The purines: Potent and versatile small molecule inhibitors and modulators of key biological targets

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 12, 2006, Pages 3987-4006

  Legraverend, Michel ^a   Grierson, David S ^a  

^a CNRS   (France)

Author keywords

Agonist; Antagonist; Inhibitor; Purine; Receptor; Therapeutic agents

Indexed keywords

(2 CHLORO 9H PURIN 6 YL)NAPHTHALEN 1 YLMETHYLAMINE; 6 O CYCLOHEXYLMETHYLGUANINE; [4 [2 CYCLOPENTYL 9 (3 HYDROXYPHENETHYL)PURIN 6 YLAMINO]PHENYL]DIMETHYLPHOSPHINE OXIDE; ADENOSINE RECEPTOR BLOCKING AGENT; ADENOSINE RECEPTOR STIMULATING AGENT; AGELASINE F; ALPHA INTERFERON; ANTINEOPLASTIC AGENT; AP 23137; CYCLIN DEPENDENT KINASE INHIBITOR; DIMINUTOL; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; IMATINIB; IMIQUIMOD; INTERFERON INDUCING AGENT; ISTRADEFYLLINE; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; MYOSEVERIN B; NG 38; ON 012380; PHOSPHODIESTERASE INHIBITOR; PROTEIN TYROSINE KINASE INHIBITOR; PURINE DERIVATIVE; PURMORPHAMINE; REVERSINE; ROSCOVITINE; SC 56938; SC 57461A; SILDENAFIL; ST 1535; SULFOTRANSFERASE INHIBITOR; TADALAFIL; THEOPHYLLINE; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; UNINDEXED DRUG; VARDENAFIL; ANTIVIRUS AGENT; ENZYME INHIBITOR; LIGAND;

ASTHMA; AUTOIMMUNE DISEASE; BINDING AFFINITY; BIOLOGICAL ACTIVITY; BONE DISEASE; CELL DIFFERENTIATION; CHRONIC MYELOID LEUKEMIA; CLINICAL TRIAL; CROHN DISEASE; DEGENERATIVE DISEASE; DERMATITIS; DRUG ACTIVITY; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; GASTROINTESTINAL DISEASE; GLOMERULONEPHRITIS; HEPATITIS C; HIGH THROUGHPUT SCREENING; HUMAN; HUNTINGTON CHOREA; LUNG NON SMALL CELL CANCER; LYMPHATIC SYSTEM TUMOR; METHODOLOGY; MICROTUBULE ASSEMBLY; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NONHUMAN; OSTEOPOROSIS; OSTEOSARCOMA; PARKINSON DISEASE; REVIEW; RHEUMATOID ARTHRITIS; TUBERCULOSIS; VIRUS INFECTION; CHEMICAL STRUCTURE; CHEMISTRY; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIVIRAL AGENTS; CELL DIFFERENTIATION; ENZYME INHIBITORS; HUMANS; LIGANDS; MOLECULAR STRUCTURE; PURINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33746827430     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.12.060     Document Type: Review

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