Ostα depletion protects liver from oral bile acid load

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 301, Issue 3, 2011, Pages

  Soroka, Carol J ^a   Velazquez, Heino ^b   Mennone, Albert ^a   Ballatori, Nazzareno ^c   Boyer, James L ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b George M O'Brien Kidney Center at Yale   (United States)

^c UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Bile acid homeostasis; Bile acids; Intestine; Kidney

Indexed keywords

BILE ACID; CHOLIC ACID; ORGANIC COMPOUND; ORGANIC SOLUTE TRANSPORTER ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILE ACID SYNTHESIS; CONTROLLED STUDY; FECES; INTESTINE FUNCTION; INULIN CLEARANCE; KIDNEY CLEARANCE; KIDNEY FUNCTION; LIVER INJURY; LIVER PROTECTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BILE ACIDS AND SALTS; CHOLIC ACID; FECES; INTESTINES; KIDNEY; LIVER; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; ORGANIC ANION TRANSPORTERS, SODIUM-DEPENDENT; SYMPORTERS;

EID: 80052287770     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00141.2011     Document Type: Article

References (19)

1. Ballatori N, Fang F, Christian WV, Li N, Hammond CL. Ostalpha-Ostbeta is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver. Am J Physiol Gastrointest Liver Physiol 295: G179-G186, 2008.
2. Boyer JL. New perspectives for the treatment of cholestasis: lessons from basic science applied clinically. J Hepatol 46: 365-371, 2007.
3. Boyer JL, Trauner M, Mennone A, Soroka CJ, Cai SY, Mounstafa T, Zollner G, Lee JY, Ballatori N. Upregulation of a basolateral RXRdependent bile acid efflux transporter OSTα-OSTβ in cholestasis in humans and rodents. Am J Physiol Gastrointest Liver Physiol 290: G1124-G1130, 2006.
4. Chen J, Terada T, Ogasawara K, Katsura T, Inui Ki. Adaptive responses of renal organic anion transporter 3 (OAT3) during cholestasis. Am J Physiol Renal Physiol 295: F247-F252, 2008
5. Christie DM, Dawson PA, Thevananther S, Shneider BL. Comparative analysis of the ontogeny of a sodium-dependent bile acid transporter in rat kidney and ileum. Am J Physiol Gastrointest Liver Physiol 271: G377-G385, 1996.
6. Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA. Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol Gastrointest Liver Physiol 274: G157-G169, 1998.
7. Gregg JA. Presence of bile acids in jaundiced human urine. Nature 214: 29-31, 1967.
8. Hofmann Bile Acids AF. In: The Liver: Biology and Pathobiology, edited by Arias IM, Boyer JL, Fausto N, Jakoby WB, Schachter D, Shafritz DA. New York: Raven, 1994, p. 677-717.
9. Jung D, Inagaki T, Gerard RD, Dawson PA, Kliewer SA, Mangelsdorf DJ, Moschetta A. FXR agonists and FGF15 reduce fecal bile acid excretion in a mouse model of bile acid malabsorption. J Lipid Res 48: 2693-2700, 2007.
10. Kim I, Ahn SH, Inagaki T, Choi M, Ito S, Guo GL, Kliewer SA, Gonzalez FJ. Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine. J Lipid Res 48: 2664-2672, 2007.
11. Li N, Cui Z, Fang F, Lee JY, Ballatori N. Heterodimerization, trafficking and membrane topology of the two proteins, OSTα and OSTα, that constiture the organic solute and steroid transporter. Biochem J 407: 363-372, 2007.
12. Makino I, Hashimoto H, Shinozaki K, Yoshino K, Nakagawa S. Sulfated and nonsulfated bile acids in urine, serum, and bile of patients with hepatobiliary diseases. Gastroenterology 68: 545-553, 1975.
13. Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA. The organic solute transporter a-b, Osta-Ostb, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci USA 105: 3891-3896, 2008.
14. Rodrigo R, Avalos N, Orellana M, Bosco C, Thielemann L. Renal effects of experimental obstructive jaundice: morphological and functional assessment. Arch Med Res 30: 275-285, 1999.
15. Rudman D, Kendall FE. Bile acid content of human serum. II. The binding of cholanic acids by human plasma proteins. J Clin Invest 36: 538-542, 1957.
16. Schlattjan JH, Winter C, Greven J. Regulation of renal tubular bile acid transport in the early phase of an obstructive cholestasis in the rat. Nephron Physiol 95: 49-56, 2003.
17. Soroka CJ, Mennone A, Hagey L, Ballatori N, Boyer JL. Organic solute transporter _ deficiency enhances renal excretion of bile acids and attenuates cholestasis. Hepatology 51: 181-190, 2010.
18. van Berge Henegouwen GP, Brandt KH, Eyssen H, Parmentier G. Sulphated and unsulphated bile acids in serum, bile, and urine of patients with cholestasis. Gut 17: 861-869, 1976.
19. Zollner G, Marschall HU, Wagner M, Trauner M. Role of nuclear receptors in the adaptive response to bile acids and cholestasis: pathogenetic and therapeutic considerations. Mol Pharmaceutics 3: 231-251, 2006.