Hepatoprotection by the farnesoid X receptor agonist GW4064 in rat models of intra- and extrahepatic cholestasis

Journal of Clinical Investigation

Volumn 112, Issue 11, 2003, Pages 1678-1687

  Liu, Yaping ^a   Binz, Jane ^a   Numerick, Mary Jo ^a   Dennis, Steve ^a   Luo, Guizhen ^a   Desai, Bhasha ^a   MacKenzie, Kathleen I ^a   Mansfield, Traci A ^b   Kliewer, Steven A ^a   Goodwin, Bryan ^a   Jones, Stacey A ^a  

^a GLAXOSMITHKLINE   (United States)

^b CURAGEN CORPORATION   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 NAPHTHYL ISOTHIOCYANATE; 3 [2 [2 CHLORO 4 [3 (2,6 DICHLOROPHENYL) 5 ISOPROPYL 4 ISOXAZOLYLMETHOXY]PHENYL]VINYL]BENZOIC ACID; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; ENZYME; FARNESOID X RECEPTOR; FARNESOID X RECEPTOR AGONIST; FLIPPASE; LACTATE DEHYDROGENASE; MULTIDRUG RESISTANCE PROTEIN 2; PHOSPHOLIPID; UNCLASSIFIED DRUG;

ADOLESCENT; ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILE ACID METABOLISM; BILE ACID SYNTHESIS; BILE ACID TRANSPORT; BILE DUCT; BYLER DISEASE; CONTROLLED STUDY; EXTRAHEPATIC BILE DUCT OBSTRUCTION; GENE; GENE EXPRESSION; GENE INDUCTION; GENE REPRESSION; GENETIC DISORDER; GENETIC TRANSCRIPTION; HISTOPATHOLOGY; INTRAHEPATIC CHOLESTASIS; LACTATE DEHYDROGENASE BLOOD LEVEL; LIVER DISEASE; LIVER INJURY; LIVER NECROSIS; LIVER PROTECTION; MALE; MDR2 GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RAT;

EID: 0346690402     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI18945     Document Type: Article

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