메뉴 건너뛰기




Volumn 51, Issue 1, 2010, Pages 181-190

Mouse organic solute transporter α deficiency enhances renal excretion of bile acids and attenuates cholestasis

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BILIRUBIN; CARRIER PROTEIN; CHOLESTEROL 7ALPHA MONOOXYGENASE; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 3A11; GLUCURONOSYLTRANSFERASE 1A1; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 2; MULTIDRUG RESISTANCE PROTEIN 3; MULTIDRUG RESISTANCE PROTEIN 4; ORGANIC SOLUTE TRANSPORTER ALPHA; UNCLASSIFIED DRUG;

EID: 73449095758     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.23265     Document Type: Article
Times cited : (72)

References (25)
  • 2
    • 41649089141 scopus 로고    scopus 로고
    • The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis
    • Rao A, Haywood J, Craddock AL, Belinsky MG, Kruh GD, Dawson PA. The organic solute transporter α-β, Ostα-Ostβ, is essential for intestinal bile acid transport and homeostasis. Proc Natl Acad Sci U S A 2008;105:3891-3896.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 3891-3896
    • Rao, A.1    Haywood, J.2    Craddock, A.L.3    Belinsky, M.G.4    Kruh, G.D.5    Dawson, P.A.6
  • 3
    • 30844460667 scopus 로고    scopus 로고
    • OSTα-OSTβ: A major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia
    • Ballatori N, Christian WV, Lee JY, Dawson PA, Soroka CJ, Boyer JL, et al. OSTα-OSTβ: a major basolateral bile acid and steroid transporter in human intestinal, renal, and biliary epithelia. HEPATOLOGY 2005;42:1270-1279.
    • (2005) HEPATOLOGY , vol.42 , pp. 1270-1279
    • Ballatori, N.1    Christian, W.V.2    Lee, J.Y.3    Dawson, P.A.4    Soroka, C.J.5    Boyer, J.L.6
  • 4
    • 14844291348 scopus 로고    scopus 로고
    • The heteromeric organic solute transporter alpha-beta, Ostα-Ostβ, is an ileal basolateral bile acid transporter
    • Dawson PA, Hubbert HJ, Craddock AL, Zeranque N, Christian WV, Ballatori N. The heteromeric organic solute transporter alpha-beta, Ostα-Ostβ, is an ileal basolateral bile acid transporter. J Biol Chem 2005;280:6960-6968.
    • (2005) J Biol Chem , vol.280 , pp. 6960-6968
    • Dawson, P.A.1    Hubbert, H.J.2    Craddock, A.L.3    Zeranque, N.4    Christian, W.V.5    Ballatori, N.6
  • 5
    • 27844546989 scopus 로고    scopus 로고
    • Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
    • Inagaki T, Choi M, Moschetta A, Peng L, Cummins CL, McDonald JG, et al. Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis. Cell Metab 2005;2:217-225.
    • (2005) Cell Metab , vol.2 , pp. 217-225
    • Inagaki, T.1    Choi, M.2    Moschetta, A.3    Peng, L.4    Cummins, C.L.5    McDonald, J.G.6
  • 6
    • 0041344702 scopus 로고    scopus 로고
    • Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ
    • Seward DJ, Koh AS, Boyer JL, Ballatori N. Functional Complementation between a Novel Mammalian Polygenic Transport Complex and an Evolutionarily Ancient Organic Solute Transporter, OSTα-OSTβ. J Biol Chem 2003;278:27473-27482.
    • (2003) J Biol Chem , vol.278 , pp. 27473-27482
    • Seward, D.J.1    Koh, A.S.2    Boyer, J.L.3    Ballatori, N.4
  • 7
    • 0035979303 scopus 로고    scopus 로고
    • Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate
    • Wang W, Seward DJ, Li L, Boyer JL, Ballatori N. Expression cloning of two genes that together mediate organic solute and steroid transport in the liver of a marine vertebrate. Proc Natl Acad Sci U S A 2001;98:9431-9436.
    • (2001) Proc Natl Acad Sci U S A , vol.98 , pp. 9431-9436
    • Wang, W.1    Seward, D.J.2    Li, L.3    Boyer, J.L.4    Ballatori, N.5
  • 9
    • 33645839049 scopus 로고    scopus 로고
    • Coordinated induction of bile acid detoxification and alternative elimination in mice: Role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids
    • Zollner G, Wagner M, Mounstafa T, Ficket P, Silbert D, Gumhold J, et al. Coordinated induction of bile acid detoxification and alternative elimination in mice: role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids. Am J Physiol Gastrointest Liver Physiol 2006;290:G923-G932.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Zollner, G.1    Wagner, M.2    Mounstafa, T.3    Ficket, P.4    Silbert, D.5    Gumhold, J.6
  • 10
    • 33846821743 scopus 로고    scopus 로고
    • New perspectives for the treatment of cholestasis: Lessons from basic science applied clinically
    • Boyer JL. New perspectives for the treatment of cholestasis: lessons from basic science applied clinically. J Hepatol 2007;46:365-371.
    • (2007) J Hepatol , vol.46 , pp. 365-371
    • Boyer, J.L.1
  • 11
    • 48749087514 scopus 로고    scopus 로고
    • Bile acid transporters in health and disease
    • Kosters A, Karpen SJ. Bile acid transporters in health and disease. Xenobiotica 2008;38:1043-1071.
    • (2008) Xenobiotica , vol.38 , pp. 1043-1071
    • Kosters, A.1    Karpen, S.J.2
  • 13
    • 33644910207 scopus 로고    scopus 로고
    • Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides
    • Zelcer N, van de Wetering K, de Waart R, Scheffer GL, Marschall H-U, Wielinga PR, et al. Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol 2006;44:768-775.
    • (2006) J Hepatol , vol.44 , pp. 768-775
    • Zelcer, N.1    van de Wetering, K.2    de Waart, R.3    Scheffer, G.L.4    Marschall, H.-U.5    Wielinga, P.R.6
  • 14
    • 33646541411 scopus 로고    scopus 로고
    • Mrp4 -/- mice have an impaired cytoprotective response in obstructive cholestasis
    • Mennone A, Soroka CJ, Cai S-Y, Harry K, Adachi M, Hagey L, et al. Mrp4 -/- mice have an impaired cytoprotective response in obstructive cholestasis. HEPATOLOGY 2006;43:1013-1021.
    • (2006) HEPATOLOGY , vol.43 , pp. 1013-1021
    • Mennone, A.1    Soroka, C.J.2    Cai, S.-Y.3    Harry, K.4    Adachi, M.5    Hagey, L.6
  • 15
    • 35748954385 scopus 로고    scopus 로고
    • Heterodimerization, trafficking and membrane topology of the two proteins, Ostα and Ostβ, that constiture the organic solute and steroid transporter
    • Li N, Cui Z, Fang F, Lee JY, Ballatori N. Heterodimerization, trafficking and membrane topology of the two proteins, Ostα and Ostβ, that constiture the organic solute and steroid transporter. Biochem J 2007;407:363-372.
    • (2007) Biochem J , vol.407 , pp. 363-372
    • Li, N.1    Cui, Z.2    Fang, F.3    Lee, J.Y.4    Ballatori, N.5
  • 16
    • 0030027622 scopus 로고    scopus 로고
    • Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis
    • Gartung C, Ananthanarayanan M, Rahman M, Schuele S, Nundy S, Soroka CJ, et al. Down-regulation of expression and function of the rat liver Na+/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology 1996;110:199-209.
    • (1996) Gastroenterology , vol.110 , pp. 199-209
    • Gartung, C.1    Ananthanarayanan, M.2    Rahman, M.3    Schuele, S.4    Nundy, S.5    Soroka, C.J.6
  • 17
    • 0030963906 scopus 로고    scopus 로고
    • The rat canalicular conjugate export pump (mrp2) is down-regulated in intrahepatic and obstructive cholestasis
    • Trauner M, Arrese M, Soroka CJ, Ananthanarayannan M, Koeppel T, Schlosser S, et al. The rat canalicular conjugate export pump (mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 1997;113:255-264.
    • (1997) Gastroenterology , vol.113 , pp. 255-264
    • Trauner, M.1    Arrese, M.2    Soroka, C.J.3    Ananthanarayannan, M.4    Koeppel, T.5    Schlosser, S.6
  • 18
    • 33144465413 scopus 로고    scopus 로고
    • Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice
    • Fickert P, Fuchsbichler A, Marschall H-U, Wagner M, Zollner G, Krause R, et al. Lithocholic acid feeding induces segmental bile duct obstruction and destructive cholangitis in mice. Am J Pathol 2006;168:410-422.
    • (2006) Am J Pathol , vol.168 , pp. 410-422
    • Fickert, P.1    Fuchsbichler, A.2    Marschall, H.-U.3    Wagner, M.4    Zollner, G.5    Krause, R.6
  • 19
    • 0346100571 scopus 로고    scopus 로고
    • Enterohepatic bile salt transporters in normal physiology and liver disease
    • Kullak-Ublick GA, Stieger B, Meier PJ. Enterohepatic bile salt transporters in normal physiology and liver disease. Gastroenterology 2004;126:322-342.
    • (2004) Gastroenterology , vol.126 , pp. 322-342
    • Kullak-Ublick, G.A.1    Stieger, B.2    Meier, P.J.3
  • 20
    • 4344632950 scopus 로고    scopus 로고
    • Mrp4 confers resistance to topotecan and protects the brain from chemotherapy
    • Leggas M, Adachi M, Scheffer GL, Sun D, Wielinga P, Du G, et al. Mrp4 confers resistance to topotecan and protects the brain from chemotherapy. Mol Cell Biol 2004;24:7612-7621.
    • (2004) Mol Cell Biol , vol.24 , pp. 7612-7621
    • Leggas, M.1    Adachi, M.2    Scheffer, G.L.3    Sun, D.4    Wielinga, P.5    Du, G.6
  • 21
    • 0242665373 scopus 로고    scopus 로고
    • Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
    • Guo GL, Lambert G, Negishi M, Ward JM, Brewer HB Jr, Kliewer SA, et al. Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity. J Biol Chem 2003;278:45062-45071.
    • (2003) J Biol Chem , vol.278 , pp. 45062-45071
    • Guo, G.L.1    Lambert, G.2    Negishi, M.3    Ward, J.M.4    Brewer Jr, H.B.5    Kliewer, S.A.6
  • 22
    • 13844315320 scopus 로고    scopus 로고
    • Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury
    • Stedman CAM, Liddle C, Coulter SA, Sonoda J, Alvarez JGA, Moore DD, et al. Nuclear receptors constitutive androstane receptor and pregnane X receptor ameliorate cholestatic liver injury. Proc Natl Acad Sci U S A 2005;102:2063-2068.
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 2063-2068
    • Stedman, C.A.M.1    Liddle, C.2    Coulter, S.A.3    Sonoda, J.4    Alvarez, J.G.A.5    Moore, D.D.6
  • 23
    • 9144231188 scopus 로고    scopus 로고
    • A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification
    • Saini SPS, Sonoda J, Xu L, Toma D, Uppal H, Mu Y, et al. A novel constitutive androstane receptor-mediated and CYP3A-independent pathway of bile acid detoxification. Mol Pharmacol 2004;65:292-300.
    • (2004) Mol Pharmacol , vol.65 , pp. 292-300
    • Saini, S.P.S.1    Sonoda, J.2    Xu, L.3    Toma, D.4    Uppal, H.5    Mu, Y.6
  • 24
    • 23044436687 scopus 로고    scopus 로고
    • CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
    • Wagner M, Halilbasic E, Marschall H-U, Zollner G, Fickert P, Langner C, et al. CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice. HEPATOLOGY 2005;42:420-430.
    • (2005) HEPATOLOGY , vol.42 , pp. 420-430
    • Wagner, M.1    Halilbasic, E.2    Marschall, H.-U.3    Zollner, G.4    Fickert, P.5    Langner, C.6
  • 25
    • 2542440464 scopus 로고    scopus 로고
    • Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice
    • Assem M, Schuetz EG, Leggas M, Sun D, Yasuda K, Reid G, et al. Interactions between hepatic Mrp4 and Sult2a as revealed by the constitutive androstane receptor and Mrp4 knockout mice. J Biol Chem 2004;279:22250-22257.
    • (2004) J Biol Chem , vol.279 , pp. 22250-22257
    • Assem, M.1    Schuetz, E.G.2    Leggas, M.3    Sun, D.4    Yasuda, K.5    Reid, G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.