Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors

Journal of Clinical Investigation

Volumn 101, Issue 10, 1998, Pages 2092-2100

  Trauner, Michael ^a,b   Arrese, Marco ^a   Lee, Hyejin ^a   Boyer, James L ^a   Karpen, Saul J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF GRAZ   (Austria)

Author keywords

Bile acid transport; Endotoxin; Hepatocyte nuclear factor 1; ntcp; Transcription factors

Indexed keywords

BILE ACID; FOOTPRINT B BINDING PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; NUCLEAR FACTOR I; SALMONELLA ENDOTOXIN; TAUROCHOLIC ACID; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE ACID METABOLISM; CELL TRANSPORT; CHOLESTASIS; CONTROLLED STUDY; ENDOTOXEMIA; GENE EXPRESSION; INTRAHEPATIC BILE DUCT; LIVER CELL; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA INTERACTION; PROTEIN EXPRESSION; RAT; SEPSIS; TRANSCRIPTION REGULATION;

EID: 0032524012     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI1680     Document Type: Article

References (59)

1. Smith, E. 1884. Practical Treatise on Disease in Children. William Wood & Company, New York. 714-721.
2. Dunham, E.C. 1933. Septicemia in the newborn. Am. J. Dis. Child. 45: 229-253.
3. Hamilton, J.R., and A. Sass-Kortsak. 1963. Jaundice associated with severe bacterial infection in young infants. J. Pediatr. 63:121-132.
4. Zimmerman, H.J., M. Fang, R. Utili, L.B. Seef, and J. Hoofnagle. 1979. Jaundice due to bacterial infection. Gastroenterology. 77:362-374.
5. Pirovino, M., F. Meister, E. Rubli, and G. Karlagunis. 1989. Preserved cytosolic and synthetic liver function in jaundice of severe extrahepatic infection. Gastroenterology. 96:1589-1595.
6. Moshage, H. 1997. Cytokines and the hepatic acute phase response. J. Pathol. 181:257-266.
7. Crawford, J.M. 1997. Cellular and molecular biology of the inflamed liver. Curr. Opin. Gastroenterol. 13:175-185.
8. Moseley, R.H. 1997. Sepsis-associated cholestasis. Gastroenterology. 112: 302-306.
9. Jones, A., P.J. Selby, C. Viner, S. Hobbs, M.E. Gore, and T.J. McElwain. 1990. Tumour necrosis factor, cholestatic jaundice, and chronic liver disease. Gut. 31:938-939.
10. Utili, R., C.O. Abernathy, and H.J. Zimmerman. 1976. Cholestatic effects of Escherichia coli endotoxin on ihe isolated perfused rat liver. Gastroenterology. 70:248-253.
11. Rustgi, V.K., D.B. Jones, C.A. Dinarello, and J.H. Hoofnagle. 1987. Lymphokines and bile secretion in the rat. Liver. 7:149-154.
12. Roelofsen, H., C.N. van der Veere, R. Ottenhoff, B. Schoemaker, P.L. Jansen, and R.P. Elferink. 1994. Decreased bilirubin transport in the perfused liver of endotoxemic rats. Gastroenterology. 107:1075-1084.
13. Roelofsen, H., B. Schoemaker, C. Bakker, R. Ottenhoff, P.L. Jansen, and R.P. Elferink. 1995. Impaired hepatocanalicular organic anion transport in endotoxemic rats. Am. J. Physiol. 269:G427-G434.
14. Whiting, J.F., R.M. Green, A.B. Rosenbluth, and J.L. Gollan. 1995. Tumor necrosis factor-alpha decreases hepatocyte bile salt uptake and mediates endotoxin-induced cholestasis. Hepatology. 22:1273-1278.
15. Moseley, R.H., W. Wang, H. Takeda, K. Lown, L. Shick, M. Ananthanarayanan, and F.J. Suchy. 1996. Effect of endotoxin on bile acid transport in rat liver: a potential model for sepsis-associated cholestasis. Am. J. Physiol. 271: G137-G146.
16. Bolder, U., H.T. Ton-Nu, C.D. Schteingart, E. Frick, and A.F. Hofmann. 1997. Hepatocyte transport of bile acids and organic anions in endotoxemic rats: impaired uptake and secretion. Gastroenterology. 112:214-225.
17. 3-excretion and blocks the choleretic effect of nitric oxide in rat liver. Hepatology. 25:1184-1191.
18. Trauner, M., M. Arrese, C.J. Soroka, M. Ananthanarayanan, T.A. Koeppel, S.F. Schlosser, F.J. Suchy, D. Keppler, and J.L. Boyer. 1997. The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology. 113:255-264.
19. Meier, P.J. 1995. Molecular mechanisms of hepatic bile salt transport from sinusoidal blood into bile. Am. J. Physiol. 269:G801-G812.
20. Green, R.M., D. Beier, and J.L. Gollan. 1996. Regulation of hepatocyte bile salt transporters by endotoxin and inflammatory cytokines in rodents. Gastroenterology. 111:193-198.
21. Karpen, S.J., A.-Q. Sun, B. Kudish, B. Hagenbuch, P.J. Meier, M. Ananthanarayanan, and F.J. Suchy. 1996. Multiple factors regulate the rat liver basolateral sodium-dependent bile acid cotransporter gene promoter. J. Biol. Chem. 271:15211-15221.
22. Ganguly, T.C., M.L. O'Brien, S.J. Karpen, J.F. Hyde, F.J. Suchy, and M. Vore. 1997. Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5. J. Clin. Invest. 99:2906-14.
23. Boyer, J.L., J.M. Phillips, and J. Graf. 1990. Preparation and specific applications of isolated hepatocyte couplets. Methods Enzymol. 192:501-516.
24. Simon, F.R., J. Fortune, M. Iwahashi, C. Gartung, A. Wolkoff, and E. Sutherland. 1996. Ethinyl estradiol cholestasis involves alterations in expression of liver sinusoidal transporters. Am. J. Physiol. 271:G1043-G1052.
25. Bradford, M.M. 1976. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:248-254.
26. Ananthanarayanan, M., O.C. Ng, J.L. Boyer, and F.J. Suchy. 1994. Characterization of cloned rat liver Na(+)-bile acid cotransporter using peptide and fusion protein antibodies. Am. J. Physiol. 267:G637-G643.
27. Chirgwin, J.M., A.E. Przybyla, R.J. MacDonald, and W.J. Rutter. 1979. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:5294-5299.
28. Chomczynski, P., and N. Sacchi. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162:156-159.
29. Hagenbuch, B., B. Stieger, M. Foguet, H. Lubbert, and P.J. Meier. 1991. Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc. Natl. Acad. Sci. USA. 88:10629-10633.
30. Baumhueter, S., D.B. Mendel, P.B. Conley, C.J. Kuo, C. Turk, M.K. Graves, C.A. Edwards, G. Courtois, and G.R. Crabtree. 1990. HNF-1 shares three sequence motifs with the POU domain proteins and is identical to LF-B1 and APF. Genes Dev. 4:372-379.
31. Sugiyama, K., Y. Hitomi, H. Adachi, and H. Esumi. 1994. Cell type specific patterns of mRNA splicing in hepatoma cells transfected with the mutated albumin minigene of Nagase analbuminemic rats. Cancer Lett. 83:221-227.
32. Gartung, C., M. Ananthanarayanan, M.A. Rahman, S. Schuele, S. Nundy, C.J. Soroka, A. Stolz, F.J. Suchy, and J.L. Boyer. 1996. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic choiestasis. Gastroenterology. 110:199-209.
33. Srivastava, K.K., E.E. Cable, and H.L. Bonkovsky. 1993. Purifying nascent mRNA from nuclear run-on assays using guanidinium isothiocyanate. Biotechniques. 15:226-227.
34. Blumenfeld, M., M. Maury, T. Chouard, M. Yaniv, and H. Condamine. 1991. Hepatic nuclear factor 1 (HNF1) shows a wider distribution than products of its known target genes in developing mouse. Development (Camb.). 113:589-599.
35. Jang, S.I., P.M. Steinert, and N.G. Markova. 1996. Activator protein 1 activity is involved in the regulation of the cell type-specific expression from the proximal promoter of the human profilaggrin gene. J. Biol. Chem. 271:24105-24114.
36. Tronche, F., I. Bach, T. Chouard, B. David-Wattine, M. Pontoglio, F. Ringeisen, D. Sourdive, D. Thepot, and M. Yaniv. 1994. Hepatocyte nuclear factor 1 (HNF1) and liver gene expression. In Liver Gene Expression. F. Tronche and M. Yaniv, editors. R.G. Landes Co., Austin. TX. 155-181.
37. Ram, P.A., S.U. Park, H.K. Choi, and D.J. Waxman. 1996. Growth hormone activation of Stat 1, Stat 3, and Stat 5 in rat liver. Differential kinetics of hormone desensitization and growth hormone stimulation of both tyrosine phosphorylation and serine/threonine phosphorylation. J. Biol. Chem. 271: 5429-5440.
38. Herschman, H.R. 1991. Primary response genes induced by growth factors and tumor promoters. Annu. Rev. Biochem. 60:281-319.
39. Hattori, M., A. Tugores, J.K. Westwick, L. Veloz, H.L. Leffert, M. Karin, and D.A. Brenner. 1993. Activation of activating protein 1 during hepatic acute phase response. Am. J. Physiol. 264:G95-G103.
40. Rollier, A., C.M. DiPersio, S. Cereghini, K. Stevens, F. Tronche, K. Zaret, and M.C. Weiss. 1993. Regulation of albumin gene expression in hepatoma cells of fetal phenotype: dominant inhibition of HNF1 function and role of ubiquitous transcription factors. Mol Biol. Cell. 4:59-69.
41. Pontoglio, M., J. Barra, M. Hadchouel, A. Doyen, C. Kress, J.P. Bach, C. Bahinet, and M. Yaniv. 1996. Hepatocyte nuclear factor 1 inactivation results in hepatic dysfunction, phenylketonuria, and renal Fanconi syndrome. Cell. 84:575-585.
42. Ripperger, J.A., S. Fritz, K. Richter, G.M. Hocke, F. Lottspeich, and G.H. Fey. 1995. Transcription factors Stat3 and Stat5b are present in rat liver nuclei late in an acute phase response and bind interleukin-6 response elements. J. Biol. Chem. 270:29998-30006.
43. Andus, T., J. Bauer, and W. Gerok. 1991. Effects of cytokines on the liver. Hepatology. 13:364-375.
44. Barnes, P.J., and M. Karin. 1997. Nuclear factor-κB: a pivotal transcription factor in chronic inflammatory diseases. N. Engl. J. Med. 336:1066-1071.
45. Baumann, H., and J. Gauldie. 1994. The acute phase response. Immunol. Today. 15:74-80.
46. Perlmutter, D.H., C.A. Dinarello, P.I. Punsal, and H.R. Colten. 1986. Cachectin/tumor necrosis factor regulates hepatic acute-phase gene expression. J. Clin. Invest. 78:1349-1354.
47. Hoffmann, R., M. Grewe, H.C. Estler, A. Schulze-Specking, and K. Decker. 1994. Regulation of tumor necrosis factor-alpha-mRNA synthesis and distribution of tumor necrosis factor-alpha-mRNA synthesizing cells in rat liver during experimental endotoxemia. J. Hepatol. 20:122-128.
48. Green, R.M., J.F. Whiting, A.B. Rosenbluth, D. Beier, and J.L. Gollan. 1994. Interleukin-6 inhibits hepatocyte taurocholate uptake and sodium-potassium-adenosinetriphosphatase activity. Am. J. Physiol. 267:G1094-G1100.
49. Perlmutter, D.H., G. Goldberger, C.A. Dinarello, S.B. Mizel, and H.R. Colten. 1986. Regulation of class III major histocompatibility complex gene products by interleukin-1. Science. 232:850-852.
50. Brenner, D.A., M. Buck, S.P. Feitelberg, and M. Chojkier. 1990. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. J. Clin. Invest. 85:248-255.
51. Deutschman, C.S., B.A. Haber, K. Andrejko, D.E. Cressman, R. Harrison, E. Elenko, and R. Taub. 1996. Increased expression of cytokine-induced neutrophil chemoattractant in septic rat liver. Am. J. Physiol. 271:R593-R600.
52. Banerjee, R., S. Karpen, M. Siekevitz, G. Lengyel, J. Bauer, and G. Acs. 1989. Tumor necrosis factor-alpha induces a kappa B sequence-specific DNA-binding protein in human hepatoblastoma HepG2 cells. Hepatology. 10:1008-1013.
53. Hu, J., and H.C. Isom. 1994. Suppression of albumin enhancer activity by H-ras and AP-1 in hepatocyte cell lines. Mol. Cell. Biol. 14:1531-1543.
54. Nolan, J.P. 1989. Intestinal endotoxins as mediators of hepatic injury -an idea whose time has come again. Hepatology. 10:887-891.
55. Mentes, B.B., E. Tatlicioglu, G. Akyol, O. Uluoglu, N. Sultan, E. Yilmaz, M. Celebi, F. Taneri, and Z. Ferahkose. 1996. Intestinal endotoxins as cofactors of liver injury in obstructive jaundice. HPB Surg. 9:61-69.
56. Gartung, C., S. Schuele, S.F. Schlosser, and J.L. Boyer. 1997. Expression of the rat liver Na+/taurocholate cotransporter is regulated in vivo by retention of biliary constituents but not their depletion. Hepatology. 25:284-290.
57. Van Bossuyt, H., C. Desmaretz, G.B. Gaeta, and E. Wisse. 1990. The role of bile acids in the development of endotoxemia during obstructive jaundice in the rat. J. Hepatol. 10:274-279.
58. Karpen, S.J., M. Ananthanarayanan, T. Potselueva, and F.J. Suchy. 1995. Bile acids suppress the rat liver Na+-dependent bile acid cotransporter gene promoter. Hepatology. 22:318a. (Abstr.)
59. Stroup, D., M. Crestani, and J.Y.L. Chiang. 1997. Identification of a bile acid response element in the cholesterol 7-α-hydroxylase gene (cyp7α). Am. J. Physiol. 273:G508-G517.