., Penuelas I., Richter J.A., Medina J.F. Assessment of biliary bicarbonate secretion in humans by positron emission tomography. Gastroenterology 1999, 117:167-172.
-
(1999)
Gastroenterology
, vol.117
, pp. 167-172
-
-
Prieto, J.1
Garcia, N.2
Marti-Climent, J.M.3
Penuelas, I.4
Richter, J.A.5
Medina, J.F.6
-
36
-
-
38849104576
-
Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells
-
Arenas F., Hervias I., Uriz M., Joplin R., Prieto J., Medina J.F. Combination of ursodeoxycholic acid and glucocorticoids upregulates the AE2 alternate promoter in human liver cells. J Clin Invest 2008, 118:695-709.
-
(2008)
J Clin Invest
, vol.118
, pp. 695-709
-
-
Arenas, F.1
Hervias, I.2
Uriz, M.3
Joplin, R.4
Prieto, J.5
Medina, J.F.6
-
37
-
-
1642338852
-
Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease
-
vi
-
Paumgartner G., Beuers U. Mechanisms of action and therapeutic efficacy of ursodeoxycholic acid in cholestatic liver disease. Clin Liver Dis 2004, 8:67-81. vi.
-
(2004)
Clin Liver Dis
, vol.8
, pp. 67-81
-
-
Paumgartner, G.1
Beuers, U.2
-
38
-
-
83455221623
-
Ursodeoxycholic acid is conjugated with taurine to promote secretinstimulated biliary hydrocholeresis in the normal rat
-
Uriz M., Saez E., Prieto J., Medina J.F., Banales J.M. Ursodeoxycholic acid is conjugated with taurine to promote secretinstimulated biliary hydrocholeresis in the normal rat. PLoS One 2011, 6:e28717.
-
(2011)
PLoS One
, vol.6
-
-
Uriz, M.1
Saez, E.2
Prieto, J.3
Medina, J.F.4
Banales, J.M.5
-
39
-
-
84865474602
-
Ursodeoxycholic acid stimulates the formation of the bile canalicular network
-
In press.
-
Ikebuchi Y, Shimizu H, Ito K, Yoshikado T, Yamanashi Y, Takada T, Suzuki H. Ursodeoxycholic acid stimulates the formation of the bile canalicular network. Biochem Pharmacol 2012;In press.
-
(2012)
Biochem Pharmacol
-
-
Ikebuchi, Y.1
Shimizu, H.2
Ito, K.3
Yoshikado, T.4
Yamanashi, Y.5
Takada, T.6
Suzuki, H.7
-
40
-
-
0027179015
-
Molecular aspects of membrane stabilization by ursodeoxycholate [see comment]
-
Guldutuna S., Zimmer G., Imhof M., Bhatti S., You T., Leuschner U. Molecular aspects of membrane stabilization by ursodeoxycholate [see comment]. Gastroenterology 1993, 104:1736-1744.
-
(1993)
Gastroenterology
, vol.104
, pp. 1736-1744
-
-
Guldutuna, S.1
Zimmer, G.2
Imhof, M.3
Bhatti, S.4
You, T.5
Leuschner, U.6
-
41
-
-
0031950282
-
Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production
-
Rodrigues C.M., Fan G., Wong P.Y., Kren B.T., Steer C.J. Ursodeoxycholic acid may inhibit deoxycholic acid-induced apoptosis by modulating mitochondrial transmembrane potential and reactive oxygen species production. Mol Med 1998, 4:165-178.
-
(1998)
Mol Med
, vol.4
, pp. 165-178
-
-
Rodrigues, C.M.1
Fan, G.2
Wong, P.Y.3
Kren, B.T.4
Steer, C.J.5
-
42
-
-
0033600824
-
Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants
-
Mitsuyoshi H., Nakashima T., Sumida Y., Yoh T., Nakajima Y., Ishikawa H., Inaba K., et al. Ursodeoxycholic acid protects hepatocytes against oxidative injury via induction of antioxidants. Biochem Biophys Res Commun 1999, 263:537-542.
-
(1999)
Biochem Biophys Res Commun
, vol.263
, pp. 537-542
-
-
Mitsuyoshi, H.1
Nakashima, T.2
Sumida, Y.3
Yoh, T.4
Nakajima, Y.5
Ishikawa, H.6
Inaba, K.7
-
43
-
-
0033740305
-
Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease
-
Ljubuncic P., Tanne Z., Bomzon A. Ursodeoxycholic acid suppresses extent of lipid peroxidation in diseased liver in experimental cholestatic liver disease. Dig Dis Sci 2000, 45:1921-1928.
-
(2000)
Dig Dis Sci
, vol.45
, pp. 1921-1928
-
-
Ljubuncic, P.1
Tanne, Z.2
Bomzon, A.3
-
44
-
-
0036109728
-
Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats
-
Rodriguez-Ortigosa C.M., Cincu R.N., Sanz S., Ruiz F., Quiroga J., Prieto J. Effect of ursodeoxycholic acid on methionine adenosyltransferase activity and hepatic glutathione metabolism in rats. Gut 2002, 50:701-706.
-
(2002)
Gut
, vol.50
, pp. 701-706
-
-
Rodriguez-Ortigosa, C.M.1
Cincu, R.N.2
Sanz, S.3
Ruiz, F.4
Quiroga, J.5
Prieto, J.6
-
45
-
-
0036129525
-
Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate
-
Bernstein C., Payne C.M., Bernstein H., Garewal H. Activation of the metallothionein IIA promoter and other key stress response elements by ursodeoxycholate in HepG2 cells: relevance to the cytoprotective function of ursodeoxycholate. Pharmacology 2002, 65:2-9.
-
(2002)
Pharmacology
, vol.65
, pp. 2-9
-
-
Bernstein, C.1
Payne, C.M.2
Bernstein, H.3
Garewal, H.4
-
46
-
-
0036890346
-
Antioxidant properties of ursodeoxycholic acid
-
Lapenna D., Ciofani G., Festi D., Neri M., Pierdomenico S.D., Giamberardino M.A., Cuccurullo F. Antioxidant properties of ursodeoxycholic acid. Biochem Pharmacol 2002, 64:1661-1667.
-
(2002)
Biochem Pharmacol
, vol.64
, pp. 1661-1667
-
-
Lapenna, D.1
Ciofani, G.2
Festi, D.3
Neri, M.4
Pierdomenico, S.D.5
Giamberardino, M.A.6
Cuccurullo, F.7
-
47
-
-
77954101086
-
Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis
-
Kawata K., Kobayashi Y., Souda K., Kawamura K., Sumiyoshi S., Takahashi Y., Noritake H., et al. Enhanced hepatic Nrf2 activation after ursodeoxycholic acid treatment in patients with primary biliary cirrhosis. Antioxid Redox Signal 2010, 13:259-268.
-
(2010)
Antioxid Redox Signal
, vol.13
, pp. 259-268
-
-
Kawata, K.1
Kobayashi, Y.2
Souda, K.3
Kawamura, K.4
Sumiyoshi, S.5
Takahashi, Y.6
Noritake, H.7
-
48
-
-
68949114163
-
Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications
-
Yang H., Ramani K., Xia M., Ko K.S., Li T.W., Oh P., Li J., et al. Dysregulation of glutathione synthesis during cholestasis in mice: molecular mechanisms and therapeutic implications. Hepatology 2009, 49:1982-1991.
-
(2009)
Hepatology
, vol.49
, pp. 1982-1991
-
-
Yang, H.1
Ramani, K.2
Xia, M.3
Ko, K.S.4
Li, T.W.5
Oh, P.6
Li, J.7
-
49
-
-
59749083235
-
Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells
-
Arisawa S., Ishida K., Kameyama N., Ueyama J., Hattori A., Tatsumi Y., Hayashi H., et al. Ursodeoxycholic acid induces glutathione synthesis through activation of PI3K/Akt pathway in HepG2 cells. Biochem Pharmacol 2009, 77:858-866.
-
(2009)
Biochem Pharmacol
, vol.77
, pp. 858-866
-
-
Arisawa, S.1
Ishida, K.2
Kameyama, N.3
Ueyama, J.4
Hattori, A.5
Tatsumi, Y.6
Hayashi, H.7
-
50
-
-
57349108021
-
Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice
-
Okada K., Shoda J., Taguchi K., Maher J.M., Ishizaki K., Inoue Y., Ohtsuki M., et al. Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice. Am J Physiol Gastrointest Liver Physiol 2008, 295:G735-G747.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.295
-
-
Okada, K.1
Shoda, J.2
Taguchi, K.3
Maher, J.M.4
Ishizaki, K.5
Inoue, Y.6
Ohtsuki, M.7
-
51
-
-
0031005366
-
Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis
-
Koga H., Sakisaka S., Ohishi M., Sata M., Tanikawa K. Nuclear DNA fragmentation and expression of Bcl-2 in primary biliary cirrhosis. Hepatology 1997, 25:1077-1084.
-
(1997)
Hepatology
, vol.25
, pp. 1077-1084
-
-
Koga, H.1
Sakisaka, S.2
Ohishi, M.3
Sata, M.4
Tanikawa, K.5
-
52
-
-
33846699177
-
T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis
-
Allina J., Hu B., Sullivan D.M., Fiel M.I., Thung S.N., Bronk S.F., Huebert R.C., et al. T cell targeting and phagocytosis of apoptotic biliary epithelial cells in primary biliary cirrhosis. J Autoimmun 2006, 27:232-241.
-
(2006)
J Autoimmun
, vol.27
, pp. 232-241
-
-
Allina, J.1
Hu, B.2
Sullivan, D.M.3
Fiel, M.I.4
Thung, S.N.5
Bronk, S.F.6
Huebert, R.C.7
-
53
-
-
0036725164
-
Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation
-
Xie Q., Khaoustov V.I., Chung C.C., Sohn J., Krishnan B., Lewis D.E., Yoffe B. Effect of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation. Hepatology 2002, 36:592-601.
-
(2002)
Hepatology
, vol.36
, pp. 592-601
-
-
Xie, Q.1
Khaoustov, V.I.2
Chung, C.C.3
Sohn, J.4
Krishnan, B.5
Lewis, D.E.6
Yoffe, B.7
-
54
-
-
0036211298
-
Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes
-
Qiao L., Yacoub A., Studer E., Gupta S., Pei X.Y., Grant S., Hylemon P.B., et al. Inhibition of the MAPK and PI3K pathways enhances UDCA-induced apoptosis in primary rodent hepatocytes. Hepatology 2002, 35:779-789.
-
(2002)
Hepatology
, vol.35
, pp. 779-789
-
-
Qiao, L.1
Yacoub, A.2
Studer, E.3
Gupta, S.4
Pei, X.Y.5
Grant, S.6
Hylemon, P.B.7
-
55
-
-
2442662132
-
Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways
-
Schoemaker M.H., Conde de la Rosa L., Buist-Homan M., Vrenken T.E., Havinga R., Poelstra K., Haisma H.J., et al. Tauroursodeoxycholic acid protects rat hepatocytes from bile acid-induced apoptosis via activation of survival pathways. Hepatology 2004, 39:1563-1573.
-
(2004)
Hepatology
, vol.39
, pp. 1563-1573
-
-
Schoemaker, M.H.1
Conde de la Rosa, L.2
Buist-Homan, M.3
Vrenken, T.E.4
Havinga, R.5
Poelstra, K.6
Haisma, H.J.7
-
56
-
-
3142580336
-
Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes
-
Sola S., Castro R.E., Kren B.T., Steer C.J., Rodrigues C.M. Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes. Biochemistry 2004, 43:8429-8438.
-
(2004)
Biochemistry
, vol.43
, pp. 8429-8438
-
-
Sola, S.1
Castro, R.E.2
Kren, B.T.3
Steer, C.J.4
Rodrigues, C.M.5
-
57
-
-
77952554792
-
The role of p53 in apoptosis
-
Amaral J.D., Xavier J.M., Steer C.J., Rodrigues C.M. The role of p53 in apoptosis. Discov Med 2010, 9:145-152.
-
(2010)
Discov Med
, vol.9
, pp. 145-152
-
-
Amaral, J.D.1
Xavier, J.M.2
Steer, C.J.3
Rodrigues, C.M.4
-
58
-
-
0025098908
-
Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid
-
Calmus Y., Gane P., Rouger P., Poupon R. Hepatic expression of class I and class II major histocompatibility complex molecules in primary biliary cirrhosis: effect of ursodeoxycholic acid. Hepatology 1990, 11:12-15.
-
(1990)
Hepatology
, vol.11
, pp. 12-15
-
-
Calmus, Y.1
Gane, P.2
Rouger, P.3
Poupon, R.4
-
59
-
-
0030043423
-
Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway
-
Tanaka H., Makino Y., Miura T., Hirano F., Okamoto K., Komura K., Sato Y., et al. Ligand-independent activation of the glucocorticoid receptor by ursodeoxycholic acid. Repression of IFN-gamma-induced MHC class II gene expression via a glucocorticoid receptor-dependent pathway. J Immunol 1996, 156:1601-1608.
-
(1996)
J Immunol
, vol.156
, pp. 1601-1608
-
-
Tanaka, H.1
Makino, Y.2
Miura, T.3
Hirano, F.4
Okamoto, K.5
Komura, K.6
Sato, Y.7
-
60
-
-
84863167924
-
Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis
-
Takahashi T., Miura T., Nakamura J., Yamada S., Miura T., Yanagi M., Matsuda Y., et al. Plasma cells and the chronic nonsuppurative destructive cholangitis of primary biliary cirrhosis. Hepatology 2012, 55:846-855.
-
(2012)
Hepatology
, vol.55
, pp. 846-855
-
-
Takahashi, T.1
Miura, T.2
Nakamura, J.3
Yamada, S.4
Miura, T.5
Yanagi, M.6
Matsuda, Y.7
-
61
-
-
65449131223
-
Ursodeoxycholic acid reduces CpG-induced IgM production in patients with primary biliary cirrhosis
-
Kikuchi K., Hsu W., Hosoya N., Moritoki Y., Kajiyama Y., Kawai T., Takai A., et al. Ursodeoxycholic acid reduces CpG-induced IgM production in patients with primary biliary cirrhosis. Hepatol Res 2009, 39:448-454.
-
(2009)
Hepatol Res
, vol.39
, pp. 448-454
-
-
Kikuchi, K.1
Hsu, W.2
Hosoya, N.3
Moritoki, Y.4
Kajiyama, Y.5
Kawai, T.6
Takai, A.7
-
62
-
-
0026642157
-
Immunomodulatory effects of ursodeoxycholic acid on immune responses
-
Yoshikawa M., Tsujii T., Matsumura K., Yamao J., Matsumura Y., Kubo R., Fukui H., et al. Immunomodulatory effects of ursodeoxycholic acid on immune responses. Hepatology 1992, 16:358-364.
-
(1992)
Hepatology
, vol.16
, pp. 358-364
-
-
Yoshikawa, M.1
Tsujii, T.2
Matsumura, K.3
Yamao, J.4
Matsumura, Y.5
Kubo, R.6
Fukui, H.7
-
63
-
-
36549034307
-
Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-alpha and macrophage inflammatory protein-2 production
-
Ishizaki K., Iwaki T., Kinoshita S., Koyama M., Fukunari A., Tanaka H., Tsurufuji M., et al. Ursodeoxycholic acid protects concanavalin A-induced mouse liver injury through inhibition of intrahepatic tumor necrosis factor-alpha and macrophage inflammatory protein-2 production. Eur J Pharmacol 2008, 578:57-64.
-
(2008)
Eur J Pharmacol
, vol.578
, pp. 57-64
-
-
Ishizaki, K.1
Iwaki, T.2
Kinoshita, S.3
Koyama, M.4
Fukunari, A.5
Tanaka, H.6
Tsurufuji, M.7
-
64
-
-
79955592279
-
Plant lectins are novel Toll-like receptor agonists
-
Unitt J., Hornigold D. Plant lectins are novel Toll-like receptor agonists. Biochem Pharmacol 2011, 81:1324-1328.
-
(2011)
Biochem Pharmacol
, vol.81
, pp. 1324-1328
-
-
Unitt, J.1
Hornigold, D.2
-
65
-
-
84856079186
-
Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression
-
Tu C.T., Han B., Yao Q.Y., Zhang Y.A., Liu H.C., Zhang S.C. Curcumin attenuates Concanavalin A-induced liver injury in mice by inhibition of Toll-like receptor (TLR) 2, TLR4 and TLR9 expression. Int Immunopharmacol 2012, 12:151-157.
-
(2012)
Int Immunopharmacol
, vol.12
, pp. 151-157
-
-
Tu, C.T.1
Han, B.2
Yao, Q.Y.3
Zhang, Y.A.4
Liu, H.C.5
Zhang, S.C.6
-
66
-
-
24144465889
-
Molecular determinants of crosstalk between nuclear receptors and toll-like receptors
-
Ogawa S., Lozach J., Benner C., Pascual G., Tangirala R.K., Westin S., Hoffmann A., et al. Molecular determinants of crosstalk between nuclear receptors and toll-like receptors. Cell 2005, 122:707-721.
-
(2005)
Cell
, vol.122
, pp. 707-721
-
-
Ogawa, S.1
Lozach, J.2
Benner, C.3
Pascual, G.4
Tangirala, R.K.5
Westin, S.6
Hoffmann, A.7
-
67
-
-
62949244071
-
Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium
-
D'Aldebert E., Biyeyeme Bi Mve M.J., Mergey M., Wendum D., Firrincieli D., Coilly A., Fouassier L., et al. Bile salts control the antimicrobial peptide cathelicidin through nuclear receptors in the human biliary epithelium. Gastroenterology 2009, 136:1435-1443.
-
(2009)
Gastroenterology
, vol.136
, pp. 1435-1443
-
-
D'Aldebert, E.1
Biyeyeme Bi Mve, M.J.2
Mergey, M.3
Wendum, D.4
Firrincieli, D.5
Coilly, A.6
Fouassier, L.7
-
68
-
-
32944464959
-
Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogenassociated molecular patterns
-
Sadeghi K., Wessner B., Laggner U., Ploder M., Tamandl D., Friedl J., Zugel U., et al. Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogenassociated molecular patterns. Eur J Immunol 2006, 36:361-370.
-
(2006)
Eur J Immunol
, vol.36
, pp. 361-370
-
-
Sadeghi, K.1
Wessner, B.2
Laggner, U.3
Ploder, M.4
Tamandl, D.5
Friedl, J.6
Zugel, U.7
-
69
-
-
43049181301
-
Liver autoimmunity triggered by microbial activation of natural killer T cells
-
Mattner J., Savage P.B., Leung P., Oertelt S.S., Wang V., Trivedi O., Scanlon S.T., et al. Liver autoimmunity triggered by microbial activation of natural killer T cells. Cell Host Microbe 2008, 3:304-315.
-
(2008)
Cell Host Microbe
, vol.3
, pp. 304-315
-
-
Mattner, J.1
Savage, P.B.2
Leung, P.3
Oertelt, S.S.4
Wang, V.5
Trivedi, O.6
Scanlon, S.T.7
-
70
-
-
0030056154
-
Ursodeoxycholic acid corrects defective natural killer activity by inhibiting prostaglandin E2 production in primary biliary cirrhosis
-
Nishigaki Y., Ohnishi H., Moriwaki H., Muto Y. Ursodeoxycholic acid corrects defective natural killer activity by inhibiting prostaglandin E2 production in primary biliary cirrhosis. Dig Dis Sci 1996, 41:1487-1493.
-
(1996)
Dig Dis Sci
, vol.41
, pp. 1487-1493
-
-
Nishigaki, Y.1
Ohnishi, H.2
Moriwaki, H.3
Muto, Y.4
-
71
-
-
0028804229
-
Role of hepatocytes in direct clearance of lipopolysaccharide in rats
-
Mimura Y., Sakisaka S., Harada M., Sata M., Tanikawa K. Role of hepatocytes in direct clearance of lipopolysaccharide in rats. Gastroenterology 1995, 109:1969-1976.
-
(1995)
Gastroenterology
, vol.109
, pp. 1969-1976
-
-
Mimura, Y.1
Sakisaka, S.2
Harada, M.3
Sata, M.4
Tanikawa, K.5
-
72
-
-
33644856860
-
On the role and fate of LPS-dephosphorylating activity in the rat liver
-
Tuin A., Huizinga-Van der Vlag A., van Loenen-Weemaes A.M., Meijer D.K., Poelstra K. On the role and fate of LPS-dephosphorylating activity in the rat liver. Am J Physiol Gastrointest Liver Physiol 2006, 290:G377-G385.
-
(2006)
Am J Physiol Gastrointest Liver Physiol
, vol.290
-
-
Tuin, A.1
Huizinga-Van der Vlag, A.2
van Loenen-Weemaes, A.M.3
Meijer, D.K.4
Poelstra, K.5
-
73
-
-
0032171526
-
Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis
-
Sasatomi K., Noguchi K., Sakisaka S., Sata M., Tanikawa K. Abnormal accumulation of endotoxin in biliary epithelial cells in primary biliary cirrhosis and primary sclerosing cholangitis. J Hepatol 1998, 29:409-416.
-
(1998)
J Hepatol
, vol.29
, pp. 409-416
-
-
Sasatomi, K.1
Noguchi, K.2
Sakisaka, S.3
Sata, M.4
Tanikawa, K.5
-
74
-
-
77953749477
-
Biliary innate immunity in the pathogenesis of biliary diseases
-
Harada K., Nakanuma Y. Biliary innate immunity in the pathogenesis of biliary diseases. Inflamm Allergy Drug Targets 2010, 9:83-90.
-
(2010)
Inflamm Allergy Drug Targets
, vol.9
, pp. 83-90
-
-
Harada, K.1
Nakanuma, Y.2
-
75
-
-
67650668741
-
Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis
-
Harada K., Shimoda S., Sato Y., Isse K., Ikeda H., Nakanuma Y. Periductal interleukin-17 production in association with biliary innate immunity contributes to the pathogenesis of cholangiopathy in primary biliary cirrhosis. Clin Exp Immunol 2009, 157:261-270.
-
(2009)
Clin Exp Immunol
, vol.157
, pp. 261-270
-
-
Harada, K.1
Shimoda, S.2
Sato, Y.3
Isse, K.4
Ikeda, H.5
Nakanuma, Y.6
-
76
-
-
84863837341
-
Cholangiopathy with respect to biliary innate immunity
-
Harada K., Nakanuma Y. Cholangiopathy with respect to biliary innate immunity. Int J Hepatol 2012, 2012:793569.
-
(2012)
Int J Hepatol
, vol.2012
, pp. 793569
-
-
Harada, K.1
Nakanuma, Y.2
-
77
-
-
0030782580
-
Increased serum IgM class anti-lipid A antibody and therapeutic effect of ursodeoxycholic acid in primary biliary cirrhosis
-
Ide T., Sata M., Nakano H., Suzuki H., Tanikawa K. Increased serum IgM class anti-lipid A antibody and therapeutic effect of ursodeoxycholic acid in primary biliary cirrhosis. Hepatogastroenterology 1997, 44:1569-1573.
-
(1997)
Hepatogastroenterology
, vol.44
, pp. 1569-1573
-
-
Ide, T.1
Sata, M.2
Nakano, H.3
Suzuki, H.4
Tanikawa, K.5
-
78
-
-
1342329687
-
Immune response to lipopolysaccharide in primary biliary cirrhosis and autoimmune diseases
-
Ballot E., Bandin O., Chazouilleres O., Johanet C., Poupon R. Immune response to lipopolysaccharide in primary biliary cirrhosis and autoimmune diseases. J Autoimmun 2004, 22:153-158.
-
(2004)
J Autoimmun
, vol.22
, pp. 153-158
-
-
Ballot, E.1
Bandin, O.2
Chazouilleres, O.3
Johanet, C.4
Poupon, R.5
-
79
-
-
80053580862
-
Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-kappaB-mediated inflammatory response in mice
-
1508 e1491-5
-
Fiorotto R., Scirpo R., Trauner M., Fabris L., Hoque R., Spirli C., Strazzabosco M. Loss of CFTR affects biliary epithelium innate immunity and causes TLR4-NF-kappaB-mediated inflammatory response in mice. Gastroenterology 2011, 141:1498-1508. 1508 e1491-5.
-
(2011)
Gastroenterology
, vol.141
, pp. 1498-1508
-
-
Fiorotto, R.1
Scirpo, R.2
Trauner, M.3
Fabris, L.4
Hoque, R.5
Spirli, C.6
Strazzabosco, M.7
-
80
-
-
0021710273
-
Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action
-
Hagmann W., Denzlinger C., Keppler D. Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action. Circ Shock 1984, 14:223-235.
-
(1984)
Circ Shock
, vol.14
, pp. 223-235
-
-
Hagmann, W.1
Denzlinger, C.2
Keppler, D.3
-
81
-
-
0028091402
-
Ursodeoxycholic acid modifies gut-derived endotoxemia in neonatal rats
-
Schwarzenberg S.J., Bundy M. Ursodeoxycholic acid modifies gut-derived endotoxemia in neonatal rats. Pediatr Res 1994, 35:214-217.
-
(1994)
Pediatr Res
, vol.35
, pp. 214-217
-
-
Schwarzenberg, S.J.1
Bundy, M.2
-
82
-
-
0031050208
-
Protective effect of the intravenous administration of ursodeoxycholic acid against endotoxemia in rats with obstructive jaundice
-
Hori Y., Ohyanagi H. Protective effect of the intravenous administration of ursodeoxycholic acid against endotoxemia in rats with obstructive jaundice. Surg Today 1997, 27:140-144.
-
(1997)
Surg Today
, vol.27
, pp. 140-144
-
-
Hori, Y.1
Ohyanagi, H.2
-
83
-
-
0035861563
-
Functional modulation of the glucocorticoid receptor and suppression of NF-kappaBdependent transcription by ursodeoxycholic acid
-
Miura T., Ouchida R., Yoshikawa N., Okamoto K., Makino Y., Nakamura T., Morimoto C., et al. Functional modulation of the glucocorticoid receptor and suppression of NF-kappaBdependent transcription by ursodeoxycholic acid. J Biol Chem 2001, 276:47371-47378.
-
(2001)
J Biol Chem
, vol.276
, pp. 47371-47378
-
-
Miura, T.1
Ouchida, R.2
Yoshikawa, N.3
Okamoto, K.4
Makino, Y.5
Nakamura, T.6
Morimoto, C.7
-
84
-
-
34848879554
-
Anti-inflammatory effects of phosphatidylcholine
-
Treede I., Braun A., Sparla R., Kuhnel M., Giese T., Turner J.R., Anes E., et al. Anti-inflammatory effects of phosphatidylcholine. J Biol Chem 2007, 282:27155-27164.
-
(2007)
J Biol Chem
, vol.282
, pp. 27155-27164
-
-
Treede, I.1
Braun, A.2
Sparla, R.3
Kuhnel, M.4
Giese, T.5
Turner, J.R.6
Anes, E.7
-
85
-
-
0030012966
-
Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene
-
Van Nieuwkerk C.M., Elferink R.P., Groen A.K., Ottenhoff R., Tytgat G.N., Dingemans K.P., Van Den Bergh Weerman M.A., et al. Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene. Gastroenterology 1996, 111:165-171.
-
(1996)
Gastroenterology
, vol.111
, pp. 165-171
-
-
Van Nieuwkerk, C.M.1
Elferink, R.P.2
Groen, A.K.3
Ottenhoff, R.4
Tytgat, G.N.5
Dingemans, K.P.6
Van Den Bergh Weerman, M.A.7
-
86
-
-
8544233530
-
Partial characterization of cytoprotective mechanisms of lecithin against bile salt-induced bile duct damage
-
Tsuboi K., Tazuma S., Nishioka T., Chayama K. Partial characterization of cytoprotective mechanisms of lecithin against bile salt-induced bile duct damage. J Gastroenterol 2004, 39:955-960.
-
(2004)
J Gastroenterol
, vol.39
, pp. 955-960
-
-
Tsuboi, K.1
Tazuma, S.2
Nishioka, T.3
Chayama, K.4
-
87
-
-
0029084190
-
Biliary secretion of bile acids and lipids in primary sclerosing cholangitis. Influence of cholestasis and effect of ursodeoxycholic acid treatment
-
Stiehl A., Rudolph G., Sauer P., Theilmann L. Biliary secretion of bile acids and lipids in primary sclerosing cholangitis. Influence of cholestasis and effect of ursodeoxycholic acid treatment. J Hepatol 1995, 23:283-289.
-
(1995)
J Hepatol
, vol.23
, pp. 283-289
-
-
Stiehl, A.1
Rudolph, G.2
Sauer, P.3
Theilmann, L.4
-
88
-
-
7344246553
-
Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones
-
Kano M., Shoda J., Irimura T., Ueda T., Iwasaki R., Urasaki T., Kawauchi Y., et al. Effects of long-term ursodeoxycholate administration on expression levels of secretory low-molecular-weight phospholipases A2 and mucin genes in gallbladders and biliary composition in patients with multiple cholesterol stones. Hepatology 1998, 28:302-313.
-
(1998)
Hepatology
, vol.28
, pp. 302-313
-
-
Kano, M.1
Shoda, J.2
Irimura, T.3
Ueda, T.4
Iwasaki, R.5
Urasaki, T.6
Kawauchi, Y.7
-
89
-
-
34547382615
-
Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene
-
Rosmorduc O., Poupon R. Low phospholipid associated cholelithiasis: association with mutation in the MDR3/ABCB4 gene. Orphanet J Rare Dis 2007, 2:29.
-
(2007)
Orphanet J Rare Dis
, vol.2
, pp. 29
-
-
Rosmorduc, O.1
Poupon, R.2
-
90
-
-
32044462778
-
Novel biotransformation and physiological properties of norursodeoxycholic acid in humans
-
Hofmann A.F., Zakko S.F., Lira M., Clerici C., Hagey L.R., Lambert K.K., Steinbach J.H., et al. Novel biotransformation and physiological properties of norursodeoxycholic acid in humans. Hepatology 2005, 42:1391-1398.
-
(2005)
Hepatology
, vol.42
, pp. 1391-1398
-
-
Hofmann, A.F.1
Zakko, S.F.2
Lira, M.3
Clerici, C.4
Hagey, L.R.5
Lambert, K.K.6
Steinbach, J.H.7
-
91
-
-
32044467118
-
24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice
-
Fickert P., Wagner M., Marschall H.U., Fuchsbichler A., Zollner G., Tsybrovskyy O., Zatloukal K., et al. 24-norUrsodeoxycholic acid is superior to ursodeoxycholic acid in the treatment of sclerosing cholangitis in Mdr2 (Abcb4) knockout mice. Gastroenterology 2006, 130:465-481.
-
(2006)
Gastroenterology
, vol.130
, pp. 465-481
-
-
Fickert, P.1
Wagner, M.2
Marschall, H.U.3
Fuchsbichler, A.4
Zollner, G.5
Tsybrovskyy, O.6
Zatloukal, K.7
-
92
-
-
78049492335
-
Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver
-
Denk G.U., Maitz S., Wimmer R., Rust C., Invernizzi P., Ferdinandusse S., Kulik W., et al. Conjugation is essential for the anticholestatic effect of NorUrsodeoxycholic acid in taurolithocholic acid-induced cholestasis in rat liver. Hepatology 2010, 52:1758-1768.
-
(2010)
Hepatology
, vol.52
, pp. 1758-1768
-
-
Denk, G.U.1
Maitz, S.2
Wimmer, R.3
Rust, C.4
Invernizzi, P.5
Ferdinandusse, S.6
Kulik, W.7
-
93
-
-
33748809238
-
Nuclear receptors in human immune cells: expression and correlations
-
Schote A.B., Turner J.D., Schiltz J., Muller C.P. Nuclear receptors in human immune cells: expression and correlations. Mol Immunol 2007, 44:1436-1445.
-
(2007)
Mol Immunol
, vol.44
, pp. 1436-1445
-
-
Schote, A.B.1
Turner, J.D.2
Schiltz, J.3
Muller, C.P.4
-
94
-
-
20344399619
-
Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor
-
Campana G., Pasini P., Roda A., Spampinato S. Regulation of ileal bile acid-binding protein expression in Caco-2 cells by ursodeoxycholic acid: role of the farnesoid X receptor. Biochem Pharmacol 2005, 69:1755-1763.
-
(2005)
Biochem Pharmacol
, vol.69
, pp. 1755-1763
-
-
Campana, G.1
Pasini, P.2
Roda, A.3
Spampinato, S.4
-
95
-
-
57349124804
-
Beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes
-
Sinha J., Chen F., Miloh T., Burns R.C., Yu Z., Shneider B.L. beta-Klotho and FGF-15/19 inhibit the apical sodium-dependent bile acid transporter in enterocytes and cholangiocytes. Am J Physiol Gastrointest Liver Physiol 2008, 295:G996-G1003.
-
(2008)
Am J Physiol Gastrointest Liver Physiol
, vol.295
-
-
Sinha, J.1
Chen, F.2
Miloh, T.3
Burns, R.C.4
Yu, Z.5
Shneider, B.L.6
-
96
-
-
27844546989
-
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
-
Inagaki T., Choi M., Moschetta A., Peng L., Cummins C.L., McDonald J.G., Luo G., et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005, 2:217-225.
-
(2005)
Cell Metab
, vol.2
, pp. 217-225
-
-
Inagaki, T.1
Choi, M.2
Moschetta, A.3
Peng, L.4
Cummins, C.L.5
McDonald, J.G.6
Luo, G.7
-
97
-
-
0033637121
-
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
-
Goodwin B., Jones S.A., Price R.R., Watson M.A., McKee D.D., Moore L.B., Galardi C., et al. A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis. Mol Cell 2000, 6:517-526.
-
(2000)
Mol Cell
, vol.6
, pp. 517-526
-
-
Goodwin, B.1
Jones, S.A.2
Price, R.R.3
Watson, M.A.4
McKee, D.D.5
Moore, L.B.6
Galardi, C.7
-
98
-
-
0034950514
-
The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp
-
Denson L.A., Sturm E., Echevarria W., Zimmerman T.L., Makishima M., Mangelsdorf D.J., Karpen S.J. The orphan nuclear receptor, shp, mediates bile acid-induced inhibition of the rat bile acid transporter, ntcp. Gastroenterology 2001, 121:140-147.
-
(2001)
Gastroenterology
, vol.121
, pp. 140-147
-
-
Denson, L.A.1
Sturm, E.2
Echevarria, W.3
Zimmerman, T.L.4
Makishima, M.5
Mangelsdorf, D.J.6
Karpen, S.J.7
-
99
-
-
0035800772
-
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
-
Ananthanarayanan M., Balasubramanian N., Makishima M., Mangelsdorf D.J., Suchy F.J. Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor. J Biol Chem 2001, 276:28857-28865.
-
(2001)
J Biol Chem
, vol.276
, pp. 28857-28865
-
-
Ananthanarayanan, M.1
Balasubramanian, N.2
Makishima, M.3
Mangelsdorf, D.J.4
Suchy, F.J.5
-
100
-
-
0346690402
-
Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis
-
Liu Y., Binz J., Numerick M.J., Dennis S., Luo G., Desai B., MacKenzie K.I., et al. Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis. J Clin Invest 2003, 112:1678-1687.
-
(2003)
J Clin Invest
, vol.112
, pp. 1678-1687
-
-
Liu, Y.1
Binz, J.2
Numerick, M.J.3
Dennis, S.4
Luo, G.5
Desai, B.6
MacKenzie, K.I.7
-
101
-
-
0037169551
-
Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
-
Kast H.R., Goodwin B., Tarr P.T., Jones S.A., Anisfeld A.M., Stoltz C.M., Tontonoz P., et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem 2002, 277:2908-2915.
-
(2002)
J Biol Chem
, vol.277
, pp. 2908-2915
-
-
Kast, H.R.1
Goodwin, B.2
Tarr, P.T.3
Jones, S.A.4
Anisfeld, A.M.5
Stoltz, C.M.6
Tontonoz, P.7
-
102
-
-
6944234902
-
Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene
-
Gnerre C., Blattler S., Kaufmann M.R., Looser R., Meyer U.A. Regulation of CYP3A4 by the bile acid receptor FXR: evidence for functional binding sites in the CYP3A4 gene. Pharmacogenetics 2004, 14:635-645.
-
(2004)
Pharmacogenetics
, vol.14
, pp. 635-645
-
-
Gnerre, C.1
Blattler, S.2
Kaufmann, M.R.3
Looser, R.4
Meyer, U.A.5
-
103
-
-
0038281429
-
FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity
-
Barbier O., Torra I.P., Sirvent A., Claudel T., Blanquart C., Duran-Sandoval D., Kuipers F., et al. FXR induces the UGT2B4 enzyme in hepatocytes: a potential mechanism of negative feedback control of FXR activity. Gastroenterology 2003, 124:1926-1940.
-
(2003)
Gastroenterology
, vol.124
, pp. 1926-1940
-
-
Barbier, O.1
Torra, I.P.2
Sirvent, A.3
Claudel, T.4
Blanquart, C.5
Duran-Sandoval, D.6
Kuipers, F.7
-
104
-
-
0035834769
-
Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor
-
Song C.S., Echchgadda I., Baek B.S., Ahn S.C., Oh T., Roy A.K., Chatterjee B. Dehydroepiandrosterone sulfotransferase gene induction by bile acid activated farnesoid X receptor. J Biol Chem 2001, 276:42549-42556.
-
(2001)
J Biol Chem
, vol.276
, pp. 42549-42556
-
-
Song, C.S.1
Echchgadda, I.2
Baek, B.S.3
Ahn, S.C.4
Oh, T.5
Roy, A.K.6
Chatterjee, B.7
-
105
-
-
0042825756
-
Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice
-
Wagner M., Fickert P., Zollner G., Fuchsbichler A., Silbert D., Tsybrovskyy O., Zatloukal K., et al. Role of farnesoid X receptor in determining hepatic ABC transporter expression and liver injury in bile duct-ligated mice. Gastroenterology 2003, 125:825-838.
-
(2003)
Gastroenterology
, vol.125
, pp. 825-838
-
-
Wagner, M.1
Fickert, P.2
Zollner, G.3
Fuchsbichler, A.4
Silbert, D.5
Tsybrovskyy, O.6
Zatloukal, K.7
-
106
-
-
84856159269
-
Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis
-
e351-4
-
Modica S., Petruzzelli M., Bellafante E., Murzilli S., Salvatore L., Celli N., Di Tullio G., et al. Selective activation of nuclear bile acid receptor FXR in the intestine protects mice against cholestasis. Gastroenterology 2012, 142:355-365. e351-4.
-
(2012)
Gastroenterology
, vol.142
, pp. 355-365
-
-
Modica, S.1
Petruzzelli, M.2
Bellafante, E.3
Murzilli, S.4
Salvatore, L.5
Celli, N.6
Di Tullio, G.7
-
107
-
-
80053334403
-
Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/-(Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO(-)(3) output
-
Baghdasaryan A., Claudel T., Gumhold J., Silbert D., Adorini L., Roda A., Vecchiotti S., et al. Dual farnesoid X receptor/TGR5 agonist INT-767 reduces liver injury in the Mdr2-/-(Abcb4-/-) mouse cholangiopathy model by promoting biliary HCO(-)(3) output. Hepatology 2011, 54:1303-1312.
-
(2011)
Hepatology
, vol.54
, pp. 1303-1312
-
-
Baghdasaryan, A.1
Claudel, T.2
Gumhold, J.3
Silbert, D.4
Adorini, L.5
Roda, A.6
Vecchiotti, S.7
-
108
-
-
29444434655
-
The human Na+- taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism
-
Eloranta J.J., Jung D., Kullak-Ublick G.A. The human Na+- taurocholate cotransporting polypeptide gene is activated by glucocorticoid receptor and peroxisome proliferator-activated receptor-gamma coactivator-1alpha, and suppressed by bile acids via a small heterodimer partner-dependent mechanism. Mol Endocrinol 2006, 20:65-79.
-
(2006)
Mol Endocrinol
, vol.20
, pp. 65-79
-
-
Eloranta, J.J.1
Jung, D.2
Kullak-Ublick, G.A.3
-
109
-
-
33644867569
-
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
-
Inagaki T., Moschetta A., Lee Y.K., Peng L., Zhao G., Downes M., Yu R.T., et al. Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor. Proc Natl Acad Sci U S A 2006, 103:3920-3925.
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 3920-3925
-
-
Inagaki, T.1
Moschetta, A.2
Lee, Y.K.3
Peng, L.4
Zhao, G.5
Downes, M.6
Yu, R.T.7
-
110
-
-
56149085041
-
X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response
-
Farnesoid
-
Wang Y.D., Chen W.D., Wang M., Yu D., Forman B.M., Huang W., Farnesoid X receptor antagonizes nuclear factor kappaB in hepatic inflammatory response. Hepatology 2008, 48:1632-1643.
-
(2008)
Hepatology
, vol.48
, pp. 1632-1643
-
-
Wang, Y.D.1
Chen, W.D.2
Wang, M.3
Yu, D.4
Forman, B.M.5
Huang, W.6
-
111
-
-
77952674868
-
The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis
-
Mencarelli A., Renga B., Migliorati M., Cipriani S., Distrutti E., Santucci L., Fiorucci S. The bile acid sensor farnesoid X receptor is a modulator of liver immunity in a rodent model of acute hepatitis. J Immunol 2009, 183:6657-6666.
-
(2009)
J Immunol
, vol.183
, pp. 6657-6666
-
-
Mencarelli, A.1
Renga, B.2
Migliorati, M.3
Cipriani, S.4
Distrutti, E.5
Santucci, L.6
Fiorucci, S.7
-
112
-
-
24144461617
-
VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium
-
Chignard N., Mergey M., Barbu V., Finzi L., Tiret E., Paul A., Housset C. VPAC1 expression is regulated by FXR agonists in the human gallbladder epithelium. Hepatology 2005, 42:549-557.
-
(2005)
Hepatology
, vol.42
, pp. 549-557
-
-
Chignard, N.1
Mergey, M.2
Barbu, V.3
Finzi, L.4
Tiret, E.5
Paul, A.6
Housset, C.7
-
113
-
-
24744436939
-
Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers
-
Lee F.Y., Kast-Woelbern H.R., Chang J., Luo G., Jones S.A., Fishbein M.C., Edwards P.A. Alpha-crystallin is a target gene of the farnesoid X-activated receptor in human livers. J Biol Chem 2005, 280:31792-31800.
-
(2005)
J Biol Chem
, vol.280
, pp. 31792-31800
-
-
Lee, F.Y.1
Kast-Woelbern, H.R.2
Chang, J.3
Luo, G.4
Jones, S.A.5
Fishbein, M.C.6
Edwards, P.A.7
-
114
-
-
0037101810
-
6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
-
Pellicciari R., Fiorucci S., Camaioni E., Clerici C., Costantino G., Maloney P.R., Morelli A., et al. 6alpha-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity. J Med Chem 2002, 45:3569-3572.
-
(2002)
J Med Chem
, vol.45
, pp. 3569-3572
-
-
Pellicciari, R.1
Fiorucci, S.2
Camaioni, E.3
Clerici, C.4
Costantino, G.5
Maloney, P.R.6
Morelli, A.7
-
115
-
-
84878669043
-
-
Hepatology, San Francisco, CA
-
Kowdley K.V., Luketic V.A., Jones D.E., Chapman R.W., Burroughs A.K., Hirschfield G.M., Poupon R., et al. The first new monotherapy therapeutic PBC study in a decade? An international study evaluating the farnesoid X receptor agonist obeticholic acid in PBC 2011, 416A-417A. Hepatology, San Francisco, CA.
-
(2011)
The first new monotherapy therapeutic PBC study in a decade? An international study evaluating the farnesoid X receptor agonist obeticholic acid in PBC
-
-
Kowdley, K.V.1
Luketic, V.A.2
Jones, D.E.3
Chapman, R.W.4
Burroughs, A.K.5
Hirschfield, G.M.6
Poupon, R.7
-
116
-
-
80053334535
-
An international study evaluating the farnesoid X receptor agonist obeticholic acid as monotherapy in PBC
-
55, 46th Annual Meeting of the European-Association-for-the-Study-of-the-Liver (EASL); 2011 Mar 30-Apr 3
-
Kowdley K.V., Jones D., Luketic V., Chapman R., Burroughs A., Hirschfield G., Poupon R., et al. An international study evaluating the farnesoid X receptor agonist obeticholic acid as monotherapy in PBC. J Hepatol 2011, S13. 55.
-
(2011)
J Hepatol
-
-
Kowdley, K.V.1
Jones, D.2
Luketic, V.3
Chapman, R.4
Burroughs, A.5
Hirschfield, G.6
Poupon, R.7
-
117
-
-
78651098672
-
Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators
-
Sharma R., Prichard D., Majer F., Byrne A.M., Kelleher D., Long A., Gilmer J.F. Ursodeoxycholic acid amides as novel glucocorticoid receptor modulators. J Med Chem 2011, 54:122-130.
-
(2011)
J Med Chem
, vol.54
, pp. 122-130
-
-
Sharma, R.1
Prichard, D.2
Majer, F.3
Byrne, A.M.4
Kelleher, D.5
Long, A.6
Gilmer, J.F.7
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