The effect of peroxisome-proliferator-activated receptor-α on the activity of the cholesterol 7α-hydroxylase gene

Biochemical Journal

Volumn 351, Issue 3, 2000, Pages 747-753

  Patel, D D ^a   Knight, B L ^a   Soutar, A K ^a   Gibbons, G F ^a   Wade, D P ^a  

^a HAMMERSMITH HOSPITAL   (United Kingdom)

Author keywords

Diurnal rhythm; Gene promoter; PPAR null mice; Transcription

Indexed keywords

ALITRETINOIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; MESSENGER RNA; NUCLEAR FACTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; RETINOIC ACID RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING SITE; CHOLESTEROL METABOLISM; CIRCADIAN RHYTHM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME ACTIVITY; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; TRANSCRIPTION REGULATION;

ANIMALS; BASE SEQUENCE; CELL LINE; CHOLESTEROL 7-ALPHA-HYDROXYLASE; DNA PRIMERS; HUMANS; MICE; MICE, KNOCKOUT; PROMOTER REGIONS (GENETICS); RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 0034331437     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/0264-6021:3510747     Document Type: Article

References (37)

1. Cholesterol 7α-hydroxylase
2. Bile acid biosynthesis
3. Disruption of cholesterol 7α-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation
4. Adenovirus-mediated transfer of a gene encoding cholesterol 7α-hydroxylase into hamsters increases hepatic enzyme activity and reduces plasma total and low density lipoprotein cholesterol
5. Linkage between cholesterol 7α-hydroxylase and high plasma low-density lipoprotein cholesterol concentrations
6. Regulation of cholesterol 7α-hydroxylase in the liver. Cloning, sequencing, and regulation of cholesterol 7α-hydroxylase mRNA
7. Regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by tau??ocholate and cholesterol in the chronic biliary diverted rat
8. Transcriptional regulation of the human cholesterol 7α-hydroxylase gene
9. Hormonal regulation of cholesterol 7α-hydroxylase mRNA levels and transcriptional activity in primary rat hepatocyte cultures
10. Transcriptional regulation of cholesterol 7α-hydroxylase mRNA by conjugated bile acids in primary cultures of rat hepatocytes
11. Hormonal regulation of the cholesterol 7α-hydroxylase gene (CYP7)
12. Feedback regulation of hepatic 7α-hydroxylase expression by bile salts in the hamster
13. Characterization of hepatic-specific regulatory elements in the promoter region of the human cholesterol 7α-hydroxylase gene
14. Transcriptional activation of the cholesterol 7α-hydroxylase gene (CYP7A) by nuclear hormone receptors
15. Expression of the human cholesterol 7α-hydroxylase gene in transgenic mice
16. Identification and characterization of a putative bile acid-responsive element in cholesterol 7α-hydroxylase gene promoter
17. Identification of a bile acid response element in the cholesterol 7α-hydroxylase gene CYP7A
18. Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7α-hydroxylase gene (CYP7A)
19. Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway
20. Endogenous bile acids are ligands for the nuclear receptor FXR/BAR
21. HNF4 and COUP-TFII interact to modulate transcription of the cholesterol 7α-hydroxylase gene (CYP7A1)
22. Hepatocyte nuclear factor 1 binds to and transactivates the human but not the rat CYP7A1 promoter
23. CPF: An orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7α-hydroxylase gene
24. Peroxisome proliferatcr-activated receptors: A nuclear receptor signaling pathway in lipid physiology
25. Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression
26. Activation of a member of the steroid hormone receptor superfamily by peroxisome proliferators
27. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators
28. Effects of different phenotypes of hyperlipoproteinemia and of treatment with fibric acid derivatives on the rates of cholesterol 7α-hydroxylation in humans
29. Peroxisome proliferator-activated receptor alpha inhibits hepatic S14 gene transcription. Evidence against the peroxisome proliferator-activated receptor alpha as the mediator of polyunsaturated fatty acid regulation of S14 gene transcription
30. The orphan nuclear hormone receptor LXRα interacts with the peroxisome proliterator-activated receptor and inhibits peroxisome proliferator signalling
31. Characterization of multiple enhancer regions upstream of the apolipoprotein(a) gene
32. The mouse peroxisome proliferator activated receptor recognizes a response element in the 5' flanking sequence of the rat acyl CoA oxidase gene
33. Convergence of 9-cis-retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors
34. Single step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
35. Increasing the complexity of coactivation in nuclear receptor signaling
36. Peroxisome proliferator-activated receptors: Structures and function